{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:32:12Z","timestamp":1772127132337,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP150231"],"award-info":[{"award-number":["RP150231"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA186892-2"],"award-info":[{"award-number":["T32 CA186892-2"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genome Med"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13073-018-0535-4","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T04:40:56Z","timestamp":1522816856000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["The emerging roles of exosomes in the modulation of immune responses in cancer"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-1003","authenticated-orcid":false,"given":"Paul","family":"Kurywchak","sequence":"first","affiliation":[]},{"given":"Jena","family":"Tavormina","sequence":"additional","affiliation":[]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"535_CR1","doi-asserted-by":"publisher","unstructured":"Lindenbergh MFS, Stoorvogel W. Antigen presentation by extracellular vesicles from professional antigen-presenting cells. Annu Rev Immunol. 2018; \n                    https:\/\/doi.org\/10.1146\/annurev-immunol-041015-055700\n                    \n                  .","DOI":"10.1146\/annurev-immunol-041015-055700"},{"key":"535_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nature15756","volume":"527","author":"A Hoshino","year":"2015","unstructured":"Hoshino A, Costa-Silva B, Shen T-L, Rodrigues G, Hashimoto A, Mark MT, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329\u201335.","journal-title":"Nature"},{"key":"535_CR3","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.cell.2017.06.031","volume":"170","author":"BY Nabet","year":"2017","unstructured":"Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoon T, Kim BC, et al. Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer. Cell. 2017;170:352\u201366. e313","journal-title":"Cell"},{"key":"535_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/s41590-017-0043-5","volume":"19","author":"L Gao","year":"2018","unstructured":"Gao L, Wang L, Dai T, Jin K, Zhang Z, Wang S, et al. Tumor-derived exosomes antagonize innate antiviral immunity. Nat Immunol. 2018;19:233\u201345.","journal-title":"Nat Immunol"},{"key":"535_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1101\/sqb.2016.81.030932","volume":"81","author":"R Kalluri","year":"2016","unstructured":"Kalluri R, LeBleu VS. Discovery of double-stranded genomic DNA in circulating exosomes. Cold Spring Harb Symp Quant Biol. 2016;81:275\u201380.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"535_CR6","doi-asserted-by":"publisher","first-page":"15287","DOI":"10.1038\/ncomms15287","volume":"8","author":"A Takahashi","year":"2017","unstructured":"Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, et al. Exosomes maintain cellular homeostasis by excreting harmful DNA from cells. Nat Commun. 2017;8:15287.","journal-title":"Nat Commun"},{"key":"535_CR7","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.4049\/jimmunol.1601694","volume":"198","author":"Y Kitai","year":"2017","unstructured":"Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, et al. DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity. J Immunol. 2017;198:1649\u201359.","journal-title":"J Immunol"},{"key":"535_CR8","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/cr.2017.54","volume":"27","author":"Q Lian","year":"2017","unstructured":"Lian Q, Xu J, Yan S, Huang M, Ding H, Sun X, et al. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Res. 2017;27:784.","journal-title":"Cell Res"},{"key":"535_CR9","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature25432","volume":"553","author":"SF Bakhoum","year":"2018","unstructured":"Bakhoum SF, Ngo B, Laughney AM, Cavallo J-A, Murphy CJ, Ly P, et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018;553:467.","journal-title":"Nature"},{"key":"535_CR10","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1080\/15384047.2017.1281499","volume":"18","author":"S Yang","year":"2017","unstructured":"Yang S, Che SP, Kurywchak P, Tavormina JL, Gansmo LB, Correa de Sampaio P, et al. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. Cancer Biol Ther. 2017;18:158\u201365.","journal-title":"Cancer Biol Ther"},{"key":"535_CR11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","volume":"546","author":"S Kamerkar","year":"2017","unstructured":"Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Ruivo CF, Melo SA, et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017;546:498.","journal-title":"Nature"}],"container-title":["Genome Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13073-018-0535-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13073-018-0535-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13073-018-0535-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T13:06:42Z","timestamp":1589548002000},"score":1,"resource":{"primary":{"URL":"https:\/\/genomemedicine.biomedcentral.com\/articles\/10.1186\/s13073-018-0535-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["535"],"URL":"https:\/\/doi.org\/10.1186\/s13073-018-0535-4","relation":{},"ISSN":["1756-994X"],"issn-type":[{"value":"1756-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]},"assertion":[{"value":"26 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The MD Anderson Cancer Center and RK hold patents in the area of exosome biology and are licensed to Codiak Biosciences Inc. The MD Anderson Cancer Center and RK are stock equity holders in Codiak Biosciences Inc. RK receives research support from Codiak Biosciences Inc. and serves as a member of the board of directors of this company. PK and JT declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"23"}}