{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:59:08Z","timestamp":1761490748448},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Clin. Androl."],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12610-018-0082-2","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T12:05:06Z","timestamp":1549541106000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide"],"prefix":"10.1186","volume":"29","author":[{"given":"Jo\u00e3o","family":"Baetas","sequence":"first","affiliation":[]},{"given":"Ana","family":"Raba\u00e7a","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Barros","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Ros\u00e1lia","family":"S\u00e1","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"82_CR1","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.eururo.2015.07.044","volume":"68","author":"P Albers","year":"2015","unstructured":"Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedemark G, Fizazi K, et al. Guidelines on testicular cancer: 2015 update. Eur Urol. 2015;68:1054\u201368.","journal-title":"Eur Urol"},{"key":"82_CR2","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.eururo.2012.03.038","volume":"61","author":"F Calabr\u00f2","year":"2012","unstructured":"Calabr\u00f2 F, Albers P, Bokemeyer C, Martin C, Einhorn LH, Horwich A, et al. The contemporary role of chemotherapy for advanced testis cancer: a systematic review of the literature. Eur Urol. 2012;61:1212\u201321.","journal-title":"Eur Urol"},{"key":"82_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ucl.2015.05.002","volume":"42","author":"C Fung","year":"2015","unstructured":"Fung C, Fossa SD, Williams A, Travis LB. Long-term morbidity of testicular cancer treatment. Urol Clin North Am. 2015;42:393\u2013408.","journal-title":"Urol Clin North Am"},{"key":"82_CR4","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1200\/JCO.2007.15.3130","volume":"27","author":"M Cvancarova","year":"2009","unstructured":"Cvancarova M, Samuelsen SO, Magelssen H, Fossa SD. Reproduction rates after cancer treatment: experience from the Norwegian radium hospital. J Clin Oncol. 2009;27:334\u201343.","journal-title":"J Clin Oncol"},{"key":"82_CR5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.juro.2008.10.023","volume":"181","author":"DH Williams","year":"2009","unstructured":"Williams DH, Karpman E, Sander JC, Spiess PE, Pisters LL, Lipshultz LI. Pretreatment semen parameters in men with cancer. J Urol. 2009;181:736\u201340.","journal-title":"J Urol"},{"key":"82_CR6","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.2174\/0929867322666150821094334","volume":"22","author":"A Raba\u00e7a","year":"2015","unstructured":"Raba\u00e7a A, Sousa M, Alves M, Oliveira PF, S\u00e1 R. Novel drug therapies for fertility preservation in men undergoing chemotherapy: clinical relevance of protector agents. Curr Med Chem. 2015;22:3347\u201369.","journal-title":"Curr Med Chem"},{"key":"82_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev.pa.34.040194.001203","volume":"34","author":"AY Chen","year":"1994","unstructured":"Chen AY, Liu LF. DNA topoisomerases: essential enzymes and lethal targets. Ann Rev Pharmacol Toxicol. 1994;34:191\u2013218.","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"82_CR8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrc2167","volume":"7","author":"L Kelland","year":"2007","unstructured":"Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer. 2007;7:573\u201384.","journal-title":"Nat Rev Cancer"},{"key":"82_CR9","doi-asserted-by":"publisher","first-page":"21429","DOI":"10.1074\/jbc.270.37.21429","volume":"270","author":"SJ Froelich-Ammon","year":"1995","unstructured":"Froelich-Ammon SJ, Osheroff N. Topoisomerase poisons: harnessing the dark side of enzyme mechanism. J Biol Chem. 1995;270:21429\u201332.","journal-title":"J Biol Chem"},{"key":"82_CR10","doi-asserted-by":"publisher","unstructured":"Auger J, Sermondade N, Eustache F. Semen quality of 4480 young cancer and systematic disease patients: baseline data and clinical considerations. Basic Clin Androl. 2016;26(3). \n                    https:\/\/doi.org\/10.1186\/s12610-016-0031-x\n                    \n                  .","DOI":"10.1186\/s12610-016-0031-x"},{"key":"82_CR11","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/and.12451","volume":"48","author":"L Caponecchia","year":"2016","unstructured":"Caponecchia L, Cimino G, Sacchetto R, Fiori C, Sebastianelli A, Salacone P, et al. Do malignant diseases affetc semen quality? Sperm parameters of men with cancer. Andrologia. 2016;48:333\u201340.","journal-title":"Andrologia"},{"key":"82_CR12","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1053\/j.seminoncol.2015.09.024","volume":"42","author":"L Santo","year":"2015","unstructured":"Santo L, Siu KT, Raje N. Targeting cyclin-dependent kinases and cell cycle progression in human cancers. Semin Oncol. 2015;42:788\u2013800.","journal-title":"Semin Oncol"},{"key":"82_CR13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.31768\/2312-8852.2015.37(3):162-172","volume":"37","author":"A Reznikov","year":"2015","unstructured":"Reznikov A. Hormonal impact on tumor growth and progression. Exp Oncol. 2015;37:162\u201372.","journal-title":"Exp Oncol"},{"key":"82_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ejca.2015.11.016","volume":"54","author":"JM Michot","year":"2016","unstructured":"Michot JM, Bigenwald C, Champiat S, Collins M, Carbonnel F, Postel-Vinay S, et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer. 2016;54:139\u201348.","journal-title":"Eur J Cancer"},{"key":"82_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.nut.2012.02.014","volume":"29","author":"V Fuchs-Tarlocsky","year":"2013","unstructured":"Fuchs-Tarlocsky V. Role of antioxidants in cancer therapy. Nutrition. 2013;29:15\u201321.","journal-title":"Nutrition"},{"key":"82_CR16","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1177\/1534735416681639","volume":"17","author":"A Thyagarajan","year":"2018","unstructured":"Thyagarajan A, Sahu RP. Potential contributions of antioxidants to cancer therapy: immunomodulation and radiosensitization. Integr Cancer Ther. 2018;17:2010\u20136.","journal-title":"Integr Cancer Ther"},{"key":"82_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0090-8258(02)00067-7","volume":"88","author":"JA Drisko","year":"2003","unstructured":"Drisko JA, Chapman J, Hunter VJ. The use of antioxidant therapies during chemotherapy. Gynecol Oncol. 2003;88:434\u20139.","journal-title":"Gynecol Oncol"},{"key":"82_CR18","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/0891-5849(89)90066-X","volume":"6","author":"OI Aruoma","year":"1989","unstructured":"Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Rad Biol Med. 1989;6:593\u20137.","journal-title":"Free Rad Biol Med"},{"key":"82_CR19","first-page":"45","volume":"111","author":"L Bonanomi","year":"1980","unstructured":"Bonanomi L, Gazzaniga A. Toxicological, pharmacokinetic and metabolic studies on acetylcysteine. Eur J Respir Dis Suppl. 1980;111:45\u201351.","journal-title":"Eur J Respir Dis Suppl"},{"issue":"1Suppl1","key":"82_CR20","first-page":"17","volume":"10","author":"RE Johnston","year":"1983","unstructured":"Johnston RE, Hawkins HC, Weikel JH Jr. The toxicity of N-acetylcysteine in laboratory animals. Semin Oncol. 1983;10(1Suppl1):17\u201324.","journal-title":"Semin Oncol"},{"key":"82_CR21","first-page":"1151","volume":"79","author":"T Cai","year":"1999","unstructured":"Cai T, Fassina G, Morini M, Aluigi MG, Masiello L, Fontanini G, et al. N-acetylcysteine inhibits endothelial cell invasion and angiogenesis. Lab Investig. 1999;79:1151\u20139.","journal-title":"Lab Investig"},{"issue":"1","key":"82_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5534\/wjmh.2014.32.1.1","volume":"32","author":"A Agarwal","year":"2014","unstructured":"Agarwal A, Virk G, Ong C, du Plessis SS. Effect of oxidative stress on male reproduction. World J mens Health. 2014;32(1):17.","journal-title":"World J mens Health"},{"key":"82_CR23","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nrurol.2017.69","volume":"14","author":"S Bisht","year":"2017","unstructured":"Bisht S, Faiq M, Tolahunase M, Dada R. Oxidative stress and male infertility. Nat Rev Urol. 2017;14:470\u201385.","journal-title":"Nat Rev Urol"},{"key":"82_CR24","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/S1472-6483(10)61641-0","volume":"8","author":"A Agarwal","year":"2004","unstructured":"Agarwal A, Nallella KP, Allamaneni SSR, Said TM. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod BioMed Online. 2004;8:616\u201327.","journal-title":"Reprod BioMed Online"},{"key":"82_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.urology.2009.02.034","volume":"74","author":"H Ciftci","year":"2009","unstructured":"Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative\/antioxidant status. Urology. 2009;74:73\u20136.","journal-title":"Urology"},{"key":"82_CR26","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/j.1442-2042.2009.02280.x","volume":"16","author":"JC Kefer","year":"2009","unstructured":"Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility. Int J Urol. 2009;16:449\u201357.","journal-title":"Int J Urol"},{"key":"82_CR27","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1200\/JCO.1995.13.9.2278","volume":"13","author":"W Stephenson","year":"1995","unstructured":"Stephenson W, Poirier SM, Rubin L, Einhorn LH. Evaluation of reproductive capacity in germ cell tumor patients following treatment with cisplatin, etoposide, and bleomycin. J Clin Oncol. 1995;13:2278\u201380.","journal-title":"J Clin Oncol"},{"key":"82_CR28","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1093\/humrep\/16.6.1204","volume":"16","author":"P Mas De","year":"2001","unstructured":"De Mas P, Daudin M, Vincent MC, Bourrouillou G, Calvas P, Mieusset R, et al. Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin. Hum Reprod. 2001;16:1204\u20138.","journal-title":"Hum Reprod"},{"key":"82_CR29","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fphar.2016.00122","volume":"7","author":"M Ghezzi","year":"2016","unstructured":"Ghezzi M, Berretta M, Bottacin A, Palego P, Sartini B, Cosci I, et al. Impact of Bep or carboplatin chemotherapy on testicular function and sperm nucleus of subjects with testicular germ cell tumor. Front Pharmacol. 2016;7:122.","journal-title":"Front Pharmacol"},{"key":"82_CR30","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1095\/biolreprod.115.137802","volume":"94","author":"N Bagheri-Sereshki","year":"2016","unstructured":"Bagheri-Sereshki N, Hales BF, Robaire B. The effects of chemotherapeutic agents, bleomycin, etoposide, and cisplatin, on chromatin remodeling in male rat germ cells. Biol Reprod. 2016;94:81.","journal-title":"Biol Reprod"},{"key":"82_CR31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0027-5107(98)00036-0","volume":"400","author":"LB Russell","year":"1998","unstructured":"Russell LB, Hunsicker PR, Johnson DK, Shelby MD. Unlike other chemicals, etoposide (a topoisomerase-II inhibitor) produces peak mutagenicity in primary spermatocytes of the mouse. Mutat Res. 1998;400:279\u201386.","journal-title":"Mutat Res"},{"key":"82_CR32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S1383-5718(99)00185-0","volume":"464","author":"LB Russell","year":"2000","unstructured":"Russell LB, Hunsicker PR, Hack AM, Ashley T. Effect of the topoisomerase-II inhibitor etoposide on meiotic recombination in male mice. Mutat Res. 2000;464:201\u201312.","journal-title":"Mutat Res"},{"key":"82_CR33","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/mrd.20508","volume":"73","author":"S Matulis","year":"2006","unstructured":"Matulis S, Handel MA. Spermatocyte responses in vitro to induced DNA damage. Mol Reprod Dev. 2006;73:1061\u201372.","journal-title":"Mol Reprod Dev"},{"key":"82_CR34","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1093\/humrep\/dei416","volume":"21","author":"F Marchetti","year":"2006","unstructured":"Marchetti F, Pearson FS, Bishop JB, Wyrobek AJ. Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia. Hum Reprod. 2006;21:888\u201395.","journal-title":"Hum Reprod"},{"key":"82_CR35","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00441-009-0801-2","volume":"337","author":"FK Okada","year":"2009","unstructured":"Okada FK, Stumpp T, Miraglia SM. Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase. Cell Tiss Res. 2009;337:269\u201380.","journal-title":"Cell Tiss Res"},{"key":"82_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.fct.2016.02.017","volume":"91","author":"KP Reddy","year":"2016","unstructured":"Reddy KP, Madhu P, Reddy PS. Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats. Food Chem Toxicol. 2016;91:65\u201372.","journal-title":"Food Chem Toxicol"},{"key":"82_CR37","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1186\/s12885-017-3898-9","volume":"17","author":"T Afsar","year":"2017","unstructured":"Afsar T, Razak S, Khan MR, Almajwal A. Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats. BMC Cancer. 2017;17:883.","journal-title":"BMC Cancer"},{"key":"82_CR38","volume-title":"WHO laboratory manual for the examination and processing of human semen","author":"World Health Organization (WHO)","year":"2010","unstructured":"World Health Organization (WHO). WHO laboratory manual for the examination and processing of human semen. Geneva: WHO Press; 2010."},{"key":"82_CR39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4103\/0976-500X.119726","volume":"4","author":"J Charan","year":"2013","unstructured":"Charan J, Kantharia ND. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013;4:303\u20136.","journal-title":"J Pharmacol Pharmacother"},{"key":"82_CR40","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0305-7372(96)90002-X","volume":"22","author":"S Joel","year":"1996","unstructured":"Joel S. The clinical pharmacology of etoposide: an update. Cancer Treat Rev. 1996;22:179\u2013221.","journal-title":"Cancer Treat Rev"},{"key":"82_CR41","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.yrtph.2005.05.004","volume":"42","author":"MA Dorato","year":"2005","unstructured":"Dorato MA, Engelhardt JA. The no-observed-adverse-effect-level in drug safety evaluations: use, issues, and definition(s). Reg Toxicol Pharmacol. 2005;42:265\u201374.","journal-title":"Reg Toxicol Pharmacol"},{"issue":"1 Suppl","key":"82_CR42","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/1097-0142(19910101)67:1+<319::AID-CNCR2820671319>3.0.CO;2-D","volume":"67","author":"ML Slevin","year":"1991","unstructured":"Slevin ML. The clinical pharmacology of etoposide. Cancer. 1991;67(1 Suppl):319\u201329.","journal-title":"Cancer"},{"key":"82_CR43","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10815-014-0370-5","volume":"32","author":"S Bucar","year":"2015","unstructured":"Bucar S, Goncalves A, Rocha E, Barros A, Sousa M, S\u00e1 R. DNA fragmentation in human sperm after magnetic-activated cell sorting. J Assist Reprod Genet. 2015;32:147\u201354.","journal-title":"J Assist Reprod Genet"},{"key":"82_CR44","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.rbmo.2015.06.019","volume":"31","author":"R S\u00e1","year":"2015","unstructured":"S\u00e1 R, Cunha M, Rocha E, Barros A, Sousa M. Sperm DNA fragmentation is related to sperm morphological staining patterns. Reprod BioMedicine Online. 2015;31:506\u201315.","journal-title":"Reprod BioMedicine Online"},{"key":"82_CR45","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1080\/10590500902885684","volume":"27","author":"A Valavanidis","year":"2009","unstructured":"Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health, Part C. 2009;27:120\u201339.","journal-title":"J Environ Sci Health, Part C"},{"key":"82_CR46","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/humrep\/dey038","volume":"33","author":"S Vorilhon","year":"2018","unstructured":"Vorilhon S, Brugnon F, Kocer A, DEollet S, Bourgne C, Berger M, et al. Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay. Hum Reprod. 2018;33:553\u201362.","journal-title":"Hum Reprod"},{"key":"82_CR47","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3322\/caac.21149","volume":"62","author":"R Siegel","year":"2012","unstructured":"Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62:220\u201341.","journal-title":"CA Cancer J Clin"},{"key":"82_CR48","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/ncpuro0508","volume":"3","author":"H Magelssen","year":"2006","unstructured":"Magelssen H, Brydoy M, Fossa SD. The effects of cancer and cancer treatments on male reproductive function. Nat Clin Pract Urol. 2006;3:312\u201322.","journal-title":"Nat Clin Pract Urol"},{"key":"82_CR49","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S0140-6736(14)60495-5","volume":"384","author":"H Tournaye","year":"2014","unstructured":"Tournaye H, Dohle GR, Barratt CLR. Fertility preservation in men with cancer. Lancet. 2014;384:1295\u2013301.","journal-title":"Lancet"},{"key":"82_CR50","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.lfs.2016.03.003","volume":"151","author":"IE Dhouib","year":"2016","unstructured":"Dhouib IE, Jallouli M, Annabi A, Gharbi N, Elfazaa S, Lasram MM. A minireview on N-acetylcysteine: an old drug with new approaches. Life Sci. 2016;151:359\u201363.","journal-title":"Life Sci"},{"key":"82_CR51","first-page":"1723","volume":"58","author":"M Liu","year":"1998","unstructured":"Liu M, Pelling JC, Ju J, Chu E, Brash DE. Antioxidant action via p53-mediated apoptosis. Cancer Res. 1998;58:1723\u20139.","journal-title":"Cancer Res"},{"key":"82_CR52","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/cyto.a.20873","volume":"77","author":"B Lohrke","year":"2010","unstructured":"Lohrke B, Xu J, Weitzel JM, Kr\u00fcger B, Goldammer T, Viergutz T. N-acetylcysteine impairs survival of luteal cells through mitochondrial dysfunction. Cytometry Part A. 2010;77:310\u201320.","journal-title":"Cytometry Part A"},{"key":"82_CR53","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1097\/WNR.0b013e328337765c","volume":"21","author":"J Sagara","year":"2010","unstructured":"Sagara J, Bannai S, Shikano N, Makino N. Conflicting effects of N-acetylcysteine on purified neurons derived from rat cortical culture. Neuroreport. 2010;21:416\u201321.","journal-title":"Neuroreport"},{"key":"82_CR54","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/pbc.22004","volume":"53","author":"ML Meistrich","year":"2009","unstructured":"Meistrich ML. Male gonadal toxicity. Pediatr Blood Cancer. 2009;53:261\u20136.","journal-title":"Pediatr Blood Cancer"},{"key":"82_CR55","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s10815-009-9343-5","volume":"26","author":"A Zini","year":"2009","unstructured":"Zini A, Gabriel MS, Baazeem A. Antioxidants and sperm DNA damage: a clinical perpective. J Assist Reprod Genet. 2009;26:427\u201332.","journal-title":"J Assist Reprod Genet"}],"container-title":["Basic and Clinical Andrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12610-018-0082-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12610-018-0082-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12610-018-0082-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:06:55Z","timestamp":1581034015000},"score":1,"resource":{"primary":{"URL":"https:\/\/bacandrology.biomedcentral.com\/articles\/10.1186\/s12610-018-0082-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["82"],"URL":"https:\/\/doi.org\/10.1186\/s12610-018-0082-2","relation":{},"ISSN":["2051-4190"],"issn-type":[{"value":"2051-4190","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]},"assertion":[{"value":"10 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JB, Biochemistry student; AR, MSc student, AG, MSc, specialist in spermiogram analysis and sperm clinical preparation; AB, MD, PhD, Full Professor, Medical Genetics specialist, clinical director; MS, MD, PhD, Full Professor, Senior Clinical Embryologist, academic director of research; RS, PhD, Associated Professor, academic director of research, MD student.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 information"}},{"value":"Ethical guidelines were followed in the conduct of research, with written informed consent obtained before the beginning of work. According to the National Law on Medically Assisted Procreation and the National Council on Medically Assisted Procreation guidelines no further authorizations were required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"3"}}