{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:54:20Z","timestamp":1776894860110,"version":"3.51.2"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-ORG\/113329\/2009"],"award-info":[{"award-number":["PTDC\/SAU-ORG\/113329\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12883-018-1025-4","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T07:48:11Z","timestamp":1519976891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Chronic kidney disease and poor outcomes in ischemic stroke: is impaired cerebral autoregulation the missing link?"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2398","authenticated-orcid":false,"given":"Pedro","family":"Castro","sequence":"first","affiliation":[]},{"given":"Elsa","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Farzaneh","family":"Sorond","sequence":"additional","affiliation":[]},{"given":"Jorge M.","family":"Serrador","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,2]]},"reference":[{"key":"1025_CR1","doi-asserted-by":"publisher","first-page":"c4249","DOI":"10.1136\/bmj.c4249","volume":"341","author":"M Lee","year":"2010","unstructured":"Lee M, Saver JL, Chang KH, Liao HW, Chang SC, Ovbiagele B. Low glomerular filtration rate and risk of stroke: meta-analysis. BMJ. 2010;341:c4249.","journal-title":"BMJ"},{"issue":"5","key":"1025_CR2","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1097\/01.ASN.0000123691.46138.E2","volume":"15","author":"DE Weiner","year":"2004","unstructured":"Weiner DE, Tighiouart H, Amin MG, Stark PC, MacLeod B, Griffith JL, Salem DN, Levey AS, Sarnak MJ. Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies. J Am Soc Nephrol. 2004;15(5):1307\u201315.","journal-title":"J Am Soc Nephrol"},{"issue":"24","key":"1025_CR3","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1212\/WNL.0b013e318259e110","volume":"78","author":"Y Kumai","year":"2012","unstructured":"Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T, Investigators FSR. Proteinuria and clinical outcomes after ischemic stroke. Neurology. 2012;78(24):1909\u201315.","journal-title":"Neurology"},{"issue":"2","key":"1025_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000321516","volume":"31","author":"M Naganuma","year":"2011","unstructured":"Naganuma M, Koga M, Shiokawa Y, Nakagawara J, Furui E, Kimura K, Yamagami H, Okada Y, Hasegawa Y, Kario K, et al. Reduced estimated glomerular filtration rate is associated with stroke outcome after intravenous rt-PA: the stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. Cerebrovasc Dis. 2011;31(2):123\u20139.","journal-title":"Cerebrovasc Dis"},{"issue":"8","key":"1025_CR5","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S1474-4422(14)70026-2","volume":"13","author":"K Toyoda","year":"2014","unstructured":"Toyoda K, Ninomiya T. Stroke and cerebrovascular diseases in patients with chronic kidney disease. Lancet Neurol. 2014;13(8):823\u201333.","journal-title":"Lancet Neurol"},{"issue":"3","key":"1025_CR6","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1088\/0967-3334\/19\/3\/001","volume":"19","author":"RB Panerai","year":"1998","unstructured":"Panerai RB. Assessment of cerebral pressure autoregulation in humans--a review of measurement methods. Physiol Meas. 1998;19(3):305\u201338.","journal-title":"Physiol Meas"},{"issue":"2","key":"1025_CR7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1152\/physrev.00042.2012","volume":"95","author":"M Carlstrom","year":"2015","unstructured":"Carlstrom M, Wilcox CS, Arendshorst WJ. Renal autoregulation in health and disease. Physiol Rev. 2015;95(2):405\u2013511.","journal-title":"Physiol Rev"},{"issue":"2","key":"1025_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1549-8719.2011.00131.x","volume":"19","author":"MJ Davis","year":"2012","unstructured":"Davis MJ. Perspective: physiological role(s) of the vascular myogenic response. Microcirculation. 2012;19(2):99\u2013114.","journal-title":"Microcirculation"},{"issue":"3","key":"1025_CR9","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1113\/jphysiol.1902.sp000911","volume":"28","author":"WM Bayliss","year":"1902","unstructured":"Bayliss WM. On the local reactions of the arterial wall to changes of internal pressure. J Physiol. 1902;28(3):220\u201331.","journal-title":"J Physiol"},{"issue":"3","key":"1025_CR10","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/BF02522477","volume":"36","author":"RB Panerai","year":"1998","unstructured":"Panerai RB, Rennie JM, Kelsall AW, Evans DH. Frequency-domain analysis of cerebral autoregulation from spontaneous fluctuations in arterial blood pressure. Med Biol Eng Comput. 1998;36(3):315\u201322.","journal-title":"Med Biol Eng Comput"},{"issue":"2","key":"1025_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1152\/physrev.1959.39.2.183","volume":"39","author":"NA Lassen","year":"1959","unstructured":"Lassen NA. Cerebral blood flow and oxygen consumption in man. Physiol Rev. 1959;39(2):183\u2013238.","journal-title":"Physiol Rev"},{"issue":"2","key":"1025_CR12","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/ana.21549","volume":"65","author":"JM Wardlaw","year":"2009","unstructured":"Wardlaw JM, Doubal F, Armitage P, Chappell F, Carpenter T, Munoz Maniega S, Farrall A, Sudlow C, Dennis M, Dhillon B. Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Ann Neurol. 2009;65(2):194\u2013202.","journal-title":"Ann Neurol"},{"issue":"1","key":"1025_CR13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1161\/01.HYP.0000168052.00426.65","volume":"46","author":"MF O'Rourke","year":"2005","unstructured":"O'Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension. 2005;46(1):200\u20134.","journal-title":"Hypertension"},{"issue":"2","key":"1025_CR14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/jcbfm.2013.180","volume":"34","author":"S Purkayastha","year":"2014","unstructured":"Purkayastha S, Fadar O, Mehregan A, Salat DH, Moscufo N, Meier DS, Guttmann CR, Fisher ND, Lipsitz LA, Sorond FA. Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage. J Cereb Blood Flow Metab. 2014;34(2):228\u201334.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"20","key":"1025_CR15","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1212\/WNL.0b013e3181df0982","volume":"74","author":"FA Sorond","year":"2010","unstructured":"Sorond FA, Galica A, Serrador JM, Kiely DK, Iloputaife I, Cupples LA, Lipsitz LA. Cerebrovascular hemodynamics, gait, and falls in an elderly population: MOBILIZE Boston study. Neurology. 2010;74(20):1627\u201333.","journal-title":"Neurology"},{"issue":"5","key":"1025_CR16","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1161\/01.HYP.0000145180.38707.84","volume":"44","author":"AK Bidani","year":"2004","unstructured":"Bidani AK, Griffin KA. Pathophysiology of hypertensive renal damage: implications for therapy. Hypertension. 2004;44(5):595\u2013601.","journal-title":"Hypertension"},{"issue":"9","key":"1025_CR17","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","volume":"43","author":"F Fazekas","year":"1993","unstructured":"Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43(9):1683\u20139.","journal-title":"Neurology"},{"issue":"12","key":"1025_CR18","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1161\/STROKEAHA.107.493593","volume":"38","author":"M Khatri","year":"2007","unstructured":"Khatri M, Wright CB, Nickolas TL, Yoshita M, Paik MC, Kranwinkel G, Sacco RL, DeCarli C. Chronic kidney disease is associated with white matter hyperintensity volume: the northern Manhattan study (NOMAS). Stroke. 2007;38(12):3121\u20136.","journal-title":"Stroke"},{"issue":"5","key":"1025_CR19","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.medengphy.2014.02.001","volume":"36","author":"AS Meel-van den Abeelen","year":"2014","unstructured":"Meel-van den Abeelen AS, van Beek AH, Slump CH, Panerai RB, Claassen JA. Transfer function analysis for the assessment of cerebral autoregulation using spontaneous oscillations in blood pressure and cerebral blood flow. Med Eng Phys. 2014;36(5):563\u201375.","journal-title":"Med Eng Phys"},{"issue":"1 Pt 2","key":"1025_CR20","first-page":"H233","volume":"274","author":"R Zhang","year":"1998","unstructured":"Zhang R, Zuckerman JH, Giller CA, Levine BD. Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Phys. 1998;274(1 Pt 2):H233\u201341.","journal-title":"Am J Phys"},{"key":"1025_CR21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1471-2377-11-108","volume":"11","author":"K Nakagawa","year":"2011","unstructured":"Nakagawa K, Serrador JM, LaRose SL, Sorond FA. Dynamic cerebral autoregulation after intracerebral hemorrhage: a case-control study. BMC Neurol. 2011;11:108.","journal-title":"BMC Neurol"},{"key":"1025_CR22","doi-asserted-by":"publisher","unstructured":"Castro P, Santos R, Freitas J, Rosengarten B, Panerai R, Azevedo E: Adaptation of cerebral pressure-velocity hemodynamic changes of neurovascular coupling to orthostatic challenge. Perspectives in Medicine 2012: https:\/\/doi.org\/10.1016\/j.permed.2012.1002.1052 [Available online 1028 March 2012].","DOI":"10.1016\/j.permed.2012.1002.1052"},{"issue":"11","key":"1025_CR23","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1161\/STROKEAHA.110.594168","volume":"41","author":"MJ Aries","year":"2010","unstructured":"Aries MJ, Elting JW, De Keyser J, Kremer BP, Vroomen PC. Cerebral autoregulation in stroke: a review of transcranial Doppler studies. Stroke. 2010;41(11):2697\u2013704.","journal-title":"Stroke"},{"issue":"1","key":"1025_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/kisup.2012.1","volume":"2","author":"Group KDIGOKAKIW","year":"2012","unstructured":"Group KDIGOKAKIW. KDIGO clinical practice guideline for acute kidney injury. Kidney International Supplements. 2012;2(1):1.","journal-title":"Kidney International Supplements"},{"issue":"9","key":"1025_CR25","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604\u201312.","journal-title":"Ann Intern Med"},{"key":"1025_CR26","doi-asserted-by":"crossref","unstructured":"Castro P, Serrador J, Rocha I, Sorond F, Azevedo E. Efficacy of cerebral autoregulation in early ischemic stroke predicts smaller infarcts and better outcomes. Front Neurol. 2017;8(113)","DOI":"10.3389\/fneur.2017.00113"},{"key":"1025_CR27","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.jns.2016.11.065","volume":"372","author":"P Castro","year":"2017","unstructured":"Castro P, Azevedo E, Serrador J, Rocha I, Sorond F. Hemorrhagic transformation and cerebral edema in acute ischemic stroke: link to cerebral autoregulation. J Neurol Sci. 2017;372:256\u201361.","journal-title":"J Neurol Sci"},{"issue":"5","key":"1025_CR28","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.medengphy.2010.12.007","volume":"33","author":"BM Deegan","year":"2011","unstructured":"Deegan BM, Serrador JM, Nakagawa K, Jones E, Sorond FA, Olaighin G. The effect of blood pressure calibrations and transcranial Doppler signal loss on transfer function estimates of cerebral autoregulation. Med Eng Phys. 2011;33(5):553\u201362.","journal-title":"Med Eng Phys"},{"issue":"8","key":"1025_CR29","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S1350-4533(03)00027-4","volume":"25","author":"RB Panerai","year":"2003","unstructured":"Panerai RB. The critical closing pressure of the cerebral circulation. Med Eng Phys. 2003;25(8):621\u201332.","journal-title":"Med Eng Phys"},{"issue":"1","key":"1025_CR30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1161\/01.STR.20.1.45","volume":"20","author":"R Aaslid","year":"1989","unstructured":"Aaslid R, Lindegaard KF, Sorteberg W, Nornes H. Cerebral autoregulation dynamics in humans. Stroke. 1989;20(1):45\u201352.","journal-title":"Stroke"},{"issue":"1","key":"1025_CR31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1152\/japplphysiol.00471.2004","volume":"98","author":"JM Serrador","year":"2005","unstructured":"Serrador JM, Sorond FA, Vyas M, Gagnon M, Iloputaife ID, Lipsitz LA. Cerebral pressure-flow relations in hypertensive elderly humans: transfer gain in different frequency domains. J Appl Physiol. 2005;98(1):151\u20139.","journal-title":"J Appl Physiol"},{"issue":"11","key":"1025_CR32","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1161\/01.STR.30.11.2280","volume":"30","author":"M Fiorelli","year":"1999","unstructured":"Fiorelli M, Bastianello S, von Kummer R, del Zoppo GJ, Larrue V, Lesaffre E, Ringleb AP, Lorenzano S, Manelfe C, Bozzao L. Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European cooperative acute stroke study I (ECASS I) cohort. Stroke. 1999;30(11):2280\u20134.","journal-title":"Stroke"},{"issue":"12","key":"1025_CR33","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1136\/jnnp.53.12.1080","volume":"53","author":"JC van Swieten","year":"1990","unstructured":"van Swieten JC, Hijdra A, Koudstaal PJ, van Gijn J. Grading white matter lesions on CT and MRI: a simple scale. J Neurol Neurosurg Psychiatry. 1990;53(12):1080\u20133.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"1025_CR34","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1161\/STROKEAHA.115.008941","volume":"46","author":"S Curtze","year":"2015","unstructured":"Curtze S, Melkas S, Sibolt G, Haapaniemi E, Mustanoja S, Putaala J, Sairanen T, Tiainen M, Tatlisumak T, Strbian D. Cerebral computed tomography-graded white matter lesions are associated with worse outcome after thrombolysis in patients with stroke. Stroke. 2015;46(6):1554\u201360.","journal-title":"Stroke"},{"issue":"6","key":"1025_CR35","doi-asserted-by":"publisher","first-page":"R411","DOI":"10.1152\/ajpregu.00383.2013","volume":"306","author":"A Saeed","year":"2014","unstructured":"Saeed A, DiBona GF, Grimberg E, Nguy L, Mikkelsen ML, Marcussen N, Guron G. High-NaCl diet impairs dynamic renal blood flow autoregulation in rats with adenine-induced chronic renal failure. Am J Physiol Regul Integr Comp Physiol. 2014;306(6):R411\u20139.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"1025_CR36","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1046\/j.1523-1755.2002.00321.x","volume":"61","author":"PC Churchill","year":"2002","unstructured":"Churchill PC, Churchill MC, Griffin KA, Picken M, Webb RC, Kurtz TW, Bidani AK. Increased genetic susceptibility to renal damage in the stroke-prone spontaneously hypertensive rat. Kidney Int. 2002;61(5):1794\u2013800.","journal-title":"Kidney Int"},{"key":"1025_CR37","doi-asserted-by":"crossref","unstructured":"Abu-Amarah I, Bidani AK, Hacioglu R, Williamson GA, Griffin KA. Differential effects of salt on renal hemodynamics and potential pressure transmission in stroke-prone and stroke-resistant spontaneously hypertensive rats. Am J Physiol Renal Physiol. 289(2):F305\u201313.","DOI":"10.1152\/ajprenal.00349.2004"},{"issue":"12 Pt 1","key":"1025_CR38","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1097\/00004872-199917120-00006","volume":"17","author":"JS Smeda","year":"1999","unstructured":"Smeda JS, VanVliet BN, King SR. Stroke-prone spontaneously hypertensive rats lose their ability to auto-regulate cerebral blood flow prior to stroke. J Hypertens. 1999;17(12 Pt 1):1697\u2013705.","journal-title":"J Hypertens"},{"issue":"4","key":"1025_CR39","doi-asserted-by":"publisher","first-page":"H1489","DOI":"10.1152\/ajpheart.00352.2003","volume":"285","author":"AS Izzard","year":"2003","unstructured":"Izzard AS, Graham D, Burnham MP, Heerkens EH, Dominiczak AF, Heagerty AM. Myogenic and structural properties of cerebral arteries from the stroke-prone spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2003;285(4):H1489\u201394.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"1025_CR40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1161\/01.HYP.34.2.273","volume":"34","author":"Y Nakamura","year":"1999","unstructured":"Nakamura Y, Ono H, Frohlich ED. Differential effects of T- and L-type calcium antagonists on glomerular dynamics in spontaneously hypertensive rats. Hypertension. 1999;34(2):273\u20138.","journal-title":"Hypertension"},{"issue":"3","key":"1025_CR41","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1213\/00000539-200009000-00027","volume":"91","author":"H Endoh","year":"2000","unstructured":"Endoh H, Honda T, Komura N, Shibue C, Watanabe I, Shimoji K. The effects of nicardipine on dynamic cerebral autoregulation in patients anesthetized with propofol and fentanyl. Anesth Analg. 2000;91(3):642\u20136.","journal-title":"Anesth Analg"},{"issue":"6","key":"1025_CR42","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1161\/STROKEAHA.114.005293","volume":"45","author":"JW Hamner","year":"2014","unstructured":"Hamner JW, Tan CO. Relative contributions of sympathetic, cholinergic, and myogenic mechanisms to cerebral autoregulation. Stroke. 2014;45(6):1771\u20137.","journal-title":"Stroke"},{"issue":"20","key":"1025_CR43","doi-asserted-by":"publisher","first-page":"5095","DOI":"10.1113\/jphysiol.2013.259747","volume":"591","author":"CO Tan","year":"2013","unstructured":"Tan CO, Hamner JW, Taylor JA. The role of myogenic mechanisms in human cerebrovascular regulation. J Physiol. 2013;591(20):5095\u2013105.","journal-title":"J Physiol"},{"issue":"Pt 13","key":"1025_CR44","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1113\/jphysiol.2011.206953","volume":"589","author":"YC Tzeng","year":"2011","unstructured":"Tzeng YC, Chan GS, Willie CK, Ainslie PN. Determinants of human cerebral pressure-flow velocity relationships: new insights from vascular modelling and ca(2)(+) channel blockade. J Physiol. 2011;589(Pt 13):3263\u201374.","journal-title":"J Physiol"},{"issue":"3","key":"1025_CR45","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S1474-4422(07)70055-8","volume":"6","author":"JM Simard","year":"2007","unstructured":"Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol. 2007;6(3):258\u201368.","journal-title":"Lancet Neurol"},{"issue":"2","key":"1025_CR46","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s00134-009-1698-7","volume":"36","author":"M Reinhard","year":"2010","unstructured":"Reinhard M, Neunhoeffer F, Gerds TA, Niesen WD, Buttler KJ, Timmer J, Schmidt B, Czosnyka M, Weiller C, Hetzel A. Secondary decline of cerebral autoregulation is associated with worse outcome after intracerebral hemorrhage. Intensive Care Med. 2010;36(2):264\u201371.","journal-title":"Intensive Care Med"},{"issue":"3","key":"1025_CR47","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1385\/MN:28:3:229","volume":"28","author":"X Wang","year":"2003","unstructured":"Wang X, Lo EH. Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol. 2003;28(3):229\u201344.","journal-title":"Mol Neurobiol"},{"issue":"4","key":"1025_CR48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S1474-4422(10)70313-6","volume":"10","author":"JS Balami","year":"2011","unstructured":"Balami JS, Chen RL, Grunwald IQ, Buchan AM. Neurological complications of acute ischaemic stroke. Lancet Neurol. 2011;10(4):357\u201371.","journal-title":"Lancet Neurol"},{"issue":"1","key":"1025_CR49","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s10558-007-9044-6","volume":"8","author":"RB Panerai","year":"2008","unstructured":"Panerai RB. Cerebral autoregulation: from models to clinical applications. Cardiovasc Eng. 2008;8(1):42\u201359.","journal-title":"Cardiovasc Eng"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-018-1025-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T00:45:09Z","timestamp":1570841109000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-018-1025-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,2]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1025"],"URL":"https:\/\/doi.org\/10.1186\/s12883-018-1025-4","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,2]]},"assertion":[{"value":"17 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted in Hospital Center S\u00e3o Jo\u00e3o, Porto, and its local ethical committee approved the study and all participants or proxy signed written informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Jorge Serrador is a member of the editorial board (Associate Editor) of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"21"}}