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Forty male<jats:italic>post<\/jats:italic>-weaned piglets, sons of Large White \u00d7 Landrace sows crossed with Pietrain boars, were allocated into 4 groups (<jats:italic>n<\/jats:italic>\u2009=\u200910) and fed during 28\u2009days one of the following diets: 1) a control basal diet (cereal and soybean meal); 2) a basal diet with 10% of<jats:italic>A. platensis<\/jats:italic>(AP); 3) the AP diet supplemented with 0.005% of Rovabio<jats:sup>\u00ae<\/jats:sup>(AP\u2009+\u2009R); 4) the AP diet supplemented with 0.01% of lysozyme (AP\u2009+\u2009L).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Arthrospira platensis<\/jats:italic>decreased BW gain of piglets, regardless the addition of feed enzymes. The majority of plasma metabolites were affected by diets.<jats:italic>A. platensis<\/jats:italic>increased total lipids, total cholesterol and LDL-cholesterol, without changing hepatic fatty acid content or modulating, in an expressive manner, the transcriptional profile of lipid sensitive mediators. The antioxidant potential in general, and total carotenoids in particular, were improved by the microalga, regardless lysozyme or Rovabio<jats:sup>\u00ae<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Summing up,<jats:italic>A. platensis<\/jats:italic>, individually and combined with feed enzymes, impacts negatively on piglets\u2019 growth but improves the systemic antioxidant potential and changes plasma lipids with a minor modulation on related hepatic metabolic pathways.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12917-021-02869-y","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T12:28:28Z","timestamp":1618316908000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dietary Arthrospira platensis improves systemic antioxidant potential and changes plasma lipids without affecting related hepatic metabolic pathways in post-weaned piglets"],"prefix":"10.1186","volume":"17","author":[{"given":"Marta Sofia Morgado","family":"dos Santos Madeira","sequence":"first","affiliation":[]},{"given":"Paula Alexandra Antunes Br\u00e1s","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"C\u00e1tia Falc\u00e3o","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Miguel Pestana","family":"Assun\u00e7\u00e3o","sequence":"additional","affiliation":[]},{"given":"Cristina Maria Riscado Pereira Mate","family":"Alfaia","sequence":"additional","affiliation":[]},{"given":"Rui Manuel Amaro","family":"Pinto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-5987","authenticated-orcid":false,"given":"Jos\u00e9 Ant\u00f3nio Mestre","family":"Prates","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"2869_CR1","unstructured":"FAO (Food and Agriculture Organization of the United Nations). 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