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The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (<jats:italic>p<\/jats:italic> &lt; 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (<jats:italic>p<\/jats:italic> &lt; 0.001). The addition of both markers further increased the AUC to 0.90 (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13195-024-01383-1","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T01:01:59Z","timestamp":1705021319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic accuracy of research criteria for prodromal frontotemporal 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