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The underlying mechanisms have not been fully understood, but gut microbiota is hypothesized to play a key role. Our aim was to evaluate the association between gut microbiota changes and anthropometric, metabolic and inflammatory profiles after metabolic surgery compared with medical therapy, in type 2 diabetic (T2DM) adults with mild obesity (BMI 30\u201335\u00a0kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>DM<jats:sup>2<\/jats:sup> was an open-label, randomised controlled clinical trial (RCT: ISRCTN53984585) with 2 arms: (i) surgical, and (ii) medical. The main outcome was gut microbiota changes after: metabolic surgery (Roux-en-Y gastric bypass\u2014RYGB) <jats:italic>versus<\/jats:italic> standard medical therapy. Secondary outcomes included anthropometric, metabolic and inflammatory profiles. Clinical visits, blood workup, and stool samples were collected at baseline and months (M)1, 3, 6, 12. Gut microbiota was profiled using 16S rRNA targeted sequencing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty patients were included: 10 in surgical and 10 in medical arm. Anthropometric and metabolic comparative analysis favoured RYGB over medical arm. At M12, the percentage of weight loss was 25.5 vs. 4.9% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and HbA1c was 6.2 vs. 7.7% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) respectively.  We observed a continuous increase of genus richness after RYGB up until M12. In the medical arm, genus richness ended-up being significantly lower at M12. Composition analysis indicated significant changes of the overall microbial ecosystem (permanova <jats:italic>p<\/jats:italic>\u2009=\u20090.004, [<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.17]) during the follow-up period after RYGB. There was a strong association between improvement of anthropometric\/metabolic\/inflammatory biomarkers and increase in microbial richness and Proteobacterial lineages.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This was the first RCT studying composite clinical, analytic, and microbiome changes in T2DM patients with class 1 obesity after RYGB <jats:italic>versus<\/jats:italic> standard medical therapy. The remarkable phenotypic improvement after surgery occurred concomitantly with changes in the gut microbiome, but at a lower level.<\/jats:p>\n                <jats:p><jats:italic>Trial registration:<\/jats:italic> ISRCTN53984585<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13098-021-00672-1","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T11:02:51Z","timestamp":1621594971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Gut microbiota changes after metabolic surgery in adult diabetic patients with mild obesity: a randomised controlled trial"],"prefix":"10.1186","volume":"13","author":[{"given":"Eva","family":"Lau","sequence":"first","affiliation":[]},{"given":"Eugeni","family":"Belda","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Picq","sequence":"additional","affiliation":[]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Ferreira-Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Maria Manuel","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Isaac","family":"Barroso","sequence":"additional","affiliation":[]},{"given":"Flora","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Cid\u00e1lia Pina","family":"Vaz","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Miranda","sequence":"additional","affiliation":[]},{"given":"Adelino","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"Karine","family":"Cl\u00e9ment","sequence":"additional","affiliation":[]},{"given":"Joel","family":"Dor\u00e9","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Freitas","sequence":"additional","affiliation":[]},{"given":"Edi","family":"Prifti","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"issue":"1","key":"672_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","volume":"377","author":"Collaborators TG 2015 O","year":"2017","unstructured":"Collaborators TG 2015 O. 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