{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:22:02Z","timestamp":1778815322380,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associazione Italiana Sindrome e Malattia di Beh\u00e7et (SIMBA) - Onlus"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>To compare the patients\u2019 and physician\u2019s global assessment of disease activity in Beh\u00e7et\u2019s syndrome (BS) and investigate the frequency, magnitude, and determinants of potential discordance.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 226 adult BS patients with a median (IQR) age of 46.9 (35.6\u201355.2) years were enrolled across Italy, Greece, Portugal, and Spain. Demographic, clinical, and therapeutic variables, as well as the patient reported outcomes, were collected at the recruitment visit. The physical (PCS) and mental (MCS) component summary scores of the Short Form Questionnaire 36 (SF-36) and the Beh\u00e7et\u2019s syndrome Overall Damage Index (BODI) were calculated. Disease activity was assessed by the patients\u2019 (PtGA) and physician\u2019s global assessment (PGA) in a 10-cm visual analog scale, as well as the Beh\u00e7et Disease Current Activity Form (BDCAF). Discordance (\u2206) was calculated by subtracting the PGA from the PtGA and defined as positive (PtGA&gt;PGA) and negative (PtGA&lt;PGA) discordance using both a more stringent (\u2206\u2009=\u2009\u00b12) and a less stringent (\u2206\u2009=\u2009\u00b11) cutoff. Univariate and multivariate logistic regressions were performed.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Median PtGA and PGA scores were 2.0 (0.3\u20135.0) and 1.0 (0.0\u20133.0) cm, respectively. The discordance prevalence varied (from 29.6 to 55.3%) according to the cutoff applied, and the majority (&gt;\u200980%) of disagreements were due to patients rating higher their disease activity. Higher values of BDCAF were associated to increased rate of positive discordance. When BDCAF\u2009=\u20090, the median (IQR) values of PtGA and PGA were 0.2 (0\u20132) and 0 (0\u20131), respectively. PCS (adjusted odds ratio (adjOR) 0.96 per unit, 95% CI 0.93\u20130.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) and MCS (adjOR 0.96 per unit, 95% CI 0.93\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) were independently associated with positive discordance using both cutoffs. Active ocular involvement emerged as a potential determinant of negative discordance (adjOR 5.88, 95% CI 1.48\u201323.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.012).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>PtGA and PGA should be considered as complementary measures in BS, as patients and physicians may be influenced by different factors when assessing active disease manifestations. Particularly, PtGA may be a useful tool in the assessment of BS disease activity, as it carries a low risk to misclassify an inactive disease, and may allow to capture aspects of the patient\u2019s health that negatively affect his well-being and the treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13075-020-02362-1","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T11:02:48Z","timestamp":1606302168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Discordance between patient and physician global assessment of disease activity in Beh\u00e7et\u2019s syndrome: a multicenter study cohort"],"prefix":"10.1186","volume":"22","author":[{"name":"the BODI Project collaborators","sequence":"first","affiliation":[]},{"given":"Alberto","family":"Floris","sequence":"first","affiliation":[]},{"given":"Gerard","family":"Espinosa","sequence":"additional","affiliation":[]},{"given":"Luisa","family":"Serpa Pinto","sequence":"additional","affiliation":[]},{"given":"Nikolaos","family":"Kougkas","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Lo Monaco","sequence":"additional","affiliation":[]},{"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[]},{"given":"Ida","family":"Orlando","sequence":"additional","affiliation":[]},{"given":"George","family":"Bertsias","sequence":"additional","affiliation":[]},{"given":"Luca","family":"Cantarini","sequence":"additional","affiliation":[]},{"given":"Ricard","family":"Cervera","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Marcello","family":"Govoni","sequence":"additional","affiliation":[]},{"given":"Florenzo","family":"Iannone","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Mathieu","sequence":"additional","affiliation":[]},{"given":"Piergiorgio","family":"Neri","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Martins Silva","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Vasconcelos","sequence":"additional","affiliation":[]},{"given":"Monica","family":"Muntoni","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Cauli","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-8315","authenticated-orcid":false,"given":"Matteo","family":"Piga","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"2362_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nrrheum.2017.208","volume":"14","author":"H Yazici","year":"2018","unstructured":"Yazici H, Seyahi E, Hatemi G, Yazici Y. 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