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In this study, we intended to evaluate the dopaminergic function in imprisoned SUD offenders through the determination of s-COMT activity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study included 46 male individuals from a Portuguese penal institution. The participants were assessed through a battery of standardised instruments: Psychopathy Checklist-Revised (PCL-R), Barratt Impulsivity Scale Version 11 (BIS-11), and the European version of the Addiction Severity Index (EuropASI). In addition, s-COMT erythrocyte activity was evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall, 73.9% (<jats:italic>n<\/jats:italic>\u2009=\u200934) of the individuals had Antisocial personality disorder (ASPD) and 58.7% (<jats:italic>n<\/jats:italic>\u2009=\u200927) presented SUD. We evidenced, for the first time, that, in individuals with SUD, s-COMT activity was correlated with the severity of drug dependence (EuropASI) (<jats:italic>p<\/jats:italic>\u2009=\u20090.009), and with BIS-11 factors self-control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and non-planning (<jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study opens new perspectives regarding the pharmacological intervention on substance dependence through the interference on dopamine pathways.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12888-022-04068-x","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T09:03:11Z","timestamp":1655802191000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Catechol-O-methyltransferase activity in individuals with substance use disorders: a case control study"],"prefix":"10.1186","volume":"22","author":[{"given":"Jacinto Nuno","family":"da Costa Azevedo","sequence":"first","affiliation":[]},{"given":"Cl\u00e1udia","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Maria Paula","family":"Serr\u00e3o","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Margarida","family":"Figueiredo-Braga","sequence":"additional","affiliation":[]},{"given":"Maria Augusta","family":"Vieira-Coelho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"4068_CR1","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1176\/appi.ajp.158.11.1783","volume":"158","author":"FG Moeller","year":"2001","unstructured":"Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. 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