{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:40:39Z","timestamp":1771911639803,"version":"3.50.1"},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Commun Signal"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function.<\/jats:p>","DOI":"10.1186\/s12964-023-01284-0","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:03:51Z","timestamp":1697447031000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Fibroblast growth factor signaling in axons: from development to disease"],"prefix":"10.1186","volume":"21","author":[{"given":"Diogo","family":"Tom\u00e9","sequence":"first","affiliation":[]},{"given":"Marta S.","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Ramiro D.","family":"Almeida","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"1284_CR1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nrn2189","volume":"8","author":"I Mason","year":"2007","unstructured":"Mason I. Initiation to end point: the multiple roles of fibroblast growth factors in neural development. Nat Rev Neurosci. 2007;8:583\u201396.","journal-title":"Nat Rev Neurosci"},{"key":"1284_CR2","doi-asserted-by":"publisher","first-page":"15694","DOI":"10.1074\/jbc.M601252200","volume":"281","author":"X Zhang","year":"2006","unstructured":"Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family: the complete mammalian FGF family. J Biol Chem. 2006;281:15694\u2013700.","journal-title":"J Biol Chem"},{"key":"1284_CR3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/wdev.176","volume":"4","author":"DM Ornitz","year":"2015","unstructured":"Ornitz DM, Itoh N. The fibroblast growth factor signaling pathway. WIREs Dev Biol. 2015;4:215\u201366.","journal-title":"WIREs Dev Biol"},{"key":"1284_CR4","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/dvdy.21388","volume":"237","author":"N Itoh","year":"2008","unstructured":"Itoh N, Ornitz DM. Functional evolutionary history of the mouseFgf gene family. Dev Dyn. 2008;237:18\u201327.","journal-title":"Dev Dyn"},{"key":"1284_CR5","doi-asserted-by":"publisher","first-page":"8083","DOI":"10.1074\/jbc.275.11.8083","volume":"275","author":"J Revest","year":"2000","unstructured":"Revest J, DeMoerlooze L, Dickson C. Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence. J Biol Chem. 2000;275:8083\u201390.","journal-title":"J Biol Chem"},{"key":"1284_CR6","doi-asserted-by":"publisher","first-page":"15464","DOI":"10.1074\/jbc.M109.066357","volume":"285","author":"SK Mohan","year":"2010","unstructured":"Mohan SK, Rani SG, Yu C. The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion. J Biol Chem. 2010;285:15464\u201375.","journal-title":"J Biol Chem"},{"key":"1284_CR7","doi-asserted-by":"publisher","first-page":"27659","DOI":"10.1074\/jbc.M112.381939","volume":"287","author":"JP Steringer","year":"2012","unstructured":"Steringer JP, Bleicken S, Andreas H, Zacherl S, Laussmann M, Temmerman K, et al. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth Factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion. J Biol Chem. 2012;287:27659\u201369.","journal-title":"J Biol Chem"},{"key":"1284_CR8","first-page":"1","volume":"8","author":"N Javidi-Sharifi","year":"2019","unstructured":"Javidi-Sharifi N, Martinez J, English I, Joshi SK, Scopim-Ribeiro R, Viola SK, et al. FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells. Elife. 2019;8:1\u201323.","journal-title":"Elife"},{"key":"1284_CR9","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1074\/jbc.M207074200","volume":"278","author":"CJ Liu","year":"2003","unstructured":"Liu CJ, Dib-Hajj SD, Renganathan M, Cummins TR, Waxman SG. Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B. J Biol Chem. 2003;278:1029\u201336.","journal-title":"J Biol Chem"},{"key":"1284_CR10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1161\/CIRCRESAHA.113.301215","volume":"113","author":"JA Hennessey","year":"2013","unstructured":"Hennessey JA, Wei EQ, Pitt GS. Fibroblast growth factor homologous factors modulate cardiac calcium channels. Circ Res. 2013;113:381\u20138.","journal-title":"Circ Res"},{"key":"1284_CR11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.celrep.2013.06.012","volume":"4","author":"H Yan","year":"2013","unstructured":"Yan H, Pablo JL, Pitt GS. FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. Cell Rep. 2013;4:66\u201375.","journal-title":"Cell Rep"},{"key":"1284_CR12","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.2741\/3007","volume":"13","author":"A Ori","year":"2008","unstructured":"Ori A, Wilkinson MC, Fernig DG. The heparanome and regulation of cell function: structures, functions and challenges. Front Biosci. 2008;13:4309\u201338.","journal-title":"Front Biosci"},{"key":"1284_CR13","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1128\/MCB.02249-06","volume":"27","author":"R Goetz","year":"2007","unstructured":"Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol. 2007;27:3417\u201328.","journal-title":"Mol Cell Biol"},{"key":"1284_CR14","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1128\/MCB.06603-11","volume":"32","author":"R Goetz","year":"2012","unstructured":"Goetz R, Ohnishi M, Ding X, Kurosu H, Wang L, Akiyoshi J, et al. Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands. Mol Cell Biol. 2012;32:1944\u201354.","journal-title":"Mol Cell Biol"},{"key":"1284_CR15","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/nrm3528","volume":"14","author":"R Goetz","year":"2013","unstructured":"Goetz R, Mohammadi M. Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol. 2013;14:166\u201380.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1284_CR16","doi-asserted-by":"publisher","first-page":"35208","DOI":"10.1074\/jbc.M608655200","volume":"281","author":"E Sanchez-Heras","year":"2006","unstructured":"Sanchez-Heras E, Howell FV, Williams G, Doherty P. The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule. J Biol Chem. 2006;281:35208\u201316.","journal-title":"J Biol Chem"},{"key":"1284_CR17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0896-6273(00)80264-0","volume":"18","author":"JL Saffell","year":"1997","unstructured":"Saffell JL, Williams EJ, Mason IJ, Walsh FS, Doherty P. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron. 1997;18:231\u201342.","journal-title":"Neuron"},{"key":"1284_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.str.2011.10.022","volume":"20","author":"J Kalinina","year":"2012","unstructured":"Kalinina J, Dutta K, Ilghari D, Beenken A, Goetz R, Eliseenkova AV, et al. The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition. Structure. 2012;20:77\u201388.","journal-title":"Structure"},{"key":"1284_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/950508","volume":"2012","author":"K Holzmann","year":"2012","unstructured":"Holzmann K, Grunt T, Heinzle C, Sampl S, Steinhoff H, Reichmann N, et al. Alternative splicing of fibroblast growth factor receptor IgIII loops in cancer. J Nucleic Acids. 2012;2012:1\u201312.","journal-title":"J Nucleic Acids"},{"key":"1284_CR20","doi-asserted-by":"publisher","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","volume":"271","author":"DM Ornitz","year":"1996","unstructured":"Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996;271:15292\u20137.","journal-title":"J Biol Chem"},{"key":"1284_CR21","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1006\/geno.2000.6332","volume":"69","author":"M Wiedemann","year":"2000","unstructured":"Wiedemann M, Trueb B. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Genomics. 2000;69:275\u20139.","journal-title":"Genomics"},{"key":"1284_CR22","doi-asserted-by":"publisher","first-page":"ra6","DOI":"10.1126\/scisignal.2000021","volume":"2","author":"ED Lew","year":"2009","unstructured":"Lew ED, Furdui CM, Anderson KS, Schlessinger J. The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations. Sci Signal. 2009;2:ra6.","journal-title":"Sci Signal"},{"key":"1284_CR23","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/S0092-8674(00)80252-4","volume":"89","author":"H Kouhara","year":"1997","unstructured":"Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, et al. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras\/MAPK signaling pathway. Cell. 1997;89:693\u2013702.","journal-title":"Cell"},{"key":"1284_CR24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","volume":"16 2 SPEC. ISS.","author":"L Dailey","year":"2005","unstructured":"Dailey L, Ambrosetti D, Mansukhani A, Basilico C. Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev. 2005;16 2 SPEC. ISS.:233\u201347.","journal-title":"Cytokine Growth Factor Rev"},{"key":"1284_CR25","doi-asserted-by":"publisher","first-page":"6074","DOI":"10.1073\/pnas.111114298","volume":"98","author":"SH Ong","year":"2001","unstructured":"Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A. 2001;98:6074\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1284_CR26","first-page":"5068","volume":"11","author":"M Mohammadi","year":"1991","unstructured":"Mohammadi M, Honegger AM, Rotin D, Fischer R, Bellot F, Li W, et al. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol. 1991;11:5068\u201378.","journal-title":"Mol Cell Biol"},{"key":"1284_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mcn.2005.05.005","volume":"30","author":"CA Webber","year":"2005","unstructured":"Webber CA, Chen YY, Hehr CL, Johnston J, McFarlane S. Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance. Mol Cell Neurosci. 2005;30:37\u201347.","journal-title":"Mol Cell Neurosci"},{"key":"1284_CR28","doi-asserted-by":"publisher","first-page":"18418","DOI":"10.1074\/jbc.M411356200","volume":"280","author":"A Harada","year":"2005","unstructured":"Harada A, Katoh H, Negishi M. Direct interaction of Rnd1 with FRS2\u03b2 regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. J Biol Chem. 2005;280:18418\u201324.","journal-title":"J Biol Chem"},{"key":"1284_CR29","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1038\/sj.onc.1203650","volume":"19","author":"KC Hart","year":"2000","unstructured":"Hart KC, Robertson SC, Kanemitsu MY, Meyer AN, Tynan JA, Donoghue DJ. Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 2000;19:3309\u201320.","journal-title":"Oncogene"},{"key":"1284_CR30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1042\/CS20140100","volume":"127","author":"SJ Coleman","year":"2014","unstructured":"Coleman SJ, Bruce C, Chioni A-M, Kocher HM, Grose RP. The ins and outs of fibroblast growth factor receptor signalling. Clin Sci. 2014;127:217\u201331.","journal-title":"Clin Sci"},{"key":"1284_CR31","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/j.1600-0854.2012.01341.x","volume":"13","author":"Y Zhen","year":"2012","unstructured":"Zhen Y, S\u00f8rensen V, Skjerpen CS, Haugsten EM, Jin Y, W\u00e4lchli S, et al. Nuclear import of exogenous FGF1 requires the ER-Protein LRRC59 and the importins Kpn\u03b11 and Kpn\u03b21. Traffic. 2012;13:650\u201364.","journal-title":"Traffic"},{"key":"1284_CR32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/ncb979","volume":"5","author":"C Bossard","year":"2003","unstructured":"Bossard C, Laurell H, Van den Berghe L, Meunier S, Zanibellato C, Prats H. Translokin is an intracellular mediator of FGF-2 trafficking. Nat Cell Biol. 2003;5:433\u20139.","journal-title":"Nat Cell Biol"},{"key":"1284_CR33","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1002\/jcb.10606","volume":"90","author":"MK Stachowiak","year":"2003","unstructured":"Stachowiak MK, Fang X, Myers JM, Dunham SM, Berezney R, Maher PA, et al. Integrative nuclear FGFR1 signaling (INFS) as a part of a universal \u201cFeed-Forward-And-Gate\u201d signaling module that controls cell growth and differentiation. J Cell Biochem. 2003;90:662\u201391.","journal-title":"J Cell Biochem"},{"key":"1284_CR34","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1091\/mbc.e11-01-0080","volume":"22","author":"CR Degnin","year":"2011","unstructured":"Degnin CR, Laederich MB, Horton WA. Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3. Mol Biol Cell. 2011;22:3861\u201373.","journal-title":"Mol Biol Cell"},{"key":"1284_CR35","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1083\/jcb.201108077","volume":"197","author":"AM Chioni","year":"2012","unstructured":"Chioni AM, Grose R. FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior. J Cell Biol. 2012;197:801\u201317.","journal-title":"J Cell Biol"},{"key":"1284_CR36","doi-asserted-by":"publisher","first-page":"108492","DOI":"10.1016\/j.steroids.2019.108492","volume":"152 August","author":"V Figueroa","year":"2019","unstructured":"Figueroa V, Rodr\u00edguez MS, Lanari C, Lamb CA. Nuclear action of FGF members in endocrine-related tissues and cancer: interplay with steroid receptor pathways. Steroids. 2019;152 August:108492.","journal-title":"Steroids"},{"key":"1284_CR37","doi-asserted-by":"publisher","first-page":"40247","DOI":"10.1074\/jbc.M104933200","volume":"276","author":"E Tassi","year":"2001","unstructured":"Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, et al. Enhancement of fibroblast growth Factor (FGF) activity by an FGF-binding protein. J Biol Chem. 2001;276:40247\u201353.","journal-title":"J Biol Chem"},{"key":"1284_CR38","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1038\/sj.onc.1208560","volume":"24","author":"HD Beer","year":"2005","unstructured":"Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, et al. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: Implications for epithelial repair. Oncogene. 2005;24:5269\u201377.","journal-title":"Oncogene"},{"key":"1284_CR39","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1016\/j.ajpath.2011.07.043","volume":"179","author":"E Tassi","year":"2011","unstructured":"Tassi E, McDonnell K, Gibby KA, Tilan JU, Kim SE, Kodack DP, et al. Impact of fibroblast growth factor-binding protein1 expression on angiogenesis and wound healing. Am J Pathol. 2011;179:2220\u201332.","journal-title":"Am J Pathol"},{"key":"1284_CR40","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1016\/j.bbadis.2018.06.009","volume":"1864","author":"T Taetzsch","year":"2018","unstructured":"Taetzsch T, Brayman VL, Valdez G. FGF binding proteins (FGFBPs): modulators of FGF signaling in the developing, adult, and stressed nervous system. Biochim Biophys Acta - Mol Basis Dis. 2018;1864:2983\u201391.","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"1284_CR41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.semcdb.2016.01.023","volume":"53","author":"L Korsensky","year":"2016","unstructured":"Korsensky L, Ron D. Regulation of FGF signaling: Recent insights from studying positive and negative modulators. Semin Cell Dev Biol. 2016;53:101\u201314.","journal-title":"Semin Cell Dev Biol"},{"key":"1284_CR42","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1038\/emboj.2011.234","volume":"30","author":"A Persaud","year":"2011","unstructured":"Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, et al. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J. 2011;30:3259\u201373.","journal-title":"EMBO J"},{"key":"1284_CR43","doi-asserted-by":"publisher","first-page":"6684","DOI":"10.1073\/pnas.052138899","volume":"99","author":"A Wong","year":"2002","unstructured":"Wong A, Lamothe B, Lee A, Schlessinger J, Lax I. FRS2\u03b1 attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci U S A. 2002;99:6684\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1284_CR44","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.bone.2008.02.009","volume":"42","author":"C Dufour","year":"2008","unstructured":"Dufour C, Guenou H, Kaabeche K, Bouvard D, Sanjay A, Marie PJ. FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K\/Akt signaling and osteoblast survival. Bone. 2008;42:1032\u20139.","journal-title":"Bone"},{"key":"1284_CR45","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.ydbio.2005.09.011","volume":"287","author":"B Thisse","year":"2005","unstructured":"Thisse B, Thisse C. Functions and regulations of fibroblast growth factor signaling during embryonic development. Dev Biol. 2005;287:390\u2013402.","journal-title":"Dev Biol"},{"key":"1284_CR46","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.devcel.2004.05.019","volume":"7","author":"S Torii","year":"2004","unstructured":"Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E. Sef is a spatial regulator for Ras\/MAP kinase signaling. Dev Cell. 2004;7:33\u201344.","journal-title":"Dev Cell"},{"key":"1284_CR47","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1016\/j.cellsig.2006.03.001","volume":"18","author":"D Kovalenko","year":"2006","unstructured":"Kovalenko D, Yang X, Chen PY, Nadeau RJ, Zubanova O, Pigeon K, et al. A role for extracellular and transmembrane domains of Sef in Sef-mediated inhibition of FGF signaling. Cell Signal. 2006;18:1958\u201366.","journal-title":"Cell Signal"},{"key":"1284_CR48","doi-asserted-by":"publisher","first-page":"32382","DOI":"10.1074\/jbc.M103369200","volume":"276","author":"Y Zhao","year":"2001","unstructured":"Zhao Y, Zhang Z-Y. The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3. J Biol Chem. 2001;276:32382\u201391.","journal-title":"J Biol Chem"},{"key":"1284_CR49","doi-asserted-by":"publisher","first-page":"ra11","DOI":"10.1126\/scisignal.2003087","volume":"6","author":"M Zakrzewska","year":"2013","unstructured":"Zakrzewska M, Haugsten EM, Nadratowska-Wesolowska B, Oppelt A, Hausott B, Jin Y, et al. ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling. Sci Signal. 2013;6:ra11.","journal-title":"Sci Signal"},{"key":"1284_CR50","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1083\/jcb.200707042","volume":"180","author":"H Witte","year":"2008","unstructured":"Witte H, Neukirchen D, Bradke F. Microtubule stabilization specifies initial neuronal polarization. J Cell Biol. 2008;180:619\u201332.","journal-title":"J Cell Biol"},{"key":"1284_CR51","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mcn.2009.07.012","volume":"43","author":"FE Poulain","year":"2010","unstructured":"Poulain FE, Sobel A. The microtubule network and neuronal morphogenesis: dynamic and coordinated orchestration through multiple players. Mol Cell Neurosci. 2010;43:15\u201332.","journal-title":"Mol Cell Neurosci"},{"key":"1284_CR52","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.cell.2012.04.046","volume":"149","author":"QF Wu","year":"2012","unstructured":"Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, et al. Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 2012;149:1549\u201364.","journal-title":"Cell"},{"key":"1284_CR53","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.neuroscience.2008.01.083","volume":"153","author":"B Hausott","year":"2008","unstructured":"Hausott B, Schlick B, Vallant N, Dorn R, Klimaschewski L. Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons. Neuroscience. 2008;153:461\u201373.","journal-title":"Neuroscience"},{"key":"1284_CR54","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ejcb.2011.09.009","volume":"91","author":"B Hausott","year":"2012","unstructured":"Hausott B, Vallant N, Hochfilzer M, Mangger S, Irschick R, Haugsten EM, et al. Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling. Eur J Cell Biol. 2012;91:129\u201338.","journal-title":"Eur J Cell Biol"},{"key":"1284_CR55","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1523\/JNEUROSCI.21-11-03932.2001","volume":"21","author":"G Szebenyi","year":"2001","unstructured":"Szebenyi G, Dent EW, Callaway JL, Seys C, Lueth H, Kalil K. Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone. J Neurosci. 2001;21:3932\u201341.","journal-title":"J Neurosci"},{"key":"1284_CR56","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0197-0186(00)00093-0","volume":"38","author":"K Abe","year":"2001","unstructured":"Abe K, Aoyagi A, Saito H. Sustained phosphorylation of mitogen-activated protein kinase is required for basic fibroblast growth factor-mediated axonal branch formation in cultured rat hippocampal neurons. Neurochem Int. 2001;38:309\u201315.","journal-title":"Neurochem Int"},{"key":"1284_CR57","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neuroscience.2011.04.064","volume":"188","author":"B Hausott","year":"2011","unstructured":"Hausott B, Rietzler A, Vallant N, Auer M, Haller I, Perkhofer S, et al. Inhibition of fibroblast growth factor receptor 1 endocytosis promotes axonal branching of adult sensory neurons. Neuroscience. 2011;188:13\u201322.","journal-title":"Neuroscience"},{"key":"1284_CR58","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1091\/mbc.e09-09-0834","volume":"21","author":"L Qiang","year":"2010","unstructured":"Qiang L, Yu W, Liu M, Solowska JM, Baas PW. Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules. Mol Biol Cell. 2010;21:334\u201344.","journal-title":"Mol Biol Cell"},{"key":"1284_CR59","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrn3650","volume":"15","author":"K Kalil","year":"2014","unstructured":"Kalil K, Dent EW. Branch management: Mechanisms of axon branching in the developing vertebrate CNS. Nat Rev Neurosci. 2014;15:7\u201318.","journal-title":"Nat Rev Neurosci"},{"key":"1284_CR60","doi-asserted-by":"publisher","first-page":"4534","DOI":"10.1523\/JNEUROSCI.1715-15.2016","volume":"36","author":"T Shimada","year":"2016","unstructured":"Shimada T, Yoshida T, Yamagata K. Neuritin mediates activity-dependent axonal branch formation in part via FGF signaling. J Neurosci. 2016;36:4534\u201348.","journal-title":"J Neurosci"},{"key":"1284_CR61","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1073\/pnas.94.6.2648","volume":"94","author":"GS Naeve","year":"1997","unstructured":"Naeve GS, Ramakrishnan M, Kramer R, Hevroni D, Citri Y, Theill LE. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc Natl Acad Sci U S A. 1997;94:2648\u201353.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1284_CR62","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.brainres.2013.07.030","volume":"1529","author":"S Garc\u00eda-Hern\u00e1ndez","year":"2013","unstructured":"Garc\u00eda-Hern\u00e1ndez S, Potashner SJ, Morest DK. Role of fibroblast growth factor 8 in neurite outgrowth from spiral ganglion neurons in vitro. Brain Res. 2013;1529:39\u201345.","journal-title":"Brain Res"},{"key":"1284_CR63","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0092-8674(02)00713-4","volume":"109","author":"N Soussi-Yanicostas","year":"2002","unstructured":"Soussi-Yanicostas N, de Castro F, Julliard AK, Perfettini I, Ch\u00e9dotal A, Petit C. Anosmin-1, defective in the X-Linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons. Cell. 2002;109:217\u201328.","journal-title":"Cell"},{"key":"1284_CR64","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.neuroscience.2008.10.022","volume":"158","author":"S Gianola","year":"2009","unstructured":"Gianola S, de Castro F, Rossi F. Anosmin-1 stimulates outgrowth and branching of developing Purkinje axons. Neuroscience. 2009;158:570\u201384.","journal-title":"Neuroscience"},{"key":"1284_CR65","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.celrep.2015.04.057","volume":"11","author":"CA D\u00edaz-Balzac","year":"2015","unstructured":"D\u00edaz-Balzac CA, L\u00e1zaro-Pe\u00f1a MI, Ramos-Ortiz GA, B\u00fclow HE. The adhesion molecule KAL-1\/anosmin-1 regulates neurite branching through a SAX-7\/L1CAM\u2013EGL-15\/FGFR receptor complex. Cell Rep. 2015;11:1377\u201384.","journal-title":"Cell Rep"},{"key":"1284_CR66","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.mcn.2009.08.005","volume":"42","author":"B Hausott","year":"2009","unstructured":"Hausott B, Vallant N, Auer M, Yang L, Dai F, Brand-Saberi B, et al. Sprouty2 down-regulation promotes axon growth by adult sensory neurons. Mol Cell Neurosci. 2009;42:328\u201340.","journal-title":"Mol Cell Neurosci"},{"key":"1284_CR67","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/hipo.20910","volume":"22","author":"B Hausott","year":"2012","unstructured":"Hausott B, Vallant N, Schlick B, Auer M, Nimmervoll B, Obermair GJ, et al. Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons. Hippocampus. 2012;22:434\u201341.","journal-title":"Hippocampus"},{"key":"1284_CR68","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nrm2679","volume":"10","author":"LA Lowery","year":"2009","unstructured":"Lowery LA, Van VD. The trip of the tip: Understanding the growth cone machinery. Nat Rev Mol Cell Biol. 2009;10:332\u201343.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1284_CR69","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/neu.20161","volume":"64","author":"P Bovolenta","year":"2005","unstructured":"Bovolenta P. Morphogen signaling at the vertebrate growth cone: a few cases or a general strategy? J Neurobiol. 2005;64:405\u201316.","journal-title":"J Neurobiol"},{"key":"1284_CR70","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0896-6273(00)80156-7","volume":"17","author":"S McFarlane","year":"1996","unstructured":"McFarlane S, Cornel E, Amaya E, Holt CE. Inhibition of FGF receptor activity in retinal ganglion cell axons causes errors in target recognition. Neuron. 1996;17:245\u201354.","journal-title":"Neuron"},{"key":"1284_CR71","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1523\/JNEUROSCI.4165-09.2010","volume":"30","author":"K Atkinson-Leadbeater","year":"2010","unstructured":"Atkinson-Leadbeater K, Bertolesi GE, Hehr CL, Webber CA, Cechmanek PB, McFarlane S. Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling. J Neurosci. 2010;30:685\u201393.","journal-title":"J Neurosci"},{"key":"1284_CR72","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1007\/s00018-018-2824-x","volume":"75","author":"JLJ Yang","year":"2018","unstructured":"Yang JLJ, Bertolesi GE, Hehr CL, Johnston J, McFarlane S. Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1. Cell Mol Life Sci. 2018;75:3649\u201361.","journal-title":"Cell Mol Life Sci"},{"key":"1284_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1523\/ENEURO.0086-19.2019","volume":"6","author":"JLJ Yang","year":"2019","unstructured":"Yang JLJ, Bertolesi GE, Dueck S, Hehr CL, McFarlane S. The expression of key guidance genes at a forebrain axon turning point is maintained by distinct fgfr isoforms but a common downstream signal transduction mechanism. eNeuro. 2019;6:1\u201319.","journal-title":"eNeuro"},{"key":"1284_CR74","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1095\/biolreprod.105.046904","volume":"74","author":"JC Gill","year":"2006","unstructured":"Gill JC, Tsai PS. Expression of a dominant negative FGF receptor in developing GNRH1 neurons disrupts axon outgrowth and targeting to the median eminence. Biol Reprod. 2006;74:463\u201372.","journal-title":"Biol Reprod"},{"key":"1284_CR75","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1242\/dev.080226","volume":"140","author":"F Liu","year":"2013","unstructured":"Liu F, Pogoda HM, Pearson CA, Ohyama K, L\u00f6hr H, Hammerschmidt M, et al. Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis. Dev. 2013;140:1111\u201322.","journal-title":"Dev"},{"key":"1284_CR76","doi-asserted-by":"publisher","first-page":"5389","DOI":"10.1242\/dev.00117","volume":"129","author":"C Irving","year":"2002","unstructured":"Irving C, Malhas A, Guthrie S, Mason I. Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8. Development. 2002;129:5389\u201398.","journal-title":"Development"},{"key":"1284_CR77","doi-asserted-by":"publisher","first-page":"4044","DOI":"10.1523\/JNEUROSCI.4794-08.2009","volume":"29","author":"K Yamauchi","year":"2009","unstructured":"Yamauchi K, Mizushima S, Tamada A, Yamamoto N, Takashima S, Murakami F. FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F. J Neurosci. 2009;29:4044\u201355.","journal-title":"J Neurosci"},{"key":"1284_CR78","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.neuron.2006.04.030","volume":"50","author":"R Shirasaki","year":"2006","unstructured":"Shirasaki R, Lewcock JW, Lettieri K, Pfaff SL. FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron. 2006;50:841\u201353.","journal-title":"Neuron"},{"key":"1284_CR79","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/jnc.13702","volume":"139","author":"MJ Pinto","year":"2016","unstructured":"Pinto MJ, Almeida RD. Puzzling out presynaptic differentiation. J Neurochem. 2016;139:921\u201342.","journal-title":"J Neurochem"},{"key":"1284_CR80","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-physiol-021317-121322","volume":"80","author":"M Yuzaki","year":"2018","unstructured":"Yuzaki M. Two classes of secreted synaptic organizers in the central nervous system. Annu Rev Physiol. 2018;80:243\u201362.","journal-title":"Annu Rev Physiol"},{"key":"1284_CR81","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1006\/mcne.1996.0032","volume":"452","author":"Z Dai","year":"1996","unstructured":"Dai Z, Peng HB. Dynamics of synaptic vesicles in cultured spinal cord neurons in relationship to synaptogenesis. Mol Cell Neurosci. 1996;452:443\u201352.","journal-title":"Mol Cell Neurosci"},{"key":"1284_CR82","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1046\/j.1460-9568.2002.02193.x","volume":"16","author":"AJ Li","year":"2002","unstructured":"Li AJ, Suzuki S, Suzuki M, Mizukoshi E, Imamura T. Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons. Eur J Neurosci. 2002;16:1313\u201324.","journal-title":"Eur J Neurosci"},{"key":"1284_CR83","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1046\/j.1471-4159.1995.65062525.x","volume":"65","author":"B Cheng","year":"1995","unstructured":"Cheng B, Furukawa K, O\u2019Keefe JA, Goodman Y, Kihiko M, Fabian T, et al. Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons. J Neurochem. 1995;65:2525\u201336.","journal-title":"J Neurochem"},{"key":"1284_CR84","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cell.2004.06.025","volume":"118","author":"H Umemori","year":"2004","unstructured":"Umemori H, Linhoff MW, Ornitz DM, Sanes JR. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell. 2004;118:257\u201370.","journal-title":"Cell"},{"key":"1284_CR85","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.cell.2007.02.035","volume":"129","author":"MA Fox","year":"2007","unstructured":"Fox MA, Sanes JR, Borza DB, Eswarakumar VP, F\u00e4ssler R, Hudson BG, et al. Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell. 2007;129:179\u201393.","journal-title":"Cell"},{"key":"1284_CR86","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nature09041","volume":"465","author":"A Terauchi","year":"2010","unstructured":"Terauchi A, Johnson-Venkatesh EM, Toth AB, Javed D, Sutton MA, Umemori H. Distinct FGFs promote differentiation of excitatory and inhibitory synapses. Nature. 2010;465:783\u20137.","journal-title":"Nature"},{"key":"1284_CR87","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1523\/JNEUROSCI.2992-16.2016","volume":"37","author":"T Taetzsch","year":"2017","unstructured":"Taetzsch T, Tenga MJ, Valdez G. Muscle fibers secrete FGFBP1 to slow degeneration of neuromuscular synapses during aging and progression of ALS. J Neurosci. 2017;37:70\u201382.","journal-title":"J Neurosci"},{"key":"1284_CR88","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1242\/dev.115568","volume":"142","author":"A Dabrowski","year":"2015","unstructured":"Dabrowski A, Terauchi A, Strong C, Umemori H. Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis. Dev. 2015;142:1818\u201330.","journal-title":"Dev"},{"key":"1284_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.12151","volume":"5","author":"A Terauchi","year":"2016","unstructured":"Terauchi A, Johnson-Venkatesh EM, Bullock B, Lehtinen MK, Umemori H. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. Elife. 2016;5:1\u201328.","journal-title":"Elife"},{"key":"1284_CR90","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.celrep.2019.06.080","volume":"28","author":"RO Costa","year":"2019","unstructured":"Costa RO, Martins H, Martins LF, Cwetsch AW, Mele M, Pedro JR, et al. Synaptogenesis stimulates a proteasome-mediated ribosome reduction in axons. Cell Rep. 2019;28:864\u2013876.e6.","journal-title":"Cell Rep"},{"key":"1284_CR91","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1073\/pnas.1610158114","volume":"114","author":"JL Pablo","year":"2017","unstructured":"Pablo JL, Pitta GS. FGF14 is a regulator of KCNQ2\/3 channels. Proc Natl Acad Sci U S A. 2017;114:154\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1284_CR92","doi-asserted-by":"publisher","first-page":"E2665","DOI":"10.1073\/pnas.1521194113","volume":"113","author":"JL Pablo","year":"2016","unstructured":"Pablo JL, Wang C, Presby MM, Pitt GS. Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. Proc Natl Acad Sci U S A. 2016;113:E2665\u201374.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1284_CR93","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1523\/JNEUROSCI.4206-13.2014","volume":"34","author":"A Battefeld","year":"2014","unstructured":"Battefeld A, Tran BT, Gavrilis J, Cooper EC, Kole MHP. Heteromeric Kv7.2\/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. J Neurosci. 2014;34:3719\u201332.","journal-title":"J Neurosci"},{"key":"1284_CR94","doi-asserted-by":"publisher","first-page":"12033","DOI":"10.1523\/JNEUROSCI.2282-07.2007","volume":"27","author":"F Laezza","year":"2007","unstructured":"Laezza F, Gerber BR, Lou J-Y, Kozel MA, Hartman H, Marie Craig A, et al. The FGF14F145S mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. J Neurosci. 2007;27:12033\u201344.","journal-title":"J Neurosci"},{"key":"1284_CR95","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.str.2012.05.001","volume":"20","author":"C Wang","year":"2012","unstructured":"Wang C, Chung BC, Yan H, Lee S-Y, Pitt GS. Crystal structure of the ternary complex of a NaV C-Terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Structure. 2012;20:1167\u201376.","journal-title":"Structure"},{"key":"1284_CR96","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.neuron.2007.07.006","volume":"55","author":"M Goldfarb","year":"2007","unstructured":"Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, et al. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron. 2007;55:449\u201363.","journal-title":"Neuron"},{"key":"1284_CR97","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1074\/mcp.M114.040055","volume":"14","author":"NC Wildburger","year":"2015","unstructured":"Wildburger NC, Ali SR, Hsu WCJ, Shavkunov AS, Nenov MN, Lichti CF, et al. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (Nav1.2) macromolecular complex in mammalian brain. Mol Cell Proteomics. 2015;14:1288\u2013300.","journal-title":"Mol Cell Proteomics"},{"key":"1284_CR98","doi-asserted-by":"publisher","first-page":"24253","DOI":"10.1074\/jbc.M111.245803","volume":"286","author":"C Wang","year":"2011","unstructured":"Wang C, Wang C, Hoch EG, Pitt GS. Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels. J Biol Chem. 2011;286:24253\u201363.","journal-title":"J Biol Chem"},{"key":"1284_CR99","doi-asserted-by":"publisher","first-page":"3884","DOI":"10.1007\/s12035-021-02367-0","volume":"58","author":"L Klimaschewski","year":"2021","unstructured":"Klimaschewski L, Claus P. Fibroblast growth factor signalling in the diseased nervous system. Mol Neurobiol. 2021;58:3884\u2013902.","journal-title":"Mol Neurobiol"},{"key":"1284_CR100","doi-asserted-by":"publisher","first-page":"13112","DOI":"10.1523\/JNEUROSCI.1472-08.2008","volume":"28","author":"S Zucchini","year":"2008","unstructured":"Zucchini S, Buzzi A, Barbieri M, Rodi D, Paradiso B, Binaschi A, et al. FGF-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss. J Neurosci. 2008;28:13112\u201324.","journal-title":"J Neurosci"},{"key":"1284_CR101","doi-asserted-by":"publisher","first-page":"8866","DOI":"10.1523\/JNEUROSCI.3470-14.2015","volume":"35","author":"RS Puranam","year":"2015","unstructured":"Puranam RS, He XP, Yao L, Le T, Jang W, Rehder CW, et al. Disruption of Fgf13 causes synaptic excitatory\u2013inhibitory imbalance and genetic epilepsy and febrile seizures plus. J Neurosci. 2015;35:8866\u201381.","journal-title":"J Neurosci"},{"key":"1284_CR102","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbr.2016.03.047","volume":"307","author":"AJ Williams","year":"2016","unstructured":"Williams AJ, Yee P, Smith MC, Murphy GG, Umemori H. Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice. Behav Brain Res. 2016;307:11\u20137.","journal-title":"Behav Brain Res"},{"key":"1284_CR103","first-page":"1","volume":"9 December","author":"A Terauchi","year":"2017","unstructured":"Terauchi A, Gavin E, Wilson J, Umemori H. Selective inactivation of fibroblast growth factor 22 (FGF22) in CA3 pyramidal neurons impairs local synaptogenesis and affective behavior without affecting dentate neurogenesis. Front Synaptic Neurosci. 2017;9 December:1\u201312.","journal-title":"Front Synaptic Neurosci"},{"key":"1284_CR104","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.conb.2016.04.005","volume":"39","author":"AL Cattin","year":"2016","unstructured":"Cattin AL, Lloyd AC. The multicellular complexity of peripheral nerve regeneration. Curr Opin Neurobiol. 2016;39:38\u201346.","journal-title":"Curr Opin Neurobiol"},{"key":"1284_CR105","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/(SICI)1096-9861(19970602)382:2<189::AID-CNE4>3.0.CO;2-#","volume":"382","author":"K Huber","year":"1997","unstructured":"Huber K, Meisinger C, Grotiie C. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury. J Comp Neurol. 1997;382:189\u201398.","journal-title":"J Comp Neurol"},{"key":"1284_CR106","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/(SICI)1097-4695(199903)38:4<499::AID-NEU6>3.0.CO;2-O","volume":"38","author":"L Klimaschewski","year":"1999","unstructured":"Klimaschewski L, Meisinger C, Grothe C. Localization and regulation of basic fibroblast growth factor (FGF-2) and FGF receptor-1 in rat superior cervical ganglion after axotomy. J Neurobiol. 1999;38:499\u2013506.","journal-title":"J Neurobiol"},{"key":"1284_CR107","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/cne.1181","volume":"434","author":"C Grothe","year":"2001","unstructured":"Grothe C, Meisinger C, Claus P. In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia. J Comp Neurol. 2001;434:342\u201357.","journal-title":"J Comp Neurol"},{"key":"1284_CR108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-5956-10-9","volume":"10","author":"DJ Bryan","year":"2012","unstructured":"Bryan DJ, Litchfield CR, Manchio JV, Logvinenko T, Holway AH, Austin J, et al. Spatiotemporal expression profiling of proteins in rat sciatic nerve regeneration using reverse phase protein arrays. Proteome Sci. 2012;10:1\u201316.","journal-title":"Proteome Sci"},{"key":"1284_CR109","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0304-3940(99)00832-0","volume":"276","author":"TS Jacques","year":"1999","unstructured":"Jacques TS, Skepper JN, Navaratnam V. Fibroblast growth factor-1 improves the survival and regeneration of rat vagal preganglionic neurones following axon injury. Neurosci Lett. 1999;276:197\u2013200.","journal-title":"Neurosci Lett"},{"key":"1284_CR110","doi-asserted-by":"publisher","first-page":"629","DOI":"10.4103\/1673-5374.205104","volume":"12","author":"SH Lee","year":"2017","unstructured":"Lee SH, Jin WP, Seo NR, Pang KM, Kim B, Kim SM, et al. Recombinant human fibroblast growth factor-2 promotes nerve regeneration and functional recovery after mental nerve crush injury. Neural Regen Res. 2017;12:629\u201336.","journal-title":"Neural Regen Res"},{"key":"1284_CR111","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.nbd.2005.06.020","volume":"21","author":"K Haastert","year":"2006","unstructured":"Haastert K, Lipokati\u0107 E, Fischer M, Timmer M, Grothe C. Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol Dis. 2006;21:138\u201353.","journal-title":"Neurobiol Dis"},{"key":"1284_CR112","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3727\/000000003108746821","volume":"12","author":"M Timmer","year":"2003","unstructured":"Timmer M, Robben S, M\u00fcller-Ostermeyer F, Nikkhah G, Grothe C. Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2. Cell Transplant. 2003;12:265\u201377.","journal-title":"Cell Transplant"},{"key":"1284_CR113","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1002\/glia.22712","volume":"62","author":"I Allodi","year":"2014","unstructured":"Allodi I, Mecollari V, Gonz\u00e1lez-P\u00e9rez F, Eggers R, Hoyng S, Verhaagen J, et al. Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury. Glia. 2014;62:1736\u201346.","journal-title":"Glia"},{"key":"1284_CR114","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1002\/neu.20265","volume":"66","author":"J Jungnickel","year":"2006","unstructured":"Jungnickel J, Haase K, Konitzer J, Timmer M, Grothe C. Faster nerve regeneration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor. J Neurobiol. 2006;66:940\u20138.","journal-title":"J Neurobiol"},{"key":"1284_CR115","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuroscience.2011.03.032","volume":"182","author":"M Seitz","year":"2011","unstructured":"Seitz M, Grosheva M, Skouras E, Angelova SK, Ankerne J, Jungnickel J, et al. Poor functional recovery and muscle polyinnervation after facial nerve injury in fibroblast growth factor-2-\/- mice can be improved by manual stimulation of denervated vibrissal muscles. Neuroscience. 2011;182:241\u20137.","journal-title":"Neuroscience"},{"key":"1284_CR116","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/dneu.22224","volume":"75","author":"L Marvaldi","year":"2015","unstructured":"Marvaldi L, Thongrong S, Koz\u0142owska A, Irschick R, Pritz CO, B\u00e4umer B, et al. Enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice. Dev Neurobiol. 2015;75:217\u201331.","journal-title":"Dev Neurobiol"},{"key":"1284_CR117","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/S1044-7431(03)00228-8","volume":"24","author":"PS Sapieha","year":"2003","unstructured":"Sapieha PS, Peltier M, Rendahl KG, Manning WC, Di Polo A. Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Mol Cell Neurosci. 2003;24:656\u201372.","journal-title":"Mol Cell Neurosci"},{"key":"1284_CR118","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1002\/jnr.20803","volume":"83","author":"PS Sapieha","year":"2006","unstructured":"Sapieha PS, Hauswirth WW, Di Polo A. Extracellular signal-regulated kinases 1\/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2. J Neurosci Res. 2006;83:985\u201395.","journal-title":"J Neurosci Res"},{"key":"1284_CR119","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1523\/JNEUROSCI.14-03-01441.1994","volume":"14","author":"S Kostyk","year":"1994","unstructured":"Kostyk S, D\u2019Amore P, Herman I, Wagner J. Optic nerve injury alters basic fibroblast growth factor localization in the retina and optic tract. J Neurosci. 1994;14:1441\u20139.","journal-title":"J Neurosci"},{"key":"1284_CR120","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jchemneu.2012.08.003","volume":"46","author":"MV Duprey-D\u00edaz","year":"2012","unstructured":"Duprey-D\u00edaz MV, Blagburn JM, Blanco RE. Changes in fibroblast growth factor-2 and FGF receptors in the frog visual system during optic nerve regeneration. J Chem Neuroanat. 2012;46:35\u201344.","journal-title":"J Chem Neuroanat"},{"key":"1284_CR121","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/jnr.23303","volume":"92","author":"GS Vega-Mel\u00e9ndez","year":"2014","unstructured":"Vega-Mel\u00e9ndez GS, Blagburn JM, Blanco RE. Ciliary neurotrophic factor and fibroblast growth factor increase the speed and number of regenerating axons after optic nerve injury in adult Rana pipiens. J Neurosci Res. 2014;92:13\u201323.","journal-title":"J Neurosci Res"},{"key":"1284_CR122","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nn1195","volume":"7","author":"FM Bareyre","year":"2004","unstructured":"Bareyre FM, Kerschensteiner M, Raineteau O, Mettenleiter TC, Weinmann O, Schwab ME. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci. 2004;7:269\u201377.","journal-title":"Nat Neurosci"},{"key":"1284_CR123","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.15252\/embj.201490578","volume":"34","author":"A Jacobi","year":"2015","unstructured":"Jacobi A, Loy K, Schmalz AM, Hellsten M, Umemori H, Kerschensteiner M, et al. FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord. EMBO J. 2015;34:1231\u201343.","journal-title":"EMBO J"},{"key":"1284_CR124","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1089\/neu.2017.5205","volume":"35","author":"J Li","year":"2018","unstructured":"Li J, Wang Q, Wang H, Wu Y, Yin J, Chen J, et al. Lentivirus mediating FGF13 enhances axon regeneration after spinal cord injury by stabilizing microtubule and improving mitochondrial function. J Neurotrauma. 2018;35:548\u201359.","journal-title":"J Neurotrauma"},{"key":"1284_CR125","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/jgm.1568","volume":"13","author":"W-C Huang","year":"2011","unstructured":"Huang W-C, Kuo H-S, Tsai M-J, Ma H, Chiu C-W, Huang M-C, et al. Adeno-associated virus-mediated human acidic fibroblast growth factor expression promotes functional recovery of spinal cord-contused rats. J Gene Med. 2011;13:283\u20139.","journal-title":"J Gene Med"},{"key":"1284_CR126","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1111\/jcmm.13566","volume":"22","author":"J Li","year":"2018","unstructured":"Li J, Wang Q, Cai H, He Z, Wang H, Chen J, et al. FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti-ROS after spinal cord injury. J Cell Mol Med. 2018;22:2727\u201338.","journal-title":"J Cell Mol Med"},{"key":"1284_CR127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-31083-4","volume":"8","author":"CC Ko","year":"2018","unstructured":"Ko CC, Tu TH, Wu JC, Huang WC, Tsai YA, Huang SF, et al. Functional improvement in chronic human spinal cord injury: four years after acidic fibroblast growth factor. Sci Rep. 2018;8:1\u201310.","journal-title":"Sci Rep"},{"key":"1284_CR128","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/brb3.172","volume":"4","author":"Y Goldshmit","year":"2014","unstructured":"Goldshmit Y, Frisca F, Pinto AR, P\u00e9bay A, Tang JKY, Siegel AL, et al. Fgf2 improves functional recovery\u2014decreasing gliosis and increasing radial glia and neural progenitor cells after spinal cord injury. Brain Behav. 2014;4:187\u2013200.","journal-title":"Brain Behav"},{"key":"1284_CR129","doi-asserted-by":"publisher","first-page":"7477","DOI":"10.1523\/JNEUROSCI.0758-12.2012","volume":"32","author":"Y Goldshmit","year":"2012","unstructured":"Goldshmit Y, Sztal TE, Jusuf PR, Hall TE, Nguyen-Chi M, Currie PD. Fgf-dependent glial cell bridges facilitate spinal cord regeneration in Zebrafish. J Neurosci. 2012;32:7477\u201392.","journal-title":"J Neurosci"}],"container-title":["Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-023-01284-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12964-023-01284-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12964-023-01284-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T00:20:54Z","timestamp":1700353254000},"score":1,"resource":{"primary":{"URL":"https:\/\/biosignaling.biomedcentral.com\/articles\/10.1186\/s12964-023-01284-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":129,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1284"],"URL":"https:\/\/doi.org\/10.1186\/s12964-023-01284-0","relation":{},"ISSN":["1478-811X"],"issn-type":[{"value":"1478-811X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]},"assertion":[{"value":"7 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"290"}}