{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:58:58Z","timestamp":1768006738908,"version":"3.49.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Norte2020","award":["Norte-01-0145-FEDER-000036"],"award-info":[{"award-number":["Norte-01-0145-FEDER-000036"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Evol Biol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12862-018-1271-5","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T06:37:08Z","timestamp":1539931028000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates"],"prefix":"10.1186","volume":"18","author":[{"given":"M\u00f3nica","family":"Lopes-Marques","sequence":"first","affiliation":[]},{"given":"Naoki","family":"Kabeya","sequence":"additional","affiliation":[]},{"given":"Yu","family":"Qian","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Ruivo","sequence":"additional","affiliation":[]},{"given":"Miguel M.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Byrappa","family":"Venkatesh","sequence":"additional","affiliation":[]},{"given":"Douglas R.","family":"Tocher","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-386X","authenticated-orcid":false,"given":"L. Filipe C.","family":"Castro","sequence":"additional","affiliation":[]},{"given":"\u00d3scar","family":"Monroig","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"issue":"2","key":"1271_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.plipres.2007.12.004","volume":"47","author":"G Schmitz","year":"2008","unstructured":"Schmitz G, Ecker J. The opposing effects of n\u22123 and n\u22126 fatty acids. Prog Lipid Res. 2008;47(2):147\u201355.","journal-title":"Prog Lipid Res"},{"issue":"2","key":"1271_CR2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","volume":"49","author":"H Guillou","year":"2010","unstructured":"Guillou H, Zadravec D, Martin PG, Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice. Prog Lipid Res. 2010;49(2):186\u201399.","journal-title":"Prog Lipid Res"},{"key":"1271_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.plipres.2016.01.001","volume":"62","author":"LFC Castro","year":"2016","unstructured":"Castro LFC, Tocher DR, Monroig O. Long-chain polyunsaturated fatty acid biosynthesis in chordates: insights into the evolution of fads and Elovl gene repertoire. Prog Lipid Res. 2016;62:25\u201340.","journal-title":"Prog Lipid Res"},{"issue":"2\u20133","key":"1271_CR4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S1388-1981(00)00077-9","volume":"1486","author":"H Sprecher","year":"2000","unstructured":"Sprecher H. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim Biophys Acta. 2000;1486(2\u20133):219\u201331.","journal-title":"Biochim Biophys Acta"},{"key":"1271_CR5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s10545-016-9922-4","volume":"39","author":"S Ferdinandusse","year":"2016","unstructured":"Ferdinandusse S, Ebberink MS, Vaz FM, Waterham HR, Wanders RJA. The important role of biochemical and functional studies in the diagnostics of peroxisomal disorders. J Inherit Metab Dis. 2016;39:531\u201343.","journal-title":"J Inherit Metab Dis"},{"issue":"39","key":"1271_CR6","doi-asserted-by":"publisher","first-page":"16840","DOI":"10.1073\/pnas.1008429107","volume":"107","author":"Y Li","year":"2010","unstructured":"Li Y, Monroig O, Zhang L, Wang S, Zheng X, Dick JR, You C, Tocher DR. Vertebrate fatty acyl desaturase with \u03944 activity. Proc Natl Acad Sci. 2010;107(39):16840\u20135.","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"1271_CR7","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1038\/s41598-017-04288-2","volume":"7","author":"A Oboh","year":"2017","unstructured":"Oboh A, Kabeya N, Carmona-Anto\u00f1anzas G, Castro LFC, Dick JR, Tocher DR, Monroig O. Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish. Sci Rep. 2017;7(1):3889.","journal-title":"Sci Rep"},{"issue":"9","key":"1271_CR8","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1096\/fj.15-271783","volume":"29","author":"HG Park","year":"2015","unstructured":"Park HG, Park WJ, Kothapalli KSD, Brenna JT. The fatty acid desaturase 2 (FADS2) gene product catalyzes \u03944 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells. FASEB J. 2015;29(9):3911\u20139.","journal-title":"FASEB J"},{"issue":"2","key":"1271_CR9","doi-asserted-by":"publisher","first-page":"e31950","DOI":"10.1371\/journal.pone.0031950","volume":"7","author":"LFC Castro","year":"2012","unstructured":"Castro LFC, Monroig \u00d3, Leaver MJ, Wilson J, Cunha I, Tocher DR. Functional desaturase Fads1 (\u03945) and Fads2 (\u03946) orthologues evolved before the origin of jawed vertebrates. PLoS One. 2012;7(2):e31950.","journal-title":"PLoS One"},{"issue":"25","key":"1271_CR10","doi-asserted-by":"publisher","first-page":"14304","DOI":"10.1073\/pnas.251516598","volume":"98","author":"N Hastings","year":"2001","unstructured":"Hastings N, Agaba M, Tocher DR, Leaver MJ, Dick JR, Sargent JR, Teale AJ. A vertebrate fatty acid desaturase with \u03945 and \u03946 activities. Proc Natl Acad Sci. 2001;98(25):14304\u20139.","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"1271_CR11","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1194\/jlr.M049791","volume":"55","author":"J Fonseca-Madrigal","year":"2014","unstructured":"Fonseca-Madrigal J, Navarro JC, Hontoria F, Tocher DR, Mart\u00ednez-Palacios CA, Monroig \u00d3. Diversification of substrate specificities in teleostei Fads2: characterization of \u03944 and \u03946\u03945 desaturases of Chirostoma estor. J Lipid Res. 2014;55(7):1408\u201319.","journal-title":"J Lipid Res"},{"issue":"3","key":"1271_CR12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bbalip.2014.12.012","volume":"1851","author":"MK Kuah","year":"2014","unstructured":"Kuah MK, Jaya-Ram A, Shu-Chien AC. The capacity for long-chain polyunsaturated fatty acid synthesis in a carnivorous vertebrate: functional characterisation and nutritional regulation of a Fads2 fatty acyl desaturase with Delta4 activity and an Elovl5 elongase in striped snakehead (Channa striata). Biochim Biophys Acta. 2014;1851(3):248\u201360.","journal-title":"Biochim Biophys Acta"},{"key":"1271_CR13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.aquaculture.2016.05.018","volume":"462","author":"A Oboh","year":"2016","unstructured":"Oboh A, Betancor MB, Tocher DR, Monroig O. Biosynthesis of long-chain polyunsaturated fatty acids in the African catfish Clarias gariepinus: molecular cloning and functional characterisation of fatty acyl desaturase (fads2) and elongase (elovl2) cDNAs7. Aquaculture. 2016;462:70\u20139.","journal-title":"Aquaculture"},{"issue":"4","key":"1271_CR14","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1534\/genetics.111.127324","volume":"188","author":"A Amores","year":"2011","unstructured":"Amores A, Catchen J, Ferrara A, Fontenot Q, Postlethwait JH. Genome evolution and meiotic maps by massively parallel DNA sequencing: spotted gar, an outgroup for the teleost genome duplication. Genetics. 2011;188(4):799\u2013808.","journal-title":"Genetics"},{"issue":"1","key":"1271_CR15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s12862-017-0958-3","volume":"17","author":"R Betancur-R","year":"2017","unstructured":"Betancur-R R, Wiley EO, Arratia G, Acero A, Bailly N, Miya M, Lecointre G, Ort\u00ed G. Phylogenetic classification of bony fishes. BMC Evol Biol. 2017;17(1):162.","journal-title":"BMC Evol Biol"},{"issue":"24","key":"1271_CR16","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.1073\/pnas.1719358115","volume":"115","author":"LC Hughes","year":"2018","unstructured":"Hughes LC, Orti G, Huang Y, Sun Y, Baldwin CC, Thompson AW, Arcila D, Betancur RR, Li C, Becker L, et al. Comprehensive phylogeny of ray-finned fishes (Actinopterygii) based on transcriptomic and genomic data. Proc Natl Acad Sci U S A. 2018;115(24):6249\u201354.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"1271_CR17","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1093\/bib\/bbn013","volume":"9","author":"K Katoh","year":"2008","unstructured":"Katoh K, Toh H. Recent developments in the MAFFT multiple sequence alignment program. Brief Bioinform. 2008;9(4):286\u201398.","journal-title":"Brief Bioinform"},{"issue":"2","key":"1271_CR18","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1093\/nar\/gki198","volume":"33","author":"K Katoh","year":"2005","unstructured":"Katoh K, Kuma K, Toh H, Miyata T. MAFFT version 5: improvement in accuracy of multiple sequence alignment. Nucleic Acids Res. 2005;33(2):511\u20138.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"1271_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/sysbio\/syq010","volume":"59","author":"S Guindon","year":"2010","unstructured":"Guindon S, Dufayard J-F, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59(3):307\u201321.","journal-title":"Syst Biol"},{"issue":"5","key":"1271_CR20","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/sysbio\/syr041","volume":"60","author":"M Anisimova","year":"2011","unstructured":"Anisimova M, Gil M, Dufayard JF, Dessimoz C, Gascuel O. Survey of branch support methods demonstrates accuracy, power, and robustness of fast likelihood-based approximation schemes. Syst Biol. 2011;60(5):685\u201399.","journal-title":"Syst Biol"},{"key":"1271_CR21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cbpb.2016.09.007","volume":"203","author":"M Lopes-Marques","year":"2017","unstructured":"Lopes-Marques M, Oz\u00f3rio R, Amaral R, Tocher DR, Monroig \u00d3, Castro LFC. Molecular and functional characterization of a fads2 orthologue in the Amazonian teleost, Arapaima gigas. Comp Biochem Physiol B Biochem Mol Biol. 2017;203:84\u201391.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"2","key":"1271_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0952-3278(02)00259-4","volume":"68","author":"SL Pereira","year":"2003","unstructured":"Pereira SL, Leonard AE, Mukerji P. Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes. Prostaglandins Leukot Essent Fatty Acids. 2003;68(2):97\u2013106.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"1","key":"1271_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0005-2760(98)00091-5","volume":"1394","author":"DA Los","year":"1998","unstructured":"Los DA, Murata N. Structure and expression of fatty acid desaturases. Biochim Biophys Acta Lipids Lipid Metab. 1998;1394(1):3\u201315.","journal-title":"Biochim Biophys Acta Lipids Lipid Metab"},{"issue":"1","key":"1271_CR24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1194\/jlr.M064121","volume":"57","author":"K Watanabe","year":"2016","unstructured":"Watanabe K, Ohno M, Taguchi M, Kawamoto S, Ono K, Aki T. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases. J Lipid Res. 2016;57(1):89\u201399.","journal-title":"J Lipid Res"},{"issue":"3","key":"1271_CR25","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.cbpb.2005.08.005","volume":"142","author":"MK Agaba","year":"2005","unstructured":"Agaba MK, Tocher DR, Zheng X, Dickson CA, Dick JR, Teale AJ. Cloning and functional characterisation of polyunsaturated fatty acid elongases of marine and freshwater teleost fish. Comp Biochem Physiol B Biochem Mol Biol. 2005;142(3):342\u201352.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"1271_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.aquaculture.2014.07.016","volume":"434","author":"S Wang","year":"2014","unstructured":"Wang S, Monroig \u00d3, Tang G, Zhang L, You C, Tocher DR, Li Y. Investigating long-chain polyunsaturated fatty acid biosynthesis in teleost fish: functional characterization of fatty acyl desaturase (Fads2) and Elovl5 elongase in the catadromous species, Japanese eel Anguilla japonica. Aquaculture. 2014;434:57\u201365.","journal-title":"Aquaculture"},{"issue":"4","key":"1271_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s11745-014-3880-0","volume":"49","author":"Z Lim","year":"2014","unstructured":"Lim Z, Senger T, Vrinten P. Four amino acid residues influence the substrate chain-length and regioselectivity of Siganus canaliculatus \u03944 and \u03945\/6 desaturases. Lipids. 2014;49(4):357\u201367.","journal-title":"Lipids"},{"issue":"5494","key":"1271_CR28","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1126\/science.290.5494.1151","volume":"290","author":"M Lynch","year":"2000","unstructured":"Lynch M, Conery JS. The evolutionary fate and consequences of duplicate genes. Science. 2000;290(5494):1151\u20135.","journal-title":"Science"},{"issue":"10","key":"1271_CR29","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/(SICI)1521-1878(199810)20:10<785::AID-BIES2>3.0.CO;2-M","volume":"20","author":"A Wagner","year":"1998","unstructured":"Wagner A. The fate of duplicated genes: loss or new function? BioEssays. 1998;20(10):785\u20138.","journal-title":"BioEssays"},{"key":"1271_CR30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1023\/A:1022656931587","volume":"3","author":"PW Holland","year":"2003","unstructured":"Holland PW. More genes in vertebrates? J Struct Funct Genom. 2003;3:75\u201384.","journal-title":"J Struct Funct Genom"},{"issue":"10","key":"1271_CR31","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1038\/jcbfm.2013.128","volume":"33","author":"P Schonfeld","year":"2013","unstructured":"Schonfeld P, Reiser G. Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain. J Cereb Blood Flow Metab. 2013;33(10):1493\u20139.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"7163","key":"1271_CR32","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/449673a","volume":"449","author":"EJ Louis","year":"2007","unstructured":"Louis EJ. Evolutionary genetics: making the most of redundancy. Nature. 2007;449(7163):673\u20134.","journal-title":"Nature"},{"issue":"11","key":"1271_CR33","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.tig.2004.09.001","volume":"20","author":"M Lynch","year":"2004","unstructured":"Lynch M, Katju V. The altered evolutionary trajectories of gene duplicates. Trends Genet. 2004;20(11):544\u20139.","journal-title":"Trends Genet"},{"key":"1271_CR34","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jtbi.2005.08.033","volume":"239","author":"FA Kondrashov","year":"2006","unstructured":"Kondrashov FA, Kondrashov AS. Role of selection in fixation of gene duplications. J Theor Biol. 2006;239:141\u201351.","journal-title":"J Theor Biol"},{"issue":"5","key":"1271_CR35","doi-asserted-by":"publisher","first-page":"R43","DOI":"10.1186\/gb-2006-7-5-r43","volume":"7","author":"T Blomme","year":"2006","unstructured":"Blomme T, Vandepoele K, De Bodt S, Simillion C, Maere S, Van de Peer Y. The gain and loss of genes during 600 million years of vertebrate evolution. Genome Biol. 2006;7(5):R43.","journal-title":"Genome Biol"},{"issue":"7","key":"1271_CR36","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrg.2016.39","volume":"17","author":"R Albalat","year":"2016","unstructured":"Albalat R, Canestro C. Evolution by gene loss. Nat Rev Genet. 2016;17(7):379\u201391.","journal-title":"Nat Rev Genet"},{"issue":"52","key":"1271_CR37","doi-asserted-by":"publisher","first-page":"37335","DOI":"10.1074\/jbc.274.52.37335","volume":"274","author":"HP Cho","year":"1999","unstructured":"Cho HP, Nakamura M, Clarke SD. Cloning, expression, and fatty acid regulation of the human \u0394-5 desaturase. J Biol Chem. 1999;274(52):37335\u20139.","journal-title":"J Biol Chem"},{"issue":"sup1","key":"1271_CR38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/10641260802325278","volume":"16","author":"MJ Leaver","year":"2008","unstructured":"Leaver MJ, Bautista JM, Bj\u00f6rnsson BT, J\u00f6nsson E, Krey G, Tocher DR, Torstensen BE. Towards fish lipid nutrigenomics: current state and prospects for fin-fish aquaculture. Rev Fish Sci. 2008;16(sup1):73\u201394.","journal-title":"Rev Fish Sci"},{"issue":"5","key":"1271_CR39","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10126-004-3002-8","volume":"6","author":"N Hastings","year":"2004","unstructured":"Hastings N, Agaba MK, Tocher DR, Zheng X, Dickson CA, Dick JR, Teale AJ. Molecular cloning and functional characterization of fatty acyl desaturase and Elongase cDNAs involved in the production of Eicosapentaenoic and docosahexaenoic acids from \u03b1-linolenic acid in Atlantic Salmon (Salmo salar). Mar Biotechnol. 2004;6(5):463\u201374.","journal-title":"Mar Biotechnol"},{"issue":"3","key":"1271_CR40","doi-asserted-by":"publisher","first-page":"e0150770","DOI":"10.1371\/journal.pone.0150770","volume":"11","author":"NK Abdul Hamid","year":"2016","unstructured":"Abdul Hamid NK, Carmona-Anto\u00f1anzas G, Monroig \u00d3, Tocher DR, Turchini GM, Donald JA. Isolation and functional characterisation of a fads2 in rainbow trout (Oncorhynchus mykiss) with \u03945 desaturase activity. PLoS One. 2016;11(3):e0150770.","journal-title":"PLoS One"},{"issue":"2","key":"1271_CR41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1006\/geno.2000.6196","volume":"66","author":"A Marquardt","year":"2000","unstructured":"Marquardt A, St\u00f6hr H, White K, Weber BHF. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000;66(2):175\u201383.","journal-title":"Genomics"},{"issue":"1","key":"1271_CR42","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.gene.2009.06.016","volume":"446","author":"WJ Park","year":"2009","unstructured":"Park WJ, Kothapalli KSD, Reardon HT, Kim LY, Brenna JT. Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing. Gene. 2009;446(1):28\u201334.","journal-title":"Gene"},{"issue":"1","key":"1271_CR43","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.biochi.2010.03.002","volume":"93","author":"H Blanchard","year":"2011","unstructured":"Blanchard H, Legrand P, P\u00e9drono F. Fatty acid desaturase 3 (Fads3) is a singular member of the fads cluster. Biochimie. 2011;93(1):87\u201390.","journal-title":"Biochimie"},{"issue":"4","key":"1271_CR44","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cbpb.2011.04.007","volume":"159","author":"\u00d3 Monroig","year":"2011","unstructured":"Monroig \u00d3, Li Y, Tocher DR. Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: high activity in delta-6 desaturases of marine species. Comp Biochem Physiol B Biochem Mol Biol. 2011;159(4):206\u201313.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"2","key":"1271_CR45","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1534\/genetics.104.037051","volume":"169","author":"X He","year":"2005","unstructured":"He X, Zhang J. Rapid subfunctionalization accompanied by prolonged and substantial Neofunctionalization in duplicate gene evolution. Genetics. 2005;169(2):1157\u201364.","journal-title":"Genetics"},{"issue":"2","key":"1271_CR46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.cbpb.2013.07.011","volume":"166","author":"S Tanomman","year":"2013","unstructured":"Tanomman S, Ketudat-Cairns M, Jangprai A, Boonanuntanasarn S. Characterization of fatty acid delta-6 desaturase gene in Nile tilapia and heterogenous expression in Saccharomyces cerevisiae. Comp Biochem Physiol B Biochem Mol Biol. 2013;166(2):148\u201356.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"Supplement C","key":"1271_CR47","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.cbpa.2016.07.007","volume":"201","author":"M-K Kuah","year":"2016","unstructured":"Kuah M-K, Jaya-Ram A, Shu-Chien AC. A fatty acyl desaturase (fads2) with dual \u03946 and \u03945 activities from the freshwater carnivorous striped snakehead Channa striata. Comp Biochem Physiol A Mol Integr Physiol. 2016;201(Supplement C):146\u201355.","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"issue":"3","key":"1271_CR48","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.plipres.2006.01.004","volume":"45","author":"A Jakobsson","year":"2006","unstructured":"Jakobsson A, Westerberg R, Jacobsson A. Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res. 2006;45(3):237\u201349.","journal-title":"Prog Lipid Res"},{"key":"1271_CR49","doi-asserted-by":"publisher","first-page":"20510","DOI":"10.1038\/srep20510","volume":"6","author":"\u00d3 Monroig","year":"2016","unstructured":"Monroig \u00d3, Lopes-Marques M, Navarro JC, Hontoria F, Ruivo R, Santos MM, Venkatesh B, Tocher DR, Castro LFC. Evolutionary functional elaboration of the Elovl2\/5 gene family in chordates. Sci Rep. 2016;6:20510.","journal-title":"Sci Rep"},{"issue":"11","key":"1271_CR50","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.bbalip.2009.07.002","volume":"1791","author":"\u00d3 Monroig","year":"2009","unstructured":"Monroig \u00d3, Rotllant J, Sanchez E, Cerda-Reverter JM, Tocher DR. Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis. Biochim Biophys Acta. 2009;1791(11):1093\u2013101.","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"1271_CR51","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10126-009-9179-0","volume":"11","author":"S Morais","year":"2009","unstructured":"Morais S, Monroig O, Zheng X, Leaver MJ, Tocher DR. Highly unsaturated fatty acid synthesis in Atlantic salmon: characterization of ELOVL5- and ELOVL2-like elongases. Mar Biotechnol (NY). 2009;11(5):627\u201339.","journal-title":"Mar Biotechnol (NY)"},{"issue":"12","key":"1271_CR52","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1016\/j.bbalip.2014.10.001","volume":"1841","author":"MK Gregory","year":"2014","unstructured":"Gregory MK, James MJ. Rainbow trout (Oncorhynchus mykiss) Elovl5 and Elovl2 differ in selectivity for elongation of omega-3 docosapentaenoic acid. Biochim Biophys Acta. 2014;1841(12):1656\u201360.","journal-title":"Biochim Biophys Acta"},{"key":"1271_CR53","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.aquaculture.2012.04.017","volume":"350\u2013353","author":"\u00d3 Monroig","year":"2012","unstructured":"Monroig \u00d3, Wang S, Zhang L, You C, Tocher DR, Li Y. Elongation of long-chain fatty acids in rabbitfish Siganus canaliculatus: cloning, functional characterisation and tissue distribution of Elovl5- and Elovl4-like elongases. Aquaculture. 2012;350\u2013353:63\u201370.","journal-title":"Aquaculture"}],"container-title":["BMC Evolutionary Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12862-018-1271-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12862-018-1271-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12862-018-1271-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T19:15:52Z","timestamp":1571426152000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcevolbiol.biomedcentral.com\/articles\/10.1186\/s12862-018-1271-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,19]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1271"],"URL":"https:\/\/doi.org\/10.1186\/s12862-018-1271-5","relation":{},"ISSN":["1471-2148"],"issn-type":[{"value":"1471-2148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,19]]},"assertion":[{"value":"27 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal tissue sampling procedures were evaluated and approved by CIIMAR Managing Animal Welfare Body (ORBEA) ethics committee, according to the European Union Directive 2010\/63\/EU.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"157"}}