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Internet-based interventions have been explored for their potential to minimize the negative effects of caring, accounting for their ubiquitous nature, convenient delivery, potential scalability and presumed (cost) effectiveness. iSupport is a self-help online program developed by the World Health Organization (WHO)\u00a0to provide education, skills training and support to IC of PwD. This paper describes the design of an intervention study aimed at determining the effectiveness of a Portuguese culturally adapted version of iSupport on mental health and other well-being outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study follows an experimental parallel between-group design with two arms: access to the five modules and twenty-three lessons of \u201ciSupport\u201d for three months (intervention group); or access to an education-only e-book (comparison group). One hundred and eighty four participants will be recruited by referral from national associations. Inclusion criteria are: being 18\u2009years or older and provide e-consent; being a self-reported non-paid caregiver for at least six months; of a person with a formal diagnosis of dementia; being skilled to use internet; and experience a clinically relevant level of burden (\u2265 21 on Zarit Burden Interview) or depression or anxiety symptoms (\u2265 8 on Hospital Anxiety and Depression Scale). Data is collected online, resorting to self-administered instruments, at baseline, 3 and 6\u2009months after baseline. The primary outcome is caregiver burden, measured by the Zarit Burden Interview. Symptoms of depression and anxiety, quality of life, positive aspects of caregiving and general self-efficacy are secondary study outcomes. The data analysis will follow an Intention-to-treat (ITT) protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This protocol is an important resource for the many organizations in several countries aiming to replicate iSupport. Findings from this intervention study will offer evidence to bolster an informed decision making on scaling up iSupport as a new intervention program with minimal costs aimed at minimizing the psychological distress of IC of PwD in Portugal and elsewhere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04104568\">NCT04104568<\/jats:ext-link>. Registered 26 September 2019.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12877-019-1364-z","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T13:03:04Z","timestamp":1578488584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Online training and support program (iSupport) for informal dementia caregivers: protocol for an intervention study in Portugal"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-4189","authenticated-orcid":false,"given":"Soraia","family":"Teles","sequence":"first","affiliation":[]},{"given":"Ana","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Katrin","family":"Seeher","sequence":"additional","affiliation":[]},{"given":"St\u00e9fanie","family":"Fr\u00e9el","sequence":"additional","affiliation":[]},{"given":"Constan\u00e7a","family":"Pa\u00fal","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"1364_CR1","unstructured":"Prince M, Wimo A, Guerchat M, Ali G-C, Wu Y-T, Prina M. 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The trial is set in Portugal and executed by the Institute of Biomedical Sciences Abel Salazar (University of Porto) and Center for Health Technology and Services Research (CINTESIS) with the support of the National Alzheimer\u2019s Association (Associa\u00e7\u00e3o Alzheimer Portugal). Confidentiality will be ensured before, during and after the study. An electronic informed consent will be used as alternative to the traditional signed paper consent. The study information and electronic informed consent are part of the online study platform. All study data will be collected via study online platform resorting to University of Porto digital questionnaires tools. This is a secure platform using encryption of communications (e.g., HTTPS) for participants\u2019 protection. Socio-demographic data are collected in an anonymized manner. Besides the consent form, where the participants\u2019 identification is mandatory, the only identifiable piece of information in the study concerns the email address, requested to the participants so they can receive all the related information. The use of the email address by the research team will be explicitly stated in the informed consent to be fully understood and accepted\/rejected by the participant. Data, including the final trial dataset will be accessed by the research team only. There is no external data monitoring board. Acknowledging the new role of the Comiss\u00e3o Nacional de Protec\u00e7\u00e3o de Dados [national data protection commission], the research team will ensure the development of an internal document explaining all measures implemented for data protection purposes, to present in case of any auditing process. There is no plan to share IPD. No discomforts, inconveniences, and\/or risks are expected for participants. As the intervention is performed online, participants are not required to make unusual travel arrangements. As sessions are accessed by participants at a time of their convenience, the study does not require the participant to be absent from work or any other usual activity or commitment, with no foreseen loss of income, for example. The devices used to access the intervention will be the participants\u2019 usual devices; therefore there will be no place for the introduction of unusual and potential uncomfortable new devices. The study team will take appropriate action in case any adverse effects are reported by the participants. Important protocol amendments must be communicated to the Ethics Committee for Health of the S\u00e3o Jo\u00e3o University Hospital Center\/Faculty of Medicine of the University of Porto, to the trial registry () and to journals publishing trial related information.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare that they have no competing interests or financial disclosures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}