{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:16:59Z","timestamp":1764645419075,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["Ciencia B\u00e1sica 2013-1-222972"],"award-info":[{"award-number":["Ciencia B\u00e1sica 2013-1-222972"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondo de Investigaci\u00f3n en Salud (FIS), Instituto Mexicano del Seguro Social.","award":["FIS\/IMSS\/PROT\/G13\/1189"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G13\/1189"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12885-019-5294-0","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T09:04:46Z","timestamp":1547456686000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer"],"prefix":"10.1186","volume":"19","author":[{"given":"Andrea Rebeca","family":"Bustos-Carpinteyro","sequence":"first","affiliation":[]},{"given":"Carla","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Abel","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Hugo","family":"Pinheiro","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda Teresa","family":"Maga\u00f1a-Torres","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda Guadalupe","family":"Flores-Miramontes","sequence":"additional","affiliation":[]},{"given":"Adriana","family":"Aguilar-Lemarroy","sequence":"additional","affiliation":[]},{"given":"Luis Felipe","family":"Jave-Su\u00e1rez","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Peregrina-Sandoval","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Alfonso","family":"Cruz-Ramos","sequence":"additional","affiliation":[]},{"given":"Josefina Yoaly","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"5294_CR1","unstructured":"Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]. International Agency for Research on Cancer. 2013. \n                    http:\/\/gco.iarc.fr\/\n                    \n                  . Accessed 10 Dec 2017."},{"key":"5294_CR2","unstructured":"A review of human carcinogens. Part B: Biological agents \/ IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 2009. \n                    https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/06\/mono100B-15.pdf\n                    \n                  . Accessed 15 Aug 2017."},{"key":"5294_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31\u201349S.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"5294_CR4","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1200\/JCO.2012.44.4612","volume":"31","author":"G Corso","year":"2013","unstructured":"Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, et al. Somatic mutations and deletions of the e-cadherin gene predict poor survival of patients with gastric cancer. J Clin Oncol. 2013;31:868\u201375.","journal-title":"J Clin Oncol"},{"key":"5294_CR5","first-page":"3845","volume":"54","author":"KF Becker","year":"1994","unstructured":"Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, et al. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res. 1994;54:3845\u201352.","journal-title":"Cancer Res"},{"key":"5294_CR6","doi-asserted-by":"publisher","first-page":"a003129","DOI":"10.1101\/cshperspect.a003129","volume":"1","author":"G Berx","year":"2009","unstructured":"Berx G, van Roy F. Involvement of members of the cadherin superfamily in cancer. Cold Spring Harb Perspect Biol. 2009;1:a003129.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"5294_CR7","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R. Fast and accurate short read alignment with burrows-wheeler transform. Bioinformatics. 2009;25:1754\u201360.","journal-title":"Bioinformatics"},{"key":"5294_CR8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/bioinformatics\/18.2.333","volume":"18","author":"X Messeguer","year":"2002","unstructured":"Messeguer X, Escudero R, Farr\u00e9 D. PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics. 2002;18:333\u20134.","journal-title":"Bioinformatics"},{"key":"5294_CR9","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1093\/nar\/gkg605","volume":"31","author":"D Farr\u00e9","year":"2003","unstructured":"Farr\u00e9 D, Roset R, Huerta M, Adsuara JE, Rosell\u00f3 L, Alb\u00e0 MM, et al. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res. 2003;31:3651\u20133.","journal-title":"Nucleic Acids Res"},{"key":"5294_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp215","volume":"37","author":"FO Desmet","year":"2009","unstructured":"Desmet FO, Hamroun D, Lalande M, Collod-B\u00e9roud G, Claustres M, B\u00e9roud C. Human splicing finder: an online bioinformatics tool to predict splicing signals. Nucleic Acid Res. 2009;37:e67.","journal-title":"Nucleic Acid Res"},{"key":"5294_CR11","doi-asserted-by":"publisher","first-page":"W597","DOI":"10.1093\/nar\/gks400","volume":"40","author":"P Artimo","year":"2012","unstructured":"Artimo P, Jonnalagedda M, Arnold K, Baratin D, Csardi G, de Castro E, et al. ExPASy: SIB bioinformatics resource portal. Nucleic Acids Res. 2012;40:W597\u2013603.","journal-title":"Nucleic Acids Res"},{"key":"5294_CR12","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1053\/j.gastro.2009.02.065","volume":"136","author":"C Oliveira","year":"2009","unstructured":"Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carri\u00e7o R, Senz J, et al. Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology. 2009;136:2137\u201348.","journal-title":"Gastroenterology"},{"key":"5294_CR13","doi-asserted-by":"publisher","first-page":"11901","DOI":"10.1073\/pnas.1613365113","volume":"113","author":"A Telenti","year":"2016","unstructured":"Telenti A, Pierce LC, Biggs WH, di Iulio J, Wong EH, Fabani MM, et al. Deep sequencing of 10,000 human genomes. Proc Natl Acad Sci U S A. 2016;113:11901\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5294_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.canlet.2017.09.015","volume":"410","author":"KS Chen","year":"2017","unstructured":"Chen KS, Lim JWC, Richards LJ, Bunt J. The convergent roles of the nuclear factor I transcription factors in development and cancer. Cancer Lett. 2017;410:124\u201338.","journal-title":"Cancer Lett"},{"key":"5294_CR15","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/path.2063","volume":"210","author":"G Regalo","year":"2006","unstructured":"Regalo G, Canedo P, Suriano G, Resende C, Campos ML, Oliveira MJ, et al. C\/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression. J Pathol. 2006;210:398\u2013404.","journal-title":"J Pathol"},{"key":"5294_CR16","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/nrc3846","volume":"12","author":"IA Murray","year":"2014","unstructured":"Murray IA, Patterson AD, Perdew GH. Ah receptor ligands in cancer: friend and foe. Nat Rev Cancer. 2014;12:801\u201314.","journal-title":"Nat Rev Cancer"},{"key":"5294_CR17","doi-asserted-by":"crossref","unstructured":"Poulet A, Privat M, Ponelle F, Viala S, Decousus S, Perin A, et al. Improved efficiency and reliability of NGS amplicon sequencing data analysis for genetic diagnostic procedures using AGSA software. Biomed Res Int. 2016;5623089.","DOI":"10.1155\/2016\/5623089"},{"key":"5294_CR18","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1186\/s40064-016-2852-7","volume":"5","author":"M L\u00f3pez","year":"2016","unstructured":"L\u00f3pez M, Cervera-Acedo C, Santib\u00e1\u00f1ez P, Salazar R, Sola JJ, Dom\u00ednguez-Garrido E. A novel mutation in the CDH1 gene in a Spanish family with hereditary diffuse gastric cancer. Springer Plus. 2016;5:1181.","journal-title":"Springer Plus"},{"key":"5294_CR19","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1007\/s10120-017-0778-6","volume":"21","author":"B Zhang","year":"2018","unstructured":"Zhang B, Zhou J, Liu Z, Gu L, Ji J, Kim WH, et al. Clinical and biological significance of a - 73A > C variation in the CDH1 promoter of patients with sporadic gastric carcinoma. Gastric Cancer. 2018;21:606\u201316.","journal-title":"Gastric Cancer"},{"key":"5294_CR20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12967-018-1504-9","volume":"16","author":"Y Hamdi","year":"2018","unstructured":"Hamdi Y, Boujemaa M, Ben Rekaya M, Ben Hamda C, Mighri N, El Benna H, et al. Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases. J Transl Med. 2018;16:158.","journal-title":"J Transl Med"},{"key":"5294_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4238\/gmr.15038715","volume":"15","author":"AR Bustos-Carpinteyro","year":"2016","unstructured":"Bustos-Carpinteyro AR, Delgado-Figueroa N, Santiago-Luna E, Maga\u00f1a-Torres MT, S\u00e1nchez-L\u00f3pez JY. Association between the CDH1 -472delA and -160C>a polymorphisms and diffuse and intestinal gastric cancer in a Mexican population. Genet Mol Res. 2016;15:1\u20139.","journal-title":"Genet Mol Res"},{"key":"5294_CR22","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1136\/gutjnl-2011-301839","volume":"61","author":"N Deng","year":"2012","unstructured":"Deng N, Goh LK, Wang H, Das K, Tao J, Tan IB, et al. A comprehensive survey of genomic alterations in gastric cancer reveals sys- tematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut. 2012;61:673\u201384.","journal-title":"Gut"},{"key":"5294_CR23","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nature13480","volume":"513","author":"The Cancer Genome Atlas Research Network","year":"2014","unstructured":"The Cancer Genome Atlas Research Network. Compre- hensive molecular characterization of gastric adenocar- cinoma. Nature. 2014;513:202\u20139.","journal-title":"Nature"},{"key":"5294_CR24","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nm.3850","volume":"21","author":"R Cristescu","year":"2015","unstructured":"Cristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, et al. Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. Nat Med. 2015;21:449\u201356.","journal-title":"Nat Med"},{"key":"5294_CR25","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.3748\/wjg.v12.i14.2168","volume":"12","author":"YC Liu","year":"2006","unstructured":"Liu YC, Shen CY, Wu HS, Hsieh TY, Chan DC, Chen CJ, et al. Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas. World J Gastroenterol. 2006;12:2168\u201373.","journal-title":"World J Gastroenterol"},{"key":"5294_CR26","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/modpathol.3880416","volume":"14","author":"JJ Asca\u00f1o","year":"2001","unstructured":"Asca\u00f1o JJ, Frierson H Jr, Moskaluk CA, Harper JC, Roviello F, Jackson CE, et al. Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer. Mod Pathol. 2001;14:942\u20139.","journal-title":"Mod Pathol"},{"key":"5294_CR27","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1038\/sj.onc.1204234","volume":"20","author":"JC Machado","year":"2001","unstructured":"Machado JC, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, et al. E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene. 2001;20:1525\u20138.","journal-title":"Oncogene"},{"key":"5294_CR28","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1002\/cncr.27519","volume":"118","author":"FY Huang","year":"2012","unstructured":"Huang FY, Chan AO, Rashid A, Wong DK, Cho CH, Yuen MF. Helicobacter pylori induces promoter methylation of E-cadherin via interleukin-1\u03b2 activation of nitric oxide production in gastric cancer cells. Cancer. 2012;118:4969\u201380.","journal-title":"Cancer"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-5294-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12885-019-5294-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-5294-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T19:10:52Z","timestamp":1578942652000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-019-5294-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,14]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["5294"],"URL":"https:\/\/doi.org\/10.1186\/s12885-019-5294-0","relation":{},"ISSN":["1471-2407"],"issn-type":[{"type":"electronic","value":"1471-2407"}],"subject":[],"published":{"date-parts":[[2019,1,14]]},"assertion":[{"value":"18 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the National Commission for Scientific Research form the Instituto Mexicano del Seguro Social (IMSS) with the number R-2012-785-179. All patients gave their written informed consent. Collection of specimens used in our study complied with institutional guidelines, it was not necessary to request any permission.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"69"}}