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Nevertheless, the economic viability of lignocellulosic ethanol is also dependent of an efficient utilization of the hemicellulosic fraction, which contains xylose as a major component in concentrations that can reach up to 40% of the total biomass in hardwoods and agricultural residues. This major bottleneck is mainly due to the necessity of chemical\/enzymatic treatments to hydrolyze hemicellulose into fermentable sugars and to the fact that xylose is not readily consumed by\n                      <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                      \u2014the most used organism for large-scale ethanol production. In this work, industrial\n                      <jats:italic>S. cerevisiae<\/jats:italic>\n                      strains, presenting robust traits such as thermotolerance and improved resistance to inhibitors, were evaluated as hosts for the cell-surface display of hemicellulolytic enzymes and optimized xylose assimilation, aiming at the development of whole-cell biocatalysts for consolidated bioprocessing of corn cob-derived hemicellulose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These modifications allowed the direct production of ethanol from non-detoxified hemicellulosic liquor obtained by hydrothermal pretreatment of corn cob, reaching an ethanol titer of 11.1\u00a0g\/L corresponding to a yield of 0.328\u00a0g\/g of potential xylose and glucose, without the need for external hydrolytic catalysts. Also, consolidated bioprocessing of pretreated corn cob was found to be more efficient for hemicellulosic ethanol production than simultaneous saccharification and fermentation with addition of commercial hemicellulases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results show the potential of industrial\n                      <jats:italic>S. cerevisiae<\/jats:italic>\n                      strains for the design of whole-cell biocatalysts and paves the way for the development of more efficient consolidated bioprocesses for lignocellulosic biomass valorization, further decreasing environmental and economic costs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13068-020-01780-2","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T06:02:48Z","timestamp":1596866568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Consolidated bioprocessing of corn cob-derived hemicellulose: engineered industrial Saccharomyces cerevisiae as efficient whole cell biocatalysts"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-1202","authenticated-orcid":false,"given":"Joana T.","family":"Cunha","sequence":"first","affiliation":[]},{"given":"Aloia","family":"Roman\u00ed","sequence":"additional","affiliation":[]},{"given":"Kentaro","family":"Inokuma","sequence":"additional","affiliation":[]},{"given":"Bj\u00f6rn","family":"Johansson","sequence":"additional","affiliation":[]},{"given":"Tomohisa","family":"Hasunuma","sequence":"additional","affiliation":[]},{"given":"Akihiko","family":"Kondo","sequence":"additional","affiliation":[]},{"given":"Luc\u00edlia","family":"Domingues","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"1780_CR1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13068-019-1541-5","volume":"12","author":"RA Cripwell","year":"2019","unstructured":"Cripwell RA, Rose SH, Favaro L, van Zyl WH. 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