{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:50:10Z","timestamp":1773456610559,"version":"3.50.1"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T00:00:00Z","timestamp":1423353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T00:00:00Z","timestamp":1423353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infiltrating lobular breast cancer (ILC) is the most common special breast cancer subtype. With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (<jats:italic>CDH1<\/jats:italic>) being confined almost exclusively to ILC, this tumor entity stands out from all other types of breast cancers. The molecular basis of ILC is linked to loss of E-cadherin, as evidenced by human <jats:italic>CDH1<\/jats:italic> germline mutations and conditional knockout mouse models. A better understanding of ILC beyond the level of descriptive studies depends on physiologically relevant and functional tools. This review provides a detailed overview on ILC models, including well-characterized cell lines, xenograft tumors and genetically engineered mouse models. We consider advantages and limitations of these models and evaluate their representativeness for human ILC. The still incompletely defined mechanisms by which loss of E-cadherin drives malignant transformation are discussed based on recent findings in these models. Moreover, candidate genes and signaling pathways potentially involved in ILC development and progression as well as anticancer drug and endocrine resistance are highlighted.<\/jats:p>","DOI":"10.1186\/s13058-015-0517-z","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:58:22Z","timestamp":1423270702000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Lobular breast cancer: molecular basis, mouse and cellular models"],"prefix":"10.1186","volume":"17","author":[{"given":"Matthias","family":"Christgen","sequence":"first","affiliation":[]},{"given":"Patrick WB","family":"Derksen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,2,8]]},"reference":[{"key":"517_CR1","first-page":"491","volume":"17","author":"FW Foote","year":"1941","unstructured":"Foote FW, Stewart FW. Lobular carcinoma in situ: a rare form of mammary cancer. Am J Pathol. 1941;17:491\u20136.","journal-title":"Am J Pathol"},{"key":"517_CR2","first-page":"208","volume-title":"Pathology of tumours","author":"RA Willis","year":"1948","unstructured":"Willis RA. Epithelial tumours of the breast. In: Willis RA, editor. Pathology of tumours. London: Butterworth Co. Ltd; 1948. p. 208\u201357."},{"key":"517_CR3","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0092-8674(81)90214-2","volume":"26","author":"F Hyafil","year":"1981","unstructured":"Hyafil F, Babinet C, Jacob F. Cell\u2013cell interactions in early embryogenesis: a molecular approach to the role of calcium. Cell. 1981;26:447\u201354.","journal-title":"Cell"},{"key":"517_CR4","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.bbamem.2007.12.015","volume":"1778","author":"CM Niessen","year":"2008","unstructured":"Niessen CM, Gottardi CJ. Molecular components of the adherens junction. Biochim Biophys Acta. 2008;1778:562\u201371.","journal-title":"Biochim Biophys Acta"},{"key":"517_CR5","first-page":"1731","volume":"143","author":"R Moll","year":"1993","unstructured":"Moll R, Mitze M, Frixen UH, Birchmeier W. Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol. 1993;143:1731\u201342.","journal-title":"Am J Pathol"},{"key":"517_CR6","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/bjc.1997.523","volume":"76","author":"CB Vos","year":"1997","unstructured":"Vos CB, Cleton-Jansen AM, Berx G, de Leeuw WJ, ter Haar NT, van Roy F, et al. E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis. Br J Cancer. 1997;76:1131\u20133.","journal-title":"Br J Cancer"},{"key":"517_CR7","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1002\/j.1460-2075.1995.tb00301.x","volume":"14","author":"G Berx","year":"1995","unstructured":"Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJ, van de Vijver M, Cornelisse C, et al. E-cadherin is a tumour\/invasion suppressor gene mutated in human lobular breast cancers. Embo J. 1995;14:6107\u201315.","journal-title":"Embo J"},{"key":"517_CR8","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/ijc.1208","volume":"92","author":"S Droufakou","year":"2001","unstructured":"Droufakou S, Deshmane V, Roylance R, Hanby A, Tomlinson I, Hart IR. Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast. Int J Cancer. 2001;92:404\u20138.","journal-title":"Int J Cancer"},{"key":"517_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1158\/2159-8290.CD-12-0462","volume":"3","author":"MJ Ellis","year":"2013","unstructured":"Ellis MJ, Perou CM. The genomic landscape of breast cancer as a therapeutic roadmap. Cancer Discov. 2013;3:27\u201334.","journal-title":"Cancer Discov"},{"key":"517_CR10","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/32918","volume":"392","author":"P Guilford","year":"1998","unstructured":"Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P, et al. E-cadherin germline mutations in familial gastric cancer. Nature. 1998;392:402\u20135.","journal-title":"Nature"},{"key":"517_CR11","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1136\/jmedgenet-2012-101472","volume":"50","author":"PR Benusiglio","year":"2013","unstructured":"Benusiglio PR, Malka D, Rouleau E, De Pauw A, Buecher B, Nogues C, et al. CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study. J Med Genet. 2013;50:486\u20139.","journal-title":"J Med Genet"},{"key":"517_CR12","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/bjc.2013.792","volume":"110","author":"C Petridis","year":"2014","unstructured":"Petridis C, Shinomiya I, Kohut K, Gorman P, Caneppele M, Shah V, et al. Germline CDH1 mutations in bilateral lobular carcinoma in situ. Br J Cancer. 2014;110:1053\u20137.","journal-title":"Br J Cancer"},{"key":"517_CR13","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1038\/sj.onc.1207439","volume":"23","author":"D Sarrio","year":"2004","unstructured":"Sarrio D, Perez-Mies B, Hardisson D, Moreno-Bueno G, Suarez A, Cano A, et al. Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene. 2004;23:3272\u201383.","journal-title":"Oncogene"},{"key":"517_CR14","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1172\/JCI41695","volume":"121","author":"RC Schackmann","year":"2011","unstructured":"Schackmann RC, van Amersfoort M, Haarhuis JH, Vlug EJ, Halim VA, Roodhart JM, et al. Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. J Clin Invest. 2011;121:3176\u201388.","journal-title":"J Clin Invest"},{"key":"517_CR15","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.1038\/onc.2008.158","volume":"27","author":"F Bertucci","year":"2008","unstructured":"Bertucci F, Orsetti B, Negre V, Finetti P, Rouge C, Ahomadegbe JC, et al. Lobular and ductal carcinomas of the breast have distinct genomic and expression profiles. Oncogene. 2008;27:5359\u201372.","journal-title":"Oncogene"},{"key":"517_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ejca.2007.10.009","volume":"44","author":"EA Rakha","year":"2008","unstructured":"Rakha EA, El-Sayed ME, Powe DG, Green AR, Habashy H, Grainge MJ, et al. Invasive lobular carcinoma of the breast: response to hormonal therapy and outcomes. Eur J Cancer. 2008;44:73\u201383.","journal-title":"Eur J Cancer"},{"key":"517_CR17","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1158\/1078-0432.CCR-13-0295","volume":"19","author":"JS Ross","year":"2013","unstructured":"Ross JS, Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Clin Cancer Res. 2013;19:2668\u201376.","journal-title":"Clin Cancer Res"},{"key":"517_CR18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/gcc.22007","volume":"52","author":"M Christgen","year":"2013","unstructured":"Christgen M, Noskowicz M, Schipper E, Christgen H, Heil C, Krech T, et al. Oncogenic PIK3CA mutations in lobular breast cancer progression. Genes Chromosomes Cancer. 2013;52:69\u201380.","journal-title":"Genes Chromosomes Cancer"},{"key":"517_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/path.2358","volume":"215","author":"PT Simpson","year":"2008","unstructured":"Simpson PT, Reis-Filho JS, Lambros MB, Jones C, Steele D, Mackay A, et al. Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas. J Pathol. 2008;215:231\u201344.","journal-title":"J Pathol"},{"key":"517_CR20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s13402-012-0071-y","volume":"35","author":"C Ercan","year":"2012","unstructured":"Ercan C, van Diest PJ, van der Ende B, Hinrichs J, Bult P, Buerger H, et al. p53 mutations in classic and pleomorphic invasive lobular carcinoma of the breast. Cell Oncol (Dordr). 2012;35:111\u20138.","journal-title":"Cell Oncol (Dordr)"},{"key":"517_CR21","first-page":"7167","volume":"63","author":"JE Korkola","year":"2003","unstructured":"Korkola JE, DeVries S, Fridlyand J, Hwang ES, Estep AL, Chen YY, et al. Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis. Cancer Res. 2003;63:7167\u201375.","journal-title":"Cancer Res"},{"key":"517_CR22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/path.2629","volume":"220","author":"B Weigelt","year":"2010","unstructured":"Weigelt B, Geyer FC, Natrajan R, Lopez-Garcia MA, Ahmad AS, Savage K, et al. The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type. J Pathol. 2010;220:45\u201357.","journal-title":"J Pathol"},{"key":"517_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/bcr2889","volume":"13","author":"DL Holliday","year":"2011","unstructured":"Holliday DL, Speirs V. Choosing the right cell line for breast cancer research. Breast Cancer Res. 2011;13:215.","journal-title":"Breast Cancer Res"},{"key":"517_CR24","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ccr.2006.10.008","volume":"10","author":"RM Neve","year":"2006","unstructured":"Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006;10:515\u201327.","journal-title":"Cancer Cell"},{"key":"517_CR25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jnci\/53.3.661","volume":"53","author":"R Cailleau","year":"1974","unstructured":"Cailleau R, Young R, Olive M, Reeves Jr WJ. Breast tumor cell lines from pleural effusions. J Natl Cancer Inst. 1974;53:661\u201374.","journal-title":"J Natl Cancer Inst"},{"key":"517_CR26","first-page":"4327","volume":"38","author":"LW Engel","year":"1978","unstructured":"Engel LW, Young NA. Human breast carcinoma cells in continuous culture: a review. Cancer Res. 1978;38:4327\u201339.","journal-title":"Cancer Res"},{"key":"517_CR27","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/(SICI)1097-0215(19961127)68:5<682::AID-IJC20>3.0.CO;2-2","volume":"68","author":"PD Rye","year":"1996","unstructured":"Rye PD, Norum L, Olsen DR, Garman-Vik S, Kaul S, Fodstad O. Brain metastasis model in athymic nude mice using a novel MUC1-secreting human breast-cancer cell line, MA11. Int J Cancer. 1996;68:682\u20137.","journal-title":"Int J Cancer"},{"key":"517_CR28","first-page":"627","volume":"53","author":"SP Ethier","year":"1993","unstructured":"Ethier SP, Mahacek ML, Gullick WJ, Frank TS, Weber BL. Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media. Cancer Res. 1993;53:627\u201335.","journal-title":"Cancer Res"},{"key":"517_CR29","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/(SICI)1097-0215(19981209)78:6<766::AID-IJC15>3.0.CO;2-L","volume":"78","author":"AF Gazdar","year":"1998","unstructured":"Gazdar AF, Kurvari V, Virmani A, Gollahon L, Sakaguchi M, Westerfield M, et al. Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer. Int J Cancer. 1998;78:766\u201374.","journal-title":"Int J Cancer"},{"key":"517_CR30","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1002\/path.2495","volume":"217","author":"M Christgen","year":"2009","unstructured":"Christgen M, Bruchhardt H, Hadamitzky C, Rudolph C, Steinemann D, Gadzicki D, et al. Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer. J Pathol. 2009;217:620\u201332.","journal-title":"J Pathol"},{"key":"517_CR31","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s10549-012-2377-x","volume":"137","author":"P Jambal","year":"2012","unstructured":"Jambal P, Badtke MM, Harrell JC, Borges VF, Post MD, Sollender GE, et al. Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features. Breast Cancer Res Treat. 2012;137:431\u201348.","journal-title":"Breast Cancer Res Treat"},{"key":"517_CR32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10549-013-2415-3","volume":"138","author":"A Hollestelle","year":"2013","unstructured":"Hollestelle A, Peeters JK, Smid M, Timmermans M, Verhoog LC, Westenend PJ, et al. Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer. Breast Cancer Res Treat. 2013;138:47\u201357.","journal-title":"Breast Cancer Res Treat"},{"key":"517_CR33","doi-asserted-by":"publisher","first-page":"e73062","DOI":"10.1371\/journal.pone.0073062","volume":"8","author":"I Karch","year":"2013","unstructured":"Karch I, Schipper E, Christgen H, Kreipe H, Lehmann U, Christgen M. Is upregulation of BCL2 a determinant of tumor development driven by inactivation of CDH1\/E-cadherin? PLoS One. 2013;8:e73062.","journal-title":"PLoS One"},{"key":"517_CR34","doi-asserted-by":"publisher","first-page":"6652","DOI":"10.1158\/1078-0432.CCR-06-1164","volume":"12","author":"JS Reis-Filho","year":"2006","unstructured":"Reis-Filho JS, Simpson PT, Turner NC, Lambros MB, Jones C, Mackay A, et al. FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin Cancer Res. 2006;12:6652\u201362.","journal-title":"Clin Cancer Res"},{"key":"517_CR35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10549-009-0460-8","volume":"121","author":"A Hollestelle","year":"2010","unstructured":"Hollestelle A, Nagel JH, Smid M, Lam S, Elstrodt F, Wasielewski M, et al. Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Res Treat. 2010;121:53\u201364.","journal-title":"Breast Cancer Res Treat"},{"key":"517_CR36","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1158\/0008-5472.CAN-13-2779","volume":"74","author":"MJ Sikora","year":"2014","unstructured":"Sikora MJ, Cooper KL, Bahreini A, Luthra S, Wang G, Chandran UR, et al. Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response. Cancer Res. 2014;74:1463\u201374.","journal-title":"Cancer Res"},{"key":"517_CR37","doi-asserted-by":"publisher","first-page":"8908","DOI":"10.1158\/0008-5472.CAN-08-2669","volume":"68","author":"RB Riggins","year":"2008","unstructured":"Riggins RB, Lan JP, Klimach U, Zwart A, Cavalli LR, Haddad BR, et al. ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer. Cancer Res. 2008;68:8908\u201317.","journal-title":"Cancer Res"},{"key":"517_CR38","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1158\/0008-5472.CAN-09-3746","volume":"70","author":"N Turner","year":"2010","unstructured":"Turner N, Pearson A, Sharpe R, Lambros M, Geyer F, Lopez-Garcia MA, et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res. 2010;70:2085\u201394.","journal-title":"Cancer Res"},{"key":"517_CR39","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/emmm.201100121","volume":"3","author":"F Sircoulomb","year":"2011","unstructured":"Sircoulomb F, Nicolas N, Ferrari A, Finetti P, Bekhouche I, Rousselet E, et al. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. EMBO Mol Med. 2011;3:153\u201366.","journal-title":"EMBO Mol Med"},{"key":"517_CR40","doi-asserted-by":"publisher","first-page":"e72053","DOI":"10.1371\/journal.pone.0072053","volume":"8","author":"X Zhang","year":"2013","unstructured":"Zhang X, Mu X, Huang O, Xie Z, Jiang M, Geng M, et al. Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt\/mTOR signaling. PLoS One. 2013;8:e72053.","journal-title":"PLoS One"},{"key":"517_CR41","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1038\/labinvest.2012.126","volume":"92","author":"M Christgen","year":"2012","unstructured":"Christgen M, Noskowicz M, Heil C, Schipper E, Christgen H, Geffers R, et al. IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes. Lab Invest. 2012;92:1635\u201347.","journal-title":"Lab Invest"},{"key":"517_CR42","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1111\/cas.12276","volume":"104","author":"M Christgen","year":"2013","unstructured":"Christgen M, Geffers R, Kreipe H, Lehmann U. IPH-926 lobular breast cancer cells are triple-negative but their microarray profile uncovers a luminal subtype. Cancer Sci. 2013;104:1726\u201330.","journal-title":"Cancer Sci"},{"key":"517_CR43","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.canlet.2011.09.038","volume":"315","author":"T Krech","year":"2012","unstructured":"Krech T, Scheuerer E, Geffers R, Kreipe H, Lehmann U, Christgen M. ABCB1\/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells. Cancer Lett. 2012;315:153\u201360.","journal-title":"Cancer Lett"},{"key":"517_CR44","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1158\/1541-7786.MCR-05-0156","volume":"4","author":"D Meijer","year":"2006","unstructured":"Meijer D, van Agthoven T, Bosma PT, Nooter K, Dorssers LC. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. Mol Cancer Res. 2006;4:379\u201386.","journal-title":"Mol Cancer Res"},{"key":"517_CR45","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1093\/carcin\/bgp117","volume":"30","author":"M Keimling","year":"2009","unstructured":"Keimling M, Wiesmuller L. DNA double-strand break repair activities in mammary epithelial cells \u2013 influence of endogenous p53 variants. Carcinogenesis. 2009;30:1260\u20138.","journal-title":"Carcinogenesis"},{"key":"517_CR46","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10549-009-0545-4","volume":"122","author":"A Hollestelle","year":"2010","unstructured":"Hollestelle A, Elstrodt F, Timmermans M, Sieuwerts AM, Klijn JG, Foekens JA, et al. Four human breast cancer cell lines with biallelic inactivating alpha-catenin gene mutations. Breast Cancer Res Treat. 2010;122:125\u201333.","journal-title":"Breast Cancer Res Treat"},{"key":"517_CR47","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1038\/nm.2454","volume":"17","author":"YS DeRose","year":"2011","unstructured":"DeRose YS, Wang G, Lin YC, Bernard PS, Buys SS, Ebbert MT, et al. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med. 2011;17:1514\u201320.","journal-title":"Nat Med"},{"key":"517_CR48","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.1158\/1078-0432.CCR-07-0078","volume":"13","author":"E Marangoni","year":"2007","unstructured":"Marangoni E, Vincent-Salomon A, Auger N, Degeorges A, Assayag F, de Cremoux P, et al. A new model of patient tumor-derived breast cancer xenografts for preclinical assays. Clin Cancer Res. 2007;13:3989\u201398.","journal-title":"Clin Cancer Res"},{"key":"517_CR49","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s10549-011-1815-5","volume":"133","author":"P Cottu","year":"2012","unstructured":"Cottu P, Marangoni E, Assayag F, de Cremoux P, Vincent-Salomon A, Guyader C, et al. Modeling of response to endocrine therapy in a panel of human luminal breast cancer xenografts. Breast Cancer Res Treat. 2012;133:595\u2013606.","journal-title":"Breast Cancer Res Treat"},{"key":"517_CR50","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1177\/0300985810393258","volume":"48","author":"M Goldschmidt","year":"2011","unstructured":"Goldschmidt M, Pena L, Rasotto R, Zappulli V. Classification and grading of canine mammary tumors. Vet Pathol. 2011;48:117\u201331.","journal-title":"Vet Pathol"},{"key":"517_CR51","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1023\/A:1018712905244","volume":"4","author":"RD Cardiff","year":"1999","unstructured":"Cardiff RD, Wellings SR. The comparative pathology of human and mouse mammary glands. J Mammary Gland Biol Neoplasia. 1999;4:105\u201322.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"517_CR52","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.jcpa.2010.08.015","volume":"144","author":"L Ressel","year":"2011","unstructured":"Ressel L, Millanta F, Poli A. Canine invasive lobular carcinoma of the mammary gland: morphological and immunohistochemical characterizations of three cases. J Comp Pathol. 2011;144:303\u20137.","journal-title":"J Comp Pathol"},{"key":"517_CR53","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1354\/vp.43-4-471","volume":"43","author":"CE Wood","year":"2006","unstructured":"Wood CE, Usborne AL, Starost MF, Tarara RP, Hill LR, Wilkinson LM, et al. Hyperplastic and neoplastic lesions of the mammary gland in macaques. Vet Pathol. 2006;43:471\u201383.","journal-title":"Vet Pathol"},{"key":"517_CR54","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10911-007-9050-8","volume":"12","author":"J Jonkers","year":"2007","unstructured":"Jonkers J, Derksen PW. Modeling metastatic breast cancer in mice. J Mammary Gland Biol Neoplasia. 2007;12:191\u2013203.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"517_CR55","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1073\/pnas.92.3.855","volume":"92","author":"D Riethmacher","year":"1995","unstructured":"Riethmacher D, Brinkmann V, Birchmeier C. A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc Natl Acad Sci U S A. 1995;92:855\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"517_CR56","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/embor.2011.88","volume":"12","author":"T Redmer","year":"2011","unstructured":"Redmer T, Diecke S, Grigoryan T, Quiroga-Negreira A, Birchmeier W, Besser D. E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming. EMBO Rep. 2011;12:720\u20136.","journal-title":"EMBO Rep"},{"key":"517_CR57","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1158\/0008-5472.CAN-08-2457","volume":"69","author":"B Humar","year":"2009","unstructured":"Humar B, Blair V, Charlton A, More H, Martin I, Guilford P. E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. Cancer Res. 2009;69:2050\u20136.","journal-title":"Cancer Res"},{"key":"517_CR58","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/0092-8674(93)90644-6","volume":"73","author":"H Gu","year":"1993","unstructured":"Gu H, Zou YR, Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 1993;73:1155\u201364.","journal-title":"Cell"},{"key":"517_CR59","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0925-4773(02)00090-4","volume":"115","author":"O Boussadia","year":"2002","unstructured":"Boussadia O, Kutsch S, Hierholzer A, Delmas V, Kemler R. E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev. 2002;115:53\u201362.","journal-title":"Mech Dev"},{"key":"517_CR60","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1073\/pnas.0307437100","volume":"101","author":"CL Tinkle","year":"2004","unstructured":"Tinkle CL, Lechler T, Pasolli HA, Fuchs E. Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A. 2004;101:552\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"517_CR61","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ccr.2006.09.013","volume":"10","author":"PW Derksen","year":"2006","unstructured":"Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006;10:437\u201349.","journal-title":"Cancer Cell"},{"key":"517_CR62","doi-asserted-by":"publisher","first-page":"R104","DOI":"10.1186\/bcr3046","volume":"13","author":"AM Kotb","year":"2011","unstructured":"Kotb AM, Hierholzer A, Kemler R. Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation. Breast Cancer Res. 2011;13:R104.","journal-title":"Breast Cancer Res"},{"key":"517_CR63","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1242\/dmm.006395","volume":"4","author":"PW Derksen","year":"2011","unstructured":"Derksen PW, Braumuller TM, van der Burg E, Hornsveld M, Mesman E, Wesseling J, et al. Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis Model Mech. 2011;4:347\u201358.","journal-title":"Dis Model Mech"},{"key":"517_CR64","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1111\/j.1349-7006.2011.01890.x","volume":"102","author":"A Mimata","year":"2011","unstructured":"Mimata A, Fukamachi H, Eishi Y, Yuasa Y. Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer. Cancer Sci. 2011;102:942\u201350.","journal-title":"Cancer Sci"},{"key":"517_CR65","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1136\/gutjnl-2011-300050","volume":"61","author":"S Shimada","year":"2012","unstructured":"Shimada S, Mimata A, Sekine M, Mogushi K, Akiyama Y, Fukamachi H, et al. Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut. 2012;61:344\u201353.","journal-title":"Gut"},{"key":"517_CR66","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1158\/1541-7786.MCR-14-0192-T","volume":"12","author":"JW Park","year":"2014","unstructured":"Park JW, Jang SH, Park DM, Lim NJ, Deng C, Kim DY, et al. Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res. 2014;12:1088\u201399.","journal-title":"Mol Cancer Res"},{"key":"517_CR67","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1158\/0008-5472.CAN-11-4208","volume":"73","author":"CW Doornebal","year":"2013","unstructured":"Doornebal CW, Klarenbeek S, Braumuller TM, Klijn CN, Ciampricotti M, Hau CS, et al. A preclinical mouse model of invasive lobular breast cancer metastasis. Cancer Res. 2013;73:353\u201363.","journal-title":"Cancer Res"},{"key":"517_CR68","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1093\/annonc\/mdl114","volume":"17","author":"M Tubiana-Hulin","year":"2006","unstructured":"Tubiana-Hulin M, Stevens D, Lasry S, Guinebretiere JM, Bouita L, Cohen-Solal C, et al. Response to neoadjuvant chemotherapy in lobular and ductal breast carcinomas: a retrospective study on 860 patients from one institution. Ann Oncol. 2006;17:1228\u201333.","journal-title":"Ann Oncol"},{"key":"517_CR69","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1128\/MCB.19.5.3614","volume":"19","author":"JM Daniel","year":"1999","unstructured":"Daniel JM, Reynolds AB. The catenin p120(ctn) interacts with Kaiso, a novel BTB\/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999;19:3614\u201323.","journal-title":"Mol Cell Biol"},{"key":"517_CR70","doi-asserted-by":"publisher","first-page":"e37864","DOI":"10.1371\/journal.pone.0037864","volume":"7","author":"JF Vermeulen","year":"2012","unstructured":"Vermeulen JF, van de Ven RA, Ercan C, van der Groep P, van der Wall E, Bult P, et al. Nuclear Kaiso expression is associated with high grade and triple-negative invasive breast cancer. PLoS One. 2012;7:e37864.","journal-title":"PLoS One"},{"key":"517_CR71","doi-asserted-by":"publisher","first-page":"4937","DOI":"10.1158\/0008-5472.CAN-13-0180","volume":"73","author":"RC Schackmann","year":"2013","unstructured":"Schackmann RC, Klarenbeek S, Vlug EJ, Stelloo S, van Amersfoort M, Tenhagen M, et al. Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling. Cancer Res. 2013;73:4937\u201349.","journal-title":"Cancer Res"},{"key":"517_CR72","doi-asserted-by":"publisher","first-page":"5371","DOI":"10.1158\/0008-5472.CAN-14-0620","volume":"74","author":"LM Arthur","year":"2014","unstructured":"Arthur LM, Turnbull AK, Webber VL, Larionov AA, Renshaw L, Kay C, et al. Molecular changes in lobular breast cancers in response to endocrine therapy. Cancer Res. 2014;74:5371\u20136.","journal-title":"Cancer Res"},{"key":"517_CR73","doi-asserted-by":"publisher","first-page":"e1004285","DOI":"10.1371\/journal.pgen.1004285","volume":"10","author":"E Sawyer","year":"2014","unstructured":"Sawyer E, Roylance R, Petridis C, Brook MN, Nowinski S, Papouli E, et al. Genetic predisposition to in situ and invasive lobular carcinoma of the breast. PLoS Genet. 2014;10:e1004285.","journal-title":"PLoS Genet"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-015-0517-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13058-015-0517-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-015-0517-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13058-015-0517-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:08:37Z","timestamp":1728922117000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/s13058-015-0517-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,8]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["517"],"URL":"https:\/\/doi.org\/10.1186\/s13058-015-0517-z","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,8]]},"assertion":[{"value":"6 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"16"}}