{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:10:48Z","timestamp":1770826248858,"version":"3.50.1"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurodevelop Disord"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurofibromatosis type 1 (NF1) is a monogenic disorder associated with cognitive impairments. In order to understand how mutations in the<jats:italic>NF1<\/jats:italic>gene impact brain structure it is essential to characterize in detail the brain structural abnormalities in patients with NF1. Previous studies have reported contradictory findings and have focused only on volumetric measurements. Here, we investigated the volumes of subcortical structures and the composite dimensions of the cortex through analysis of cortical volume, cortical thickness, cortical surface area and gyrification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 14 children with NF1 and 14 typically developing children matched for age, gender, IQ and right\/left-handedness. Regional subcortical volumes and cortical gyral measurements were obtained using the FreeSurfer software. Between-group differences were evaluated while controlling for the increase in total intracranial volume observed in NF1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subcortical analysis revealed disproportionately larger thalami, right caudate and middle corpus callosum in patients with NF1. Cortical analyses on volume, thickness and surface area were however not indicative of significant alterations in patients. Interestingly, patients with NF1 had significantly lower gyrification indices than typically developing children primarily in the frontal and temporal lobes, but also affecting the insula, cingulate cortex, parietal and occipital regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The neuroanatomic abnormalities observed were localized to specific brain regions, indicating that particular areas might constitute selective targets for<jats:italic>NF1<\/jats:italic>gene mutations. Furthermore, the lower gyrification indices were accompanied by a disproportionate increase in brain size without the corresponding increase in folding in patients with NF1. Taken together these findings suggest that specific neurodevelopmental processes, such as gyrification, are more vulnerable to<jats:italic>NF1<\/jats:italic>dysfunction than others. The identified changes in brain organization are consistent with the patterns of cognitive dysfunction in the NF1 phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1866-1955-5-3","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T01:14:26Z","timestamp":1360804466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities"],"prefix":"10.1186","volume":"5","author":[{"given":"In\u00eas R","family":"Violante","sequence":"first","affiliation":[]},{"given":"Maria J","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Eduardo D","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"30_CR1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/B0-12-370878-8\/00004-5","volume-title":"Evolution of Nervous Systems","author":"P Rakic","year":"2007","unstructured":"Rakic P, Kornack DR: The Development and Evolutionary Expansion of the Cerebral Cortex in Primates. Evolution of Nervous Systems. Edited by: Kaas JH. 2007, Oxford: Academic Press, 243-259."},{"key":"30_CR2","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/nn758","volume":"4","author":"PM Thompson","year":"2001","unstructured":"Thompson PM, Cannon TD, Narr KL, van Erp T, Poutanen VP, Huttunen M, Lonnqvist J, Standertskjold-Nordenstam CG, Kaprio J, Khaledy M, Dail R, Zoumalan CI, Toga AW: Genetic influences on brain structure. Nat Neurosci. 2001, 4: 1253-1258. 10.1038\/nn758.","journal-title":"Nat Neurosci"},{"key":"30_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/1098-2779(2000)6:2<117::AID-MRDD5>3.0.CO;2-X","volume":"6","author":"AE Kayl","year":"2000","unstructured":"Kayl AE, Moore BD: Behavioral phenotype of neurofibromatosis, type 1. Ment Retard Dev Disabil Res Rev. 2000, 6: 117-124. 10.1002\/1098-2779(2000)6:2<117::AID-MRDD5>3.0.CO;2-X.","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"30_CR4","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1212\/01.wnl.0000179303.72345.ce","volume":"65","author":"SL Hyman","year":"2005","unstructured":"Hyman SL, Shores A, North KN: The nature and frequency of cognitive deficits in children with neurofibromatosis type 1. Neurology. 2005, 65: 1037-1044. 10.1212\/01.wnl.0000179303.72345.ce.","journal-title":"Neurology"},{"key":"30_CR5","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/S1474-4422(07)70075-3","volume":"6","author":"RE Ferner","year":"2007","unstructured":"Ferner RE: Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective. Lancet Neurol. 2007, 6: 340-351. 10.1016\/S1474-4422(07)70075-3.","journal-title":"Lancet Neurol"},{"key":"30_CR6","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/aja.1001950307","volume":"195","author":"MM Daston","year":"1992","unstructured":"Daston MM, Ratner N: Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development. Dev Dyn. 1992, 195: 216-226. 10.1002\/aja.1001950307.","journal-title":"Dev Dyn"},{"key":"30_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ccr.2005.07.004","volume":"8","author":"Y Zhu","year":"2005","unstructured":"Zhu Y, Guignard F, Zhao D, Liu L, Burns DK, Mason RP, Messing A, Parada LF: Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell. 2005, 8: 119-130. 10.1016\/j.ccr.2005.07.004.","journal-title":"Cancer Cell"},{"key":"30_CR8","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1523\/JNEUROSCI.5236-07.2008","volume":"28","author":"ME Lush","year":"2008","unstructured":"Lush ME, Li Y, Kwon CH, Chen J, Parada LF: Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci. 2008, 28: 1580-1587. 10.1523\/JNEUROSCI.5236-07.2008.","journal-title":"J Neurosci"},{"key":"30_CR9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.stem.2007.07.008","volume":"1","author":"B Hegedus","year":"2007","unstructured":"Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH: Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 2007, 1: 443-457. 10.1016\/j.stem.2007.07.008.","journal-title":"Cell Stem Cell"},{"key":"30_CR10","doi-asserted-by":"publisher","first-page":"26958","DOI":"10.1074\/jbc.M209413200","volume":"278","author":"S Yunoue","year":"2003","unstructured":"Yunoue S, Tokuo H, Fukunaga K, Feng L, Ozawa T, Nishi T, Kikuchi A, Hattori S, Kuratsu J, Saya H, Araki N: Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras. J Biol Chem. 2003, 278: 26958-26969. 10.1074\/jbc.M209413200.","journal-title":"J Biol Chem"},{"key":"30_CR11","first-page":"170","volume":"1815","author":"A Fernandez-Medarde","year":"2011","unstructured":"Fernandez-Medarde A, Santos E: The RasGrf family of mammalian guanine nucleotide exchange factors. Biochim Biophys Acta. 2011, 1815: 170-188.","journal-title":"Biochim Biophys Acta"},{"key":"30_CR12","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1136\/jnnp.2009.179630","volume":"81","author":"JM Payne","year":"2010","unstructured":"Payne JM, Moharir MD, Webster R, North KN: Brain structure and function in neurofibromatosis type 1: current concepts and future directions. J Neurol Neurosurg Psychiatry. 2010, 81: 304-309. 10.1136\/jnnp.2009.179630.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"30_CR13","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1097\/00001756-199608120-00015","volume":"7","author":"SM Said","year":"1996","unstructured":"Said SM, Yeh TL, Greenwood RS, Whitt JK, Tupler LA, Krishnan KR: MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis. Neuroreport. 1996, 7: 1941-1944. 10.1097\/00001756-199608120-00015.","journal-title":"Neuroreport"},{"key":"30_CR14","first-page":"810","volume":"22","author":"RG Steen","year":"2001","unstructured":"Steen RG, Taylor JS, Langston JW, Glass JO, Brewer VR, Reddick WE, Mages R, Pivnick EK: Prospective evaluation of the brain in asymptomatic children with neurofibromatosis type 1: relationship of macrocephaly to T1 relaxation changes and structural brain abnormalities. AJNR Am J Neuroradiol. 2001, 22: 810-817.","journal-title":"AJNR Am J Neuroradiol"},{"key":"30_CR15","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1017\/S135561770286012X","volume":"8","author":"LE Cutting","year":"2002","unstructured":"Cutting LE, Huang GH, Zeger S, Koth CW, Thompson RE, Denckl MB: Growth curve analyses of neuropsychological profiles in children with neurofibromatosis type 1: specific cognitive tests remain \"spared\" and \"impaired\" over time. J Int Neuropsychol Soc. 2002, 8: 838-846. 10.1017\/S135561770286012X.","journal-title":"J Int Neuropsychol Soc"},{"key":"30_CR16","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1001\/archneur.62.12.1904","volume":"62","author":"RS Greenwood","year":"2005","unstructured":"Greenwood RS, Tupler LA, Whitt JK, Buu A, Dombeck CB, Harp AG, Payne ME, Eastwood JD, Krishnan KR, MacFall JR: Brain morphometry, T2-weighted hyperintensities, and IQ in children with neurofibromatosis type 1. Arch Neurol. 2005, 62: 1904-1908. 10.1001\/archneur.62.12.1904.","journal-title":"Arch Neurol"},{"key":"30_CR17","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1212\/WNL.54.4.914","volume":"54","author":"BD Moore 3rd","year":"2000","unstructured":"Moore BD, Slopis JM, Jackson EF, De Winter AE, Leeds NE: Brain volume in children with neurofibromatosis type 1: relation to neuropsychological status. Neurology. 2000, 54: 914-920. 10.1212\/WNL.54.4.914.","journal-title":"Neurology"},{"key":"30_CR18","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1001\/archneur.56.11.1343","volume":"56","author":"FJ DiMario Jr","year":"1999","unstructured":"DiMario FJ, Ramsby GR, Burleson JA: Brain morphometric analysis in neurofibromatosis 1. Arch Neurol. 1999, 56: 1343-1346. 10.1001\/archneur.56.11.1343.","journal-title":"Arch Neurol"},{"key":"30_CR19","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1001\/archneur.59.4.616","volume":"59","author":"RL Billingsley","year":"2002","unstructured":"Billingsley RL, Schrimsher GW, Jackson EF, Slopis JM, Moore BD: Significance of planum temporale and planum parietale morphologic features in neurofibromatosis type 1. Arch Neurol. 2002, 59: 616-622. 10.1001\/archneur.59.4.616.","journal-title":"Arch Neurol"},{"key":"30_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1177\/088307389701200807","volume":"12","author":"AM Kaplan","year":"1997","unstructured":"Kaplan AM, Chen K, Lawson MA, Wodrich DL, Bonstelle CT, Reiman EM: Positron emission tomography in children with neurofibromatosis-1. J Child Neurol. 1997, 12: 499-506. 10.1177\/088307389701200807.","journal-title":"J Child Neurol"},{"key":"30_CR21","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/1531-8249(200004)47:4<477::AID-ANA11>3.0.CO;2-C","volume":"47","author":"PY Wang","year":"2000","unstructured":"Wang PY, Kaufmann WE, Koth CW, Denckla MB, Barker PB: Thalamic involvement in neurofibromatosis type 1: evaluation with proton magnetic resonance spectroscopic imaging. Ann Neurol. 2000, 47: 477-484. 10.1002\/1531-8249(200004)47:4<477::AID-ANA11>3.0.CO;2-C.","journal-title":"Ann Neurol"},{"key":"30_CR22","volume-title":"Hum Brain Mapp","author":"JV Duarte","year":"2012","unstructured":"Duarte JV, Ribeiro MJ, Violante IR, Cunha G, Silva E, Castelo-Branco M: Multivariate pattern analysis reveals subtle brain anomalies relevant to the cognitive phenotype in neurofibromatosis type 1. Hum Brain Mapp. 2012, 10.1002\/hbm.22161. Epub ahead of print"},{"key":"30_CR23","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0166-2236(95)93934-P","volume":"18","author":"P Rakic","year":"1995","unstructured":"Rakic P: A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution. Trends Neurosci. 1995, 18: 383-388. 10.1016\/0166-2236(95)93934-P.","journal-title":"Trends Neurosci"},{"key":"30_CR24","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1093\/cercor\/1.5.426","volume":"1","author":"E Armstrong","year":"1991","unstructured":"Armstrong E, Curtis M, Buxhoeveden DP, Fregoe C, Zilles K, Casanova MF, McCarthy WF: Cortical gyrification in the rhesus monkey: a test of the mechanical folding hypothesis. Cereb Cortex. 1991, 1: 426-432. 10.1093\/cercor\/1.5.426.","journal-title":"Cereb Cortex"},{"key":"30_CR25","doi-asserted-by":"publisher","first-page":"7174","DOI":"10.1523\/JNEUROSCI.0054-11.2011","volume":"31","author":"A Raznahan","year":"2011","unstructured":"Raznahan A, Shaw P, Lalonde F, Stockman M, Wallace GL, Greenstein D, Clasen L, Gogtay N, Giedd JN: How does your cortex grow?. J Neurosci. 2011, 31: 7174-7177. 10.1523\/JNEUROSCI.0054-11.2011.","journal-title":"J Neurosci"},{"key":"30_CR26","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1093\/cercor\/bhp026","volume":"19","author":"MS Panizzon","year":"2009","unstructured":"Panizzon MS, Fennema-Notestine C, Eyler LT, Jernigan TL, Prom-Wormley E, Neale M, Jacobson K, Lyons MJ, Grant MD, Franz CE, Xian H, Tsuang M, Fischl B, Seidman L, Dale A, Kremen WS: Distinct genetic influences on cortical surface area and cortical thickness. Cereb Cortex. 2009, 19: 2728-2735. 10.1093\/cercor\/bhp026.","journal-title":"Cereb Cortex"},{"key":"30_CR27","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/hbm.20187","volume":"27","author":"E Luders","year":"2006","unstructured":"Luders E, Narr KL, Thompson PM, Rex DE, Woods RP, Deluca H, Jancke L, Toga AW: Gender effects on cortical thickness and the influence of scaling. Hum Brain Mapp. 2006, 27: 314-324. 10.1002\/hbm.20187.","journal-title":"Hum Brain Mapp"},{"key":"30_CR28","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1093\/cercor\/bhm227","volume":"18","author":"E Luders","year":"2008","unstructured":"Luders E, Narr KL, Bilder RM, Szeszko PR, Gurbani MN, Hamilton L, Toga AW, Gaser C: Mapping the relationship between cortical convolution and intelligence: effects of gender. Cereb Cortex. 2008, 18: 2019-2026.","journal-title":"Cereb Cortex"},{"key":"30_CR29","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nature04513","volume":"440","author":"P Shaw","year":"2006","unstructured":"Shaw P, Greenstein D, Lerch J, Clasen L, Lenroot R, Gogtay N, Evans A, Rapoport J, Giedd J: Intellectual ability and cortical development in children and adolescents. Nature. 2006, 440: 676-679. 10.1038\/nature04513.","journal-title":"Nature"},{"key":"30_CR30","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.neuroimage.2006.08.052","volume":"34","author":"KL Narr","year":"2007","unstructured":"Narr KL, Bilder RM, Luders E, Thompson PM, Woods RP, Robinson D, Szeszko PR, Dimtcheva T, Gurbani M, Toga AW: Asymmetries of cortical shape: effects of handedness, sex and schizophrenia. Neuroimage. 2007, 34: 939-948. 10.1016\/j.neuroimage.2006.08.052.","journal-title":"Neuroimage"},{"key":"30_CR31","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1212\/01.WNL.0000032370.68306.8A","volume":"59","author":"LE Cutting","year":"2002","unstructured":"Cutting LE, Cooper KL, Koth CW, Mostofsky SH, Kates WR, Denckla MB, Kaufmann WE: Megalencephaly in NF1: predominantly white matter contribution and mitigation by ADHD. Neurology. 2002, 59: 1388-1394. 10.1212\/01.WNL.0000032370.68306.8A.","journal-title":"Neurology"},{"key":"30_CR32","first-page":"190","volume":"22","author":"EC Dubovsky","year":"2001","unstructured":"Dubovsky EC, Booth TN, Vezina G, Samango-Sprouse CA, Palmer KM, Brasseux CO: MR imaging of the corpus callosum in pediatric patients with neurofibromatosis type 1. AJNR Am J Neuroradiol. 2001, 22: 190-195.","journal-title":"AJNR Am J Neuroradiol"},{"key":"30_CR33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1177\/088307380001500206","volume":"15","author":"AE Kayl","year":"2000","unstructured":"Kayl AE, Moore BD, Slopis JM, Jackson EF, Leeds NE: Quantitative morphology of the corpus callosum in children with neurofibromatosis and attention-deficit hyperactivity disorder. J Child Neurol. 2000, 15: 90-96. 10.1177\/088307380001500206.","journal-title":"J Child Neurol"},{"key":"30_CR34","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1177\/0883073809350723","volume":"25","author":"N Pride","year":"2010","unstructured":"Pride N, Payne JM, Webster R, Shores EA, Rae C, North KN: Corpus callosum morphology and its relationship to cognitive function in neurofibromatosis type 1. J Child Neurol. 2010, 25: 834-841. 10.1177\/0883073809350723.","journal-title":"J Child Neurol"},{"key":"30_CR35","doi-asserted-by":"publisher","first-page":"e38785","DOI":"10.1371\/journal.pone.0038785","volume":"7","author":"IR Violante","year":"2012","unstructured":"Violante IR, Ribeiro MJ, Cunha G, Bernardino I, Duarte JV, Ramos F, Saraiva J, Silva E, Castelo-Branco M: Abnormal Brain Activation in Neurofibromatosis Type 1: A Link between Visual Processing and the Default Mode Network. PLoS One. 2012, 7: e38785-10.1371\/journal.pone.0038785.","journal-title":"PLoS One"},{"key":"30_CR36","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1001\/archneur.1988.00520290115023","volume":"45","author":"National Institutes of Health Consensus Development Conference","year":"1988","unstructured":"National Institutes of Health Consensus Development Conference: Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol. 1988, 45: 575-578.","journal-title":"Arch Neurol"},{"key":"30_CR37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<45::AID-AJMG9>3.0.CO;2-J","volume":"89","author":"S Ozonoff","year":"1999","unstructured":"Ozonoff S: Cognitive impairment in neurofibromatosis type 1. Am J Med Genet. 1999, 89: 45-52. 10.1002\/(SICI)1096-8628(19990326)89:1<45::AID-AJMG9>3.0.CO;2-J.","journal-title":"Am J Med Genet"},{"key":"30_CR38","volume-title":"Escala de Intelig\u00eancia para Crian\u00e7as - Terceira Edi\u00e7\u00e3o (WISC-III): Manual","author":"D Wechsler","year":"2003","unstructured":"Wechsler D: Escala de Intelig\u00eancia para Crian\u00e7as - Terceira Edi\u00e7\u00e3o (WISC-III): Manual. 2003, Lisboa, Portugal: Cegoc-Tea"},{"key":"30_CR39","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/nimg.1998.0395","volume":"9","author":"AM Dale","year":"1999","unstructured":"Dale AM, Fischl B, Sereno MI: Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage. 1999, 9: 179-194. 10.1006\/nimg.1998.0395.","journal-title":"Neuroimage"},{"key":"30_CR40","doi-asserted-by":"publisher","first-page":"11050","DOI":"10.1073\/pnas.200033797","volume":"97","author":"B Fischl","year":"2000","unstructured":"Fischl B, Dale AM: Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A. 2000, 97: 11050-11055. 10.1073\/pnas.200033797.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"30_CR41","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002, 33: 341-355. 10.1016\/S0896-6273(02)00569-X.","journal-title":"Neuron"},{"issue":"Suppl 1","key":"30_CR42","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.neuroimage.2004.07.016","volume":"23","author":"B Fischl","year":"2004","unstructured":"Fischl B, Salat DH, van der Kouwe AJ, Makris N, Segonne F, Quinn BT, Dale AM: Sequence-independent segmentation of magnetic resonance images. Neuroimage. 2004, 23 (Suppl 1): S69-84.","journal-title":"Neuroimage"},{"key":"30_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1109\/42.906426","volume":"20","author":"B Fischl","year":"2001","unstructured":"Fischl B, Liu A, Dale AM: Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging. 2001, 20: 70-80. 10.1109\/42.906426.","journal-title":"IEEE Trans Med Imaging"},{"key":"30_CR44","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1109\/TMI.2006.887364","volume":"26","author":"F Segonne","year":"2007","unstructured":"Segonne F, Pacheco J, Fischl B: Geometrically accurate topology-correction of cortical surfaces using nonseparating loops. IEEE Trans Med Imaging. 2007, 26: 518-529.","journal-title":"IEEE Trans Med Imaging"},{"key":"30_CR45","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4","volume":"8","author":"B Fischl","year":"1999","unstructured":"Fischl B, Sereno MI, Tootell RB, Dale AM: High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp. 1999, 8: 272-284. 10.1002\/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4.","journal-title":"Hum Brain Mapp"},{"key":"30_CR46","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1109\/TMI.2007.903576","volume":"27","author":"M Schaer","year":"2008","unstructured":"Schaer M, Cuadra MB, Tamarit L, Lazeyras F, Eliez S, Thiran JP: A surface-based approach to quantify local cortical gyrification. IEEE Trans Med Imaging. 2008, 27: 161-170.","journal-title":"IEEE Trans Med Imaging"},{"key":"30_CR47","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006, 31: 968-980. 10.1016\/j.neuroimage.2006.01.021.","journal-title":"Neuroimage"},{"key":"30_CR48","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.neuroimage.2004.06.018","volume":"23","author":"RL Buckner","year":"2004","unstructured":"Buckner RL, Head D, Parker J, Fotenos AF, Marcus D, Morris JC, Snyder AZ: A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume. Neuroimage. 2004, 23: 724-738. 10.1016\/j.neuroimage.2004.06.018.","journal-title":"Neuroimage"},{"key":"30_CR49","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.neuroimage.2008.10.030","volume":"44","author":"DH Salat","year":"2009","unstructured":"Salat DH, Greve DN, Pacheco JL, Quinn BT, Helmer KG, Buckner RL, Fischl B: Regional white matter volume differences in nondemented aging and Alzheimer's disease. Neuroimage. 2009, 44: 1247-1258. 10.1016\/j.neuroimage.2008.10.030.","journal-title":"Neuroimage"},{"key":"30_CR50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y: Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society Series B-Methodological. 1995, 57: 289-300.","journal-title":"Journal of the Royal Statistical Society Series B-Methodological"},{"key":"30_CR51","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1093\/cercor\/bhm261","volume":"18","author":"R Toro","year":"2008","unstructured":"Toro R, Perron M, Pike B, Richer L, Veillette S, Pausova Z, Paus T: Brain size and folding of the human cerebral cortex. Cereb Cortex. 2008, 18: 2352-2357. 10.1093\/cercor\/bhm261.","journal-title":"Cereb Cortex"},{"key":"30_CR52","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/BF00199545","volume":"73","author":"JM Murre","year":"1995","unstructured":"Murre JM, Sturdy DP: The connectivity of the brain: multi-level quantitative analysis. Biol Cybern. 1995, 73: 529-545. 10.1007\/BF00199545.","journal-title":"Biol Cybern"},{"key":"30_CR53","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/BF00202570","volume":"70","author":"E Ruppin","year":"1993","unstructured":"Ruppin E, Schwartz EL, Yeshurun Y: Examining the volume efficiency of the cortical architecture in a multi-processor network model. Biol Cybern. 1993, 70: 89-94. 10.1007\/BF00202570.","journal-title":"Biol Cybern"},{"key":"30_CR54","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/cercor\/bhn064","volume":"19","author":"CE Bearden","year":"2009","unstructured":"Bearden CE, van Erp TG, Dutton RA, Lee AD, Simon TJ, Cannon TD, Emanuel BS, McDonald-McGinn D, Zackai EH, Thompson PM: Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions. Cereb Cortex. 2009, 19: 115-126.","journal-title":"Cereb Cortex"},{"key":"30_CR55","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1093\/cercor\/bhl109","volume":"17","author":"JJ Lin","year":"2007","unstructured":"Lin JJ, Salamon N, Lee AD, Dutton RA, Geaga JA, Hayashi KM, Luders E, Toga AW, Engel J, Thompson PM: Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cereb Cortex. 2007, 17: 2007-2018.","journal-title":"Cereb Cortex"},{"key":"30_CR56","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1523\/JNEUROSCI.0165-05.2005","volume":"25","author":"PM Thompson","year":"2005","unstructured":"Thompson PM, Lee AD, Dutton RA, Geaga JA, Hayashi KM, Eckert MA, Bellugi U, Galaburda AM, Korenberg JR, Mills DL, Toga AW, Reiss AL: Abnormal cortical complexity and thickness profiles mapped in Williams syndrome. J Neurosci. 2005, 25: 4146-4158. 10.1523\/JNEUROSCI.0165-05.2005.","journal-title":"J Neurosci"},{"key":"30_CR57","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.cortex.2008.04.004","volume":"44","author":"JD Schmahmann","year":"2008","unstructured":"Schmahmann JD, Pandya DN: Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems. Cortex. 2008, 44: 1037-1066. 10.1016\/j.cortex.2008.04.004.","journal-title":"Cortex"},{"key":"30_CR58","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.spen.2006.01.006","volume":"13","author":"TM Levine","year":"2006","unstructured":"Levine TM, Materek A, Abel J, O'Donnell M, Cutting LE: Cognitive profile of neurofibromatosis type 1. Semin Pediatr Neurol. 2006, 13: 8-20. 10.1016\/j.spen.2006.01.006.","journal-title":"Semin Pediatr Neurol"},{"key":"30_CR59","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1017\/S135561771000086X","volume":"16","author":"A Roy","year":"2010","unstructured":"Roy A, Roulin JL, Charbonnier V, Allain P, Fasotti L, Barbarot S, Stalder JF, Terrien A, Le Gall D: Executive dysfunction in children with neurofibromatosis type 1: a study of action planning. J Int Neuropsychol Soc. 2010, 16: 1056-1063. 10.1017\/S135561771000086X.","journal-title":"J Int Neuropsychol Soc"},{"key":"30_CR60","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.pneurobio.2008.09.004","volume":"86","author":"JA Grahn","year":"2008","unstructured":"Grahn JA, Parkinson JA, Owen AM: The cognitive functions of the caudate nucleus. Prog Neurobiol. 2008, 86: 141-155. 10.1016\/j.pneurobio.2008.09.004.","journal-title":"Prog Neurobiol"},{"key":"30_CR61","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1093\/brain\/93.3.525","volume":"93","author":"JM Kemp","year":"1970","unstructured":"Kemp JM, Powell TP: The cortico-striate projection in the monkey. Brain. 1970, 93: 525-546. 10.1093\/brain\/93.3.525.","journal-title":"Brain"},{"key":"30_CR62","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0006-8993(78)90059-8","volume":"139","author":"EH Yeterian","year":"1978","unstructured":"Yeterian EH, Van Hoesen GW: Cortico-striate projections in the rhesus monkey: the organization of certain cortico-caudate connections. Brain Res. 1978, 139: 43-63. 10.1016\/0006-8993(78)90059-8.","journal-title":"Brain Res"},{"key":"30_CR63","doi-asserted-by":"publisher","first-page":"13141","DOI":"10.1073\/pnas.1004829107","volume":"107","author":"C Shilyansky","year":"2010","unstructured":"Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ: Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A. 2010, 107: 13141-13146. 10.1073\/pnas.1004829107.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"30_CR64","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1177\/08830738020170122001","volume":"17","author":"GW Schrimsher","year":"2002","unstructured":"Schrimsher GW, Billingsley RL, Jackson EF, Moore BD: Caudate nucleus volume asymmetry predicts attention-deficit hyperactivity disorder (ADHD) symptomatology in children. J Child Neurol. 2002, 17: 877-884. 10.1177\/08830738020170122001.","journal-title":"J Child Neurol"},{"key":"30_CR65","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3174\/ajnr.A2005","volume":"31","author":"EL Wignall","year":"2010","unstructured":"Wignall EL, Griffiths PD, Papadakis NG, Wilkinson ID, Wallis LI, Bandmann O, Cowell PE, Hoggard N: Corpus callosum morphology and microstructure assessed using structural MR imaging and diffusion tensor imaging: initial findings in adults with neurofibromatosis type 1. AJNR Am J Neuroradiol. 2010, 31: 856-861. 10.3174\/ajnr.A2005.","journal-title":"AJNR Am J Neuroradiol"},{"key":"30_CR66","first-page":"773","volume":"28","author":"SL Zamboni","year":"2007","unstructured":"Zamboni SL, Loenneker T, Boltshauser E, Martin E, Il'yasov KA: Contribution of diffusion tensor MR imaging in detecting cerebral microstructural changes in adults with neurofibromatosis type 1. AJNR Am J Neuroradiol. 2007, 28: 773-776.","journal-title":"AJNR Am J Neuroradiol"},{"key":"30_CR67","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1159\/000124422","volume":"7","author":"RE Passingham","year":"1973","unstructured":"Passingham RE: Anatomical differences between the neocortex of man and other primates. Brain Behav Evol. 1973, 7: 337-359. 10.1159\/000124422.","journal-title":"Brain Behav Evol"},{"key":"30_CR68","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF00304699","volume":"179","author":"K Zilles","year":"1988","unstructured":"Zilles K, Armstrong E, Schleicher A, Kretschmann HJ: The human pattern of gyrification in the cerebral cortex. Anat Embryol (Berl). 1988, 179: 173-179. 10.1007\/BF00304699.","journal-title":"Anat Embryol (Berl)"},{"key":"30_CR69","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/09297049.2010.542746","volume":"17","author":"JM Payne","year":"2011","unstructured":"Payne JM, Hyman SL, Shores EA, North KN: Assessment of executive function and attention in children with neurofibromatosis type 1: relationships between cognitive measures and real-world behavior. Child Neuropsychol. 2011, 17: 313-329. 10.1080\/09297049.2010.542746.","journal-title":"Child Neuropsychol"},{"key":"30_CR70","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1093\/brain\/awl244","volume":"129","author":"F du Boisgueheneuc","year":"2006","unstructured":"du Boisgueheneuc F, Levy R, Volle E, Seassau M, Duffau H, Kinkingnehun S, Samson Y, Zhang S, Dubois B: Functions of the left superior frontal gyrus in humans: a lesion study. Brain. 2006, 129: 3315-3328. 10.1093\/brain\/awl244.","journal-title":"Brain"},{"key":"30_CR71","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.tics.2011.02.001","volume":"15","author":"S Tsujimoto","year":"2011","unstructured":"Tsujimoto S, Genovesio A, Wise SP: Frontal pole cortex: encoding ends at the end of the endbrain. Trends Cogn Sci. 2011, 15: 169-176. 10.1016\/j.tics.2011.02.001.","journal-title":"Trends Cogn Sci"},{"key":"30_CR72","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/cercor\/10.3.308","volume":"10","author":"R Elliott","year":"2000","unstructured":"Elliott R, Dolan RJ, Frith CD: Dissociable functions in the medial and lateral orbitofrontal cortex: evidence from human neuroimaging studies. Cereb Cortex. 2000, 10: 308-317. 10.1093\/cercor\/10.3.308.","journal-title":"Cereb Cortex"},{"key":"30_CR73","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1016\/j.neuropsychologia.2010.08.012","volume":"48","author":"DH Zald","year":"2010","unstructured":"Zald DH, Andreotti C: Neuropsychological assessment of the orbital and ventromedial prefrontal cortex. Neuropsychologia. 2010, 48: 3377-3391. 10.1016\/j.neuropsychologia.2010.08.012.","journal-title":"Neuropsychologia"},{"key":"30_CR74","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1364-6613(00)01483-2","volume":"4","author":"G Bush","year":"2000","unstructured":"Bush G, Luu P, Posner MI: Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci. 2000, 4: 215-222. 10.1016\/S1364-6613(00)01483-2.","journal-title":"Trends Cogn Sci"},{"key":"30_CR75","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0093-934X(02)00563-1","volume":"85","author":"RL Billingsley","year":"2003","unstructured":"Billingsley RL, Slopis JM, Swank PR, Jackson EF, Moore BD: Cortical morphology associated with language function in neurofibromatosis, type I. Brain Lang. 2003, 85: 125-139. 10.1016\/S0093-934X(02)00563-1.","journal-title":"Brain Lang"},{"key":"30_CR76","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.tics.2005.07.004","volume":"9","author":"P Hagoort","year":"2005","unstructured":"Hagoort P: On Broca, brain, and binding: a new framework. Trends Cogn Sci. 2005, 9: 416-423. 10.1016\/j.tics.2005.07.004.","journal-title":"Trends Cogn Sci"},{"key":"30_CR77","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1093\/cercor\/bhp119","volume":"20","author":"HD Xiang","year":"2010","unstructured":"Xiang HD, Fonteijn HM, Norris DG, Hagoort P: Topographical functional connectivity pattern in the perisylvian language networks. Cereb Cortex. 2010, 20: 549-560. 10.1093\/cercor\/bhp119.","journal-title":"Cereb Cortex"},{"key":"30_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1162\/08989290051137585","volume":"12","author":"R Cabeza","year":"2000","unstructured":"Cabeza R, Nyberg L: Imaging cognition II: An empirical review of 275 PET and fMRI studies. J Cogn Neurosci. 2000, 12: 1-47.","journal-title":"J Cogn Neurosci"},{"key":"30_CR79","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/13217","volume":"2","author":"LL Chao","year":"1999","unstructured":"Chao LL, Haxby JV, Martin A: Attribute-based neural substrates in temporal cortex for perceiving and knowing about objects. Nat Neurosci. 1999, 2: 913-919. 10.1038\/13217.","journal-title":"Nat Neurosci"},{"key":"30_CR80","doi-asserted-by":"publisher","first-page":"8010","DOI":"10.1523\/JNEUROSCI.2307-05.2005","volume":"25","author":"PM Gough","year":"2005","unstructured":"Gough PM, Nobre AC, Devlin JT: Dissociating linguistic processes in the left inferior frontal cortex with transcranial magnetic stimulation. J Neurosci. 2005, 25: 8010-8016. 10.1523\/JNEUROSCI.2307-05.2005.","journal-title":"J Neurosci"},{"key":"30_CR81","doi-asserted-by":"publisher","first-page":"16494","DOI":"10.1073\/pnas.1008121107","volume":"107","author":"G Hartwigsen","year":"2010","unstructured":"Hartwigsen G, Baumgaertner A, Price CJ, Koehnke M, Ulmer S, Siebner HR: Phonological decisions require both the left and right supramarginal gyri. Proc Natl Acad Sci U S A. 2010, 107: 16494-16499. 10.1073\/pnas.1008121107.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"30_CR82","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1212\/01.WNL.0000098881.95854.5F","volume":"61","author":"R Feldmann","year":"2003","unstructured":"Feldmann R, Denecke J, Grenzebach M, Schuierer G, Weglage J: Neurofibromatosis type 1: motor and cognitive function and T2-weighted MRI hyperintensities. Neurology. 2003, 61: 1725-1728. 10.1212\/01.WNL.0000098881.95854.5F.","journal-title":"Neurology"},{"key":"30_CR83","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1037\/a0013927","volume":"23","author":"I Rowbotham","year":"2009","unstructured":"Rowbotham I, Pit-ten Cate IM, Sonuga-Barke EJ, Huijbregts SC: Cognitive control in adolescents with neurofibromatosis type 1. Neuropsychology. 2009, 23: 50-60.","journal-title":"Neuropsychology"},{"key":"30_CR84","volume-title":"Neuroscience","author":"D Purves","year":"2001","unstructured":"Purves D, Williams SM: Neuroscience. 2001, Sunderland, MA: Sinauer Associates, 2","edition":"2"},{"key":"30_CR85","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.neuropsychologia.2007.09.013","volume":"46","author":"AM Clements-Stephens","year":"2008","unstructured":"Clements-Stephens AM, Rimrodt SL, Gaur P, Cutting LE: Visuospatial processing in children with neurofibromatosis type 1. Neuropsychologia. 2008, 46: 690-697. 10.1016\/j.neuropsychologia.2007.09.013.","journal-title":"Neuropsychologia"},{"key":"30_CR86","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.neuroimage.2010.02.020","volume":"53","author":"J Rogers","year":"2010","unstructured":"Rogers J, Kochunov P, Zilles K, Shelledy W, Lancaster J, Thompson P, Duggirala R, Blangero J, Fox PT, Glahn DC: On the genetic architecture of cortical folding and brain volume in primates. Neuroimage. 2010, 53: 1103-1108. 10.1016\/j.neuroimage.2010.02.020.","journal-title":"Neuroimage"},{"key":"30_CR87","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1523\/JNEUROSCI.5458-10.2011","volume":"31","author":"V Rajagopalan","year":"2011","unstructured":"Rajagopalan V, Scott J, Habas PA, Kim K, Corbett-Detig J, Rousseau F, Barkovich AJ, Glenn OA, Studholme C: Local tissue growth patterns underlying normal fetal human brain gyrification quantified in utero. J Neurosci. 2011, 31: 2878-2887. 10.1523\/JNEUROSCI.5458-10.2011.","journal-title":"J Neurosci"},{"key":"30_CR88","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00429-007-0161-1","volume":"212","author":"A Afif","year":"2007","unstructured":"Afif A, Bouvier R, Buenerd A, Trouillas J, Mertens P: Development of the human fetal insular cortex: study of the gyration from 13 to 28 gestational weeks. Brain Struct Funct. 2007, 212: 335-346. 10.1007\/s00429-007-0161-1.","journal-title":"Brain Struct Funct"},{"key":"30_CR89","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1126\/science.1135626","volume":"189","author":"VS Caviness Jr","year":"1975","unstructured":"Caviness VS: Mechanical model of brain convolutional development. Science. 1975, 189: 18-21. 10.1126\/science.1135626.","journal-title":"Science"},{"key":"30_CR90","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/cne.902970309","volume":"297","author":"I Kostovic","year":"1990","unstructured":"Kostovic I, Rakic P: Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. J Comp Neurol. 1990, 297: 441-470. 10.1002\/cne.902970309.","journal-title":"J Comp Neurol"},{"key":"30_CR91","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/385313a0","volume":"385","author":"DC Van Essen","year":"1997","unstructured":"Van Essen DC: A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature. 1997, 385: 313-318. 10.1038\/385313a0.","journal-title":"Nature"}],"container-title":["Journal of Neurodevelopmental Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1866-1955-5-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T01:21:54Z","timestamp":1714958514000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneurodevdisorders.biomedcentral.com\/articles\/10.1186\/1866-1955-5-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["30"],"URL":"https:\/\/doi.org\/10.1186\/1866-1955-5-3","relation":{},"ISSN":["1866-1947","1866-1955"],"issn-type":[{"value":"1866-1947","type":"print"},{"value":"1866-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]},"assertion":[{"value":"1 August 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"3"}}