{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:22:17Z","timestamp":1778631737193,"version":"3.51.4"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-024-02720-0","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T19:35:37Z","timestamp":1726774537000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Brain-on-a-chip: an emerging platform for studying the nanotechnology-biology interface for neurodegenerative disorders"],"prefix":"10.1186","volume":"22","author":[{"given":"Raquel O.","family":"Rodrigues","sequence":"first","affiliation":[]},{"given":"Su-Ryon","family":"Shin","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Ba\u00f1obre-L\u00f3pez","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"issue":"12","key":"2720_CR1","doi-asserted-by":"publisher","first-page":"2002119","DOI":"10.1002\/adhm.202002119","volume":"10","author":"S Bang","year":"2021","unstructured":"Bang S, et al. Emerging brain-pathophysiology-mimetic platforms for studying neurodegenerative diseases: Brain Organoids and brains-on-a-Chip. Adv Healthc Mater. 2021;10(12):2002119.","journal-title":"Adv Healthc Mater"},{"issue":"5","key":"2720_CR2","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1111\/brv.12626","volume":"95","author":"Y Chang","year":"2020","unstructured":"Chang Y, et al. Modelling neurodegenerative diseases with 3D brain organoids. Biol Rev. 2020;95(5):1497\u2013509.","journal-title":"Biol Rev"},{"issue":"3","key":"2720_CR3","doi-asserted-by":"publisher","first-page":"030902","DOI":"10.1063\/5.0055812","volume":"5","author":"BM Maoz","year":"2021","unstructured":"Maoz BM. Brain-on-a-Chip: characterizing the next generation of advanced in vitro platforms for modeling the central nervous system. APL Bioeng. 2021;5(3):030902.","journal-title":"APL Bioeng"},{"key":"2720_CR4","doi-asserted-by":"crossref","unstructured":"Teleanu DM, et al. Nanomaterials for drug delivery to the Central Nervous System. Nanomaterials (Basel); 2019;9:3.","DOI":"10.3390\/nano9030371"},{"key":"2720_CR5","doi-asserted-by":"publisher","first-page":"117957352090739","DOI":"10.1177\/1179573520907397","volume":"12","author":"KG Yiannopoulou","year":"2020","unstructured":"Yiannopoulou KG, Papageorgiou SG. Current and future treatments in Alzheimer Disease: an update. J Cent Nerv Syst Dis. 2020;12:1179573520907397.","journal-title":"J Cent Nerv Syst Dis"},{"issue":"1","key":"2720_CR6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","volume":"7","author":"J Guo","year":"2022","unstructured":"Guo J, et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Therapy. 2022;7(1):391.","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"2720_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3390\/antiox12010131","volume":"12","author":"D Korovesis","year":"2023","unstructured":"Korovesis D, Rubio-Tom\u00e1s T, Tavernarakis N. Oxidative stress in Age-related neurodegenerative diseases: an overview of recent tools and findings. Antioxidants. 2023;12(1):131.","journal-title":"Antioxidants"},{"issue":"5","key":"2720_CR8","doi-asserted-by":"publisher","first-page":"051301","DOI":"10.1063\/1.5120555","volume":"13","author":"S Bang","year":"2019","unstructured":"Bang S, et al. Brain-on-a-chip: a history of development and future perspective. Biomicrofluidics. 2019;13(5):051301.","journal-title":"Biomicrofluidics"},{"key":"2720_CR9","doi-asserted-by":"crossref","unstructured":"Osaki T et al. In Vitro Microfluidic models for neurodegenerative disorders. Adv Healthc Mater. 2018;7(2).","DOI":"10.1002\/adhm.201700489"},{"key":"2720_CR10","doi-asserted-by":"crossref","unstructured":"Wang Y et al. Emerging trends in organ-on-a-chip systems for drug screening. Acta Pharm Sinica B. 2023.","DOI":"10.1016\/j.apsb.2023.02.006"},{"issue":"4","key":"2720_CR11","first-page":"422","volume":"21","author":"M Mustapha","year":"2021","unstructured":"Mustapha M, Mat Taib CN. MPTP-induced mouse model of Parkinson\u2019s disease: a promising direction of therapeutic strategies. Bosn J Basic Med Sci. 2021;21(4):422\u201333.","journal-title":"Bosn J Basic Med Sci"},{"key":"2720_CR12","doi-asserted-by":"publisher","first-page":"912995","DOI":"10.3389\/fnmol.2022.912995","volume":"15","author":"M Yokoyama","year":"2022","unstructured":"Yokoyama M, et al. Mouse models of Alzheimer\u2019s Disease. Front Mol Neurosci. 2022;15:912995.","journal-title":"Front Mol Neurosci"},{"key":"2720_CR13","doi-asserted-by":"crossref","unstructured":"The principles of Humane experimental technique. Med J Aust. 1960;1(13):500\u2013500.","DOI":"10.5694\/j.1326-5377.1960.tb73127.x"},{"issue":"6","key":"2720_CR14","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1021\/acs.biomac.0c00045","volume":"21","author":"J Nicolas","year":"2020","unstructured":"Nicolas J, et al. 3D extracellular matrix mimics: fundamental concepts and Role of materials Chemistry to Influence Stem Cell Fate. Biomacromolecules. 2020;21(6):1968\u201394.","journal-title":"Biomacromolecules"},{"issue":"1","key":"2720_CR15","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1021\/acsbiomaterials.9b01512","volume":"6","author":"Y Seo","year":"2020","unstructured":"Seo Y, et al. Development of an Anisotropically Organized Brain dECM hydrogel-based 3D neuronal culture platform for recapitulating the brain microenvironment in vivo. ACS Biomaterials Sci Eng. 2020;6(1):610\u201320.","journal-title":"ACS Biomaterials Sci Eng"},{"issue":"4","key":"2720_CR16","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s44222-023-00027-7","volume":"1","author":"N Rouleau","year":"2023","unstructured":"Rouleau N, Murugan NJ, Kaplan DL. Functional bioengineered models of the central nervous system. Nat Reviews Bioeng. 2023;1(4):252\u201370.","journal-title":"Nat Reviews Bioeng"},{"key":"2720_CR17","doi-asserted-by":"publisher","first-page":"105033","DOI":"10.1016\/j.neuint.2021.105033","volume":"146","author":"B Ucar","year":"2021","unstructured":"Ucar B. Natural biomaterials in brain repair: a focus on collagen. Neurochem Int. 2021;146:105033.","journal-title":"Neurochem Int"},{"issue":"162","key":"2720_CR18","doi-asserted-by":"publisher","first-page":"20190505","DOI":"10.1098\/rsif.2019.0505","volume":"17","author":"P Madhusudanan","year":"2020","unstructured":"Madhusudanan P, Raju G, Shankarappa S. Hydrogel systems and their role in neural tissue engineering. J R Soc Interface. 2020;17(162):20190505.","journal-title":"J R Soc Interface"},{"issue":"21\u201322","key":"2720_CR19","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1089\/ten.tea.2010.0724","volume":"17","author":"JA DeQuach","year":"2011","unstructured":"DeQuach JA, et al. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A. 2011;17(21\u201322):2583\u201392.","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"2720_CR20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/mi11010021","volume":"11","author":"J-H Choi","year":"2020","unstructured":"Choi J-H, Santhosh M, Choi J-W. Vitro blood\u2013brain barrier-integrated neurological disorder models using a Microfluidic device. Micromachines. 2020;11(1):21.","journal-title":"Micromachines"},{"issue":"1","key":"2720_CR21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s43586-022-00118-6","volume":"2","author":"CM Leung","year":"2022","unstructured":"Leung CM, et al. A guide to the organ-on-a-chip. Nat Reviews Methods Primers. 2022;2(1):33.","journal-title":"Nat Reviews Methods Primers"},{"issue":"2","key":"2720_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.tips.2020.11.009","volume":"42","author":"C Ma","year":"2021","unstructured":"Ma C, et al. Organ-on-a-Chip: a New Paradigm for Drug Development. Trends Pharmacol Sci. 2021;42(2):119\u201333.","journal-title":"Trends Pharmacol Sci"},{"issue":"9","key":"2720_CR23","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","volume":"41","author":"MV Sofroniew","year":"2020","unstructured":"Sofroniew MV. Astrocyte reactivity: subtypes, States, and functions in CNS innate immunity. Trends Immunol. 2020;41(9):758\u201370.","journal-title":"Trends Immunol"},{"issue":"1","key":"2720_CR24","doi-asserted-by":"publisher","first-page":"6233","DOI":"10.1038\/s41467-022-33932-3","volume":"13","author":"T Zhou","year":"2022","unstructured":"Zhou T, et al. Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun. 2022;13(1):6233.","journal-title":"Nat Commun"},{"issue":"3","key":"2720_CR25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00401-018-1812-4","volume":"135","author":"NJ Abbott","year":"2018","unstructured":"Abbott NJ, et al. The role of brain barriers in fluid movement in the CNS: is there a \u2018glymphatic\u2019 system? Acta Neuropathol. 2018;135(3):387\u2013407.","journal-title":"Acta Neuropathol"},{"issue":"5986","key":"2720_CR26","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1188302","volume":"328","author":"D Huh","year":"2010","unstructured":"Huh D, et al. Reconstituting organ-level lung functions on a chip. Science. 2010;328(5986):1662\u20138.","journal-title":"Science"},{"issue":"1","key":"2720_CR27","doi-asserted-by":"publisher","first-page":"2000526","DOI":"10.1002\/adbi.202000526","volume":"6","author":"P Zarrintaj","year":"2022","unstructured":"Zarrintaj P, et al. Human organs-on-Chips: a review of the state-of-the-Art, current prospects, and Future challenges. Adv Biology. 2022;6(1):2000526.","journal-title":"Adv Biology"},{"issue":"51","key":"2720_CR28","doi-asserted-by":"publisher","first-page":"2003517","DOI":"10.1002\/smll.202003517","volume":"16","author":"RO Rodrigues","year":"2020","unstructured":"Rodrigues RO, et al. Organ-on-a-Chip: a preclinical microfluidic platform for the Progress of Nanomedicine. Small. 2020;16(51):2003517.","journal-title":"Small"},{"issue":"4","key":"2720_CR29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41551-022-00882-6","volume":"6","author":"K Ronaldson-Bouchard","year":"2022","unstructured":"Ronaldson-Bouchard K, et al. A multi-organ chip with matured tissue niches linked by vascular flow. Nat Biomedical Eng. 2022;6(4):351\u201371.","journal-title":"Nat Biomedical Eng"},{"issue":"1","key":"2720_CR30","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1038\/s41467-020-17245-x","volume":"11","author":"E Axpe","year":"2020","unstructured":"Axpe E, et al. Towards brain-tissue-like biomaterials. Nat Commun. 2020;11(1):3423.","journal-title":"Nat Commun"},{"key":"2720_CR31","doi-asserted-by":"publisher","first-page":"103979","DOI":"10.1016\/j.jmbbm.2020.103979","volume":"111","author":"T Distler","year":"2020","unstructured":"Distler T, et al. Alginate-based hydrogels show the same complex mechanical behavior as brain tissue. J Mech Behav Biomed Mater. 2020;111:103979.","journal-title":"J Mech Behav Biomed Mater"},{"issue":"8","key":"2720_CR32","doi-asserted-by":"publisher","first-page":"104813","DOI":"10.1016\/j.isci.2022.104813","volume":"25","author":"I Pediaditakis","year":"2022","unstructured":"Pediaditakis I, et al. A microengineered brain-chip to model neuroinflammation in humans. iScience. 2022;25(8):104813.","journal-title":"iScience"},{"key":"2720_CR33","doi-asserted-by":"crossref","unstructured":"Shou Y et al. The application of Brain organoids: from neuronal development to neurological diseases. Front Cell Dev Biology. 2020;8.","DOI":"10.3389\/fcell.2020.579659"},{"issue":"11","key":"2720_CR34","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s41582-022-00723-9","volume":"18","author":"OL Eichm\u00fcller","year":"2022","unstructured":"Eichm\u00fcller OL, Knoblich JA. Human cerebral organoids \u2014 a new tool for clinical neurology research. Nat Reviews Neurol. 2022;18(11):661\u201380.","journal-title":"Nat Reviews Neurol"},{"issue":"2","key":"2720_CR35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.14348\/molcells.2022.2023","volume":"45","author":"N Hong","year":"2022","unstructured":"Hong N, Nam Y. Neurons-on-a-Chip. : Vitro NeuroTools Mol Cells. 2022;45(2):76\u201383.","journal-title":": Vitro NeuroTools Mol Cells"},{"issue":"18","key":"2720_CR36","doi-asserted-by":"publisher","first-page":"14842","DOI":"10.1021\/acs.chemrev.2c00212","volume":"122","author":"R Habibey","year":"2022","unstructured":"Habibey R, et al. Microfluidics for Neuronal Cell and Circuit Engineering. Chem Rev. 2022;122(18):14842\u201380.","journal-title":"Chem Rev"},{"issue":"1","key":"2720_CR37","doi-asserted-by":"publisher","first-page":"8083","DOI":"10.1038\/s41598-017-07416-0","volume":"7","author":"S Bang","year":"2017","unstructured":"Bang S, et al. A low permeability microfluidic blood-brain barrier platform with direct contact between Perfusable Vascular Network and astrocytes. Sci Rep. 2017;7(1):8083.","journal-title":"Sci Rep"},{"issue":"9","key":"2720_CR38","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/nbt.4226","volume":"36","author":"BM Maoz","year":"2018","unstructured":"Maoz BM, et al. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nat Biotechnol. 2018;36(9):865\u201374.","journal-title":"Nat Biotechnol"},{"key":"2720_CR39","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jiec.2021.06.021","volume":"101","author":"M-H Kim","year":"2021","unstructured":"Kim M-H, Kim D, Sung JH. A gut-brain Axis-on-a-Chip for studying transport across epithelial and endothelial barriers. J Ind Eng Chem. 2021;101:126\u201334.","journal-title":"J Ind Eng Chem"},{"issue":"1","key":"2720_CR40","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41378-022-00406-x","volume":"8","author":"BGC Maisonneuve","year":"2022","unstructured":"Maisonneuve BGC, et al. Deposition chamber technology as building blocks for a standardized brain-on-chip framework. Microsystems Nanoengineering. 2022;8(1):86.","journal-title":"Microsystems Nanoengineering"},{"key":"2720_CR41","doi-asserted-by":"crossref","unstructured":"Hayashi I et al. Acquisition of logicality in living neuronal networks and its operation to fuzzy bio-robot system. in International Conference on Fuzzy Systems. 2010.","DOI":"10.1109\/FUZZY.2010.5584887"},{"issue":"2","key":"2720_CR42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41928-022-00913-9","volume":"6","author":"X Tang","year":"2023","unstructured":"Tang X, et al. Flexible brain\u2013computer interfaces. Nat Electron. 2023;6(2):109\u201318.","journal-title":"Nat Electron"},{"key":"2720_CR43","unstructured":"DeMarse TB, Dockendorf KP. Adaptive flight control with living neuronal networks on microelectrode arrays. in Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005. 2005."},{"key":"2720_CR44","doi-asserted-by":"crossref","unstructured":"Kasuba KC et al. Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks. Nat Nanotechnol. 2024.","DOI":"10.1038\/s41565-024-01609-1"},{"issue":"2","key":"2720_CR45","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1124\/mi.3.2.90","volume":"3","author":"WM Pardridge","year":"2003","unstructured":"Pardridge WM. Blood-brain barrier drug targeting: the future of brain drug development. Mol Interv. 2003;3(2):90\u2013105.","journal-title":"Mol Interv"},{"key":"2720_CR46","doi-asserted-by":"publisher","first-page":"104952","DOI":"10.1016\/j.neuint.2020.104952","volume":"144","author":"F Gosselet","year":"2021","unstructured":"Gosselet F, et al. Central nervous system delivery of molecules across the blood-brain barrier. Neurochem Int. 2021;144:104952.","journal-title":"Neurochem Int"},{"issue":"1","key":"2720_CR47","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","volume":"8","author":"D Wu","year":"2023","unstructured":"Wu D, et al. The blood\u2013brain barrier: structure, regulation, and drug delivery. Signal Transduct Target Therapy. 2023;8(1):217.","journal-title":"Signal Transduct Target Therapy"},{"issue":"2","key":"2720_CR48","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13052-018-0563-0","volume":"44","author":"CM Bellettato","year":"2018","unstructured":"Bellettato CM, Scarpa M. Possible strategies to cross the blood\u2013brain barrier. Ital J Pediatr. 2018;44(2):131.","journal-title":"Ital J Pediatr"},{"issue":"8","key":"2720_CR49","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3390\/pharmaceutics13081183","volume":"13","author":"MK Satapathy","year":"2021","unstructured":"Satapathy MK, et al. Solid lipid nanoparticles (SLNs): an Advanced Drug Delivery System Targeting Brain through BBB. Pharmaceutics. 2021;13(8):1183.","journal-title":"Pharmaceutics"},{"issue":"2","key":"2720_CR50","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.20131660","volume":"211","author":"N Bien-Ly","year":"2014","unstructured":"Bien-Ly N, et al. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. J Exp Med. 2014;211(2):233\u201344.","journal-title":"J Exp Med"},{"issue":"5","key":"2720_CR51","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1096\/fj.201600827R","volume":"31","author":"Y Molino","year":"2017","unstructured":"Molino Y, et al. Use of LDL receptor\u2014targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier. FASEB J. 2017;31(5):1807\u201327.","journal-title":"FASEB J"},{"issue":"3","key":"2720_CR52","doi-asserted-by":"publisher","first-page":"e22208","DOI":"10.1096\/fj.202101644R","volume":"36","author":"W Alata","year":"2022","unstructured":"Alata W, et al. Targeting insulin-like growth factor-1 receptor (IGF1R) for brain delivery of biologics. Faseb j. 2022;36(3):e22208.","journal-title":"Faseb j"},{"issue":"11","key":"2720_CR53","doi-asserted-by":"publisher","first-page":"9999","DOI":"10.1021\/acsnano.6b04268","volume":"10","author":"T Lin","year":"2016","unstructured":"Lin T, et al. Blood\u2013brain-barrier-penetrating albumin nanoparticles for Biomimetic Drug Delivery via Albumin-binding protein pathways for Antiglioma Therapy. ACS Nano. 2016;10(11):9999\u201310012.","journal-title":"ACS Nano"},{"issue":"1","key":"2720_CR54","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11373-006-9121-7","volume":"14","author":"R-q Huang","year":"2007","unstructured":"Huang R-q, et al. Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain. J Biomed Sci. 2007;14(1):121\u20138.","journal-title":"J Biomed Sci"},{"issue":"5","key":"2720_CR55","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/j.1471-4159.2010.07002.x","volume":"115","author":"BV Zlokovic","year":"2010","unstructured":"Zlokovic BV, et al. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer\u2019s amyloid \u03b2-peptide elimination from the brain. J Neurochem. 2010;115(5):1077\u201389.","journal-title":"J Neurochem"},{"issue":"10","key":"2720_CR56","doi-asserted-by":"publisher","first-page":"2003937","DOI":"10.1002\/advs.202003937","volume":"8","author":"W Zhang","year":"2021","unstructured":"Zhang W, et al. Development of polymeric nanoparticles for blood\u2013brain barrier transfer\u2014strategies and challenges. Adv Sci. 2021;8(10):2003937.","journal-title":"Adv Sci"},{"issue":"6","key":"2720_CR57","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nn.4288","volume":"19","author":"MD Sweeney","year":"2016","unstructured":"Sweeney MD, Ayyadurai S, Zlokovic BV. Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci. 2016;19(6):771\u201383.","journal-title":"Nat Neurosci"},{"key":"2720_CR58","doi-asserted-by":"crossref","unstructured":"Lenz KM, Nelson LH. Microglia and Beyond: Innate Immune cells as regulators of Brain Development and behavioral function. Frontiers in Immunology. 2018:9.","DOI":"10.3389\/fimmu.2018.00698"},{"issue":"10","key":"2720_CR59","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/s41583-018-0057-5","volume":"19","author":"O Butovsky","year":"2018","unstructured":"Butovsky O, Weiner HL. Microglial signatures and their role in health and disease. Nat Rev Neurosci. 2018;19(10):622\u201335.","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"2720_CR60","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1177\/0271678X16630991","volume":"36","author":"HC Helms","year":"2016","unstructured":"Helms HC, et al. In vitro models of the blood-brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use. J Cereb Blood Flow Metab. 2016;36(5):862\u201390.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"2720_CR61","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/ana.410140403","volume":"14","author":"PD Bowman","year":"1983","unstructured":"Bowman PD, et al. Brain microvessel endothelial cells in tissue culture: a model for study of blood-brain barrier permeability. Ann Neurol. 1983;14(4):396\u2013402.","journal-title":"Ann Neurol"},{"issue":"3","key":"2720_CR62","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1006\/exmp.2002.2424","volume":"72","author":"AM M\u00fcller","year":"2002","unstructured":"M\u00fcller AM, et al. Expression of the endothelial markers PECAM-1, vWf, and CD34 in vivo and in vitro. Exp Mol Pathol. 2002;72(3):221\u20139.","journal-title":"Exp Mol Pathol"},{"issue":"1","key":"2720_CR63","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1083\/jcb.147.1.185","volume":"147","author":"K Morita","year":"1999","unstructured":"Morita K, et al. Endothelial claudin: claudin-5\/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol. 1999;147(1):185\u201394.","journal-title":"J Cell Biol"},{"issue":"6 Pt 2","key":"2720_CR64","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1083\/jcb.123.6.1777","volume":"123","author":"M Furuse","year":"1993","unstructured":"Furuse M, et al. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol. 1993;123(6 Pt 2):1777\u201388.","journal-title":"J Cell Biol"},{"issue":"4","key":"2720_CR65","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/S0006-291X(02)00376-5","volume":"293","author":"T Eisenbl\u00e4tter","year":"2002","unstructured":"Eisenbl\u00e4tter T, Galla HJ. A new multidrug resistance protein at the blood-brain barrier. Biochem Biophys Res Commun. 2002;293(4):1273\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5990","key":"2720_CR66","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/312162a0","volume":"312","author":"WA Jefferies","year":"1984","unstructured":"Jefferies WA, et al. Transferrin receptor on endothelium of brain capillaries. Nature. 1984;312(5990):162\u20133.","journal-title":"Nature"},{"issue":"2","key":"2720_CR67","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jneumeth.2011.05.012","volume":"199","author":"K Hatherell","year":"2011","unstructured":"Hatherell K, et al. Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation transwell models. J Neurosci Methods. 2011;199(2):223\u20139.","journal-title":"J Neurosci Methods"},{"issue":"4","key":"2720_CR68","doi-asserted-by":"publisher","first-page":"258","DOI":"10.2174\/156720211798121016","volume":"8","author":"E Vandenhaute","year":"2011","unstructured":"Vandenhaute E, et al. Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes. Curr Neurovasc Res. 2011;8(4):258\u201369.","journal-title":"Curr Neurovasc Res"},{"issue":"2","key":"2720_CR69","doi-asserted-by":"publisher","first-page":"e10126","DOI":"10.1002\/btm2.10126","volume":"4","author":"TD Brown","year":"2019","unstructured":"Brown TD, et al. A microfluidic model of human brain (\u00b5HuB) for assessment of blood brain barrier. Bioeng Transl Med. 2019;4(2):e10126.","journal-title":"Bioeng Transl Med"},{"issue":"1","key":"2720_CR70","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41467-019-13896-7","volume":"11","author":"SI Ahn","year":"2020","unstructured":"Ahn SI, et al. Microengineered human blood\u2013brain barrier platform for understanding nanoparticle transport mechanisms. Nat Commun. 2020;11(1):175.","journal-title":"Nat Commun"},{"issue":"10","key":"2720_CR71","doi-asserted-by":"publisher","first-page":"2106860","DOI":"10.1002\/adfm.202106860","volume":"32","author":"S Seo","year":"2022","unstructured":"Seo S, et al. Triculture model of in Vitro BBB and its application to Study BBB-Associated Chemosensitivity and Drug Delivery in Glioblastoma. Adv Funct Mater. 2022;32(10):2106860.","journal-title":"Adv Funct Mater"},{"issue":"1","key":"2720_CR72","doi-asserted-by":"publisher","first-page":"H1","DOI":"10.1530\/VB-19-0033","volume":"2","author":"L Marchetti","year":"2020","unstructured":"Marchetti L, Engelhardt B. Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation. Vasc Biol. 2020;2(1):H1\u201318.","journal-title":"Vasc Biol"},{"issue":"2","key":"2720_CR73","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1159\/000330247","volume":"19","author":"MA Erickson","year":"2012","unstructured":"Erickson MA, Dohi K, Banks WA. Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier. Neuroimmunomodulation. 2012;19(2):121\u201330.","journal-title":"Neuroimmunomodulation"},{"issue":"5","key":"2720_CR74","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.immuni.2014.10.008","volume":"41","author":"S Nourshargh","year":"2014","unstructured":"Nourshargh S, Alon R. Leukocyte Migration into Inflamed tissues. Immunity. 2014;41(5):694\u2013707.","journal-title":"Immunity"},{"issue":"8","key":"2720_CR75","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.4049\/jimmunol.0903732","volume":"185","author":"O Steiner","year":"2010","unstructured":"Steiner O, et al. Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-resistant T cell arrest, polarization, and Directed crawling on blood\u2013brain barrier endothelium. J Immunol. 2010;185(8):4846\u201355.","journal-title":"J Immunol"},{"issue":"6","key":"2720_CR76","doi-asserted-by":"publisher","first-page":"e09575","DOI":"10.1016\/j.heliyon.2022.e09575","volume":"8","author":"SRK Pandian","year":"2022","unstructured":"Pandian SRK, et al. Liposomes: an emerging carrier for targeting Alzheimer\u2019s and Parkinson\u2019s diseases. Heliyon. 2022;8(6):e09575.","journal-title":"Heliyon"},{"issue":"1","key":"2720_CR77","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1038\/s41467-019-11593-z","volume":"10","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, et al. Brain-targeted drug delivery by manipulating protein corona functions. Nat Commun. 2019;10(1):3561.","journal-title":"Nat Commun"},{"issue":"22","key":"2720_CR78","doi-asserted-by":"publisher","first-page":"5954","DOI":"10.1016\/j.biomaterials.2014.03.082","volume":"35","author":"YC Kuo","year":"2014","unstructured":"Kuo YC, Wang CT. Protection of SK-N-MC cells against \u03b2-amyloid peptide-induced degeneration using neuron growth factor-loaded liposomes with surface lactoferrin. Biomaterials. 2014;35(22):5954\u201364.","journal-title":"Biomaterials"},{"key":"2720_CR79","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jbiotec.2021.03.010","volume":"331","author":"AR Neves","year":"2021","unstructured":"Neves AR, et al. Transferrin-functionalized lipid nanoparticles for curcumin brain delivery. J Biotechnol. 2021;331:108\u201317.","journal-title":"J Biotechnol"},{"key":"2720_CR80","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3389\/fbioe.2020.00238","volume":"8","author":"SZ Moradi","year":"2020","unstructured":"Moradi SZ, et al. Nanoformulations of herbal extracts in treatment of neurodegenerative disorders. Front Bioeng Biotechnol. 2020;8:238.","journal-title":"Front Bioeng Biotechnol"},{"issue":"6","key":"2720_CR81","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"P Anand","year":"2007","unstructured":"Anand P, et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807\u201318.","journal-title":"Mol Pharm"},{"key":"2720_CR82","doi-asserted-by":"crossref","unstructured":"Topal GR et al. ApoE-Targeting increases the transfer of solid lipid nanoparticles with Donepezil Cargo across a culture model of the blood-brain barrier. Pharmaceutics. 2020;13(1).","DOI":"10.3390\/pharmaceutics13010038"},{"key":"2720_CR83","doi-asserted-by":"crossref","unstructured":"Annu et al. An insight to Brain Targeting utilizing polymeric nanoparticles: effective treatment modalities for neurological disorders and Brain Tumor. Front Bioeng Biotechnol. 2022;10.","DOI":"10.3389\/fbioe.2022.788128"},{"issue":"11","key":"2720_CR84","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.3390\/polym15112516","volume":"15","author":"VE Silant\u2019ev","year":"2023","unstructured":"Silant\u2019ev VE, et al. How to develop Drug Delivery System based on Carbohydrate nanoparticles targeted to brain tumors. Polymers. 2023;15(11):2516.","journal-title":"Polymers"},{"issue":"46","key":"2720_CR85","doi-asserted-by":"publisher","first-page":"81001","DOI":"10.18632\/oncotarget.20944","volume":"8","author":"N Huang","year":"2017","unstructured":"Huang N, et al. PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A\u03b2 generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer\u2019s disease mice. Oncotarget. 2017;8(46):81001\u201313.","journal-title":"Oncotarget"},{"key":"2720_CR86","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jcis.2021.02.058","volume":"592","author":"E Kirbas Cilingir","year":"2021","unstructured":"Kirbas Cilingir E, et al. Metformin derived carbon dots: highly biocompatible fluorescent nanomaterials as mitochondrial targeting and blood-brain barrier penetrating biomarkers. J Colloid Interface Sci. 2021;592:485\u201397.","journal-title":"J Colloid Interface Sci"},{"issue":"2","key":"2720_CR87","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.apsb.2019.11.003","volume":"10","author":"C Xiang","year":"2020","unstructured":"Xiang C, et al. Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication. Acta Pharm Sin B. 2020;10(2):239\u201348.","journal-title":"Acta Pharm Sin B"},{"issue":"3","key":"2720_CR88","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.toxlet.2011.09.014","volume":"207","author":"J Yuan","year":"2011","unstructured":"Yuan J, Gao H, Ching CB. Comparative protein profile of human hepatoma HepG2 cells treated with graphene and single-walled carbon nanotubes: an iTRAQ-coupled 2D LC-MS\/MS proteome analysis. Toxicol Lett. 2011;207(3):213\u201321.","journal-title":"Toxicol Lett"},{"issue":"7","key":"2720_CR89","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nnano.2016.23","volume":"11","author":"X Xue","year":"2016","unstructured":"Xue X, et al. Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice. Nat Nanotechnol. 2016;11(7):613\u201320.","journal-title":"Nat Nanotechnol"},{"issue":"3","key":"2720_CR90","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.jsps.2023.01.009","volume":"31","author":"MS Attia","year":"2023","unstructured":"Attia MS, et al. Mesoporous silica nanoparticles: their potential as drug delivery carriers and nanoscavengers in Alzheimer\u2019s and Parkinson\u2019s diseases. Saudi Pharm J. 2023;31(3):417\u201332.","journal-title":"Saudi Pharm J"},{"issue":"3","key":"2720_CR91","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/adhm.201200067","volume":"1","author":"J Geng","year":"2012","unstructured":"Geng J, et al. Mesoporous silica nanoparticle-based H2O2 responsive controlled-release system used for Alzheimer\u2019s Disease Treatment. Adv Healthc Mater. 2012;1(3):332\u20136.","journal-title":"Adv Healthc Mater"},{"issue":"37","key":"2720_CR92","doi-asserted-by":"publisher","first-page":"7721","DOI":"10.1039\/C7TB01385J","volume":"5","author":"M Bouchoucha","year":"2017","unstructured":"Bouchoucha M, et al. Antibody-conjugated mesoporous silica nanoparticles for brain microvessel endothelial cell targeting. J Mater Chem B. 2017;5(37):7721\u201335.","journal-title":"J Mater Chem B"},{"issue":"2","key":"2720_CR93","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/hum.2010.111","volume":"22","author":"H Zhao","year":"2011","unstructured":"Zhao H, et al. Postacute ischemia vascular endothelial growth factor transfer by transferrin-targeted liposomes attenuates ischemic brain injury after experimental stroke in rats. Hum Gene Ther. 2011;22(2):207\u201315.","journal-title":"Hum Gene Ther"},{"issue":"3","key":"2720_CR94","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/jgm.1152","volume":"10","author":"C-F Xia","year":"2008","unstructured":"Xia C-F, et al. Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson\u2019s disease with trojan horse liposomes and a tyrosine hydroxylase promoter. J Gene Med. 2008;10(3):306\u201315.","journal-title":"J Gene Med"},{"key":"2720_CR95","doi-asserted-by":"crossref","unstructured":"Yan D et al. Functionalized curcumin\/ginsenoside Rb1 dual-loaded liposomes: targeting the blood-brain barrier and improving pathological features associated in APP\/PS-1 mice. J Drug Deliv Sci Technol. 2023:104633.","DOI":"10.1016\/j.jddst.2023.104633"},{"issue":"5","key":"2720_CR96","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1021\/acsabm.8b00502","volume":"1","author":"Q Lu","year":"2018","unstructured":"Lu Q, et al. Synthetic polymer nanoparticles functionalized with different ligands for receptor-mediated transcytosis across the blood\u2013brain barrier. ACS Appl Bio Mater. 2018;1(5):1687\u201394.","journal-title":"ACS Appl Bio Mater"},{"issue":"S1","key":"2720_CR97","doi-asserted-by":"publisher","first-page":"p7858","DOI":"10.1096\/fasebj.2019.33.1_supplement.785.8","volume":"33","author":"ES Seven","year":"2019","unstructured":"Seven ES, et al. Crossing blood-brain barrier with Carbon Quantum Dots. FASEB J. 2019;33(S1):p7858\u20137858.","journal-title":"FASEB J"},{"key":"2720_CR98","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jcis.2022.02.124","volume":"617","author":"W Zhang","year":"2022","unstructured":"Zhang W, et al. Drug delivery of memantine with carbon dots for Alzheimer\u2019s disease: blood\u2013brain barrier penetration and inhibition of tau aggregation. J Colloid Interface Sci. 2022;617:20\u201331.","journal-title":"J Colloid Interface Sci"},{"key":"2720_CR99","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.biomaterials.2018.04.011","volume":"170","author":"YJ Sei","year":"2018","unstructured":"Sei YJ, et al. Detecting the functional complexities between high-density lipoprotein mimetics. Biomaterials. 2018;170:58\u201369.","journal-title":"Biomaterials"},{"issue":"1","key":"2720_CR100","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s12951-023-01798-2","volume":"21","author":"S Palma-Florez","year":"2023","unstructured":"Palma-Florez S, et al. BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer\u2019s disease. J Nanobiotechnol. 2023;21(1):115.","journal-title":"J Nanobiotechnol"},{"issue":"7","key":"2720_CR101","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/s41401-020-0429-z","volume":"41","author":"S Hanif","year":"2020","unstructured":"Hanif S, et al. Nanomedicine-based immunotherapy for central nervous system disorders. Acta Pharmacol Sin. 2020;41(7):936\u201353.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2720_CR102","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41392-019-0063-8","volume":"4","author":"P-P Liu","year":"2019","unstructured":"Liu P-P, et al. History and progress of hypotheses and clinical trials for Alzheimer\u2019s disease. Signal Transduct Target Therapy. 2019;4(1):29.","journal-title":"Signal Transduct Target Therapy"},{"issue":"10","key":"2720_CR103","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0165-6147(91)90609-V","volume":"12","author":"J Hardy","year":"1991","unstructured":"Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer\u2019s disease. Trends Pharmacol Sci. 1991;12(10):383\u20138.","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"2720_CR104","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1039\/C4LC00962B","volume":"15","author":"J Park","year":"2015","unstructured":"Park J, et al. Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer\u2019s disease. Lab Chip. 2015;15(1):141\u201350.","journal-title":"Lab Chip"},{"key":"2720_CR105","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3389\/fnagi.2018.00370","volume":"10","author":"G Zhang","year":"2018","unstructured":"Zhang G, et al. New perspectives on roles of Alpha-Synuclein in Parkinson\u2019s Disease. Front Aging Neurosci. 2018;10:370.","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"2720_CR106","doi-asserted-by":"publisher","first-page":"5907","DOI":"10.1038\/s41467-021-26066-5","volume":"12","author":"I Pediaditakis","year":"2021","unstructured":"Pediaditakis I, et al. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption. Nat Commun. 2021;12(1):5907.","journal-title":"Nat Commun"},{"issue":"1","key":"2720_CR107","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.celrep.2017.12.013","volume":"22","author":"A Virlogeux","year":"2018","unstructured":"Virlogeux A, et al. Reconstituting Corticostriatal Network on-a-Chip reveals the contribution of the presynaptic compartment to Huntington\u2019s Disease. Cell Rep. 2018;22(1):110\u201322.","journal-title":"Cell Rep"},{"issue":"5","key":"2720_CR108","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/s44222-023-00032-w","volume":"1","author":"J Wu","year":"2023","unstructured":"Wu J, et al. Device integration of electrochemical biosensors. Nat Reviews Bioeng. 2023;1(5):346\u201360.","journal-title":"Nat Reviews Bioeng"},{"key":"2720_CR109","doi-asserted-by":"publisher","first-page":"115100","DOI":"10.1016\/j.bios.2023.115100","volume":"225","author":"B Cecen","year":"2023","unstructured":"Cecen B, et al. Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation. Biosens Bioelectron. 2023;225:115100.","journal-title":"Biosens Bioelectron"},{"key":"2720_CR110","doi-asserted-by":"publisher","first-page":"100031","DOI":"10.1016\/j.snr.2021.100031","volume":"3","author":"Y Liang","year":"2021","unstructured":"Liang Y, Yoon J-Y. In situ sensors for blood-brain barrier (BBB) on a chip. Sens Actuators Rep. 2021;3:100031.","journal-title":"Sens Actuators Rep"},{"issue":"10","key":"2720_CR111","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.2174\/1567201819666220303102614","volume":"19","author":"B Shah","year":"2022","unstructured":"Shah B, Dong X. Current status of in vitro models of the blood-brain barrier. Curr Drug Deliv. 2022;19(10):1034\u201346.","journal-title":"Curr Drug Deliv"},{"issue":"5","key":"2720_CR112","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1021\/acssensors.2c00333","volume":"7","author":"M Mir","year":"2022","unstructured":"Mir M, et al. Biosensors integration in blood-brain barrier-on-a-Chip: emerging platform for monitoring neurodegenerative diseases. ACS Sens. 2022;7(5):1237\u201347.","journal-title":"ACS Sens"},{"issue":"33","key":"2720_CR113","doi-asserted-by":"publisher","first-page":"eabq5031","DOI":"10.1126\/sciadv.abq5031","volume":"8","author":"Q Huang","year":"2022","unstructured":"Huang Q, et al. Shell microelectrode arrays (MEAs) for brain organoids. Sci Adv. 2022;8(33):eabq5031.","journal-title":"Sci Adv"},{"issue":"16","key":"2720_CR114","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1039\/D3LC00294B","volume":"23","author":"O Phouphetlinthong","year":"2023","unstructured":"Phouphetlinthong O, et al. Protruding cantilever microelectrode array to monitor the inner electrical activity of cerebral organoids. Lab Chip. 2023;23(16):3603\u201314.","journal-title":"Lab Chip"},{"issue":"1","key":"2720_CR115","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41378-019-0049-2","volume":"5","author":"Y Yu","year":"2019","unstructured":"Yu Y, et al. A microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. Microsystems Nanoengineering. 2019;5(1):10.","journal-title":"Microsystems Nanoengineering"},{"issue":"5","key":"2720_CR116","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3390\/bios13050568","volume":"13","author":"MA Butt","year":"2023","unstructured":"Butt MA, et al. A review on Photonic Sensing technologies: Status and Outlook. Biosensors. 2023;13(5):568.","journal-title":"Biosensors"},{"key":"2720_CR117","doi-asserted-by":"publisher","first-page":"115030","DOI":"10.1016\/j.bios.2022.115030","volume":"224","author":"S-H Su","year":"2023","unstructured":"Su S-H, et al. A tissue chip with integrated digital immunosensors: in situ brain endothelial barrier cytokine secretion monitoring. Biosens Bioelectron. 2023;224:115030.","journal-title":"Biosens Bioelectron"},{"key":"2720_CR118","doi-asserted-by":"publisher","first-page":"121531","DOI":"10.1016\/j.biomaterials.2022.121531","volume":"285","author":"L Amirifar","year":"2022","unstructured":"Amirifar L, et al. Brain-on-a-chip: recent advances in design and techniques for microfluidic models of the brain in health and disease. Biomaterials. 2022;285:121531.","journal-title":"Biomaterials"},{"issue":"1","key":"2720_CR119","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s43586-022-00136-4","volume":"2","author":"V Emiliani","year":"2022","unstructured":"Emiliani V, et al. Optogenetics for light control of biological systems. Nat Reviews Methods Primers. 2022;2(1):55.","journal-title":"Nat Reviews Methods Primers"},{"key":"2720_CR120","doi-asserted-by":"publisher","first-page":"867863","DOI":"10.3389\/fnagi.2022.867863","volume":"14","author":"W Chen","year":"2022","unstructured":"Chen W, et al. The roles of optogenetics and Technology in Neurobiology: a review. Front Aging Neurosci. 2022;14:867863.","journal-title":"Front Aging Neurosci"},{"key":"2720_CR121","doi-asserted-by":"crossref","unstructured":"Convergence of Artificial Intelligence and Neuroscience towards the Diagnosis of Neurological Disorders\u2014A Scoping Review. Sensors. 2023;23(6):3062.","DOI":"10.3390\/s23063062"},{"key":"2720_CR122","doi-asserted-by":"publisher","first-page":"4538","DOI":"10.1016\/j.csbj.2021.08.011","volume":"19","author":"P Carracedo-Reboredo","year":"2021","unstructured":"Carracedo-Reboredo P, et al. A review on machine learning approaches and trends in drug discovery. Comput Struct Biotechnol J. 2021;19:4538\u201358.","journal-title":"Comput Struct Biotechnol J"},{"issue":"1","key":"2720_CR123","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s44172-022-00043-2","volume":"1","author":"A Waqas","year":"2022","unstructured":"Waqas A, et al. Exploring robust architectures for deep artificial neural networks. Commun Eng. 2022;1(1):46.","journal-title":"Commun Eng"},{"issue":"3","key":"2720_CR124","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1002\/med.21764","volume":"41","author":"S Vatansever","year":"2021","unstructured":"Vatansever S, et al. Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: state-of-the-arts and future directions. Med Res Rev. 2021;41(3):1427\u201373.","journal-title":"Med Res Rev"},{"key":"2720_CR125","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jpsychires.2021.08.011","volume":"142","author":"J Choi","year":"2021","unstructured":"Choi J, et al. Evaluation of postmortem microarray data in bipolar disorder using traditional data comparison and artificial intelligence reveals novel gene targets. J Psychiatr Res. 2021;142:328\u201336.","journal-title":"J Psychiatr Res"},{"key":"2720_CR126","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.biotno.2024.01.001","volume":"5","author":"SK Srivastava","year":"2024","unstructured":"Srivastava SK, et al. Organ-on-chip technology: opportunities and challenges. Biotechnol Notes. 2024;5:8\u201312.","journal-title":"Biotechnol Notes"},{"issue":"9","key":"2720_CR127","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1016\/j.stemcr.2021.06.015","volume":"16","author":"M Mastrangeli","year":"2021","unstructured":"Mastrangeli M. J van den Eijnden-van Raaij. Organs-on-chip: the way forward. Stem Cell Rep. 2021;16(9):2037\u201343.","journal-title":"Stem Cell Rep"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-02720-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-024-02720-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-02720-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T19:38:17Z","timestamp":1726774697000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-024-02720-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":127,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2720"],"URL":"https:\/\/doi.org\/10.1186\/s12951-024-02720-0","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,18]]},"assertion":[{"value":"2 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"573"}}