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Future doctors working with generative artificial intelligence (AI) need to judge the value of any outputs from LLMs to safely direct the management of patients. We set out to investigate medical students\u2019 ability to evaluate LLM responses to clinical vignettes, identify which prior learning they utilised to scrutinise the LLM answers, and assess their awareness of \u2018clinical prompt engineering\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Final year medical students were asked in a survey to assess the accuracy of the answers provided by generative pre-trained transformer (GPT) 3.5 in response to ten clinical scenarios, five of which GPT 3.5 had answered incorrectly, and to identify which prior training enabled them to evaluate the GPT 3.5 output. A content analysis was conducted amongst 148 consenting medical students.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median percentage of students who correctly evaluated the LLM output was 56%. Students reported interactive case-based and pathology teaching using questions to be the most helpful training provided by the medical school for evaluating AI outputs. Only 5% were familiar with the concept of \u2018clinical prompt engineering\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pathology and interactive case-based teaching using questions were the self-reported best training for medical students to safely interact with the outputs of LLMs. This study can inform the design of medical training for future doctors graduating into AI-enhanced health services.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12909-025-06735-5","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T09:46:53Z","timestamp":1738835213000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Which curriculum components do medical students find most helpful for evaluating AI outputs?"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-4096","authenticated-orcid":false,"given":"William J.","family":"Waldock","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6011-0154","authenticated-orcid":false,"given":"George","family":"Lam","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Baptista","sequence":"additional","affiliation":[]},{"given":"Risheka","family":"Walls","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9599-9069","authenticated-orcid":false,"given":"Amir H.","family":"Sam","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"6735_CR1","unstructured":"Jurafsky D, Martin JH. 2024. 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