{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:49:43Z","timestamp":1772596183903,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"BioMedical Materials institute","award":["Project P2.01 IDiDAS"],"award-info":[{"award-number":["Project P2.01 IDiDAS"]}]},{"name":"Grant Dutch Arthritis Foundation","award":["LLP14"],"award-info":[{"award-number":["LLP14"]}]},{"DOI":"10.13039\/501100005635","name":"Funda\u00e7\u00e3o Calouste Gulbenkian (PT)","doi-asserted-by":"publisher","award":["Programme for Advanced Medical Education"],"award-info":[{"award-number":["Programme for Advanced Medical Education"]}],"id":[{"id":"10.13039\/501100005635","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o Champalimaud, Minist\u00e9rio da Sa\u00fade"},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia and Apifarma"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12891-016-0979-x","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T14:02:00Z","timestamp":1458309720000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell types"],"prefix":"10.1186","volume":"17","author":[{"given":"Guus G. H.","family":"van den Akker","sequence":"first","affiliation":[]},{"given":"Don A. M.","family":"Surtel","sequence":"additional","affiliation":[]},{"given":"Andy","family":"Cremers","sequence":"additional","affiliation":[]},{"given":"Martijn F. G. A.","family":"Hoes","sequence":"additional","affiliation":[]},{"given":"Marjolein M.","family":"Caron","sequence":"additional","affiliation":[]},{"given":"Stephen M.","family":"Richardson","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Rodrigues-Pinto","sequence":"additional","affiliation":[]},{"given":"Lodewijk W.","family":"van Rhijn","sequence":"additional","affiliation":[]},{"given":"Judith A.","family":"Hoyland","sequence":"additional","affiliation":[]},{"given":"Tim J. M.","family":"Welting","sequence":"additional","affiliation":[]},{"given":"Jan Willem","family":"Voncken","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,3,14]]},"reference":[{"issue":"6","key":"979_CR1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1469-7580.2012.01521.x","volume":"221","author":"G Pattappa","year":"2012","unstructured":"Pattappa G, Li Z, Peroglio M, Wismer N, Alini M, Grad S. Diversity of intervertebral disc cells: phenotype and function. J Anat. 2012;221(6):480\u201396.","journal-title":"J Anat"},{"key":"979_CR2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.spinee.2007.10.005","volume":"8","author":"S Dagenais","year":"2008","unstructured":"Dagenais S, Caro J, Haldeman S. A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J. 2008;8:8\u201320.","journal-title":"Spine J"},{"issue":"3","key":"979_CR3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/ar629","volume":"5","author":"JP Urban","year":"2003","unstructured":"Urban JP, Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther. 2003;5(3):120\u201330.","journal-title":"Arthritis Res Ther"},{"key":"979_CR4","doi-asserted-by":"crossref","unstructured":"Sivakamasundari V, Lufkin T. Bridging the gap: understanding embryonic intervertebral disc development. Cell Dev Biol. 2012; 1(2).","DOI":"10.4172\/2168-9296.1000103"},{"issue":"2","key":"979_CR5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jbspin.2013.07.012","volume":"81","author":"P Colombier","year":"2014","unstructured":"Colombier P, Clouet J, Hamel O, Lescaudron L, Guicheux J. The lumbar intervertebral disc: from embryonic development to degeneration. Joint Bone Spine. 2014;81(2):125\u20139.","journal-title":"Joint Bone Spine"},{"issue":"3","key":"979_CR6","doi-asserted-by":"crossref","first-page":"R135","DOI":"10.1186\/ar4597","volume":"16","author":"GGH Akker van den","year":"2014","unstructured":"van den Akker GGH, Surtel DAM, Cremers A, Rodrigues-Pinto R, Richardson SM, Hoyland JA, van Rhijn LW, Welting TJM, Voncken JW. Novel immortal human cell lines reveal subpopulations in the nucleus pulposus. Arthritis Res Ther. 2014; 16(3):R135.","journal-title":"Arthritis Res Ther"},{"key":"979_CR7","doi-asserted-by":"crossref","unstructured":"Goldring MB, Birkhead JR, Suen LF, Yamin R, Mizuno S, Glowacki J, Arbiser JL, Apperley JF. Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J Clin Invest. 1994;94(6):2307\u201316.","DOI":"10.1172\/JCI117595"},{"key":"979_CR8","doi-asserted-by":"crossref","unstructured":"Risbud M, Guttapalli A, Tsai T, Lee J, Danielson K, Vaccaro A, Albert T, Gazit Z, Gazit D, Shapiro I. Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine. 2007;32(23):2537\u201344.","DOI":"10.1097\/BRS.0b013e318158dea6"},{"issue":"14","key":"979_CR9","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/01.BRS.0000131419.25265.23","volume":"29","author":"DMD Sakai","year":"2004","unstructured":"Sakai DMD, Mochida JMD, Yamamoto YMD, Toh EMD, Iwashina TMD, Miyazaki TMD, Inokuchi SMD, Ando KMD, Hotta TMD. Immortalization of human nucleus pulposus cells by a recombinant SV40 adenovirus vector: establishment of a novel cell line for the study of human nucleus pulposus cells. [Miscellaneous article]. Spine (Phila Pa 1976). 2004;29(14):1515\u201323.","journal-title":"Spine (Phila Pa 1976)"},{"issue":"10","key":"979_CR10","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00586-010-1392-z","volume":"19","author":"C Weiler","year":"2010","unstructured":"Weiler C, Nerlich A, Schaaf R, Bachmeier B, Wuertz K, Boos N. Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc. Eur Spine J. 2010;19(10):1761\u201370.","journal-title":"Eur Spine J"},{"key":"979_CR11","doi-asserted-by":"crossref","unstructured":"Liu MC, Chen WH, Wu LC, Hsu WC, Lo WC, Yeh SD, Wang MF, Zeng R, Deng WP. Establishment of a promising human nucleus pulposus cell line for intervertebral disc tissue engineering. Tissue Eng Part C Methods. 2013;20(1):1\u201310.","DOI":"10.1089\/ten.tec.2013.0048"},{"key":"979_CR12","doi-asserted-by":"crossref","unstructured":"van den Akker GG, Surtel DA, Cremers A, Richardson SM, Hoyland JA, van Rhijn LW, Voncken JW, Welting TJ. Novel immortal cell lines support cellular heterogeneity in the human annulus fibrosus.PloS one 2016;11(1):e0144497.","DOI":"10.1371\/journal.pone.0144497"},{"key":"979_CR13","doi-asserted-by":"crossref","unstructured":"Boyle KB, Hadaschik D, Virtue S, Cawthorn WP, Ridley SH, O\u2019Rahilly S, Siddle K. The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation. Cell Death Differ. 2009;16(5):782\u20139.","DOI":"10.1038\/cdd.2009.11"},{"key":"979_CR14","doi-asserted-by":"crossref","unstructured":"Guerquin MJ, Charvet B, Nourissat G, Havis E, Ronsin O, Bonnin MA, Ruggiu M, Olivera-Martinez I, Robert N, Lu Y et al. Transcription factor EGR1 directs tendon differentiation and promotes tendon repair. J Clin Invest. 2013;123(8):3564\u201376.","DOI":"10.1172\/JCI67521"},{"key":"979_CR15","doi-asserted-by":"crossref","unstructured":"Lejard V, Blais F, Guerquin MJ, Bonnet A, Bonnin MA, Havis E, Malbouyres M, Bidaud CB, Maro G, Gilardi-Hebenstreit P et al. EGR1 and EGR2 involvement in vertebrate tendon differentiation. J Biol Chem. 2011;286(7):5855\u201367.","DOI":"10.1074\/jbc.M110.153106"},{"key":"979_CR16","doi-asserted-by":"crossref","unstructured":"Spaapen F, van den Akker GG, Caron MM, Prickaerts P, Rofel C, Dahlmans VE, Surtel DA, Paulis Y, Schweizer F, Welting TJ et al. The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis. PLoS One. 2013;8(3), e58083.","DOI":"10.1371\/journal.pone.0058083"},{"key":"979_CR17","doi-asserted-by":"crossref","unstructured":"Nebbaki SS, El Mansouri FE, Afif H, Kapoor M, Benderdour M, Duval N, Pelletier JP, Martel-Pelletier J, Fahmi H. Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor gamma expression in human osteoarthritic chondrocytes. Arthritis Res Ther. 2012;14(2):R69.","DOI":"10.1186\/ar3788"},{"issue":"4","key":"979_CR18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1158\/1541-7786.MCR-09-0454","volume":"8","author":"SY Shin","year":"2010","unstructured":"Shin SY, Kim JH, Baker A, Lim Y, Lee YH. Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha. Mol Cancer Res. 2010;8(4):507\u201319.","journal-title":"Mol Cancer Res"},{"issue":"6","key":"979_CR19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/ar331","volume":"3","author":"MP Vincenti","year":"2001","unstructured":"Vincenti MP, Brinckerhoff CE. Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta. Arthritis Res. 2001;3(6):381\u20138.","journal-title":"Arthritis Res"},{"key":"979_CR20","doi-asserted-by":"crossref","unstructured":"Walters JN, Bickford JS, Newsom KJ, Beachy DE, Barilovits SJ, Herlihy JD, Nick HS. Regulation of human microsomal prostaglandin E synthase-1 by IL-1beta requires a distal enhancer element with a unique role for C\/EBPbeta. Biochem J. 2012;443(2):561\u201371.","DOI":"10.1042\/BJ20111801"},{"key":"979_CR21","doi-asserted-by":"crossref","unstructured":"Reumann MK, Strachna O, Yagerman S, Torrecilla D, Kim J, Doty SB, Lukashova L, Boskey AL, Mayer-Kuckuk P. Loss of transcription factor early growth response gene 1 results in impaired endochondral bone repair. Bone. 2011;49(4):743\u201352.","DOI":"10.1016\/j.bone.2011.06.023"},{"issue":"2","key":"979_CR22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biocel.2010.03.013","volume":"43","author":"S Kurinna","year":"2011","unstructured":"Kurinna S, Barton MC. Cascades of transcription regulation during liver regeneration. Int J Biochem Cell Biol. 2011;43(2):189\u201397.","journal-title":"Int J Biochem Cell Biol"},{"key":"979_CR23","doi-asserted-by":"crossref","unstructured":"Caron MM, Emans PJ, Surtel DA, Cremers A, Voncken JW, Welting TJ, van Rhijn LW. Activation of NF-kappaB\/p65 facilitates early chondrogenic differentiation during endochondral ossification. PLoS One. 2012;7(3), e33467.","DOI":"10.1371\/journal.pone.0033467"},{"issue":"1\u20132","key":"979_CR24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.molbrainres.2004.11.011","volume":"135","author":"P Szot","year":"2005","unstructured":"Szot P, White SS, Shen DD, Anderson GD. Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expression. Brain Res Mol Brain Res. 2005;135(1\u20132):285\u20139.","journal-title":"Brain Res Mol Brain Res"},{"issue":"4","key":"979_CR25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/bdra.20131","volume":"73","author":"A Okada","year":"2005","unstructured":"Okada A, Kushima K, Aoki Y, Bialer M, Fujiwara M. Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Birth Defects Res A Clin Mol Teratol. 2005;73(4):229\u201338.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"3","key":"979_CR26","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/nar\/gkg186","volume":"31","author":"EL Decker","year":"2003","unstructured":"Decker EL, Nehmann N, Kampen E, Eibel H, Zipfel PF, Skerka C. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res. 2003;31(3):911\u201321.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"979_CR27","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1186\/ar2595","volume":"11","author":"JS Rockel","year":"2009","unstructured":"Rockel JS, Bernier SM, Leask A. Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK\/ERK signalling. Arthritis Res Ther. 2009;11(1):R8.","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"979_CR28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/1568010053586372","volume":"4","author":"S Roberts","year":"2005","unstructured":"Roberts S, Butler RC. Inflammatory mediators as potential therapeutic targets in the spine. Curr Drug Targets Inflamm Allergy. 2005;4(2):257\u201366.","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"979_CR29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.22203\/eCM.v022a31","volume":"22","author":"TJ Welting","year":"2011","unstructured":"Welting TJ, Caron MM, Emans PJ, Janssen MP, Sanen K, Coolsen MM, Voss L, Surtel DA, Cremers A, Voncken JW, et al. Inhibition of cyclooxygenase-2 impacts chondrocyte hypertrophic differentiation during endochondral ossification. Eur Cell Mater. 2011;22:420\u201336. discussion 436\u2013427.","journal-title":"Eur Cell Mater"},{"issue":"8","key":"979_CR30","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1007\/s00586-010-1378-x","volume":"19","author":"JP Rutges","year":"2010","unstructured":"Rutges JP, Nikkels PG, Oner FC, Ottink KD, Verbout AJ, Castelein RJ, Creemers LB, Dhert WJ. The presence of extracellular matrix degrading metalloproteinases during fetal development of the intervertebral disc. Eur Spine J. 2010;19(8):1340\u20136.","journal-title":"Eur Spine J"},{"issue":"3","key":"979_CR31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0167-4781(00)00207-4","volume":"1493","author":"G Thiel","year":"2000","unstructured":"Thiel G, Kaufmann K, Magin A, Lietz M, Bach K, Cramer M. The human transcriptional repressor protein NAB1: expression and biological activity. Biochim Biophys Acta. 2000;1493(3):289\u2013301.","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"979_CR32","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1128\/MCB.16.7.3545","volume":"16","author":"J Svaren","year":"1996","unstructured":"Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol Cell Biol. 1996;16(7):3545\u201353.","journal-title":"Mol Cell Biol"},{"issue":"22","key":"979_CR33","doi-asserted-by":"crossref","first-page":"15129","DOI":"10.1074\/jbc.M600775200","volume":"281","author":"R Srinivasan","year":"2006","unstructured":"Srinivasan R, Mager GM, Ward RM, Mayer J, Svaren J. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 2006;281(22):15129\u201337.","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"979_CR34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bj3360183","volume":"336","author":"ES Silverman","year":"1998","unstructured":"Silverman ES, Du J, Williams AJ, Wadgaonkar R, Drazen JM, Collins T. cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). Biochem J. 1998;336(Pt 1):183\u20139.","journal-title":"Biochem J"},{"issue":"1","key":"979_CR35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molcel.2004.06.030","volume":"15","author":"J Yu","year":"2004","unstructured":"Yu J, de Belle I, Liang H, Adamson ED. Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell. 2004;15(1):83\u201394.","journal-title":"Mol Cell"},{"key":"979_CR36","doi-asserted-by":"crossref","unstructured":"Weaver ICG, D\u2019Alessio AC, Brown SE, Hellstrom IC, Dymov S, Sharma S, Szyf M, Meaney MJ. The transcription factor nerve growth factor-inducible protein A mediates epigenetic programming: altering epigenetic marks by immediate-early genes. J Neurosci. 2007;27(7):1756\u201368.","DOI":"10.1523\/JNEUROSCI.4164-06.2007"},{"issue":"1","key":"979_CR37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2012.08.033","volume":"151","author":"Z Nie","year":"2012","unstructured":"Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, Wang R, Green Douglas\u00c2 R, Tessarollo L, Casellas R, et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell. 2012;151(1):68\u201379.","journal-title":"Cell"},{"key":"979_CR38","doi-asserted-by":"crossref","unstructured":"Lin C, Y, Lov\u00e9n J, Rahl Peter B, Paranal Ronald M, Burge Christopher B, Bradner James E, Lee Tong I, Young Richard A. Transcriptional amplification in tumor cells with elevated c-Myc. Cell. 2012;151(1):56\u201367.","DOI":"10.1016\/j.cell.2012.08.026"},{"issue":"12","key":"979_CR39","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1038\/sj.emboj.7601152","volume":"25","author":"PS Knoepfler","year":"2006","unstructured":"Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. Myc influences global chromatin structure. Embo J. 2006;25(12):2723\u201334.","journal-title":"Embo J"},{"issue":"2","key":"979_CR40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/faat.1994.1029","volume":"22","author":"MG Narotsky","year":"1994","unstructured":"Narotsky MG, Francis EZ, Kavlock RJ. Developmental toxicity and structure-activity relationships of aliphatic acids, including dose\u2013response assessment of valproic acid in mice and rats. Fundam Appl Toxicol. 1994;22(2):251\u201365.","journal-title":"Fundam Appl Toxicol"},{"issue":"3","key":"979_CR41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ajmg.10781","volume":"112","author":"LB Holmes","year":"2002","unstructured":"Holmes LB. Teratogen-induced limb defects. Am J Med Genet. 2002;112(3):297\u2013303.","journal-title":"Am J Med Genet"},{"issue":"2","key":"979_CR42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/tera.1420450208","volume":"45","author":"K Ehlers","year":"1992","unstructured":"Ehlers K, Sturje H, Merker HJ, Nau H. Valproic acid-induced spina bifida: a mouse model. Teratology. 1992;45(2):145\u201354.","journal-title":"Teratology"},{"issue":"3","key":"979_CR43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2165\/00002512-199711030-00006","volume":"11","author":"AE Yu","year":"1997","unstructured":"Yu AE, Hewitt RE, Connor EW, Stetler-Stevenson WG. Matrix metalloproteinases. Novel targets for directed cancer therapy. Drugs Aging. 1997;11(3):229\u201344.","journal-title":"Drugs Aging"},{"key":"979_CR44","doi-asserted-by":"crossref","unstructured":"Muroski ME, Roycik MD, Newcomer RG, Van den Steen PE, Opdenakker G, Monroe HR, Sahab ZJ, Sang QX. Matrix metalloproteinase-9\/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis. Curr Pharm Biotechnol. 2008;9(1):34\u201346.","DOI":"10.2174\/138920108783497631"},{"issue":"6","key":"979_CR45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2174\/138945009788488404","volume":"10","author":"C Ruiz-Romero","year":"2009","unstructured":"Ruiz-Romero C, Blanco FJ. The role of proteomics in osteoarthritis pathogenesis research. Curr Drug Targets. 2009;10(6):543\u201356.","journal-title":"Curr Drug Targets"},{"issue":"3","key":"979_CR46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/BRS.0b013e31821a874b","volume":"37","author":"H Hamamoto","year":"2012","unstructured":"Hamamoto H, Miyamoto H, Doita M, Takada T, Nishida K, Kurosaka M. Capability of nondegenerated and degenerated discs in producing inflammatory agents with or without macrophage interaction. Spine (Phila Pa 1976). 2012;37(3):161\u20137.","journal-title":"Spine (Phila Pa 1976)"},{"key":"979_CR47","doi-asserted-by":"crossref","unstructured":"Liu H, Zhu S, Zhang C, Lu P, Hu J, Yin Z, Ma Y, Chen X, OuYang H. Crucial transcription factors in tendon development and differentiation: their potential for tendon regeneration. Cell Tissue Res. 2014;1\u201312.","DOI":"10.1007\/s00441-014-1834-8"},{"issue":"47","key":"979_CR48","doi-asserted-by":"crossref","first-page":"39942","DOI":"10.1074\/jbc.M112.375964","volume":"287","author":"N Fujita","year":"2012","unstructured":"Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-alpha (TNF-alpha) on cells of the nucleus pulposus through co-activation of nuclear factor kappaB (NF-kappaB)\/p65 signaling. J Biol Chem. 2012;287(47):39942\u201353.","journal-title":"J Biol Chem"},{"key":"979_CR49","doi-asserted-by":"crossref","unstructured":"Balamotis MA, Tamberg N, Woo YJ, Li J, Davy B, Kohwi-Shigematsu T, Kohwi Y. Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development. Mol Cell Biol. 2012;32(2):333\u201347.","DOI":"10.1128\/MCB.05917-11"},{"key":"979_CR50","doi-asserted-by":"crossref","unstructured":"Morice E, Farley S, Poirier R, Dallerac G, Chagneau C, Pannetier S, Hanauer A, Davis S, Vaillend C, Laroche S. Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. Neurobiol Dis. 2013;58:156\u201368.","DOI":"10.1016\/j.nbd.2013.05.016"},{"key":"979_CR51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.brainres.2010.05.041","volume":"1345","author":"AC Nunes","year":"2010","unstructured":"Nunes AC, Duarte RB, Sousa TB, dos Santos JR, Freire MA, Costa MS. Expression of the immediate-early gene egr-1 and substance P in the spinal cord following locomotor training in adult rats. Brain Res. 2010;1345:125\u201336.","journal-title":"Brain Res"},{"issue":"17","key":"979_CR52","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1073\/pnas.1220558110","volume":"110","author":"A Veyrac","year":"2013","unstructured":"Veyrac A, Gros A, Bruel-Jungerman E, Rochefort C, Kleine Borgmann FB, Jessberger S, Laroche S. Zif268\/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning. Proc Natl Acad Sci U S A. 2013;110(17):7062\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"979_CR53","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/jnc.12210","volume":"125","author":"L Xie","year":"2013","unstructured":"Xie L, Korkmaz KS, Braun K, Bock J. Early life stress-induced histone acetylations correlate with activation of the synaptic plasticity genes Arc and Egr1 in the mouse hippocampus. J Neurochem. 2013;125(3):457\u201364.","journal-title":"J Neurochem"},{"issue":"2","key":"979_CR54","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/eji.200737157","volume":"38","author":"S Collins","year":"2008","unstructured":"Collins S, Lutz MA, Zarek PE, Anders RA, Kersh GJ, Powell JD. Opposing regulation of T cell function by Egr-1\/NAB2 and Egr-2\/Egr-3. Eur J Immunol. 2008;38(2):528\u201336.","journal-title":"Eur J Immunol"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12891-016-0979-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T14:09:18Z","timestamp":1567692558000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1471-2474\/17\/124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,14]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["979"],"URL":"https:\/\/doi.org\/10.1186\/s12891-016-0979-x","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,14]]},"article-number":"124"}}