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We addressed this question using a novel task-based fMRI virtual-reality task mimicking a challenging daily-life chore that may present some difficulties to individuals with ASD: the EcoSupermarketX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included 29 adolescents: 15 with ASD and 15 with typical neurodevelopment (TD). They performed the EcoSupermarketX (a shopping simulation with three goal-oriented sub-tasks including \u201cno cue\u201d, \u201cnon-social\u201d or \u201csocial\u201d cues), during neuroimaging and eye-tracking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ASD differed from TD only in total time and distance to complete the \u201csocial cue\u201d sub-task with matched eye-tracking measures. Neuroimaging revealed simultaneous hyperactivation across social, executive, and saliency circuits in ASD. In contrast, ASD showed reduced activation in the parahippocampal gyrus, involved in scene recognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When performing a virtual shopping task matching the performance of controls, ASD adolescents hyperactivate three core networks: executive, saliency and social cognition. Parahippocampal hypoactivation is consistent with effortless eidetic scene processing, in line with the notion of peaks and valleys of neural recruitment in individuals with ASD. These hyperactivation\/hypoactivation patterns in daily life tasks provide a circuit-level signature of neural diversity in ASD, a possible intervention target.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s11689-022-09417-1","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T13:03:26Z","timestamp":1643115806000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder"],"prefix":"10.1186","volume":"14","author":[{"given":"Susana","family":"Mouga","sequence":"first","affiliation":[]},{"given":"Isabel Catarina","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"C\u00e1tia","family":"Caf\u00e9","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Frederico","family":"Duque","sequence":"additional","affiliation":[]},{"given":"Guiomar","family":"Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-6373","authenticated-orcid":false,"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"9417_CR1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association. 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