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Singlefibre analysis showed that this modification spans the entire body of the gene.Furthermore, H4K16ac genes cluster in regions up to 500 Kb alternating active andinactive chromatin. The introduction of H4K16ac in chromatin induces stiffness in thechromatin fibre. The result of this change in flexibility is that chromatin couldbehave like a multi-block copolymer with repetitions of stiff-flexible(active-inactive chromatin) components. Copolymers with such structure self-organizethrough spontaneous phase separation into microdomains. Consistent with such modelH4K16ac chromatin form foci that associates with nascent transcripts. We propose thattranscription factories are the result of the spontaneous concentration of H4K16acchromatin that are in proximity, mainly in cis.<\/jats:p>","DOI":"10.1186\/2046-1682-6-2","type":"journal-article","created":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T15:14:03Z","timestamp":1360422843000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A biophysical model for transcription factories"],"prefix":"10.1186","volume":"6","author":[{"given":"Ana Z","family":"Canals-Hamann","sequence":"first","affiliation":[]},{"given":"Ricardo Pires","family":"das Neves","sequence":"additional","affiliation":[]},{"given":"Joyce E","family":"Reittie","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"I\u00f1iguez","sequence":"additional","affiliation":[]},{"given":"Shamit","family":"Soneji","sequence":"additional","affiliation":[]},{"given":"Tariq","family":"Enver","sequence":"additional","affiliation":[]},{"given":"Veronica J","family":"Buckle","sequence":"additional","affiliation":[]},{"given":"Francisco J","family":"Iborra","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,2,9]]},"reference":[{"key":"44_CR1","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1242\/jcs.111.15.2269","volume":"111","author":"FJ Iborra","year":"1998","unstructured":"Iborra FJ, Jackson DA, Cook PR: The path of transcripts from extra-nucleolar synthetic sites to nuclear pores:transcripts in transit are concentrated in discrete structures containing SRproteins. 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