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Studies on host genetic polymorphisms that confer resistance to HIV-1 infection or delay HIV disease progression are scarce in African countries. Herein, we investigate the proportion of the mutated phenotype of the AIDS-related polymorphisms CCR5-Delta32, CCR2-64I, and SDF1-3\u2019A in HIV-infected and uninfected individuals in Luanda, the capital of Angola, a sub-Saharan African country.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This was a cross-sectional study conducted with 284 individuals, of whom 159 were HIV-negative and 125 were HIV-positive. The CCR5-Delta32, CCR2-64I, and SDF1-3\u2032A genotypes were detected by conventional PCR and visualised on 2% agarose gel. A Chi-square test determined the frequency of each genetic variant and was deemed significant when <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The frequency of CCR5-Delta32, CCR2-64I, and SDF1-3\u00a0A was 0% (0\/272), 60.2% (154\/256), and 42.5% (114\/268), respectively. CCR2-64I and SDF1-3\u00a0A polymorphisms were statistically related to HIV infection (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Statistically significant was observed between ABO blood groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and HIV-1 subtype (<jats:italic>p<\/jats:italic>\u2009=\u20090.015) with CCR2-64I. Also, the age group (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) and RH blood group (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) were statistically related to the distribution of SDF1-3\u00a0A polymorphism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We found no CCR5-Delta32 allele, while CCR2-64I and SDF1-3\u2019A were found and presented a relationship with HIV infection, age, ABO\/RH blood group, and HIV-1 subtypes. The observed associations of CCR2-64I and SDF1-3\u2032A with HIV underscore the urgent need for further multidisciplinary research, with potential implications for targeted prevention and public health strategies. Therefore, studies investigating biological and non-biological factors related to susceptibility to HIV infection and AIDS progression or death should be conducted in Angola.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12981-025-00751-7","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T06:11:45Z","timestamp":1748067105000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3\u2019A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angola"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1232-0119","authenticated-orcid":false,"given":"Cruz S.","family":"Sebasti\u00e3o","sequence":"first","affiliation":[]},{"given":"Victor","family":"Pimentel","sequence":"additional","affiliation":[]},{"given":"Domingos","family":"Jandondo","sequence":"additional","affiliation":[]},{"given":"Joana M.K.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[]},{"given":"Euclides","family":"Sacomboio","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Pingarilho","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Brito","sequence":"additional","affiliation":[]},{"given":"Edson Kuatelela","family":"Cassinela","sequence":"additional","affiliation":[]},{"given":"Jocelyne Neto","family":"de Vasconcelos","sequence":"additional","affiliation":[]},{"given":"Ana B.","family":"Abecasis","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Morais","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"751_CR1","unstructured":"WHO. 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This study was approved by the National Ethics Committee of the Angolan Ministry of Health (nr. 39\/2021, approved on 01 December 2021) and the direction board of the National Blood Transfusion Service (nr.128\/GDG\/INS\/2022, approved on 24 February 2022). Participants were informed about the objectives of the study, and verbal informed consent was obtained from all enrolled participants even before they were considered part of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}