{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:12:49Z","timestamp":1772165569822,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Older people are currently the fastest growing segment of the worldwide population. The present study aimed to estimate propofol dose in older patients based on size descriptors measured by bioelectrical impedance analysis (BIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross sectional study in adult and older patients with body mass index equal to or lower than 35\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was carried out. BIA and Clinical Frail Scale scoring were performed during pre-operative evaluation. Propofol infusion was started at 2000\u2009mg\/h until loss of consciousness (LOC) which was defined by \u201closs of eye-lash reflex\u201d and \u201closs of response to name calling\u201d. Total dose of propofol at LOC was recorded. Propofol plasma concentration was measured using gas chromatography\/ion trap-mass spectrometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty patients were enrolled in the study. Total propofol dose required to LOC was lower in Age\u2009\u2265\u200965 group and a higher plasma propofol concentration was measured in this group. 60% of old patients were classified as \u201capparently vulnerable\u201d or \u201cfrail\u201d and narrow phase angle values were associated with increasing vulnerability scores. In the Age\u2009\u2265\u200965 group, the correlation analysis showed that the relationship between propofol dose and total body weight (TBW) scaled by the corresponding phase angle value is stronger than the correlation between propofol dose and TBW or fat free mass (FFM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that weight-based reduction of propofol is suitable in older patients; however FFM was not seen to be more effective than TBW to predict the propofol induction dose in these patients. Guiding propofol induction dose according to baseline frailty score should also be considered to estimate individualized dosage profiles. Determination of phase angle value appears to be an easy and reliable tool to assess frailty in older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov Identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02713698\">NCT02713698<\/jats:ext-link>\n                      . Registered on 23 February 2016.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12871-019-0856-x","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T12:04:12Z","timestamp":1570795452000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-6549","authenticated-orcid":false,"given":"Ana M.","family":"Ara\u00fajo","sequence":"first","affiliation":[]},{"given":"Humberto S.","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Am\u00edlcar C.","family":"Falc\u00e3o","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcio","family":"Soares-da-Silva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"issue":"Suppl 1","key":"856_CR1","first-page":"81","volume":"69","author":"R Griffiths","year":"2014","unstructured":"Griffiths R, Beech F, Brown A, Dhesi J, Foo I, Goodall J, Harrop-Griffiths W, Jameson J, Love N, Pappenheim K, et al. 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