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Additionally, we found that B*51 genotype-phenotype correlations do not survive Bonferroni correction, while carriers of the rs76546355 risk allele predominate in BD cases with genital ulcers, positive pathergy test and positive BD family history (2.31\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>\u2009\u2264\u2009<jats:italic>P<\/jats:italic>\u2009\u2264\u20091.59\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>We found that the HLA-B*51 allele and the rs76546355\/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355\/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical manifestations in BD patients.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/s13075-015-0585-6","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T02:23:59Z","timestamp":1426645439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Characterization of the major histocompatibility complex locus association with Beh\u00e7et\u2019s disease in Iran"],"prefix":"10.1186","volume":"17","author":[{"given":"Joana M","family":"Xavier","sequence":"first","affiliation":[]},{"given":"Fereydoun","family":"Davatchi","sequence":"additional","affiliation":[]},{"given":"Olga","family":"Abade","sequence":"additional","affiliation":[]},{"given":"Farhad","family":"Shahram","sequence":"additional","affiliation":[]},{"given":"V\u00e2nia","family":"Francisco","sequence":"additional","affiliation":[]},{"given":"Bahar Sadeghi","family":"Abdollahi","sequence":"additional","affiliation":[]},{"given":"H\u00e9lder","family":"Trindade","sequence":"additional","affiliation":[]},{"given":"Abdolhadi","family":"Nadji","sequence":"additional","affiliation":[]},{"given":"Niloofar Mojarad","family":"Shafiee","sequence":"additional","affiliation":[]},{"given":"Fahmida","family":"Ghaderibarmi","sequence":"additional","affiliation":[]},{"given":"D\u00e1rio","family":"Ligeiro","sequence":"additional","affiliation":[]},{"given":"Sofia A","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"585_CR1","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S0198-8859(00)00249-4","volume":"62","author":"F Choukri","year":"2001","unstructured":"Choukri F, Chakib A, Himmich H, H\u00fce S, Caillat-Zucman S. 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