{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:43:20Z","timestamp":1771994600003,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T00:00:00Z","timestamp":1435622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Marie Curie Fellowship","award":["FP7-PEOPLE-2010-IEF, Proposal 272927"],"award-info":[{"award-number":["FP7-PEOPLE-2010-IEF, Proposal 272927"]}]},{"name":"Portuguese Science Foundation","award":["PTDC\/MAR\/115347\/2009, COMPETE-FCOMP-01-012; FEDER-015453"],"award-info":[{"award-number":["PTDC\/MAR\/115347\/2009, COMPETE-FCOMP-01-012; FEDER-015453"]}]},{"name":"Danish Basic Research Foundation","award":["DNRF94"],"award-info":[{"award-number":["DNRF94"]}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"crossref","award":["R52-A5062"],"award-info":[{"award-number":["R52-A5062"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["DFF-10-081390"],"award-info":[{"award-number":["DFF-10-081390"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Evol Biol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12862-015-0409-y","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T11:17:47Z","timestamp":1435576667000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis"],"prefix":"10.1186","volume":"15","author":[{"given":"\u00c2ngela M.","family":"Ribeiro","sequence":"first","affiliation":[]},{"given":"M. Lisandra","family":"Zepeda-Mendoza","sequence":"additional","affiliation":[]},{"given":"Mads F.","family":"Bertelsen","sequence":"additional","affiliation":[]},{"given":"Annemarie T.","family":"Kristensen","sequence":"additional","affiliation":[]},{"given":"Erich D.","family":"Jarvis","sequence":"additional","affiliation":[]},{"given":"M. Thomas P.","family":"Gilbert","sequence":"additional","affiliation":[]},{"given":"Rute R.","family":"da Fonseca","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"409_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ejogrb.2004.06.038","volume":"119","author":"EH Uchikova","year":"2005","unstructured":"Uchikova EH, Ledjev II. Changes in haemostasis during normal pregnancy. Eur J Obstet Gynecol Reprod Biol. 2005;119:185\u20138.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"409_CR2","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1213\/ane.0b013e31819bcc9c","volume":"108","author":"KA Tanaka","year":"2009","unstructured":"Tanaka KA, Key NS, Levy JH. Blood Coagulation: Hemostasis and Thrombin Regulation. Anesth Analg. 2009;108:1433\u201346.","journal-title":"Anesth Analg"},{"key":"409_CR3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1055\/s-0037-1615947","volume":"85","author":"M Hoffman","year":"2001","unstructured":"Hoffman M, Monroe 3rd DM. A cell-based model of hemostasis. Thromb Haemost. 2001;85:958\u201365.","journal-title":"Thromb Haemost"},{"key":"409_CR4","doi-asserted-by":"crossref","unstructured":"Saeed SA, Urfy MZS, Khimani FWA, Saeed SO. From Evolution of Platelets to Their Role in Heart Attacks. J Med Sci. 2004;4(1):47\u201351.","DOI":"10.3923\/jms.2004.47.51"},{"key":"409_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/1043454206298693","volume":"24","author":"JP Riddel","year":"2007","unstructured":"Riddel JP, Aouizerat BE, Miaskowski C, Lillicrap DP. Theories of Blood Coagulation. J Pediatr Oncol Nurs. 2007;24:123\u201331.","journal-title":"J Pediatr Oncol Nurs"},{"key":"409_CR6","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1182\/blood-2009-09-199182","volume":"115","author":"J Emsley","year":"2010","unstructured":"Emsley J, McEwan PA, Gailani D. Structure and function of factor XI. Blood. 2010;115:2569\u201377.","journal-title":"Blood"},{"key":"409_CR7","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/j.1538-7836.2010.03815.x","volume":"8","author":"MR Lang","year":"2010","unstructured":"Lang MR, Gihr G, Gawas MP, M\u00fcller I. Hemostasis in Danio rerio: is the zebrafish a useful model for platelet research? J Thromb Haemost. 2010;8:1159\u201369.","journal-title":"J Thromb Haemost"},{"key":"409_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1101\/sqb.2009.74.001","volume":"74","author":"RF Doolittle","year":"2010","unstructured":"Doolittle RF. Step-by-Step Evolution of Vertebrate Blood Coagulation. Cold Spring Harb Symp Quant Biol. 2010;74:35\u201340.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"409_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000321005","volume":"3","author":"RF Doolittle","year":"2011","unstructured":"Doolittle RF. Coagulation in vertebrates with a focus on evolution and inflammation. J Innate Immun. 2011;3:9\u201316.","journal-title":"J Innate Immun"},{"key":"409_CR10","doi-asserted-by":"publisher","first-page":"5628","DOI":"10.4049\/jimmunol.0903678","volume":"185","author":"U Amara","year":"2010","unstructured":"Amara U, Flierl MA, Rittirsch D, Klos A, Chen H, Acker B, Br\u00fcckner UB, Nilsson B, Gebhard F, Lambris JD, Huber-Lang M. Molecular Intercommunication between the Complement and Coagulation Systems. J Immunol. 2010;185:5628\u201336.","journal-title":"J Immunol"},{"key":"409_CR11","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.febslet.2009.12.022","volume":"584","author":"RR Da Fonseca","year":"2010","unstructured":"Da Fonseca RR, Kosiol C, Vinar T, Siepel A, Nielsen R. Positive selection on apoptosis related genes. FEBS Lett. 2010;584:469\u201376.","journal-title":"FEBS Lett"},{"key":"409_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004148","volume":"10","author":"S Qanbari","year":"2014","unstructured":"Qanbari S, Pausch H, Jansen S, Somel M, Strom TM, Fries R, Simianer H. Classic selective sweeps revealed by massive sequencing in cattle. PLoS Genet. 2014;10, e1004148.","journal-title":"PLoS Genet"},{"key":"409_CR13","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.tvjl.2003.09.013","volume":"168","author":"P Gentry","year":"2004","unstructured":"Gentry P. Comparative aspects of blood coagulation. Vet J. 2004;168:238\u201351.","journal-title":"Vet J"},{"key":"409_CR14","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1111\/j.1538-7836.2008.03143.x","volume":"6","author":"MB Ponczek","year":"2008","unstructured":"Ponczek MB, Gailani D, Doolittle RF. Evolution of the contact phase of vertebrate blood coagulation. J Thromb Haemost. 2008;6:1876\u201383.","journal-title":"J Thromb Haemost"},{"key":"409_CR15","doi-asserted-by":"crossref","unstructured":"Schulte K, Kunter U, Moeller MJ. The evolution of blood pressure and the rise of mankind. Nephrol Dial Transplant. 2015;30(5):713\u201323.","DOI":"10.1093\/ndt\/gfu275"},{"key":"409_CR16","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1182\/blood-2011-02-338244","volume":"118","author":"AA Schmaier","year":"2011","unstructured":"Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Clich\u00e9 S, Gari\u00e9py C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML. Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. Blood. 2011;118:3661\u20139.","journal-title":"Blood"},{"key":"409_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0162-3109(99)00058-2","volume":"45","author":"CL Frost","year":"1999","unstructured":"Frost CL, Naud\u00e9 RJ, Oelofsen W, Jacobson B. Comparative blood coagulation studies in the ostrich. Immunopharmacology. 1999;45:75\u201381.","journal-title":"Immunopharmacology"},{"key":"409_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.thromres.2004.02.019","volume":"113","author":"J Weir-M","year":"2004","unstructured":"Weir-M J, Acurero Z, Salas-A R, Arteaga-Vizcaino M. Blood coagulation factors in the black headed vulture (Coragyps atratus), a potential animal model for the study of haemostasis. Thromb Res. 2004;113:269\u201373.","journal-title":"Thromb Res"},{"key":"409_CR19","doi-asserted-by":"crossref","unstructured":"Strindberg S, Nielsen TW, Ribeiro \u00c2M, Wiinberg B, Kristensen AT, Bertelsen MF. Thromboelastography in selected avian species. J Avian Med Surg 2015, in press.","DOI":"10.1647\/2014-034"},{"key":"409_CR20","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1126\/science.1251385","volume":"346","author":"G Zhang","year":"2014","unstructured":"Zhang G, Li C, Li Q, Li B, Larkin DM, Lee C, Storz JF, Antunes A, Meredith RW, \u00d6deen A, Cui J, Zhou Q, Xu L, Pan H, Wang Z, Jin L, Zhang P, Hu H, Yang W, Hu J, Xiao J, Yang Z, Liu Y, Xie Q, Lian J, Wen P, Zhang F, Li H, Zeng Y, Xiong Z, et al. Comparative Genomics Across Modern Bird Species Reveal Insights into Panavian Genome evolution and Trait Biodiversity. Science (80-). 2014;346:1311\u201320.","journal-title":"Science (80-)"},{"key":"409_CR21","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1126\/science.1253451","volume":"346","author":"ED Jarvis","year":"2014","unstructured":"Jarvis ED, Mirarab S, Aberer AJ, Li B, Houde P, Li C, Ho SYW, Faircloth BC, Nabholz B, Howard JT, Suh A, Weber CC, da Fonseca RR, Li J, Zhang F, Li H, Zhou L, Narula N, Liu L, Ganapathy G, Boussau B, Bayzid MS, Zavidovych V, Subramanian S, Gabald\u00f3n T, Capella-Guti\u00e9rrez S, Huerta-Cepas J, Rekepalli B, Munch K, Schierup M, et al. Whole Genome Analyses Resolve the Early Branches in the Tree of Life of Modern Birds. Science (80-). 2014;346:1320\u201331.","journal-title":"Science (80-)"},{"key":"409_CR22","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/jth.12144","volume":"11","author":"R Li","year":"2013","unstructured":"Li R, Emsley J. The organizing principle of the platelet glycoprotein Ib-IX-V complex. J Thromb Haemost. 2013;11:605\u201314.","journal-title":"J Thromb Haemost"},{"key":"409_CR23","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1161\/ATVBAHA.109.187393","volume":"29","author":"TC White-Adams","year":"2009","unstructured":"White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, de Groot PG, Gruber A, McCarty OJT. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol. 2009;29:1602\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"409_CR24","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1111\/j.1538-7836.2007.02770.x","volume":"5","author":"AH Schmaier","year":"2007","unstructured":"Schmaier AH, McCrae KR. The plasma kallikrein\u2013kinin system: its evolution from contact activation. J Thromb Haemost. 2007;5:2323\u20139.","journal-title":"J Thromb Haemost"},{"key":"409_CR25","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1093\/molbev\/mst054","volume":"30","author":"R Cagliani","year":"2013","unstructured":"Cagliani R, Forni D, Riva S, Pozzoli U, Colleoni M, Bresolin N, Clerici M, Sironi M. Evolutionary analysis of the contact system indicates that kininogen evolved adaptively in mammals and in human populations. Mol Biol Evol. 2013;30:1397\u2013408.","journal-title":"Mol Biol Evol"},{"key":"409_CR26","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1647\/2001-045","volume":"17","author":"JK Morrisey","year":"2003","unstructured":"Morrisey JK, Paul-Murphy J, Fialkowski JP, Hart A, Darien BJ. Estimation of Prothrombin Times of Hispaniolan Amazon Parrots (Amazona ventralis) and Umbrella Cockatoos (Cacatua alba). J Avian Med Surg. 2003;17:72\u20137.","journal-title":"J Avian Med Surg"},{"key":"409_CR27","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1182\/blood-2012-10-460360","volume":"122","author":"GN Adams","year":"2013","unstructured":"Adams GN, Stavrou EX, Fang C, Merkulova A, Alaiti MA, Nakajima K, Morooka T, Merkulov S, Larusch GA, Simon DI, Jain MK, Schmaier AH. Prolylcarboxypeptidase promotes angiogenesis and vascular repair. Blood. 2013;122:1522\u201331.","journal-title":"Blood"},{"key":"409_CR28","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1182\/blood-2010-11-318527","volume":"117","author":"GN Adams","year":"2011","unstructured":"Adams GN, LaRusch GA, Stavrou E, Zhou Y, Nieman MT, Jacobs GH, Cui Y, Lu Y, Jain MK, Mahdi F, Shariat-Madar Z, Okada Y, D\u2019Alecy LG, Schmaier AH. Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis. Blood. 2011;117:3929\u201337.","journal-title":"Blood"},{"key":"409_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/icb\/icp034","volume":"49","author":"K Schwenk","year":"2009","unstructured":"Schwenk K, Padilla DK, Bakken GS, Full RJ. Grand challenges in organismal biology. Integr Comp Biol. 2009;49:7\u201314.","journal-title":"Integr Comp Biol"},{"key":"409_CR30","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.tig.2010.02.002","volume":"26","author":"JK Hubbard","year":"2010","unstructured":"Hubbard JK, Uy JAC, Hauber ME, Hoekstra HE, Safran RJ. Vertebrate pigmentation: from underlying genes to adaptive function. Trends Genet. 2010;26:231\u20139.","journal-title":"Trends Genet"},{"key":"409_CR31","doi-asserted-by":"publisher","first-page":"D363","DOI":"10.1093\/nar\/gkj123","volume":"34","author":"F Chen","year":"2006","unstructured":"Chen F, Mackey AJ, Stoeckert CJ, Roos DS. OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups. Nucleic Acids Res. 2006;34:D363\u20138.","journal-title":"Nucleic Acids Res"},{"key":"409_CR32","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/bioinformatics\/btq706","volume":"27","author":"KP Schliep","year":"2011","unstructured":"Schliep KP. phangorn: phylogenetic analysis in R. Bioinformatics. 2011;27:592\u20133.","journal-title":"Bioinformatics"},{"key":"409_CR33","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1093\/oxfordjournals.molbev.a003851","volume":"18","author":"S Whelan","year":"2001","unstructured":"Whelan S, Goldman N. A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Mol Biol Evol. 2001;18:691\u20139.","journal-title":"Mol Biol Evol"},{"key":"409_CR34","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/1471-2105-13-133","volume":"13","author":"J Pel\u00e9","year":"2012","unstructured":"Pel\u00e9 J, B\u00e9cu J-M, Abdi H, Chabbert M. Bios2mds: an R package for comparing orthologous protein families by metric multidimensional scaling. BMC Bioinformatics. 2012;13:133.","journal-title":"BMC Bioinformatics"},{"key":"409_CR35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-1-62703-646-7_10","volume":"1079","author":"A L\u00f6ytynoja","year":"2014","unstructured":"L\u00f6ytynoja A. Phylogeny-aware alignment with PRANK. Methods Mol Biol. 2014;1079:155\u201370.","journal-title":"Methods Mol Biol"},{"key":"409_CR36","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1093\/nar\/gkf436","volume":"30","author":"K Katoh","year":"2002","unstructured":"Katoh K. MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res. 2002;30:3059\u201366.","journal-title":"Nucleic Acids Res"},{"key":"409_CR37","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1055\/s-0030-1265291","volume":"36","author":"B Wiinberg","year":"2010","unstructured":"Wiinberg B, Kristensen AT. Thromboelastography in veterinary medicine. Semin Thromb Hemost. 2010;36:747\u201356.","journal-title":"Semin Thromb Hemost"},{"key":"409_CR38","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/bioinformatics\/btm538","volume":"24","author":"LJ Harmon","year":"2008","unstructured":"Harmon LJ, Weir JT, Brock CD, Glor RE, Challenger W. GEIGER: investigating evolutionary radiations. Bioinformatics. 2008;24:129\u201331.","journal-title":"Bioinformatics"},{"key":"409_CR39","first-page":"275","volume":"8","author":"DT Jones","year":"1992","unstructured":"Jones DT, Taylor WR, Thornton JM. The rapid generation of mutation data matrices from protein sequences. Comput Appl Biosci. 1992;8:275\u201382.","journal-title":"Comput Appl Biosci"},{"key":"409_CR40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a pratical and powerful approach to multiple testing. JR Stat Soc B. 1995;57:289\u2013300.","journal-title":"JR Stat Soc B"},{"key":"409_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v022.i07","volume":"22","author":"SC Goslee","year":"2007","unstructured":"Goslee SC, Urban DL. The ecodist package for dissimilarity-based analysis of ecological data. J Stat Softw. 2007;22:1\u201319.","journal-title":"J Stat Softw"}],"container-title":["BMC Evolutionary Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12862-015-0409-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12862-015-0409-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12862-015-0409-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12862-015-0409-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T19:05:00Z","timestamp":1717959900000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcevolbiol.biomedcentral.com\/articles\/10.1186\/s12862-015-0409-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,30]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["409"],"URL":"https:\/\/doi.org\/10.1186\/s12862-015-0409-y","relation":{},"ISSN":["1471-2148"],"issn-type":[{"value":"1471-2148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,30]]},"assertion":[{"value":"2 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"124"}}