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We report a case of a splenectomised patient, hospitalised due to invasive pneumococcal disease, who was diagnosed with retinitis in the right eye, with good visual acuity (0.1 LogMAR). Given the presence of HHV-6 Polymerase chain reaction (PCR) in the cerebrospinal fluid and the serum and the coexistence of a severe central nervous system infection, the ophthalmological features were attributed to the HHV-6 infection. He was treated with topical corticosteroid eyedrops, cyclopentolate, and prednisolone acetate ointment and systemically with intravenous ganciclovir 5\u00a0mg\/kg bid for 14 days and then oral valganciclovir 900\u00a0mg bid for 4 weeks. The diagnosis was promptly presumed, enabling the early initiation of appropriate treatment and contributing to the preservation of the good visual acuity initially observed.<\/jats:p>","DOI":"10.1186\/s12348-025-00460-2","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T11:35:11Z","timestamp":1739187311000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinitis linked to human herpesvirus type 6: a case study in a splenectomised patient"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-8469","authenticated-orcid":false,"given":"Joana","family":"Santos-Oliveira","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-8786","authenticated-orcid":false,"given":"Ana Maria","family":"Cunha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-0016","authenticated-orcid":false,"given":"Ana Filipa","family":"Moleiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0196-3840","authenticated-orcid":false,"given":"Margarida","family":"Ribeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-9554","authenticated-orcid":false,"given":"S\u00f3nia","family":"Torres-Costa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-7140","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Oliveira-Ferreira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-5488","authenticated-orcid":false,"given":"Ana Catarina","family":"Pedrosa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6140-096X","authenticated-orcid":false,"given":"Joana","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-882X","authenticated-orcid":false,"given":"Lu\u00eds","family":"Figueira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5906-6061","authenticated-orcid":false,"given":"Marta","family":"Silva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"460_CR1","unstructured":"Harris E, Epstein HF, Zaki Salahuddin S, Ablashi D, v, Markhiam PD, Josephs SF et al (1984) A modification of the procedure of H isolation of a New Virus, HBLV, in patients with Lymphoproliferative disorders [Internet]. 225, Biochem BSophys Res Commun. 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