{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:04:55Z","timestamp":1775592295803,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"FCT","award":["SFRH\/BD\/93073\/2013"],"award-info":[{"award-number":["SFRH\/BD\/93073\/2013"]}]},{"name":"FCT","award":["PTDC\/AGR-TEC\/2227\/2012"],"award-info":[{"award-number":["PTDC\/AGR-TEC\/2227\/2012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr Metab (Lond)"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12986-016-0089-7","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T01:25:03Z","timestamp":1461979503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["The role of I-FABP as a biomarker of intestinal barrier dysfunction driven by gut microbiota changes in obesity"],"prefix":"10.1186","volume":"13","author":[{"given":"Eva","family":"Lau","sequence":"first","affiliation":[]},{"given":"Cl\u00e1udia","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Diogo","family":"Pestana","sequence":"additional","affiliation":[]},{"given":"Mariana","family":"Santoalha","sequence":"additional","affiliation":[]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Freitas","sequence":"additional","affiliation":[]},{"given":"Concei\u00e7\u00e3o","family":"Calhau","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,4,30]]},"reference":[{"key":"89_CR1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"PD Cani","year":"2007","unstructured":"Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delm\u00e9e E, Cousin B, Sulpice T, Chamontin B, Ferri\u00e8res J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761\u201372.","journal-title":"Diabetes"},{"key":"89_CR2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","volume":"58","author":"PD Cani","year":"2009","unstructured":"Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, Geurts L, Naslain D, Neyrinck A, Lambert DM, Muccioli GG, Delzenne NM. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009;58:1091\u2013103.","journal-title":"Gut"},{"key":"89_CR3","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","volume":"101","author":"F B\u00e4ckhed","year":"2004","unstructured":"B\u00e4ckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101:15718\u201323.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"89_CR4","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","volume":"57","author":"PD Cani","year":"2008","unstructured":"Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57:1470\u201381.","journal-title":"Diabetes"},{"key":"89_CR5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0009-9120(03)00096-1","volume":"36","author":"MMA Pelsers","year":"2003","unstructured":"Pelsers MMA, Namiot Z, Kisielewski W, Namiot A, Januszkiewicz M, Hermens WT, Glatz JF. Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. Clin Biochem. 2003;36:529\u201335.","journal-title":"Clin Biochem"},{"key":"89_CR6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/apt.12194","volume":"37","author":"MPM Adriaanse","year":"2013","unstructured":"Adriaanse MPM, Tack GJ, Passos VL, Damoiseaux JGMC, Schreurs MWJ, van Wijck K, Riedl RG, Masclee AAM, Buurman WA, Mulder CJJ, Vreugdenhil ACE. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies. Aliment Pharmacol Ther. 2013;37:482\u201390.","journal-title":"Aliment Pharmacol Ther"},{"key":"89_CR7","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.3109\/00365521.2011.627447","volume":"46","author":"AC Vreugdenhil","year":"2011","unstructured":"Vreugdenhil AC, Wolters VM, Adriaanse MP, Van den Neucker AM, van Bijnen AA, Houwen R, Buurman WA. Additional value of serum I-FABP levels for evaluating celiac disease activity in children. Scand J Gastroenterol. 2011;46:1435\u201341.","journal-title":"Scand J Gastroenterol"},{"key":"89_CR8","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1097\/SLA.0b013e3181d778c4","volume":"251","author":"G Thuijls","year":"2010","unstructured":"Thuijls G, Derikx JPM, van Wijck K, Zimmermann LJI, Degraeuwe PL, Mulder TL, Van der Zee DC, Brouwers HAA, Verhoeven BH, van Heurn LWE, Kramer BW, Buurman WA, Heineman E. Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. Ann Surg. 2010;251:1174\u201380.","journal-title":"Ann Surg"},{"key":"89_CR9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1258\/002367798780559356","volume":"32","author":"K Rutter","year":"1998","unstructured":"Rutter K, Hennoste L, Ward LC, Cornish BH, Thomas BJ. Bioelectrical impedance analysis for the estimation of body composition in rats. Lab Anim. 1998;32:65\u201371.","journal-title":"Lab Anim"},{"issue":"July","key":"89_CR10","first-page":"1","volume":"3945","author":"C Marques","year":"2015","unstructured":"Marques C, Meireles M, Norberto S, Leite J, Freitas J, Pestana D, Faria A, Calhau C. High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague\u2013Dawley Rat. Adipocyte. 2015;3945(July):1\u201311.","journal-title":"Adipocyte"},{"key":"89_CR11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.14310\/horm.2002.1571","volume":"14","author":"E Lau","year":"2015","unstructured":"Lau E, Carvalho D, Pina-Vaz C, Barbosa JA, Freitas P. Beyond gut microbiota: understanding obesity and type 2 diabetes. Hormones. 2015;14:358\u201369.","journal-title":"Hormones"},{"key":"89_CR12","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.0605374104","volume":"104","author":"F B\u00e4ckhed","year":"2007","unstructured":"B\u00e4ckhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007;104:979\u201384.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"89_CR13","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","volume":"102","author":"RE Ley","year":"2005","unstructured":"Ley RE, B\u00e4ckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. 2005;102:11070\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"89_CR14","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.274.16.10689","volume":"274","author":"JC Chow","year":"1999","unstructured":"Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction. J Biol Chem. 1999;274(16):10689\u201392.","journal-title":"J Biol Chem"},{"key":"89_CR15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1139\/cjpp-2012-0349","volume":"91","author":"ORL Wright","year":"2013","unstructured":"Wright ORL, Netzel GA, Sakzewski AR. A randomized, double-blind, placebo-controlled trial of the effect of dried purple carrot on body mass, lipids, blood pressure, body composition, and inflammatory markers in overweight and obese adults: the QUENCH trial. Can J Physiol Pharmacol. 2013;91:480\u20138.","journal-title":"Can J Physiol Pharmacol"},{"key":"89_CR16","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1073\/pnas.1220180110","volume":"110","author":"K Kaliannan","year":"2013","unstructured":"Kaliannan K, Hamarneh SR, Economopoulos KP, Nasrin Alam S, Moaven O, Patel P, Malo NS, Ray M, Abtahi SM, Muhammad N, Raychowdhury A, Teshager A, Mohamed MMR, Moss AK, Ahmed R, Hakimian S, Narisawa S, Mill\u00e1n JL, Hohmann E, Warren HS, Bhan AK, Malo MS, Hodin RA. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2013;110:7003\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"89_CR17","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3748\/wjg.v18.i9.923","volume":"18","author":"LK Stenman","year":"2012","unstructured":"Stenman LK, Holma R, Korpela R. High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids. World J Gastroenterol. 2012;18:923\u20139.","journal-title":"World J Gastroenterol"},{"key":"89_CR18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MCG.0b013e3182a87e3e","volume":"48","author":"DHSM Schellekens","year":"2014","unstructured":"Schellekens DHSM, Grootjans J, Dello SAWG, van Bijnen AA, van Dam RM, Dejong CHC, Derikx JPM, Buurman WA. Plasma intestinal fatty acid-binding protein levels correlate with morphologic epithelial intestinal damage in a human translational ischemia-reperfusion model. J Clin Gastroenterol. 2014;48:253\u201360.","journal-title":"J Clin Gastroenterol"},{"key":"89_CR19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121336","volume":"10","author":"M Schurink","year":"2015","unstructured":"Schurink M, Kooi EMW, Hulzebos CV, Kox RG, Groen H, Heineman E, Bos AF, Hulscher JBF. Intestinal fatty acid-binding protein as a diagnostic marker for complicated and uncomplicated necrotizing enterocolitis: a prospective cohort study. PLoS One. 2015;10, e0121336.","journal-title":"PLoS One"},{"key":"89_CR20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12876-014-0189-7","volume":"14","author":"SC Bischoff","year":"2014","unstructured":"Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells J. Intestinal permeability \u00bf a new target for disease prevention and therapy. BMC Gastroenterol. 2014;14:189.","journal-title":"BMC Gastroenterol"},{"key":"89_CR21","doi-asserted-by":"crossref","first-page":"E379","DOI":"10.1210\/jc.2010-1333","volume":"96","author":"FJ Verdam","year":"2011","unstructured":"Verdam FJ, Greve JWM, Roosta S, van Eijk H, Bouvy N, Buurman WA, Rensen SS. Small intestinal alterations in severely obese hyperglycemic subjects. J Clin Endocrinol Metab. 2011;96:E379\u201383.","journal-title":"J Clin Endocrinol Metab"},{"key":"89_CR22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1194\/jlr.M600283-JLR200","volume":"48","author":"V Petit","year":"2007","unstructured":"Petit V, Arnould L, Martin P, Monnot MC, Pineau T, Besnard P, Niot I. Chronic high-fat diet affects intestinal fat absorption and postprandial triglyceride levels in the mouse. J Lipid Res. 2007;48:278\u201387.","journal-title":"J Lipid Res"},{"key":"89_CR23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/JOE-12-0500","volume":"217","author":"S Baldassano","year":"2013","unstructured":"Baldassano S, Amato A, Cappello F, Rappa F, Mul\u00e8 F. Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet. J Endocrinol. 2013;217:11\u201320.","journal-title":"J Endocrinol"}],"container-title":["Nutrition & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12986-016-0089-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T23:12:15Z","timestamp":1748905935000},"score":1,"resource":{"primary":{"URL":"http:\/\/nutritionandmetabolism.biomedcentral.com\/articles\/10.1186\/s12986-016-0089-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,30]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["89"],"URL":"https:\/\/doi.org\/10.1186\/s12986-016-0089-7","relation":{},"ISSN":["1743-7075"],"issn-type":[{"value":"1743-7075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,30]]},"article-number":"31"}}