{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:02:08Z","timestamp":1774728128639,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,2,15]],"date-time":"2015-02-15T00:00:00Z","timestamp":1423958400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12876-015-0245-y","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T11:19:16Z","timestamp":1424171956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Beyond Maastricht IV: are standard empiric triple therapies for Helicobacter pylori still useful in a South-European country?"],"prefix":"10.1186","volume":"15","author":[{"given":"Nuno","family":"Almeida","sequence":"first","affiliation":[]},{"given":"Maria Manuel","family":"Donato","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Manuel","family":"Rom\u00e3ozinho","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Luxo","sequence":"additional","affiliation":[]},{"given":"Olga","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Maria Augusta","family":"Cipriano","sequence":"additional","affiliation":[]},{"given":"Carol","family":"Marinho","sequence":"additional","affiliation":[]},{"given":"Alexandra","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Calhau","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Sofia","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,2,15]]},"reference":[{"issue":"7","key":"245_CR1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.dld.2008.02.035","volume":"40","author":"P Correa","year":"2008","unstructured":"Correa P, Piazuelo MB. Natural history of Helicobacter pylori infection. Dig Liver Dis. 2008;40(7):490\u20136.","journal-title":"Dig Liver Dis"},{"issue":"5","key":"245_CR2","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","volume":"61","author":"P Malfertheiner","year":"2012","unstructured":"Malfertheiner P, Megraud F, O\u2019Morain CA, Atherton J, Axon AT, Bazzoli F, et al. Management of Helicobacter pylori infection\u2013the Maastricht IV\/Florence Consensus Report. Gut. 2012;61(5):646\u201364.","journal-title":"Gut"},{"issue":"35","key":"245_CR3","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.3748\/wjg.v17.i35.3971","volume":"17","author":"SK Chuah","year":"2011","unstructured":"Chuah SK, Tsay FW, Hsu PI, Wu DC. A new look at anti-Helicobacter pylori therapy. World J Gastroenterol. 2011;17(35):3971\u20135.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"245_CR4","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1136\/gut.2006.101634","volume":"56","author":"P Malfertheiner","year":"2007","unstructured":"Malfertheiner P, Megraud F, O\u2019Morain C, Bazzoli F, El-Omar E, Graham D, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007;56(6):772\u201381.","journal-title":"Gut"},{"issue":"8","key":"245_CR5","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1136\/gut.2009.192757","volume":"59","author":"DY Graham","year":"2010","unstructured":"Graham DY, Fischbach L. Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut. 2010;59(8):1143\u201353.","journal-title":"Gut"},{"issue":"1","key":"245_CR6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1093\/ije\/31.1.128","volume":"31","author":"LA Fischbach","year":"2002","unstructured":"Fischbach LA, Goodman KJ, Feldman M, Aragaki C. Sources of variation of Helicobacter pylori treatment success in adults worldwide: a meta-analysis. Int J Epidemiol. 2002;31(1):128\u201339.","journal-title":"Int J Epidemiol"},{"issue":"3","key":"245_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4291\/wjgp.v4.i3.43","volume":"4","author":"F Giorgio","year":"2013","unstructured":"Giorgio F, Principi M, De Francesco V, Zullo A, Losurdo G, Di Leo A, et al. Primary clarithromycin resistance to Helicobacter pylori: is this the main reason for triple therapy failure? World J Gastrointest Pathophysiol. 2013;4(3):43\u20136.","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"11","key":"245_CR8","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/s100960100611","volume":"20","author":"Y Glupczynski","year":"2001","unstructured":"Glupczynski Y, Megraud F, Lopez-Brea M, Andersen LP. European multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori. Eur J Clin Microbiol Infect Dis. 2001;20(11):820\u20133.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"245_CR9","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1136\/gutjnl-2012-302254","volume":"62","author":"F Megraud","year":"2013","unstructured":"Megraud F, Coenen S, Versporten A, Kist M, Lopez-Brea M, Hirschl AM, et al. Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. Gut. 2013;62(1):34\u201342.","journal-title":"Gut"},{"issue":"1","key":"245_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1365-2036.2006.02737.x","volume":"23","author":"JP Gisbert","year":"2006","unstructured":"Gisbert JP, Morena F. Systematic review and meta-analysis: levofloxacin-based rescue regimens after Helicobacter pylori treatment failure. Aliment Pharmacol Ther. 2006;23(1):35\u201344.","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"245_CR11","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/j.1523-5378.2005.00324.x","volume":"10","author":"JP Gisbert","year":"2005","unstructured":"Gisbert JP, Pajares JM. Helicobacter pylori \u201crescue\u201d therapy after failure of two eradication treatments. Helicobacter. 2005;10(5):363\u201372.","journal-title":"Helicobacter"},{"issue":"3","key":"245_CR12","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1572-0241.2006.00637.x","volume":"101","author":"RJ Saad","year":"2006","unstructured":"Saad RJ, Schoenfeld P, Kim HM, Chey WD. Levofloxacin-based triple therapy versus bismuth-based quadruple therapy for persistent Helicobacter pylori infection: a meta-analysis. Am J Gastroenterol. 2006;101(3):488\u201396.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"245_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1365-2036.2005.02522.x","volume":"22","author":"L Gatta","year":"2005","unstructured":"Gatta L, Zullo A, Perna F, Ricci C, De Francesco V, Tampieri A, et al. A 10-day levofloxacin-based triple therapy in patients who have failed two eradication courses. Aliment Pharmacol Ther. 2005;22(1):45\u20139.","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"245_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00005-009-0007-z","volume":"57","author":"M Sugimoto","year":"2009","unstructured":"Sugimoto M, Yamaoka Y. Virulence factor genotypes of Helicobacter pylori affect cure rates of eradication therapy. Arch Immunol Ther Exp (Warsz). 2009;57(1):45\u201356.","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"6","key":"245_CR15","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/hel.12061","volume":"18","author":"J Bastos","year":"2013","unstructured":"Bastos J, Peleteiro B, Barros R, Alves L, Severo M, de Fatima PM, et al. Sociodemographic determinants of prevalence and incidence of Helicobacter pylori infection in Portuguese adults. Helicobacter. 2013;18(6):413\u201322.","journal-title":"Helicobacter"},{"issue":"7","key":"245_CR16","first-page":"641","volume":"8","author":"WA Boer de","year":"1996","unstructured":"de Boer WA, Thys JC, Borody TJ, Graham DY, O\u2019Morain C, Tytgat GN. Proposal for use of a standard side effect scoring system in studies exploring Helicobacter pylori treatment regimens. Eur J Gastroenterol Hepatol. 1996;8(7):641\u20133.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"245_CR17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/hel.12106","volume":"19","author":"N Almeida","year":"2014","unstructured":"Almeida N, Romaozinho JM, Donato MM, Luxo C, Cardoso O, Cipriano MA, et al. Triple therapy with high-dose proton-pump inhibitor, amoxicillin, and doxycycline is useless for Helicobacter pylori eradication: a proof-of-concept study. Helicobacter. 2014;19(2):90\u20137.","journal-title":"Helicobacter"},{"issue":"30","key":"245_CR18","doi-asserted-by":"publisher","first-page":"17771","DOI":"10.1074\/jbc.270.30.17771","volume":"270","author":"JC Atherton","year":"1995","unstructured":"Atherton JC, Cao P, Peek Jr RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori, association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995;270(30):17771\u20137.","journal-title":"J Biol Chem"},{"issue":"4","key":"245_CR19","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1128\/JCM.41.4.1651-1655.2003","volume":"41","author":"A Santos","year":"2003","unstructured":"Santos A, Queiroz DM, Menard A, Marais A, Rocha GA, Oliveira CA, et al. New pathogenicity marker found in the plasticity region of the Helicobacter pylori genome. J Clin Microbiol. 2003;41(4):1651\u20135.","journal-title":"J Clin Microbiol"},{"issue":"3","key":"245_CR20","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1053\/j.gastro.2007.07.008","volume":"133","author":"N Vakil","year":"2007","unstructured":"Vakil N, Megraud F. Eradication therapy for Helicobacter pylori. Gastroenterology. 2007;133(3):985\u20131001.","journal-title":"Gastroenterology"},{"issue":"1","key":"245_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1586\/eri.09.113","volume":"8","author":"L Boyanova","year":"2010","unstructured":"Boyanova L, Mitov I. Geographic map and evolution of primary Helicobacter pylori resistance to antibacterial agents. Expert Rev Anti Infect Ther. 2010;8(1):59\u201370.","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"4","key":"245_CR22","first-page":"409","volume":"19","author":"V Francesco De","year":"2010","unstructured":"De Francesco V, Giorgio F, Hassan C, Manes G, Vannella L, Panella C, et al. Worldwide H. pylori antibiotic resistance: a systematic review. J Gastrointestin Liver Dis. 2010;19(4):409\u201314.","journal-title":"J Gastrointestin Liver Dis"},{"issue":"9","key":"245_CR23","doi-asserted-by":"publisher","first-page":"E506","DOI":"10.1503\/cmaj.101460","volume":"183","author":"DY Graham","year":"2011","unstructured":"Graham DY, Fischbach LA. Empiric therapies for Helicobacter pylori infections. CMAJ. 2011;183(9):E506\u20138.","journal-title":"CMAJ"},{"issue":"10","key":"245_CR24","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1111\/j.1440-1746.2009.05982.x","volume":"24","author":"KM Fock","year":"2009","unstructured":"Fock KM, Katelaris P, Sugano K, Ang TL, Hunt R, Talley NJ, et al. Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection. J Gastroenterol Hepatol. 2009;24(10):1587\u2013600.","journal-title":"J Gastroenterol Hepatol"},{"key":"245_CR25","doi-asserted-by":"publisher","first-page":"974594","DOI":"10.1155\/2012\/974594","volume":"2012","author":"JP Gisbert","year":"2012","unstructured":"Gisbert JP. Rescue therapy for Helicobacter pylori infection 2012. Gastroenterol Res Pract. 2012;2012:974594.","journal-title":"Gastroenterol Res Pract."},{"issue":"35","key":"245_CR26","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.3748\/wjg.14.5385","volume":"14","author":"JP Gisbert","year":"2008","unstructured":"Gisbert JP. \u201cRescue\u201d regimens after Helicobacter pylori treatment failure. World J Gastroenterol. 2008;14(35):5385\u2013402.","journal-title":"World J Gastroenterol."},{"issue":"4","key":"245_CR27","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.1365-2036.2007.03573.x","volume":"27","author":"JP Gisbert","year":"2008","unstructured":"Gisbert JP, Gisbert JL, Marcos S, Jimenez-Alonso I, Moreno-Otero R, Pajares JM. Empirical rescue therapy after Helicobacter pylori treatment failure: a 10-year single-centre study of 500 patients. Aliment Pharmacol Ther. 2008;27(4):346\u201354.","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"245_CR28","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/ncpgasthep1138","volume":"5","author":"DY Graham","year":"2008","unstructured":"Graham DY, Shiotani A. New concepts of resistance in the treatment of Helicobacter pylori infections. Nat Clin Pract Gastroenterol Hepatol. 2008;5(6):321\u201331.","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"245_CR29","first-page":"192","volume":"15","author":"Gastrenterologia SPd","year":"2008","unstructured":"Gastrenterologia SPd. Normas de orienta\u00e7\u00e3o cl\u00ednica - helicobacter pylori. GE - Jornal Portugu\u00eas de Gastrenterologia. 2008;15:192\u20134.","journal-title":"GE - Jornal Portugu\u00eas de Gastrenterologia"},{"issue":"6","key":"245_CR30","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1093\/jac\/46.6.1029","volume":"46","author":"J Cabrita","year":"2000","unstructured":"Cabrita J, Oleastro M, Matos R, Manhente A, Cabral J, Barros R, et al. Features and trends in Helicobacter pylori antibiotic resistance in Lisbon area, Portugal (1990\u20131999). J Antimicrob Chemother. 2000;46(6):1029\u201331.","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"245_CR31","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11695-012-0747-4","volume":"23","author":"RM Cerqueira","year":"2013","unstructured":"Cerqueira RM, Correia MR, Fernandes CD, Vilar H, Manso MC. Cumulative Helicobacter pylori eradication therapy in obese patients undergoing gastric bypass surgery. Obes Surg. 2013;23(2):145\u20139.","journal-title":"Obes Surg"},{"key":"245_CR32","first-page":"vi3","volume":"66 Suppl 6","author":"N Adriaenssens","year":"2011","unstructured":"Adriaenssens N, Coenen S, Versporten A, Muller A, Minalu G, Faes C, et al. European surveillance of antimicrobial consumption (ESAC): outpatient antibiotic use in Europe (1997\u20132009). J Antimicrob Chemother. 2011;66 Suppl 6:vi3\u2013vi12.","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"245_CR33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/j.1523-5378.2011.00858.x","volume":"16","author":"M Oleastro","year":"2011","unstructured":"Oleastro M, Pelerito A, Nogueira P, Benoliel J, Santos A, Cabral J, et al. Prevalence and incidence of Helicobacter pylori Infection in a healthy pediatric population in the Lisbon area. Helicobacter. 2011;16(5):363\u201372.","journal-title":"Helicobacter"},{"issue":"3","key":"245_CR34","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1046\/j.1523-5378.2003.00145.x","volume":"8","author":"JJ Kim","year":"2003","unstructured":"Kim JJ, Kim JG, Kwon DH. Mixed-infection of antibiotic susceptible and resistant Helicobacter pylori isolates in a single patient and underestimation of antimicrobial susceptibility testing. Helicobacter. 2003;8(3):202\u20136.","journal-title":"Helicobacter"},{"issue":"4","key":"245_CR35","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S0016-5085(99)70065-X","volume":"116","author":"LJ Doorn Van","year":"1999","unstructured":"Van Doorn LJ, Figueiredo C, Megraud F, Pena S, Midolo P, Queiroz DM, et al. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology. 1999;116(4):823\u201330.","journal-title":"Gastroenterology"},{"issue":"3","key":"245_CR36","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3748\/wjg.v20.i3.699","volume":"20","author":"TF Kanizaj","year":"2014","unstructured":"Kanizaj TF, Kunac N. Helicobacter pylori: future perspectives in therapy reflecting three decades of experience. World J Gastroenterol. 2014;20(3):699\u2013705.","journal-title":"World J Gastroenterol"},{"issue":"Pt 3","key":"245_CR37","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1099\/jmm.0.067942-0","volume":"63","author":"V Francesco De","year":"2014","unstructured":"De Francesco V, Zullo A, Giorgio F, Saracino I, Zaccaro C, Hassan C, et al. Change of point mutations in Helicobacter pylori rRNA associated with clarithromycin resistance in Italy. J Med Microbiol. 2014;63(Pt 3):453\u20137.","journal-title":"J Med Microbiol"},{"issue":"3","key":"245_CR38","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.amjmed.2005.10.003","volume":"119","author":"T Suzuki","year":"2006","unstructured":"Suzuki T, Matsuo K, Ito H, Sawaki A, Hirose K, Wakai K, et al. Smoking increases the treatment failure for Helicobacter pylori eradication. Am J Med. 2006;119(3):217\u201324.","journal-title":"Am J Med"},{"issue":"11","key":"245_CR39","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S1473-3099(06)70627-2","volume":"6","author":"MM Gerrits","year":"2006","unstructured":"Gerrits MM, van Vliet AH, Kuipers EJ, Kusters JG. Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications. Lancet Infect Dis. 2006;6(11):699\u2013709.","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"245_CR40","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1128\/JCM.37.8.2740-2741.1999","volume":"37","author":"SR Han","year":"1999","unstructured":"Han SR, Bhakdi S, Maeurer MJ, Schneider T, Gehring S. Stable and unstable amoxicillin resistance in Helicobacter pylori: should antibiotic resistance testing be performed prior to eradication therapy? J Clin Microbiol. 1999;37(8):2740\u20131.","journal-title":"J Clin Microbiol"},{"issue":"10","key":"245_CR41","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1128\/JCM.00144-10","volume":"48","author":"S Agudo","year":"2010","unstructured":"Agudo S, Perez-Perez G, Alarcon T, Lopez-Brea M. High prevalence of clarithromycin-resistant Helicobacter pylori strains and risk factors associated with resistance in Madrid. Spain J Clin Microbiol. 2010;48(10):3703\u20137.","journal-title":"Spain J Clin Microbiol"},{"issue":"3","key":"245_CR42","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1136\/gut.46.3.321","volume":"46","author":"LJ Doorn van","year":"2000","unstructured":"van Doorn LJ, Schneeberger PM, Nouhan N, Plaisier AP, Quint WG, de Boer WA. Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment. Gut. 2000;46(3):321\u20136.","journal-title":"Gut"},{"issue":"2","key":"245_CR43","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1365-2036.2006.02993.x","volume":"24","author":"S Miehlke","year":"2006","unstructured":"Miehlke S, Hansky K, Schneider-Brachert W, Kirsch C, Morgner A, Madisch A, et al. Randomized trial of rifabutin-based triple therapy and high-dose dual therapy for rescue treatment of Helicobacter pylori resistant to both metronidazole and clarithromycin. Aliment Pharmacol Ther. 2006;24(2):395\u2013403.","journal-title":"Aliment Pharmacol Ther"},{"issue":"8","key":"245_CR44","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00228-007-0302-8","volume":"63","author":"N Shirai","year":"2007","unstructured":"Shirai N, Sugimoto M, Kodaira C, Nishino M, Ikuma M, Kajimura M, et al. Dual therapy with high doses of rabeprazole and amoxicillin versus triple therapy with rabeprazole, amoxicillin, and metronidazole as a rescue regimen for Helicobacter pylori infection after the standard triple therapy. Eur J Clin Pharmacol. 2007;63(8):743\u20139.","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"245_CR45","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1046\/j.1365-2036.2003.01396.x","volume":"17","author":"N Broutet","year":"2003","unstructured":"Broutet N, Tchamgoue S, Pereira E, Lamouliatte H, Salamon R, Megraud F. Risk factors for failure of Helicobacter pylori therapy\u2013results of an individual data analysis of 2751 patients. Aliment Pharmacol Ther. 2003;17(1):99\u2013109.","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"245_CR46","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.bpg.2006.11.001","volume":"21","author":"K Wolle","year":"2007","unstructured":"Wolle K, Malfertheiner P. Treatment of Helicobacter pylori. Best Pract Res Clin Gastroenterol. 2007;21(2):315\u201324.","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"4","key":"245_CR47","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/ajg.2010.58","volume":"105","author":"M Schmulson","year":"2010","unstructured":"Schmulson M, Adeyemo M, Gutierrez-Reyes G, Charua-Guindic L, Farfan-Labonne B, Ostrosky-Solis F, et al. Differences in gastrointestinal symptoms according to gender in Rome II positive IBS and dyspepsia in a Latin American population. Am J Gastroenterol. 2010;105(4):925\u201332.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"245_CR48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cgh.2008.10.024","volume":"7","author":"DY Graham","year":"2009","unstructured":"Graham DY. Efficient identification and evaluation of effective Helicobacter pylori therapies. Clin Gastroenterol Hepatol. 2009;7(2):145\u20138.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"245_CR49","doi-asserted-by":"publisher","first-page":"932478","DOI":"10.1155\/2013\/932478","volume":"2013","author":"WC Tai","year":"2013","unstructured":"Tai WC, Chiu CH, Liang CM, Chang KC, Kuo CM, Chiu YC, et al. Ten-Day versus 14-Day levofloxacin-containing triple therapy for second-line anti-Helicobacter pylori Eradication in Taiwan. Gastroenterol Res Pract. 2013;2013:932478.","journal-title":"Gastroenterol Res Pract."},{"issue":"2","key":"245_CR50","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/MCG.0b013e318254ebdd","volume":"47","author":"JP Gisbert","year":"2013","unstructured":"Gisbert JP, Perez-Aisa A, Bermejo F, Castro-Fernandez M, Almela P, Barrio J, et al. Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients. J Clin Gastroenterol. 2013;47(2):130\u20135.","journal-title":"J Clin Gastroenterol"},{"issue":"Pt 5","key":"245_CR51","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1099\/jmm.0.072322-0","volume":"63","author":"V Francesco De","year":"2014","unstructured":"De Francesco V, Hassan C, Ridola L, Giorgio F, Ierardi E, Zullo A. Sequential, concomitant and hybrid first-line therapies for Helicobacter pylori eradication: a prospective randomized study. J Med Microbiol. 2014;63(Pt 5):748\u201352.","journal-title":"J Med Microbiol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12876-015-0245-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-015-0245-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-015-0245-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-015-0245-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T02:11:58Z","timestamp":1598753518000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgastroenterol.biomedcentral.com\/articles\/10.1186\/s12876-015-0245-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,15]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["245"],"URL":"https:\/\/doi.org\/10.1186\/s12876-015-0245-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,15]]},"assertion":[{"value":"17 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"23"}}