{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:31:31Z","timestamp":1773923491326,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (PT)","doi-asserted-by":"publisher","award":["SFRH\/BD\/87516\/2012"],"award-info":[{"award-number":["SFRH\/BD\/87516\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (PT)","doi-asserted-by":"publisher","award":["SFRH\/BPD\/63618\/2009"],"award-info":[{"award-number":["SFRH\/BPD\/63618\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (PT)","doi-asserted-by":"publisher","award":["SFRH\/BPD\/75285\/2010"],"award-info":[{"award-number":["SFRH\/BPD\/75285\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12967-016-0950-5","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T11:13:34Z","timestamp":1467890014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Immune response and innervation signatures in aseptic hip implant loosening"],"prefix":"10.1186","volume":"14","author":[{"given":"Daniel M.","family":"Vasconcelos","sequence":"first","affiliation":[]},{"given":"Manuel","family":"Ribeiro-da-Silva","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Mateus","sequence":"additional","affiliation":[]},{"given":"Cec\u00edlia Juliana","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Gil Costa","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Machado-Santos","sequence":"additional","affiliation":[]},{"given":"Diogo","family":"Paramos-de-Carvalho","sequence":"additional","affiliation":[]},{"given":"In\u00eas S.","family":"Alencastre","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Henrique","sequence":"additional","affiliation":[]},{"given":"Gilberto","family":"Costa","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio A.","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"Meriem","family":"Lamghari","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"950_CR1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","volume":"21","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21:16\u201321.","journal-title":"Osteoarthritis Cartilage"},{"issue":"9991","key":"950_CR2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"S Glyn-Jones","year":"2015","unstructured":"Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ. Osteoarthritis. Lancet. 2015;386(9991):376\u201387.","journal-title":"Lancet"},{"key":"950_CR3","doi-asserted-by":"crossref","first-page":"e30195","DOI":"10.1371\/journal.pone.0030195","volume":"7","author":"C Jourdan","year":"2012","unstructured":"Jourdan C, Poiraudeau S, Descamps S, Nizard R, Hamadouche M, Anract P, Boisgard S, Galvin M, Ravaud P. Comparison of patient and surgeon expectations of total hip arthroplasty. PLoS One. 2012;7:e30195.","journal-title":"PLoS One"},{"key":"950_CR4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-799X-7-13","volume":"7","author":"GH Smith","year":"2012","unstructured":"Smith GH, Johnson S, Ballantyne JA, Dunstan E, Brenkel IJ. Predictors of excellent early outcome after total hip arthroplasty. J Orthop Surg Res. 2012;7:13.","journal-title":"J Orthop Surg Res"},{"key":"950_CR5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00264-007-0364-3","volume":"32","author":"SD Ulrich","year":"2008","unstructured":"Ulrich SD, Seyler TM, Bennett D, Delanois RE, Saleh KJ, Thongtrangan I, Kuskowski M, Cheng EY, Sharkey PF, Parvizi J, Stiehl JB, Mont MA. Total hip arthroplasties: what are the reasons for revision? Int Orthop. 2008;32:597\u2013604.","journal-title":"Int Orthop"},{"key":"950_CR6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2106\/JBJS.F.00222","volume":"89","author":"S Kurtz","year":"2007","unstructured":"Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89:780\u20135.","journal-title":"J Bone Joint Surg Am"},{"key":"950_CR7","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joca.2012.08.027","volume":"20","author":"BJ Lange-Brokaar de","year":"2012","unstructured":"de Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE, Huizinga TW, Kloppenburg M. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage. 2012;20:1484\u201399.","journal-title":"Osteoarthritis Cartilage"},{"key":"950_CR8","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1016\/j.actbio.2013.05.005","volume":"9","author":"J Gallo","year":"2013","unstructured":"Gallo J, Goodman SB, Konttinen YT, Wimmer MA, Holinka M. Osteolysis around total knee arthroplasty: a review of pathogenetic mechanisms. Acta Biomater. 2013;9:8046\u201358.","journal-title":"Acta Biomater"},{"key":"950_CR9","doi-asserted-by":"publisher","first-page":"14002","DOI":"10.1038\/boneres.2014.2","volume":"2","author":"J Shen","year":"2014","unstructured":"Shen J, Li S, Chen D. TGF-beta signaling and the development of osteoarthritis. Bone Res. 2014;2:14002. doi: 10.1038\/boneres.2014.2 .","journal-title":"Bone Res"},{"key":"950_CR10","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00776-004-0774-7","volume":"9","author":"MP Loria","year":"2004","unstructured":"Loria MP, Dambra P, Moretti B, Patella V, Capuzzimati L, Cavallo E, Nettis E, Pesce V, Dell\u2019Osso A, Simone C, Tursi A. Role of cytokines in gonarthrosis and knee prosthesis aseptic loosening. J Orthop Sci. 2004;9:274\u20139.","journal-title":"J Orthop Sci"},{"key":"950_CR11","doi-asserted-by":"crossref","first-page":"R149","DOI":"10.1186\/ar3884","volume":"14","author":"MJ Martinez-Calatrava","year":"2012","unstructured":"Martinez-Calatrava MJ, Prieto-Potin I, Roman-Blas JA, Tardio L, Largo R, Herrero-Beaumont G. RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis. Arthritis Res Ther. 2012;14:R149.","journal-title":"Arthritis Res Ther"},{"key":"950_CR12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/1753425912451779","volume":"19","author":"J Gallo","year":"2013","unstructured":"Gallo J, Goodman SB, Konttinen YT, Raska M. Particle disease: biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty. Innate Immun. 2013;19:213\u201324.","journal-title":"Innate Immun"},{"key":"950_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrfmmm.2008.05.004","volume":"643","author":"I Papageorgiou","year":"2008","unstructured":"Papageorgiou I, Shadrick V, Davis S, Hails L, Schins R, Newson R, Fisher J, Ingham E, Case CP. Macrophages detoxify the genotoxic and cytotoxic effects of surgical cobalt chrome alloy particles but not quartz particles on human cells in vitro. Mutat Res. 2008;643:11\u20139.","journal-title":"Mutat Res"},{"key":"950_CR14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0142-9612(02)00360-5","volume":"24","author":"MA Germain","year":"2003","unstructured":"Germain MA, Hatton A, Williams S, Matthews JB, Stone MH, Fisher J, Ingham E. Comparison of the cytotoxicity of clinically relevant cobalt\u2013chromium and alumina ceramic wear particles in vitro. Biomaterials. 2003;24:469\u201379.","journal-title":"Biomaterials"},{"key":"950_CR15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jbm.b.31638","volume":"94","author":"J Gallo","year":"2010","unstructured":"Gallo J, Slouf M, Goodman SB. The relationship of polyethylene wear to particle size, distribution, and number: a possible factor explaining the risk of osteolysis after hip arthroplasty. J Biomed Mater Res B Appl Biomater. 2010;94:171\u20137.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"950_CR16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/ldr011","volume":"101","author":"A Buono Del","year":"2012","unstructured":"Del Buono A, Denaro V, Maffulli N. Genetic susceptibility to aseptic loosening following total hip arthroplasty: a systematic review. Br Med Bull. 2012;101:39\u201355.","journal-title":"Br Med Bull"},{"key":"950_CR17","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1309\/AJCPLTNEUAH8XI4W","volume":"134","author":"TS Watters","year":"2010","unstructured":"Watters TS, Cardona DM, Menon KS, Vinson EN, Bolognesi MP, Dodd LG. Aseptic lymphocyte-dominated vasculitis-associated lesion: a clinicopathologic review of an underrecognized cause of prosthetic failure. Am J Clin Pathol. 2010;134:886\u201393.","journal-title":"Am J Clin Pathol"},{"issue":"9783","key":"950_CR18","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","volume":"377","author":"JWJ Bijlsma","year":"2011","unstructured":"Bijlsma JWJ, Berenbaum F, Lafeber FPJG. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115\u201326.","journal-title":"Lancet"},{"key":"950_CR19","first-page":"796","volume":"29","author":"S Niissalo","year":"2002","unstructured":"Niissalo S, Li TF, Santavirta S, Takagi M, Hietanen J, Konttinen YT. Dense innervation in pseudocapsular tissue compared to aneural interface tissue in loose totally replaced hips. J Rheumatol. 2002;29:796\u2013803.","journal-title":"J Rheumatol"},{"key":"950_CR20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2006.10.010","volume":"15","author":"AD Pearle","year":"2007","unstructured":"Pearle AD, Scanzello CR, George S, Mandl LA, DiCarlo EF, Peterson M, Sculco TP, Crow MK. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage. 2007;15:516\u201323.","journal-title":"Osteoarthritis Cartilage"},{"key":"950_CR21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s13075-014-0485-1","volume":"16","author":"S Gr\u00e4ssel","year":"2014","unstructured":"Gr\u00e4ssel S. The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology. Arthritis Res Ther. 2014;16:485.","journal-title":"Arthritis Res Ther"},{"key":"950_CR22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1302\/0301-620X.80B1.8138","volume":"80B","author":"M Ahmed","year":"1998","unstructured":"Ahmed M, Bergstrom J, Lundblad H, Gillespie WJ, Kreicbergs A. Sensory nerves in the interface membrane of aseptic loose hip prostheses. J Bone Joint Surg Br. 1998;80B:151\u20135.","journal-title":"J Bone Joint Surg Br"},{"key":"950_CR23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0883-5403(94)90135-X","volume":"9","author":"WG Paprosky","year":"1994","unstructured":"Paprosky WG, Perona PG, Lawrence JM. Acetabular defect classification and surgical reconstruction in revision arthroplasty. A 6-year follow-up evaluation. J Arthroplasty. 1994;9:33\u201344.","journal-title":"J Arthroplasty"},{"key":"950_CR24","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-71038-4","volume-title":"Dysplasia and dislocation of the hip in children and adults","author":"D T\u00f6nnis","year":"1987","unstructured":"T\u00f6nnis D. Dysplasia and dislocation of the hip in children and adults. New York: Springer; 1987."},{"key":"950_CR25","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/000164701753532835","volume":"72","author":"SA Clarke","year":"2001","unstructured":"Clarke SA, Brooks RA, Hobby JL, Wimhurst JA, Myer BJ, Rushton N. Correlation of synovial fluid cytokine levels with histological and clinical parameters of primary and revision total hip and total knee replacements. Acta Orthop Scand. 2001;72:491\u20138.","journal-title":"Acta Orthop Scand"},{"key":"950_CR26","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/jor.22658","volume":"32","author":"E Jamsen","year":"2014","unstructured":"Jamsen E, Kouri VP, Olkkonen J, Cor A, Goodman SB, Konttinen YT, Pajarinen J. Characterization of macrophage polarizing cytokines in the aseptic loosening of total hip replacements. J Orthop Res. 2014;32:1241\u20136.","journal-title":"J Orthop Res"},{"key":"950_CR27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","volume":"55","author":"SA Bustin","year":"2009","unstructured":"Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55:611\u201322.","journal-title":"Clin Chem"},{"key":"950_CR28","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1002\/jbm.a.34599","volume":"101","author":"C Nich","year":"2013","unstructured":"Nich C, Takakubo Y, Pajarinen J, Ainola M, Salem A, Sillat T, Rao AJ, Raska M, Tamaki Y, Takagi M, Konttinen YT, Goodman SB, Gallo J. Macrophages-Key cells in the response to wear debris from joint replacements. J Biomed Mater Res A. 2013;101:3033\u201345.","journal-title":"J Biomed Mater Res A"},{"key":"950_CR29","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1302\/0301-620X.79B5.7602","volume":"79","author":"A Kobayashi","year":"1997","unstructured":"Kobayashi A, Freeman MA, Bonfield W, Kadoya Y, Yamac T, Al-Saffar N, Scott G, Revell PA. Number of polyethylene particles and osteolysis in total joint replacements. A quantitative study using a tissue-digestion method. J Bone Joint Surg Br. 1997;79:844\u20138.","journal-title":"J Bone Joint Surg Br"},{"key":"950_CR30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biomaterials.2009.09.017","volume":"31","author":"CT Wang","year":"2010","unstructured":"Wang CT, Lin YT, Chiang BL, Lee SS, Hou SM. Over-expression of receptor activator of nuclear factor-kappaB ligand (RANKL), inflammatory cytokines, and chemokines in periprosthetic osteolysis of loosened total hip arthroplasty. Biomaterials. 2010;31:77\u201382.","journal-title":"Biomaterials"},{"key":"950_CR31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.lfs.2013.11.008","volume":"97","author":"GA Obando-Pereda","year":"2014","unstructured":"Obando-Pereda GA, Fischer L, Stach-Machado DR. Titanium and zirconia particle-induced pro-inflammatory gene expression in cultured macrophages and osteolysis, inflammatory hyperalgesia and edema in vivo. Life Sci. 2014;97:96\u2013106.","journal-title":"Life Sci"},{"key":"950_CR32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1743-8977-6-14","volume":"6","author":"S Lanone","year":"2009","unstructured":"Lanone S, Rogerieux F, Geys J, Dupont A, Maillot-Marechal E, Boczkowski J, Lacroix G, Hoet P. Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines. Part Fibre Toxicol. 2009;6:14.","journal-title":"Part Fibre Toxicol"},{"key":"950_CR33","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1016\/j.actbio.2014.04.034","volume":"10","author":"TH Lin","year":"2014","unstructured":"Lin TH, Yao Z, Sato T, Keeney M, Li C, Pajarinen J, Yang F, Egashira K, Goodman SB. Suppression of wear-particle-induced pro-inflammatory cytokine and chemokine production in macrophages via NF-kappaB decoy oligodeoxynucleotide: a preliminary report. Acta Biomater. 2014;10:3747\u201355.","journal-title":"Acta Biomater"},{"key":"950_CR34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1749-799X-3-6","volume":"3","author":"NJ Hallab","year":"2008","unstructured":"Hallab NJ, Caicedo M, Finnegan A, Jacobs JJ. Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg Res. 2008;3:6.","journal-title":"J Orthop Surg Res"},{"key":"950_CR35","doi-asserted-by":"crossref","first-page":"20130962","DOI":"10.1098\/rsif.2013.0962","volume":"11","author":"SB Goodman","year":"2014","unstructured":"Goodman SB, Gibon E, Pajarinen J, Lin TH, Keeney M, Ren PG, Nich C, Yao Z, Egashira K, Yang F, Konttinen YT. Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement. J R Soc Interface. 2014;11:20130962.","journal-title":"J R Soc Interface"},{"issue":"1","key":"950_CR36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jbm.a.35159","volume":"103","author":"TH Lin","year":"2014","unstructured":"Lin TH, Kao S, Sato T, Pajarinen J, Zhang R, Loi F, Goodman SB, Yao Z. Exposure of polyethylene particles induces interferon-gamma expression in a natural killer T lymphocyte and dendritic cell coculture system in vitro: a preliminary study. J Biomed Mater Res A. 2014;103(1):71\u20135.","journal-title":"J Biomed Mater Res A"},{"key":"950_CR37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1302\/0301-620X.79B3.7469","volume":"79-B","author":"M Hukkanen","year":"1997","unstructured":"Hukkanen M, Corbett SA, Batten J, Konttinen YT, McCarthy ID, Maclouf J, Santavirta S, Hughes SPF, Polak JM. Aseptic loosening of total hip replacement: macrophage expression of inducible nitric oxide synthase and cyclo-oxygenase-2, together with peroxynitrite formation, as a possible mechanism for early prosthesis failure. J Bone Joint Surg Br. 1997;79-B:467\u201374.","journal-title":"J Bone Joint Surg Br"},{"key":"950_CR38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jor.20486","volume":"26","author":"P Koulouvaris","year":"2008","unstructured":"Koulouvaris P, Ly K, Ivashkiv LB, Bostrom MP, Nestor BJ, Sculco TP, Purdue PE. Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis. J Orthop Res. 2008;26:106\u201316.","journal-title":"J Orthop Res"},{"key":"950_CR39","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1128\/MCB.18.10.5678","volume":"18","author":"M Baer","year":"1998","unstructured":"Baer M, Dillner A, Schwartz RC, Sedon C, Nedospasov S, Johnson PF. Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50. Mol Cell Biol. 1998;18:5678\u201389.","journal-title":"Mol Cell Biol"},{"key":"950_CR40","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/j.actbio.2014.02.003","volume":"10","author":"J Gallo","year":"2014","unstructured":"Gallo J, Vaculova J, Goodman SB, Konttinen YT, Thyssen JP. Contributions of human tissue analysis to understanding the mechanisms of loosening and osteolysis in total hip replacement. Acta Biomater. 2014;10:2354\u201366.","journal-title":"Acta Biomater"},{"key":"950_CR41","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bone.2012.05.007","volume":"51","author":"H Koivu","year":"2012","unstructured":"Koivu H, Mackiewicz Z, Takakubo Y, Trokovic N, Pajarinen J, Konttinen YT. RANKL in the osteolysis of AES total ankle replacement implants. Bone. 2012;51:546\u201352.","journal-title":"Bone"},{"key":"950_CR42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1479-5876-12-74","volume":"12","author":"U Dapunt","year":"2014","unstructured":"Dapunt U, Giese T, Lasitschka F, Reinders J, Lehner B, Kretzer JP, Ewerbeck V, Hansch GM. On the inflammatory response in metal-on-metal implants. J Transl Med. 2014;12:74.","journal-title":"J Transl Med"},{"key":"950_CR43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/ar2896","volume":"12","author":"PM Kraan van der","year":"2010","unstructured":"van der Kraan PM, Blaney Davidson EN, van den Berg WB. A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis. Arthritis Res Ther. 2010;12:201.","journal-title":"Arthritis Res Ther"},{"key":"950_CR44","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/ard.2008.090217","volume":"68","author":"M Pombo-Suarez","year":"2009","unstructured":"Pombo-Suarez M, Castano-Oreja MT, Calaza M, Gomez-Reino J, Gonzalez A. Differential upregulation of the three transforming growth factor beta isoforms in human osteoarthritic cartilage. Ann Rheum Dis. 2009;68:568\u201371.","journal-title":"Ann Rheum Dis"},{"key":"950_CR45","first-page":"694","volume":"24","author":"YT Konttinen","year":"1997","unstructured":"Konttinen YT, Waris V, Xu JW, Jiranek WA, Sorsa T, Virtanen I, Santavirta S. Transforming growth factor-beta 1 and 2 in the synovial-like interface membrane between implant and bone in loosening of total hip arthroplasty. J Rheumatol. 1997;24:694\u2013701.","journal-title":"J Rheumatol"},{"key":"950_CR46","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2249.2002.01785.x","volume":"127","author":"H Cheon","year":"2002","unstructured":"Cheon H, Yu SJ, Yoo DH, Chae IJ, Song GG, Sohn J. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol. 2002;127:547\u201352.","journal-title":"Clin Exp Immunol"},{"key":"950_CR47","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbadis.2009.06.004","volume":"1792","author":"D Pohlers","year":"2009","unstructured":"Pohlers D, Brenmoehl J, Loffler I, Muller CK, Leipner C, Schultze-Mosgau S, Stallmach A, Kinne RW, Wolf G. TGF-beta and fibrosis in different organs\u2014molecular pathway imprints. Biochim Biophys Acta. 2009;1792:746\u201356.","journal-title":"Biochim Biophys Acta"},{"key":"950_CR48","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.joca.2008.11.010","volume":"17","author":"AE Nelson","year":"2009","unstructured":"Nelson AE, Fang F, Shi XA, Kraus VB, Stabler T, Renner JB, Schwartz TA, Helmick CG, Jordan JM. Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2009;17:772\u20136.","journal-title":"Osteoarthritis Cartilage"},{"key":"950_CR49","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.joca.2010.02.013","volume":"18","author":"AE Nelson","year":"2010","unstructured":"Nelson AE, Golightly YM, Kraus VB, Stabler T, Renner JB, Helmick CG, Jordan JM. Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2010;18:825\u20139.","journal-title":"Osteoarthritis Cartilage"},{"key":"950_CR50","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/s13075-014-0504-2","volume":"16","author":"G Pongratz","year":"2014","unstructured":"Pongratz G, Straub RH. The sympathetic nervous response in inflammation. Arthritis Res Ther. 2014;16:504.","journal-title":"Arthritis Res Ther"},{"key":"950_CR51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.it.2006.02.003","volume":"27","author":"T Prod\u2019homme","year":"2006","unstructured":"Prod\u2019homme T, Weber MS, Steinman L, Zamvil SS. A neuropeptide in immune-mediated inflammation, Y? Trends Immunol. 2006;27:164\u20137.","journal-title":"Trends Immunol"},{"key":"950_CR52","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1096\/fj.99-1082com","volume":"14","author":"LE Miller","year":"2000","unstructured":"Miller LE, Justen HP, Scholmerich J, Straub RH. The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J. 2000;14:2097\u2013107.","journal-title":"FASEB J"},{"key":"950_CR53","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/art.24860","volume":"60","author":"A Fassold","year":"2009","unstructured":"Fassold A, Falk W, Anders S, Hirsch T, Mirsky VM, Straub RH. Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis. Arthritis Rheum. 2009;60:2892\u2013901.","journal-title":"Arthritis Rheum"},{"key":"950_CR54","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/art.33431","volume":"64","author":"S Capellino","year":"2012","unstructured":"Capellino S, Weber K, Gelder M, Harle P, Straub RH. First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy. Arthritis Rheum. 2012;64:1110\u20138.","journal-title":"Arthritis Rheum"},{"key":"950_CR55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.joca.2007.02.005","volume":"15","author":"EN Blaney Davidson","year":"2007","unstructured":"Blaney Davidson EN, van der Kraan PM, van den Berg WB. TGF-beta and osteoarthritis. Osteoarthritis Cartilage. 2007;15:597\u2013604.","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-016-0950-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T04:12:58Z","timestamp":1718683978000},"score":1,"resource":{"primary":{"URL":"http:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-016-0950-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["950"],"URL":"https:\/\/doi.org\/10.1186\/s12967-016-0950-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]},"article-number":"205"}}