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This paper offers a conceptual framework for healthcare professionals by exploring the ontological status of the human being and the concept of personhood, grounded in classical metaphysical principles. Through a phenomenological, epistemological, axiological, and ontological lens, it proposes a unified understanding of human dignity that can inform and elevate clinical practice. While the dialogue between Greek philosophy and the Judeo-Christian tradition established a robust and enduring notion of dignity, and Kantian ethics reinforced the centrality of the human being as an end in itself, the increasing compartmentalization of knowledge\u2014though fruitful in some respects\u2014has obscured the integral vision of the human person. In the medical field, this fragmentation can diminish awareness of the relational, existential, and spiritual dimensions essential to humane care. In response, this paper reaffirms the relevance of philosophical anthropology for medical ethics. It contends that safeguarding human dignity amid contemporary scientific and technological challenges requires returning to an ontological vision of the person-one that transcends functionalist and reductionist models and restores the human being to the center of healthcare. By doing so, it offers professionals a deeper foundation for ethical discernment and compassionate practice.<\/jats:p>","DOI":"10.1186\/s13010-025-00207-w","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:09:47Z","timestamp":1767870587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human dignity and ontological foundations: a philosophical perspective for the health professions"],"prefix":"10.1186","volume":"21","author":[{"given":"Patr\u00edcia","family":"Frantz","sequence":"first","affiliation":[]},{"given":"Francisca","family":"Rego","sequence":"additional","affiliation":[]},{"given":"Stela","family":"Barbas","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"207_CR1","doi-asserted-by":"crossref","unstructured":"Singer, P. In: Practical ethics. 3rd ed. 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