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The anti-tumour potential of these molecules is being studied, although results are still scarce and few data are available regarding the mechanisms underlying such activity. In this work, the anti-tumour activity of a surfactin produced by <jats:italic>Bacillus subtilis<\/jats:italic> 573 and a glycoprotein (BioEG) produced by <jats:italic>Lactobacillus paracasei<\/jats:italic> subsp. <jats:italic>paracasei<\/jats:italic> A20 was evaluated. Both biosurfactants were tested against two breast cancer cell lines, T47D and MDA-MB-231, and a non-tumour fibroblast cell line (MC-3\u00a0T3-E1), specifically regarding cell viability and proliferation. Surfactin was found to decrease viability of both breast cancer cell lines studied. A 24\u00a0h exposure to 0.05\u00a0g\u00a0l<jats:sup>-1<\/jats:sup> surfactin led to inhibition of cell proliferation as shown by cell cycle arrest at G1 phase. Similarly, exposure of cells to 0.15\u00a0g\u00a0l<jats:sup>-1<\/jats:sup> BioEG for 48\u00a0h decreased cancer cells\u2019 viability, without affecting normal fibroblasts. Moreover, BioEG induced the cell cycle arrest at G1 for both breast cancer cell lines. The biosurfactant BioEG was shown to be more active than surfactin against the studied breast cancer cells. The results gathered in this work are very promising regarding the biosurfactants potential for breast cancer treatment and encourage further work with the BioEG glycoprotein.<\/jats:p>","DOI":"10.1186\/s13568-014-0040-0","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T13:34:26Z","timestamp":1397482466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Effects of biosurfactants on the viability and proliferation of human breast cancer cells"],"prefix":"10.1186","volume":"4","author":[{"given":"Cristina","family":"Duarte","sequence":"first","affiliation":[]},{"given":"Eduardo J","family":"Gudi\u00f1a","sequence":"additional","affiliation":[]},{"given":"Cristovao F","family":"Lima","sequence":"additional","affiliation":[]},{"given":"Ligia R","family":"Rodrigues","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"40_CR1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00253-010-2589-0","volume":"87","author":"IM Banat","year":"2010","unstructured":"Banat IM, Franzetti A, Gandolfi I, Bestetti G, Martinotti MG, Fracchia L, Smyth TJ, Marchant R: Microbial biosurfactants production, applications and future potential. 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