{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T19:50:59Z","timestamp":1775937059752,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,2,20]],"date-time":"2004-02-20T00:00:00Z","timestamp":1077235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2004,2,20]],"date-time":"2004-02-20T00:00:00Z","timestamp":1077235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The objective of the present study was to compare the health-related quality of life (HR-QoL) of survivors from severe sepsis and septic shock with HR-QoL in others who survived critical illness not involving sepsis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>From March 1997 to March 2001, adult patients in an eight-bed medical\/surgical intensive care unit (ICU) of a tertiary care hospital admitted with severe sepsis or septic shock (sepsis group; <jats:italic>n<\/jats:italic> = 305) were enrolled and compared with patients admitted without sepsis (control group; <jats:italic>n<\/jats:italic> = 392). Patients younger than 18 years (<jats:italic>n<\/jats:italic> = 48) and those whose ICU stay was 1 day or less (<jats:italic>n<\/jats:italic> = 453) were excluded. In addition, patients exhibiting nonsevere sepsis on admission were excluded (<jats:italic>n<\/jats:italic> = 87). Finally, patients who developed nonsevere sepsis or severe sepsis\/septic shock after admission were also excluded (<jats:italic>n<\/jats:italic> = 88).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>In-hospital mortality rates were 34% in the sepsis group and 26% in the control group. There were no differences in sex, age, main activity (work status), and previous health state between groups. Survivors in the sepsis group had a significantly higher Acute Physiology and Chronic Health Evaluation II score on admission (17 versus 12) and stayed significantly longer in the ICU. A follow-up appointment was held 6 months after ICU discharge, and an EQ-5D (EuroQol five-dimension) questionnaire was administered. A total of 104 sepsis survivors and 133 survivors in the control group answered the EQ-5D questionnaire. Sepsis survivors reported significantly fewer problems only in the anxiety\/depression dimension. Although there were no significant differences in the other dimensions of the EQ-5D, there was a trend towards fewer problems being reported by sepsis survivors.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>Evaluation using the EQ-5D at 6 months after ICU discharge indicated that survivors from severe sepsis and septic shock have a similar HR-QoL to that of survivors from critical illness admitted without sepsis.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc2818","type":"journal-article","created":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T07:22:10Z","timestamp":1078298530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Quality of life of survivors from severe sepsis and septic shock may be similar to that of others who survive critical illness"],"prefix":"10.1186","volume":"8","author":[{"given":"Cristina","family":"Granja","sequence":"first","affiliation":[]},{"given":"Cl\u00e1udia","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Altamiro","family":"Costa-Pereira","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Sarmento","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2004,2,20]]},"reference":[{"key":"2820_CR1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","volume":"29","author":"DC Angus","year":"2001","unstructured":"Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care.\n                           Crit Care Med 2001, 29:1303\u20131310.","journal-title":"Crit Care Med"},{"key":"2820_CR2","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1001\/jama.1997.03540370048035","volume":"277","author":"A Quartin","year":"1997","unstructured":"Quartin A, Schein RMH, Kett DH, Peduzzi PN: Magnitude and duration of the effect of sepsis on survival.\n                           JAMA 1997, 277:1058\u20131063.","journal-title":"JAMA"},{"key":"2820_CR3","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1001\/jama.1995.03530120060042","volume":"274","author":"C Brun-Buisson","year":"1995","unstructured":"Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, Mercirer J-C, Offensladt G, R\u00e9gnier B, for the French ICU Group for Severe Sepsis: Incidence, risk factors and outcome of severe sepsis and septic shock in adults: a multicenter, prospective study in intensive care units.\n                           JAMA 1995, 274:968\u2013974.","journal-title":"JAMA"},{"key":"2820_CR4","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/BF01705408","volume":"21","author":"D Pittet","year":"1995","unstructured":"Pittet D, Rangel-Frausto S, Li N, Tarara D, Costigan M, Rempe L, Jebson P, Wenzel RP: Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes of surgical ICU patients.\n                           Intensive Care Med 1995, 21:302\u2013309.","journal-title":"Intensive Care Med"},{"key":"2820_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1164\/rccm.200208-785OC","volume":"168","author":"C Alberti","year":"2003","unstructured":"Alberti C, Brun-Buisson C, Goodman SV, Guidici D, Granton J, Moreno R, Smithies M, Thomas O, Artigas A, Le Gall JR, for the European Sepsis Group: Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients.\n                           Am J Resp Crit Care Med 2003, 168:77\u201384.","journal-title":"Am J Resp Crit Care Med"},{"key":"2820_CR6","first-page":"3","volume-title":"In: Surviving Intensive Care: Update in Intensive Care and Emergency Medicine","author":"SP Keenan","year":"2003","unstructured":"Keenan SP, Dodek P: Survival as an outcome for ICU patients.\n                           In: Surviving Intensive Care: Update in Intensive Care and Emergency Medicine\n                           (Edited by: Angus D, Carlet J). 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