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The aim of this study was to analyze the impact of the interaction of multiple variables in the susceptibility to OIEARR.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study evaluated 195 patients requiring orthodontic treatment. Nine clinical and treatment variables, single nucleotide polymorphisms (SNPs) from five genes and variables interactions were analyzed as risk factors for OIEARR using a multiple linear regression model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The model explained 29% of OIEARR variability (ANOVA: <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Duration of treatment was the most important predictor and gender was the second, closely followed by premolar extraction. For genes encoding osteoprotegerin (OPG), the receptor activator of nuclear factor \u03ba B (RANK) and the IL1 receptor antagonist (IL1RN), the effect of analyzed variants changed from protective to deleterious depending on the duration of treatment and the age of the patient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This work shows that in OIEARR the impact of genetic susceptibility factors is dynamic changing according to clinical variables.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12903-022-02306-y","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T16:03:24Z","timestamp":1656950604000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-0416","authenticated-orcid":false,"given":"Henriqueta Coimbra","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-3086","authenticated-orcid":false,"given":"Nuno","family":"Lavado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-2558","authenticated-orcid":false,"given":"Filomena","family":"Canova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7814-1653","authenticated-orcid":false,"given":"Miguel Guevara","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-8871","authenticated-orcid":false,"given":"Fernando J.","family":"Regateiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2409-5748","authenticated-orcid":false,"given":"S\u00f3nia A.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"2306_CR1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/s0889-5406(96)80014-x","volume":"110","author":"R Taithongchai","year":"1996","unstructured":"Taithongchai R, Sookkorn K, Killiany DM. 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The study was approved by the Ethics Committee of The Faculty of Medicine of the University of Coimbra. All patients were informed of all procedures and signed a written informed consent. This is an observational retrospective study and no experimental protocol was applied. Our patients were orthodontically treated following the usual guidelines. The collection of salivary samples and of clinical data, as well as genetic studies, were approved by the Ethics Committee of The Faculty of Medicine of the University of Coimbra.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. This is not a case report. Patients are not identified.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"270"}}