{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:11:49Z","timestamp":1770063109164,"version":"3.49.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                        <jats:title>Introduction\n<\/jats:title>\n                        <jats:p>Erectile dysfunction (ED) is common in men with systemic sclerosis (SSc) but the demographics, risk factors and treatment coverage for ED are not well known.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Method\n<\/jats:title>\n                        <jats:p>This study was carried out prospectively in the multinational EULAR Scleroderma Trial and Research database by amending the electronic data-entry system with the International Index of Erectile Function-5 and items related to ED risk factors and treatment. Centres participating in this EULAR Scleroderma Trial and Research substudy were asked to recruit patients consecutively.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results\n<\/jats:title>\n                        <jats:p>Of the 130 men studied, only 23 (17.7%) had a normal International Index of Erectile Function-5 score. Thirty-eight per cent of all participants had severe ED (International Index of Erectile Function-5 score \u2264 7). Men with ED were significantly older than subjects without ED (54.8 years vs. 43.3 years, <jats:italic>P<\/jats:italic> &lt; 0.001) and more frequently had simultaneous non-SSc-related risk factors such as alcohol consumption. In 82% of SSc patients, the onset of ED was after the manifestation of the first non-Raynaud's symptom (median delay 4.1 years). ED was associated with severe cutaneous, muscular or renal involvement of SSc, elevated pulmonary pressures and restrictive lung disease. ED was treated in only 27.8% of men. The most common treatment was sildenafil, whose efficacy is not established in ED of SSc patients.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions\n<\/jats:title>\n                        <jats:p>Severe ED is a common and early problem in men with SSc. Physicians should address modifiable risk factors actively. More research into the pathophysiology, longitudinal development, treatment and psychosocial impact of ED is needed.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar3748","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T15:15:19Z","timestamp":1329750919000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research group"],"prefix":"10.1186","volume":"14","author":[{"given":"Chingching","family":"Foocharoen","sequence":"first","affiliation":[]},{"given":"Alan","family":"Tyndall","sequence":"additional","affiliation":[]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[]},{"given":"Edoardo","family":"Rosato","sequence":"additional","affiliation":[]},{"given":"Yannick","family":"Allanore","sequence":"additional","affiliation":[]},{"given":"Dominique","family":"Farge-Bancel","sequence":"additional","affiliation":[]},{"given":"Paola","family":"Caramaschi","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Air\u00f3","sequence":"additional","affiliation":[]},{"given":"Starovojtova M","family":"Nikolaevna","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Ant\u00f3nio","family":"Pereira da Silva","sequence":"additional","affiliation":[]},{"given":"Bojana","family":"Stamenkovic","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Riemekasten","sequence":"additional","affiliation":[]},{"given":"Simona","family":"Rednic","sequence":"additional","affiliation":[]},{"given":"Jean","family":"Sibilia","sequence":"additional","affiliation":[]},{"given":"Piotr","family":"Wiland","sequence":"additional","affiliation":[]},{"given":"Ingo","family":"Tarner","sequence":"additional","affiliation":[]},{"given":"Vanessa","family":"Smith","sequence":"additional","affiliation":[]},{"given":"Anna T","family":"Onken","sequence":"additional","affiliation":[]},{"given":"Walid Ahmed","family":"Abdel Atty Mohamed","sequence":"additional","affiliation":[]},{"given":"Oliver","family":"Distler","sequence":"additional","affiliation":[]},{"given":"Jadranka","family":"Morovi\u0107-Vergles","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Himsel","sequence":"additional","affiliation":[]},{"given":"Paloma Garcia","family":"de la Pe\u00f1a Lefebvre","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"H\u00fcgle","sequence":"additional","affiliation":[]},{"given":"Ulrich A","family":"Walker","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,2,20]]},"reference":[{"key":"3495_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.rdc.2007.11.006","volume":"34","author":"A Herrick","year":"2008","unstructured":"Herrick A: Diagnosis and management of scleroderma peripheral vascular disease. 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