{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T16:16:55Z","timestamp":1771777015523,"version":"3.50.1"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BBB-BEP\/0385\/2014"],"award-info":[{"award-number":["PTDC\/BBB-BEP\/0385\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/78058\/2011"],"award-info":[{"award-number":["SFRH\/BD\/78058\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIO\/04565\/2013"],"award-info":[{"award-number":["UID\/BIO\/04565\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa Operacional Regional de Lisboa 2020","award":["N. 007317"],"award-info":[{"award-number":["N. 007317"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biotechnol Biofuels"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13068-017-0781-5","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:21:13Z","timestamp":1492550473000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants"],"prefix":"10.1186","volume":"10","author":[{"given":"S\u00edlvia F.","family":"Henriques","sequence":"first","affiliation":[]},{"given":"Nuno P.","family":"Mira","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"S\u00e1-Correia","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"issue":"3","key":"781_CR1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1063\/1.555833","volume":"18","author":"J Sangster","year":"1989","unstructured":"Sangster J. Octanol\u2013water partition-coefficients of simple organic-compounds. J Phys Chem Ref Data. 1989;18(3):1111\u2013229.","journal-title":"J Phys Chem Ref Data"},{"key":"781_CR2","doi-asserted-by":"publisher","unstructured":"Reutemann W, Kieczka H. Formic acid. In: Ullmann\u2019s encyclopedia of industrial chemistry. Wiley-VCH Verlag GmbH & Co. KGaA; 2000.","DOI":"10.1002\/14356007.a12_013"},{"key":"781_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.carres.2013.08.029","volume":"385","author":"H Rasmussen","year":"2014","unstructured":"Rasmussen H, Sorensen HR, Meyer AS. Formation of degradation compounds from lignocellulosic biomass in the biorefinery: sugar reaction mechanisms. Carbohydr Res. 2014;385:45\u201357.","journal-title":"Carbohydr Res"},{"issue":"6","key":"781_CR4","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s10295-014-1431-6","volume":"41","author":"D Greetham","year":"2014","unstructured":"Greetham D, Wimalasena T, Kerruish DW, Brindley S, Ibbett RN, Linforth RL, Tucker G, Phister TG, Smart KA. Development of a phenotypic assay for characterisation of ethanologenic yeast strain sensitivity to inhibitors released from lignocellulosic feedstocks. J Ind Microbiol Biotechnol. 2014;41(6):931\u201345.","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"6","key":"781_CR5","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1002\/bit.21849","volume":"100","author":"E Tomas-Pejo","year":"2008","unstructured":"Tomas-Pejo E, Oliva JM, Ballesteros M, Olsson L. Comparison of SHF and SSF processes from steam-exploded wheat straw for ethanol production by xylose-fermenting and robust glucose-fermenting Saccharomyces cerevisiae strains. Biotechnol Bioeng. 2008;100(6):1122\u201331.","journal-title":"Biotechnol Bioeng"},{"key":"781_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.biortech.2015.10.009","volume":"199","author":"LJ Jonsson","year":"2016","unstructured":"Jonsson LJ, Martin C. Pretreatment of lignocellulose: formation of inhibitory by-products and strategies for minimizing their effects. Bioresour Technol. 2016;199:103\u201312.","journal-title":"Bioresour Technol"},{"key":"781_CR7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.copbio.2015.03.001","volume":"33","author":"SC Santos dos","year":"2015","unstructured":"dos Santos SC, Sa-Correia I. Yeast toxicogenomics: lessons from a eukaryotic cell model and cell factory. Curr Opin Biotechnol. 2015;33:183\u201391.","journal-title":"Curr Opin Biotechnol"},{"issue":"5","key":"781_CR8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1089\/omi.2010.0072","volume":"14","author":"NP Mira","year":"2010","unstructured":"Mira NP, Teixeira MC, Sa-Correia I. Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view. OMICS. 2010;14(5):525\u201340.","journal-title":"OMICS"},{"issue":"2","key":"781_CR9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.copbio.2010.10.011","volume":"22","author":"MC Teixeira","year":"2011","unstructured":"Teixeira MC, Mira NP, Sa-Correia I. A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae. Curr Opin Biotechnol. 2011;22(2):150\u20136.","journal-title":"Curr Opin Biotechnol"},{"issue":"4","key":"781_CR10","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.copbio.2011.11.021","volume":"23","author":"B Jong de","year":"2012","unstructured":"de Jong B, Siewers V, Nielsen J. Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels. Curr Opin Biotechnol. 2012;23(4):624\u201330.","journal-title":"Curr Opin Biotechnol"},{"key":"781_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13068-015-0418-5","volume":"9","author":"Y Chen","year":"2016","unstructured":"Chen Y, Sheng J, Jiang T, Stevens J, Feng X, Wei N. Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae. Biotechnol Biofuels. 2016;9:9.","journal-title":"Biotechnol Biofuels"},{"issue":"6205","key":"781_CR12","first-page":"75","volume":"346","author":"L Caspeta","year":"2014","unstructured":"Caspeta L, Chen Y, Ghiaci P, Feizi A, Buskov S, Hallstrom BM, Petranovic D, Nielsen J. Altered sterol composition renders yeast thermotolerant. Biofuels. 2014;346(6205):75\u20138.","journal-title":"Biofuels."},{"issue":"1","key":"781_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsyr\/fou003","volume":"15","author":"M Li","year":"2015","unstructured":"Li M, Borodina I. Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2015;15(1):1\u201312.","journal-title":"FEMS Yeast Res"},{"key":"781_CR14","doi-asserted-by":"publisher","first-page":"41868","DOI":"10.1038\/srep41868","volume":"7","author":"L Lindahl","year":"2017","unstructured":"Lindahl L, Santos AX, Olsson H, Olsson L, Bettiga M. Membrane engineering of S. cerevisiae targeting sphingolipid metabolism. Sci Rep. 2017;7:41868.","journal-title":"Sci Rep."},{"key":"781_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1475-2859-9-79","volume":"9","author":"NP Mira","year":"2010","unstructured":"Mira NP, Palma M, Guerreiro JF, Sa-Correia I. Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid. Microb Cell Fact. 2010;9:79.","journal-title":"Microb Cell Fact"},{"issue":"2","key":"781_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1567-1364.2008.00473.x","volume":"9","author":"NP Mira","year":"2009","unstructured":"Mira NP, Lourenco AB, Fernandes AR, Becker JD, Sa-Correia I. The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids. FEMS Yeast Res. 2009;9(2):202\u201316.","journal-title":"FEMS Yeast Res"},{"issue":"1","key":"781_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1475-2859-10-2","volume":"10","author":"T Hasunuma","year":"2011","unstructured":"Hasunuma T, Sanda T, Yamada R, Yoshimura K, Ishii J, Kondo A. Metabolic pathway engineering based on metabolomics confers acetic and formic acid tolerance to a recombinant xylose-fermenting strain of Saccharomyces cerevisiae. Microb Cell Fact. 2011;10(1):2.","journal-title":"Microb Cell Fact"},{"issue":"18","key":"781_CR18","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1128\/AEM.01030-08","volume":"74","author":"DA Abbott","year":"2008","unstructured":"Abbott DA, Suir E, van Maris AJ, Pronk JT. Physiological and transcriptional responses to high concentrations of lactic acid in anaerobic chemostat cultures of Saccharomyces cerevisiae. Appl Environ Microbiol. 2008;74(18):5759\u201368.","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"781_CR19","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1128\/AEM.03718-15","volume":"82","author":"Y Chen","year":"2016","unstructured":"Chen Y, Stabryla L, Wei N. Improved acetic acid resistance in Saccharomyces cerevisiae by overexpression of the WHI2 gene identified through inverse metabolic engineering. Appl Environ Microbiol. 2016;82(7):2156\u201366.","journal-title":"Appl Environ Microbiol"},{"issue":"4","key":"781_CR20","doi-asserted-by":"publisher","first-page":"302","DOI":"10.4489\/MYCO.2010.38.4.302","volume":"38","author":"SE Lee","year":"2010","unstructured":"Lee SE, Park BS, Yoon JJ. Proteomic evaluation of cellular responses of Saccharomyces cerevisiae to formic acid stress. Mycobiology. 2010;38(4):302\u20139.","journal-title":"Mycobiology."},{"issue":"4","key":"781_CR21","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1567-1364.2008.00375.x","volume":"8","author":"L Du","year":"2008","unstructured":"Du L, Su Y, Sun D, Zhu W, Wang J, Zhuang X, Zhou S, Lu Y. Formic acid induces Yca1p-independent apoptosis-like cell death in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2008;8(4):531\u20139.","journal-title":"FEMS Yeast Res"},{"issue":"11\u201312","key":"781_CR22","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/S0891-5849(99)00147-1","volume":"27","author":"PW Piper","year":"1999","unstructured":"Piper PW. Yeast superoxide dismutase mutants reveal a pro-oxidant action of weak organic acid food preservatives. Free Radic Biol Med. 1999;27(11\u201312):1219\u201327.","journal-title":"Free Radic Biol Med."},{"issue":"1","key":"781_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0005-2736(96)00245-3","volume":"1325","author":"V Carmelo","year":"1997","unstructured":"Carmelo V, Santos H, Sa-Correia I. Effect of extracellular acidification on the activity of plasma membrane ATPase and on the cytosolic and vacuolar pH of Saccharomyces cerevisiae. Biochim Biophys Acta. 1997;1325(1):63\u201370.","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"781_CR24","doi-asserted-by":"publisher","first-page":"4016","DOI":"10.1099\/mic.0.2007\/010298-0","volume":"153","author":"V Makrantoni","year":"2007","unstructured":"Makrantoni V, Dennison P, Stark MJ, Coote PJ. A novel role for the yeast protein kinase Dbf2p in vacuolar H+-ATPase function and sorbic acid stress tolerance. Microbiology. 2007;153(12):4016\u201326.","journal-title":"Microbiology"},{"issue":"23","key":"781_CR25","doi-asserted-by":"publisher","first-page":"4311","DOI":"10.1042\/BCJ20160565","volume":"473","author":"JF Guerreiro","year":"2016","unstructured":"Guerreiro JF, Muir A, Ramachandran S, Thorner J, Sa-Correia I. Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress. Biochem J. 2016;473(23):4311\u201325.","journal-title":"Biochem J."},{"issue":"3","key":"781_CR26","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/pmic.200700816","volume":"9","author":"B Almeida","year":"2009","unstructured":"Almeida B, Ohlmeier S, Almeida AJ, Madeo F, Leao C, Rodrigues F, Ludovico P. Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway. Proteomics. 2009;9(3):720\u201332.","journal-title":"Proteomics"},{"issue":"1","key":"781_CR27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.bbrc.2005.09.010","volume":"337","author":"AR Fernandes","year":"2005","unstructured":"Fernandes AR, Mira NP, Vargas RC, Canelhas I, Sa-Correia I. Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes. Biochem Biophys Res Commun. 2005;337(1):95\u2013103.","journal-title":"Biochem Biophys Res Commun"},{"issue":"16","key":"781_CR28","doi-asserted-by":"publisher","first-page":"6896","DOI":"10.1093\/nar\/gkr228","volume":"39","author":"NP Mira","year":"2011","unstructured":"Mira NP, Henriques SF, Keller G, Teixeira MC, Matos RG, Arraiano CM, Winge DR, Sa-Correia I. Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress. Nucleic Acids Res. 2011;39(16):6896\u2013907.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"781_CR29","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/2191-0855-3-74","volume":"3","author":"T Inaba","year":"2013","unstructured":"Inaba T, Watanabe D, Yoshiyama Y, Tanaka K, Ogawa J, Takagi H, Shimoi H, Shima J. An organic acid-tolerant HAA1-overexpression mutant of an industrial bioethanol strain of Saccharomyces cerevisiae and its application to the production of bioethanol from sugarcane molasses. AMB Express. 2013;3(1):74.","journal-title":"AMB Express."},{"issue":"3","key":"781_CR30","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jbiosc.2014.09.004","volume":"119","author":"Y Sakihama","year":"2015","unstructured":"Sakihama Y, Hasunuma T, Kondo A. Improved ethanol production from xylose in the presence of acetic acid by the overexpression of the HAA1 gene in Saccharomyces cerevisiae. J Biosci Bioeng. 2015;119(3):297\u2013302.","journal-title":"J Biosci Bioeng"},{"issue":"22","key":"781_CR31","doi-asserted-by":"publisher","first-page":"8161","DOI":"10.1128\/AEM.02356-12","volume":"78","author":"K Tanaka","year":"2012","unstructured":"Tanaka K, Ishii Y, Ogawa J, Shima J. Enhancement of acetic acid tolerance in Saccharomyces cerevisiae by overexpression of the HAA1 gene, encoding a transcriptional activator. Appl Environ Microbiol. 2012;78(22):8161\u20133.","journal-title":"Appl Environ Microbiol"},{"key":"781_CR32","unstructured":"Kondo A, Hasunuma T, Sakihama Y. Method For Producing Ethanol From Biomass. 2015. US20150218592."},{"issue":"1","key":"781_CR33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12934-016-0621-5","volume":"16","author":"S Swinnen","year":"2017","unstructured":"Swinnen S, Henriques SF, Shrestha R, Ho PW, Sa-Correia I, Nevoigt E. Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms. Microb Cell Fact. 2017;16(1):7.","journal-title":"Microb Cell Fact"},{"key":"781_CR34","unstructured":"Zahn K, Jacobson S. Acetate resistance in yeast based on introduction of a mutant haa1 allele. 2014. WO\/2014\/018450."},{"issue":"3","key":"781_CR35","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/abio.370130302","volume":"13","author":"W Babel","year":"1993","unstructured":"Babel W, Brinkmann U, Muller RH. The auxiliary substrate concept\u2014an approach for overcoming limits of microbial performances. Acta Biotechnol. 1993;13(3):211\u201342.","journal-title":"Acta Biotechnol"},{"issue":"6","key":"781_CR36","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/yea.856","volume":"19","author":"KM Overkamp","year":"2002","unstructured":"Overkamp KM, Kotter P, van der Hoek R, Schoondermark-Stolk S, Luttik MA, van Dijken JP, Pronk JT. Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae. Yeast. 2002;19(6):509\u201320.","journal-title":"Yeast"},{"issue":"6","key":"781_CR37","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/BF00131280","volume":"5","author":"W Hazeu","year":"1983","unstructured":"Hazeu W, Donker RA. A continuous culture study of methanol and formate utilization by the yeast Pichia pastoris. Biotechnol Lett. 1983;5(6):399\u2013404.","journal-title":"Biotechnol Lett"},{"issue":"3","key":"781_CR38","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00253-011-3085-x","volume":"90","author":"T Hasunuma","year":"2011","unstructured":"Hasunuma T, Sung KM, Sanda T, Yoshimura K, Matsuda F, Kondo A. Efficient fermentation of xylose to ethanol at high formic acid concentrations by metabolically engineered Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2011;90(3):997\u20131004.","journal-title":"Appl Microbiol Biotechnol"},{"issue":"8","key":"781_CR39","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1021\/ja039320j","volume":"126","author":"M Iwaki","year":"2004","unstructured":"Iwaki M, Rich PR. Direct detection of formate ligation in cytochrome c oxidase by ATR-FTIR spectroscopy. J Am Chem Soc. 2004;126(8):2386\u20139.","journal-title":"J Am Chem Soc"},{"issue":"2","key":"781_CR40","first-page":"135","volume":"136","author":"VS Haritos","year":"2003","unstructured":"Haritos VS, Dojchinov G. Cytochrome c oxidase inhibition in the rice weevil Sitophilus oryzae (L.) by formate, the toxic metabolite of volatile alkyl formates. Comp Biochem Physiol C: Toxicol Pharmacol. 2003;136(2):135\u201343.","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"issue":"2","key":"781_CR41","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/0006-291X(75)90856-6","volume":"67","author":"P Nicholls","year":"1975","unstructured":"Nicholls P. Formate as an inhibitor of cytochrome c oxidase. Biochem Biophys Res Commun. 1975;67(2):610\u20136.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"781_CR42","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0041-008X(91)90336-D","volume":"107","author":"E Chacon","year":"1991","unstructured":"Chacon E, Acosta D. Mitochondrial regulation of superoxide by Ca2+: an alternate mechanism for the cardiotoxicity of doxorubicin. Toxicol Appl Pharmacol. 1991;107(1):117\u201328.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"781_CR43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0006-8993(91)90703-X","volume":"539","author":"J Bralet","year":"1991","unstructured":"Bralet J, Bouvier C, Schreiber L, Boquillon M. Effect of acidosis on lipid peroxidation in brain slices. Brain Res. 1991;539(1):175\u20137.","journal-title":"Brain Res"},{"issue":"24","key":"781_CR44","doi-asserted-by":"publisher","first-page":"13549","DOI":"10.1073\/pnas.251091098","volume":"98","author":"AE Dikalova","year":"2001","unstructured":"Dikalova AE, Kadiiska MB, Mason RP. An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication\u2014role of the Fenton reaction. Proc Natl Acad Sci USA. 2001;98(24):13549\u201353.","journal-title":"Proc Natl Acad Sci USA."},{"issue":"6","key":"781_CR45","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.freeradbiomed.2012.07.021","volume":"53","author":"S Srinivasan","year":"2012","unstructured":"Srinivasan S, Avadhani NG. Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med. 2012;53(6):1252\u201363.","journal-title":"Free Radic Biol Med."},{"issue":"7","key":"781_CR46","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1128\/MCB.8.7.2848","volume":"8","author":"RF Gaber","year":"1988","unstructured":"Gaber RF, Styles CA, Fink GR. TRK1 encodes a plasma membrane protein required for high-affinity potassium transport in Saccharomyces cerevisiae. Mol Cell Biol. 1988;8(7):2848\u201359.","journal-title":"Mol Cell Biol"},{"issue":"5","key":"781_CR47","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.1128\/MCB.19.5.3328","volume":"19","author":"JM Mulet","year":"1999","unstructured":"Mulet JM, Leube MP, Kron SJ, Rios G, Fink GR, Serrano R. A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1\u2013Trk2 potassium transporter. Mol Cell Biol. 1999;19(5):3328\u201337.","journal-title":"Mol Cell Biol"},{"issue":"5","key":"781_CR48","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1093\/emboj\/21.5.920","volume":"21","author":"L Yenush","year":"2002","unstructured":"Yenush L, Mulet JM, Arino J, Serrano R. The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J. 2002;21(5):920\u20139.","journal-title":"EMBO J"},{"issue":"19","key":"781_CR49","doi-asserted-by":"publisher","first-page":"8683","DOI":"10.1128\/MCB.25.19.8683-8692.2005","volume":"25","author":"L Yenush","year":"2005","unstructured":"Yenush L, Merchan S, Holmes J, Serrano R. pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase. Mol Cell Biol. 2005;25(19):8683\u201392.","journal-title":"Mol Cell Biol"},{"key":"781_CR50","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/0076-6879(91)94030-G","volume":"194","author":"K Kohrer","year":"1991","unstructured":"Kohrer K, Domdey H. Preparation of high molecular weight RNA. Methods Enzymol. 1991;194:398\u2013405.","journal-title":"Methods Enzymol"},{"issue":"10","key":"781_CR51","doi-asserted-by":"publisher","first-page":"5470","DOI":"10.1128\/MCB.15.10.5470","volume":"15","author":"A Ferrando","year":"1995","unstructured":"Ferrando A, Kron SJ, Rios G, Fink GR, Serrano R. Regulation of cation transport in Saccharomyces cerevisiae by the salt tolerance gene HAL3. Mol Cell Biol. 1995;15(10):5470\u201381.","journal-title":"Mol Cell Biol"},{"issue":"24","key":"781_CR52","doi-asserted-by":"publisher","first-page":"14838","DOI":"10.1074\/jbc.273.24.14838","volume":"273","author":"R Madrid","year":"1998","unstructured":"Madrid R, Gomez MJ, Ramos J, Rodriguez-Navarro A. Ectopic potassium uptake in trk1 trk2 mutants of Saccharomyces cerevisiae correlates with a highly hyperpolarized membrane potential. J Biol Chem. 1998;273(24):14838\u201344.","journal-title":"J Biol Chem"},{"issue":"5874","key":"781_CR53","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1126\/science.1150021","volume":"320","author":"ME Hillenmeyer","year":"2008","unstructured":"Hillenmeyer ME, Fung E, Wildenhain J, Pierce SE, Hoon S, Lee W, Proctor M, St Onge RP, Tyers M, Koller D, et al. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science. 2008;320(5874):362\u20135.","journal-title":"Science"},{"issue":"3","key":"781_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsle\/fnu041","volume":"362","author":"M Duskova","year":"2015","unstructured":"Duskova M, Borovikova D, Herynkova P, Rapoport A, Sychrova H. The role of glycerol transporters in yeast cells in various physiological and stress conditions. FEMS Microbiol Lett. 2015;362(3):1\u20138.","journal-title":"FEMS Microbiol Lett"},{"issue":"11","key":"781_CR55","doi-asserted-by":"publisher","first-page":"5487","DOI":"10.1128\/MCB.11.11.5487","volume":"11","author":"ME Dumont","year":"1991","unstructured":"Dumont ME, Cardillo TS, Hayes MK, Sherman F. Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11(11):5487\u201396.","journal-title":"Mol Cell Biol"},{"issue":"2","key":"781_CR56","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0891-5849(03)00307-1","volume":"35","author":"MH Barros","year":"2003","unstructured":"Barros MH, Netto LE, Kowaltowski AJ. H(2)O(2) generation in Saccharomyces cerevisiae respiratory pet mutants: effect of cytochrome c. Free Radic Biol Med. 2003;35(2):179\u201388.","journal-title":"Free Radic Biol Med."},{"issue":"4","key":"781_CR57","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1046\/j.1365-2958.1999.01248.x","volume":"31","author":"MJ Tamas","year":"1999","unstructured":"Tamas MJ, Luyten K, Sutherland FC, Hernandez A, Albertyn J, Valadi H, Li H, Prior BA, Kilian SG, Ramos J, et al. Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol. 1999;31(4):1087\u2013104.","journal-title":"Mol Microbiol"},{"issue":"8","key":"781_CR58","doi-asserted-by":"publisher","first-page":"e0135626","DOI":"10.1371\/journal.pone.0135626","volume":"10","author":"CE Oshoma","year":"2015","unstructured":"Oshoma CE, Greetham D, Louis EJ, Smart KA, Phister TG, Powell C, Du C. Screening of non-Saccharomyces cerevisiae strains for tolerance to formic acid in bioethanol fermentation. PLoS One. 2015;10(8):e0135626.","journal-title":"PLoS One"},{"issue":"9","key":"781_CR59","doi-asserted-by":"publisher","first-page":"e0139306","DOI":"10.1371\/journal.pone.0139306","volume":"10","author":"M Kodedova","year":"2015","unstructured":"Kodedova M, Sychrova H. Changes in the sterol composition of the plasma membrane affect membrane potential, salt tolerance and the activity of multidrug resistance pumps in Saccharomyces cerevisiae. PLoS One. 2015;10(9):e0139306.","journal-title":"PLoS One"},{"issue":"9","key":"781_CR60","doi-asserted-by":"publisher","first-page":"e73936","DOI":"10.1371\/journal.pone.0073936","volume":"8","author":"L Lindberg","year":"2013","unstructured":"Lindberg L, Santos AX, Riezman H, Olsson L, Bettiga M. Lipidomic profiling of Saccharomyces cerevisiae and Zygosaccharomyces bailii reveals critical changes in lipid composition in response to acetic acid stress. PLoS One. 2013;8(9):e73936.","journal-title":"PLoS One"},{"issue":"16","key":"781_CR61","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1002\/(SICI)1097-0061(199812)14:16<1471::AID-YEA353>3.0.CO;2-Y","volume":"14","author":"G Daum","year":"1998","unstructured":"Daum G, Lees ND, Bard M, Dickson R. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast. 1998;14(16):1471\u2013510.","journal-title":"Yeast"},{"issue":"15","key":"781_CR62","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1046\/j.1432-1033.2003.03701.x","volume":"270","author":"BE Bauer","year":"2003","unstructured":"Bauer BE, Rossington D, Mollapour M, Mamnun Y, Kuchler K, Piper PW. Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants. Eur J Biochem. 2003;270(15):3189\u201395.","journal-title":"Eur J Biochem"},{"issue":"1","key":"781_CR63","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1042\/BJ20111264","volume":"441","author":"G Hueso","year":"2012","unstructured":"Hueso G, Aparicio-Sanchis R, Montesinos C, Lorenz S, Murguia JR, Serrano R. A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress. Biochem J. 2012;441(1):255\u201364.","journal-title":"Biochem J."},{"issue":"5","key":"781_CR64","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.molcel.2009.06.033","volume":"35","author":"M Binda","year":"2009","unstructured":"Binda M, Peli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C. The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell. 2009;35(5):563\u201373.","journal-title":"Mol Cell"},{"issue":"4","key":"781_CR65","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1534\/genetics.111.133363","volume":"189","author":"R Loewith","year":"2011","unstructured":"Loewith R, Hall MN. Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics. 2011;189(4):1177\u2013201.","journal-title":"Genetics"},{"issue":"2","key":"781_CR66","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00424-011-0959-9","volume":"462","author":"A Rivetta","year":"2011","unstructured":"Rivetta A, Kuroda T, Slayman C. Anion currents in yeast K+ transporters (TRK) characterize a structural homologue of ligand-gated ion channels. Pflugers Arch. 2011;462(2):315\u201330.","journal-title":"Pflugers Arch"}],"container-title":["Biotechnology for Biofuels"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13068-017-0781-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:22:03Z","timestamp":1492550523000},"score":1,"resource":{"primary":{"URL":"http:\/\/biotechnologyforbiofuels.biomedcentral.com\/articles\/10.1186\/s13068-017-0781-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,19]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["781"],"URL":"https:\/\/doi.org\/10.1186\/s13068-017-0781-5","relation":{},"ISSN":["1754-6834"],"issn-type":[{"value":"1754-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,19]]},"article-number":"96"}}