{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:32:07Z","timestamp":1777944727145,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Endocr Disord"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce. We aimed to assess prediabetes remission rate and clinical predictors of remission in a 4 year follow up period.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Observational longitudinal study including patients with obesity and prediabetes who had undergone bariatric surgery in our centre. Prediabetes was defined as having a baseline glycated haemoglobin (A1c) between 5.7% and 6.4% and absence of anti-diabetic drug treatment. We used logistic regression models to evaluate the association between the predictors and prediabetes remission rate.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 669 patients were included, 84% being female. The population had a mean age of 45.4\u2009\u00b1\u200910.1 years-old, body mass index of 43.8\u2009\u00b1\u20095.7\u00a0kg\/m<jats:sup>2<\/jats:sup>, and median A1c of 5.9 [5.8, 6.1]%. After bariatric surgery, prediabetes remission rate was 82%, 73%, 66%, and 58%, respectively in the 1st, 2nd, 3rd, and 4th years of follow-up. Gastric sleeve (GS) surgery was associated with higher prediabetes remission rate than Roux-en-Y gastric bypass surgery in the 3rd year of follow-up. Men had a higher remission rate than women, in the 1st and 3nd years of follow-up in the unadjusted analysis. Younger patients presented a higher remission rate comparing to older patients in the 3rd year of follow-up.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We showed a high prediabetes remission rate after bariatric surgery. The remission rate decreases over the follow-up period, although most of the patients maintain the normoglycemia. Prediabetes remission seems to be more significant in patients who had undergone GS, in male and in younger patients.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12902-024-01537-0","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T03:02:36Z","timestamp":1704942156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prediabetes remission after bariatric surgery: a 4-years follow-up study"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-3751","authenticated-orcid":false,"given":"Marta","family":"Borges-Canha","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o S\u00e9rgio","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Maria Manuel","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Mendon\u00e7a","sequence":"additional","affiliation":[]},{"given":"Telma","family":"Moreno","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"Vale","sequence":"additional","affiliation":[]},{"given":"Juliana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Helena Urbano","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Gil-Santos","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Calheiros","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Meira","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Menino","sequence":"additional","affiliation":[]},{"given":"Vanessa","family":"Guerreiro","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Pedro","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Sande","sequence":"additional","affiliation":[]},{"given":"Selma B.","family":"Souto","sequence":"additional","affiliation":[]},{"given":"Eduardo Lima","family":"da Costa","sequence":"additional","affiliation":[]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Freitas","sequence":"additional","affiliation":[]},{"name":"CRIO group","sequence":"additional","affiliation":[]},{"given":"John Rodrigues","family":"Preto","sequence":"additional","affiliation":[]},{"given":"Hugo Miguel Santos","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9 Manuel Costa","family":"Pinho","sequence":"additional","affiliation":[]},{"given":"Carla Cristina Oliveira Rodrigues T","family":"Galego","sequence":"additional","affiliation":[]},{"given":"Maria Flora Ferreira Sampaio Carval","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Cid\u00e1lia F\u00e1tima Castro","family":"Gil","sequence":"additional","affiliation":[]},{"given":"Diva Bizarro Figueiredo","family":"Melim","sequence":"additional","affiliation":[]},{"given":"Eduardo Gil Ferreira Rodrigues","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Marco Ant\u00f3nio Costa","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Cristina Sarmento Pontes","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds Miguel Gon\u00e7alves","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"In\u00eas Vasconcelos Sousa","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Isabel Maria Boavista Vieira Marque","family":"Brand\u00e3o","sequence":"additional","affiliation":[]},{"given":"Sert\u00f3rio Manuel Freitas","family":"Andrade","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcia Maria Lopes","family":"Nunes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"1537_CR1","unstructured":"Perreault L. 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Written informed consent for participation was not required for this study, ethical committee of our centre (<i>Comiss\u00e3o de \u00c9tica do Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o<\/i>) waived the need for informed consent. All methods were carried out in accordance with the national legislation and the institutional requirements. Privacy of the patients included was preserved throughout the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}