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In the present study, we investigated potential apolipoprotein E (<jats:italic>APOE<\/jats:italic>)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the <jats:italic>APOE<\/jats:italic> \u03b54 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>WM hyperintensity volume was significantly greater in non-carriers of the <jats:italic>APOE<\/jats:italic> \u03b54 allele. Lesion distribution was similar among \u03b54 carriers and non-carriers. Only \u03b54 non-carriers showed a correlation between lesion volume and cognitive performance.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the <jats:italic>APOE<\/jats:italic> \u03b54 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without <jats:italic>APOE<\/jats:italic> \u03b54-mediated risk.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/s13195-015-0111-8","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T09:22:27Z","timestamp":1425892947000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer\u2019s disease: a voxel-based lesion mapping study"],"prefix":"10.1186","volume":"7","author":[{"given":"Katrin","family":"Morgen","sequence":"first","affiliation":[]},{"given":"Michael","family":"Schneider","sequence":"additional","affiliation":[]},{"given":"Lutz","family":"Fr\u00f6lich","sequence":"additional","affiliation":[]},{"given":"Heike","family":"Tost","sequence":"additional","affiliation":[]},{"given":"Michael M","family":"Plichta","sequence":"additional","affiliation":[]},{"given":"Heike","family":"K\u00f6lsch","sequence":"additional","affiliation":[]},{"given":"Fabian","family":"Rakebrandt","sequence":"additional","affiliation":[]},{"given":"Otto","family":"Rienhoff","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[]},{"given":"Holger","family":"Jahn","sequence":"additional","affiliation":[]},{"given":"Christian","family":"Luckhaus","sequence":"additional","affiliation":[]},{"given":"Michael","family":"H\u00fcll","sequence":"additional","affiliation":[]},{"given":"Hermann-Josef","family":"Gertz","sequence":"additional","affiliation":[]},{"given":"Johannes","family":"Schr\u00f6der","sequence":"additional","affiliation":[]},{"given":"Harald","family":"Hampel","sequence":"additional","affiliation":[]},{"given":"Stefan J","family":"Teipel","sequence":"additional","affiliation":[]},{"given":"Johannes","family":"Pantel","sequence":"additional","affiliation":[]},{"given":"Isabella","family":"Heuser","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[]},{"given":"Eckart","family":"R\u00fcther","sequence":"additional","affiliation":[]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Meyer-Lindenberg","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"111_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","volume":"9","author":"L Pantoni","year":"2010","unstructured":"Pantoni L. 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