{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T04:14:09Z","timestamp":1728965649259},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dosing of antibiotics in critically ill patients is a significant challenge. The increasing number of patients undergoing extracorporeal membrane oxygenation further complicates the issue due to inflammatory activation and to drug sequestration in the circuit. Since patients receiving extracorporeal membrane oxygenation commonly face severe infections, appropriate antibiotic selection and correct dosing is of paramount importance to improve survival. Therapeutic drug monitoring (whenever available) or population pharmacokinetics, based on readily available clinical and laboratory data, should help tailor antibiotic dosing to the individual patient.<\/jats:p>","DOI":"10.1186\/s13054-014-0695-6","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T20:28:21Z","timestamp":1418934501000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibiotics and extracorporeal circulation \u2013 one size does not fit all"],"prefix":"10.1186","volume":"18","author":[{"given":"Jo\u00e3o","family":"Gon\u00e7alves-Pereira","sequence":"first","affiliation":[]},{"given":"Bruno","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,12,19]]},"reference":[{"key":"695_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1186\/s13054-014-0565-2","volume":"18","author":"K Shekar","year":"2014","unstructured":"Shekar K, Fraser JF, Taccone FS, Welch S, Wallis SC, Mullany DV, Lipman J, Roberts JA: The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study. Critical Care. 2014, 18: 565-10.1186\/s13054-014-0565-2.","journal-title":"Critical Care"},{"key":"695_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/PCC.0b013e3181e28894","volume":"12","author":"MJ Bizzarro","year":"2011","unstructured":"Bizzarro MJ, Conrad SA, Kaufman DA, Rycus P: Infections acquired during extracorporeal membrane oxygenation in neonates, children, and adults. Pediatr Crit Care Med. 2011, 12: 277-281. 10.1097\/PCC.0b013e3181e28894.","journal-title":"Pediatr Crit Care Med"},{"key":"695_CR3","doi-asserted-by":"publisher","first-page":"R126","DOI":"10.1186\/cc9091","volume":"14","author":"FS Taccone","year":"2010","unstructured":"Taccone FS, Laterre PF, Dugernier T, Spapen H, Delattre I, Witebolle X, De Backer D, Layeux B, Wallemacq P, Vincent JL, Jacobs F: Insufficient beta-lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care. 2010, 14: R126-10.1186\/cc9091.","journal-title":"Crit Care"},{"key":"695_CR4","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.ijantimicag.2011.12.011","volume":"39","author":"JP Baptista","year":"2012","unstructured":"Baptista JP, Sousa E, Martins PJ, Pimentel JM: Augmented renal clearance in septic patients and implications for vancomycin optimisation. Int J Antimicrob Agents. 2012, 39: 420-423. 10.1016\/j.ijantimicag.2011.12.011.","journal-title":"Int J Antimicrob Agents"},{"key":"695_CR5","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1111\/j.1469-0691.2009.03074.x","volume":"16","author":"J Goncalves-Pereira","year":"2010","unstructured":"Goncalves-Pereira J, Martins A, Povoa P: Pharmacokinetics of gentamicin in critically ill patients: pilot study evaluating the first dose. Clin Microbiol Infect. 2010, 16: 1258-1263. 10.1111\/j.1469-0691.2009.03074.x.","journal-title":"Clin Microbiol Infect"},{"key":"695_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/BF01706354","volume":"16","author":"C Triginer","year":"1990","unstructured":"Triginer C, Izquierdo I, Fernandez R, Rello J, Torrent J, Benito S, Net A: Gentamicin volume of distribution in critically ill septic patients. Intensive Care Med. 1990, 16: 303-306. 10.1007\/BF01706354.","journal-title":"Intensive Care Med"},{"key":"695_CR7","doi-asserted-by":"publisher","first-page":"R206","DOI":"10.1186\/cc10441","volume":"15","author":"J Goncalves-Pereira","year":"2011","unstructured":"Goncalves-Pereira J, Povoa P: Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of beta-lactams. Crit Care. 2011, 15: R206-10.1186\/cc10441.","journal-title":"Crit Care"},{"key":"695_CR8","doi-asserted-by":"publisher","first-page":"R194","DOI":"10.1186\/cc11679","volume":"16","author":"K Shekar","year":"2012","unstructured":"Shekar K, Roberts JA, McDonald CI, Fisquet S, Barnett AG, Mullany DV, Ghassabian S, Wallis SC, Fung YL, Smith MT, Fraser JF: Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Crit Care. 2012, 16: R194-10.1186\/cc11679.","journal-title":"Crit Care"},{"key":"695_CR9","doi-asserted-by":"crossref","unstructured":"Sauer CM, Yuh DD, Bonde P: Extracorporeal membrane oxygenation (ECMO) use has increased by 433% in adults in the United States from 2006 to 2011. ASAIO J 2014. [Epub ahead of print],","DOI":"10.1097\/MAT.0000000000000160"},{"key":"695_CR10","doi-asserted-by":"publisher","first-page":"R105","DOI":"10.1186\/cc13886","volume":"18","author":"M Beumier","year":"2014","unstructured":"Beumier M, Casu GS, Hites M, Seyler L, Cotton F, Vincent JL, Jacobs F, Taccone FS: Beta-lactam antibiotic concentrations during continuous renal replacement therapy. Crit Care. 2014, 18: R105-10.1186\/cc13886.","journal-title":"Crit Care"},{"key":"695_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S0924-8579(02)00188-7","volume":"20","author":"F Pea","year":"2002","unstructured":"Pea F, Bertolissi M, Di Silvestre A, Poz D, Giordano F, Furlanut M: TDM coupled with Bayesian forecasting should be considered an invaluable tool for optimizing vancomycin daily exposure in unstable critically ill patients. Int J Antimicrob Agents. 2002, 20: 326-332. 10.1016\/S0924-8579(02)00188-7.","journal-title":"Int J Antimicrob Agents"},{"key":"695_CR12","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ijantimicag.2010.06.008","volume":"36","author":"JA Roberts","year":"2010","unstructured":"Roberts JA, Ulldemolins M, Roberts MS, McWhinney B, Ungerer J, Paterson DL, Lipman J: Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept. Int J Antimicrob Agents. 2010, 36: 332-339. 10.1016\/j.ijantimicag.2010.06.008.","journal-title":"Int J Antimicrob Agents"},{"key":"695_CR13","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jcrc.2012.11.018","volume":"28","author":"J Goncalves-Pereira","year":"2013","unstructured":"Goncalves-Pereira J, Paiva JA: Dose modulation: a new concept of antibiotic therapy in the critically ill patient?. J Crit Care. 2013, 28: 341-346. 10.1016\/j.jcrc.2012.11.018.","journal-title":"J Crit Care"},{"key":"695_CR14","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1007\/s00134-014-3403-8","volume":"40","author":"JJ De Waele","year":"2014","unstructured":"De Waele JJ, Lipman J, Akova M, Bassetti M, Dimopoulos G, Kaukonen M, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Udy AA, Starr T, Wallis SC, Roberts JA: Risk factors for target non-attainment during empirical treatment with beta-lactam antibiotics in critically ill patients. Intensive Care Med. 2014, 40: 1340-1351. 10.1007\/s00134-014-3403-8.","journal-title":"Intensive Care Med"},{"key":"695_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1471-2253-12-29","volume":"12","author":"K Shekar","year":"2012","unstructured":"Shekar K, Roberts JA, Welch S, Buscher H, Rudham S, Burrows F, Ghassabian S, Wallis SC, Levkovich B, Pellegrino V, McGuinness S, Parke R, Gilder E, Barnett AG, Walsham J, Mullany DV, Fung YL, Smith MT, Fraser JF: ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiol. 2012, 12: 29-10.1186\/1471-2253-12-29.","journal-title":"BMC Anesthesiol"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-014-0695-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13054-014-0695-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-014-0695-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13054-014-0695-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:10:10Z","timestamp":1728922210000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/s13054-014-0695-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,19]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,12]]}},"alternative-id":["695"],"URL":"https:\/\/doi.org\/10.1186\/s13054-014-0695-6","relation":{},"ISSN":["1364-8535"],"issn-type":[{"type":"electronic","value":"1364-8535"}],"subject":[],"published":{"date-parts":[[2014,12,19]]},"assertion":[{"value":"19 December 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"695"}}