{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:27:38Z","timestamp":1761920858370},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The Brief Repeatable Battery of Neuropsychological Tests (BRBN-T) is one of the most sensitive and used measures for detecting cognitive impairment in Multiple Sclerosis (MS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The aim of this study was to adapt and validate this battery to the Portuguese population of MS patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The Portuguese version of the BRBN-T was applied to a stratified control national sample of 326 individuals considering sex, age, educational level and geographic location and also a clinical sample of 115 MS patients from several national hospitals. Through the exploration of its psychometrics properties, the Portuguese BRBN-T norms were produced.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The normative data is presented as a regression-based formula to adjust test scores for gender, education and age, and the results reveal the BRBN-T has the ability to differentiate between MS patients and healthy participant\u2019s cognitive performance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study demonstrated in our clinical population a good ability to detect cognitive impairment. Its clearly contributed to reinforcing the neuropsychological assessment in Portugal in patients with MS, by providing a new set of instruments, which can be used in the clinical practice, and in future studies. Moreover, it will allow a rigorous and precise support in relation to neuropsychological assessment for future longitudinal studies and clinical trials.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12883-021-02193-w","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T03:04:38Z","timestamp":1618974278000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of cognitive functions in patients with multiple sclerosis applying the normative values of the Rao\u2019s brief repeatable battery in the Portuguese population"],"prefix":"10.1186","volume":"21","author":[{"name":"on behalf of the Group for Validation of the BRBN-T in the Portuguese MS Population","sequence":"first","affiliation":[]},{"given":"Claudia","family":"Sousa","sequence":"first","affiliation":[]},{"given":"Mariana","family":"Rigueiro-Neves","sequence":"additional","affiliation":[]},{"given":"Ana Margarida","family":"Passos","sequence":"additional","affiliation":[]},{"given":"Aristides","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Maria Jos\u00e9","family":"S\u00e1","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"issue":"5","key":"2193_CR1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1212\/WNL.41.5.685","volume":"41","author":"SM Rao","year":"1991","unstructured":"Rao SM, Leo GJ, Bernardin L, Unverzagt F. 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The Portuguese Data Protection Authority had approved data collection beforehand (N\u00b0 3313\/2013). The Ethics Committees of Centro Hospital Universit\u00e1rio S. Jo\u00e3o, Porto (CE\/63\/2012) and all participating hospitals, approved the research project.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"MJS has received consulting\/speaker fees from Bayer, Biogen, CSL Behring, Merck, Novartis, Roche, Sanofi and Teva.The other authors have nothing to disclose regarding this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"170"}}