{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:24:01Z","timestamp":1728447841338},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T00:00:00Z","timestamp":1260403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T00:00:00Z","timestamp":1260403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Normal gene expression variation is thought to play a central role in inter-individual variation and susceptibility to disease. Regulatory polymorphisms in cis-acting elements result in the unequal expression of alleles. Differential allelic expression (DAE) in heterozygote individuals could be used to develop a new approach to discover regulatory breast cancer susceptibility loci. As access to large numbers of fresh breast tissue to perform such studies is difficult, a suitable surrogate test tissue must be identified for future studies.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We measured differential allelic expression of 12 candidate genes possibly related to breast cancer susceptibility (<jats:italic>BRCA1<\/jats:italic>, <jats:italic>BRCA2<\/jats:italic>, <jats:italic>C1qA<\/jats:italic>, <jats:italic>CCND3<\/jats:italic>, <jats:italic>EMSY<\/jats:italic>, <jats:italic>GPX1<\/jats:italic>, <jats:italic>GPX4<\/jats:italic>, <jats:italic>MLH3<\/jats:italic>, <jats:italic>MTHFR<\/jats:italic>, <jats:italic>NBS1<\/jats:italic>, <jats:italic>TP53<\/jats:italic> and <jats:italic>TRXR2<\/jats:italic>) in breast tissue (n = 40) and fresh blood (n = 170) of healthy individuals and EBV-transformed lymphoblastoid cells (n = 19). Differential allelic expression ratios were determined by Taqman assay. Ratio distributions were compared using t-test and Wilcoxon rank sum test, for mean ratios and variances respectively.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>We show that differential allelic expression is common among these 12 candidate genes and is comparable between breast and blood (fresh and transformed lymphoblasts) in a significant proportion of them. We found that eight out of nine genes with DAE in breast and fresh blood were comparable, as were 10 out of 11 genes between breast and transformed lymphoblasts.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Our findings support the use of differential allelic expression in blood as a surrogate for breast tissue in future studies on predisposition to breast cancer.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr2458","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T19:15:02Z","timestamp":1260472502000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast"],"prefix":"10.1186","volume":"11","author":[{"given":"Ana-Teresa","family":"Maia","sequence":"first","affiliation":[]},{"given":"Inmaculada","family":"Spiteri","sequence":"additional","affiliation":[]},{"given":"Alvin JX","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Martin","family":"O'Reilly","sequence":"additional","affiliation":[]},{"given":"Linda","family":"Jones","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Caldas","sequence":"additional","affiliation":[]},{"given":"Bruce AJ","family":"Ponder","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,12,10]]},"reference":[{"key":"2420_CR1","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/nature05887","volume":"447","author":"DF Easton","year":"2007","unstructured":"Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, Healey CS, Bowman R, collaborators S, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, et al: Genome-wide association study identifies novel breast cancer susceptibility loci. 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