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Recent studies suggest that different unhealthy sleep characteristics jointly increase the risks for cardiovascular disease (CVD). This study aimed to estimate the differences in CVD-free life expectancy between people with different sleep profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 308,683 middle-aged adults from the UK Biobank among whom 140,181 had primary care data linkage. We used an established composite sleep score comprising self-reported chronotype, duration, insomnia complaints, snoring, and daytime sleepiness to derive three sleep categories: poor, intermediate, and healthy. We also identified three clinical sleep disorders captured by primary care and inpatient records within 2\u00a0years before enrollment in the cohort: insomnia, sleep-related breathing disorders, and other sleep disorders. We estimated sex-specific CVD-free life expectancy with three-state Markov models conditioning on survival at age 40 across different sleep profiles and clinical disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a gradual loss in CVD-free life expectancy toward poor sleep such as, compared with healthy sleepers, poor sleepers lost 1.80 [95% CI 0.96\u20132.75] and 2.31 [1.46\u20133.29] CVD-free years in females and males, respectively, while intermediate sleepers lost 0.48 [0.41\u20130.55] and 0.55 [0.49\u20130.61] years. Among men, those with clinical insomnia or sleep-related breathing disorders lost CVD-free life by 3.84 [0.61\u20138.59] or 6.73 [5.31\u20138.48] years, respectively. Among women, sleep-related breathing disorders or other sleep disorders were associated with 7.32 [5.33\u201310.34] or 1.43 [0.20\u20133.29] years lost, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both self-reported and doctor-diagnosed poor sleep are negatively associated with CVD-free life, especially pronounced in participants with sleep-related breathing disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12916-023-02732-x","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T20:02:51Z","timestamp":1677700971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-3152","authenticated-orcid":false,"given":"Bo-Huei","family":"Huang","sequence":"first","affiliation":[]},{"given":"Borja","family":"del Pozo Cruz","sequence":"additional","affiliation":[]},{"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[]},{"given":"Peter A.","family":"Cistulli","sequence":"additional","affiliation":[]},{"given":"Emmanuel","family":"Stamatakis","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"2732_CR1","unstructured":"World Health Organization. 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