{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:58:14Z","timestamp":1776434294035,"version":"3.51.2"},"reference-count":274,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MASK-Air"},{"name":"Aria"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Allergy"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR\u03b3:Peroxisome proliferator-activated receptor, NF\u03baB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2\u03b1:Elongation initiation factor 2\u03b1). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT<jats:sub>1<\/jats:sub>R axis (AT<jats:sub>1<\/jats:sub>R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and\/or TRPV1.\u00a0Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.<\/jats:p>","DOI":"10.1186\/s13601-020-00362-7","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T12:03:07Z","timestamp":1606996987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies"],"prefix":"10.1002","volume":"10","author":[{"name":"the ARIA group","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9226-7762","authenticated-orcid":false,"given":"Jean","family":"Bousquet","sequence":"first","affiliation":[]},{"given":"Jean-Paul","family":"Cristol","sequence":"additional","affiliation":[]},{"given":"Wienczyslawa","family":"Czarlewski","sequence":"additional","affiliation":[]},{"given":"Josep M.","family":"Anto","sequence":"additional","affiliation":[]},{"given":"Adrian","family":"Martineau","sequence":"additional","affiliation":[]},{"given":"Tari","family":"Haahtela","sequence":"additional","affiliation":[]},{"given":"Susana C.","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Guido","family":"Iaccarino","sequence":"additional","affiliation":[]},{"given":"Hubert","family":"Blain","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Fiocchi","sequence":"additional","affiliation":[]},{"given":"G. Walter","family":"Canonica","sequence":"additional","affiliation":[]},{"given":"Joao A.","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Alain","family":"Vidal","sequence":"additional","affiliation":[]},{"given":"Hak-Jong","family":"Choi","sequence":"additional","affiliation":[]},{"given":"Hyun Ju","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Le Moing","sequence":"additional","affiliation":[]},{"given":"Jacques","family":"Reynes","sequence":"additional","affiliation":[]},{"given":"Aziz","family":"Sheikh","sequence":"additional","affiliation":[]},{"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[]},{"given":"Torsten","family":"Zuberbier","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"issue":"6493","key":"362_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1126\/science.abb5793","volume":"368","author":"SM Kissler","year":"2020","unstructured":"Kissler SM, Tedijanto C, Goldstein E, Grad YH, Lipsitch M. Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period. Science. 2020;368(6493):860\u20138.","journal-title":"Science."},{"key":"362_CR2","doi-asserted-by":"crossref","unstructured":"Bousquet J, Czarlewski W, Blain H, Zuberbier T, Anto J. Rapid Response: Why Germany\u2019s case fatality rate seems so low: Is nutrition another possibility. bmj. 2020. https:\/\/www.bmj.com\/content\/369\/bmj.m1395\/rr-12.","DOI":"10.1136\/bmj.m1395"},{"key":"362_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13601-020-00323-0","volume":"10","author":"J Bousquet","year":"2020","unstructured":"Bousquet J, Anto JM, Iaccarino G, Czarlewski W, Haahtela T, Anto A, et al. Is diet partly responsible for differences in COVID-19 death rates between and within countries? Clin Transl Allergy. 2020;10:16.","journal-title":"Clin Transl Allergy"},{"issue":"12","key":"362_CR4","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1021\/acschemneuro.0c00239","volume":"11","author":"Y Elsayed","year":"2020","unstructured":"Elsayed Y, Khan NA. Immunity-boosting spices and the novel coronavirus. ACS Chem Neurosci. 2020;11(12):1696\u20138.","journal-title":"ACS Chem Neurosci"},{"key":"362_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/all.14549","author":"J Bousquet","year":"2020","unstructured":"Bousquet J, Anto JM, Czarlewski W, Haahtela T, Fonseca SC, Iaccarino G, et al. Cabbage and fermented vegetables: from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19. Allergy. 2020. https:\/\/doi.org\/10.1111\/all.14549.","journal-title":"Allergy."},{"key":"362_CR6","doi-asserted-by":"crossref","unstructured":"Fonseca S, Rivas I, Romaguera D, Quijal M, Czarlewski W, Vidal A, et al. Association between consumption of fermented vegetables and COVID-19 mortality at a country level in Europe MEDRXIV\/2020\/147025 2020.","DOI":"10.1101\/2020.07.06.20147025"},{"key":"362_CR7","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.17.20155846","author":"S Fonseca","year":"2020","unstructured":"Fonseca S, Rivas I, Romaguera D, Quijal M, Czarlewski W, Vidal A, et al. Association between consumption of vegetables and COVID-19 mortality at a country level in Europe. MedRix. 2020. https:\/\/doi.org\/10.1101\/2020.07.17.20155846.","journal-title":"MedRix."},{"issue":"17","key":"362_CR8","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1089\/ars.2017.7342","volume":"29","author":"C Tonelli","year":"2018","unstructured":"Tonelli C, Chio IIC, Tuveson DA. Transcriptional regulation by Nrf2. Antioxid Redox Signal. 2018;29(17):1727\u201345.","journal-title":"Antioxid Redox Signal"},{"key":"362_CR9","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.cca.2015.07.009","volume":"448","author":"AS Jimenez-Osorio","year":"2015","unstructured":"Jimenez-Osorio AS, Gonzalez-Reyes S, Pedraza-Chaverri J. Natural Nrf2 activators in diabetes. Clin Chim Acta. 2015;448:182\u201392.","journal-title":"Clin Chim Acta"},{"issue":"1","key":"362_CR10","first-page":"1","volume":"67","author":"ML Pall","year":"2015","unstructured":"Pall ML, Levine S. Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. Sheng Li Xue Bao. 2015;67(1):1\u201318.","journal-title":"Sheng Li Xue Bao"},{"issue":"6","key":"362_CR11","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.3390\/nu12061562","volume":"12","author":"M Iddir","year":"2020","unstructured":"Iddir M, Brito A, Dingeo G, Fernandez Del Campo SS, Samouda H, La Frano MR, et al. Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis. Nutrients. 2020;12(6):1562.","journal-title":"Nutrients."},{"issue":"2","key":"362_CR12","doi-asserted-by":"publisher","first-page":"134","DOI":"10.5455\/medarh.2020.74.134-138","volume":"74","author":"SM Hassan","year":"2020","unstructured":"Hassan SM, Jawad MJ, Ahjel SW, Singh RB, Singh J, Awad SM, et al. The Nrf2 activator (DMF) and covid-19: is there a possible role? Med Arch. 2020;74(2):134\u20138.","journal-title":"Med Arch"},{"key":"362_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.07.003","author":"A Cuadrado","year":"2020","unstructured":"Cuadrado A, Pajares M, Benito C, Jimenez-Villegas J, Escoll M, Fernandez-Gines R, et al. Can activation of NRF2 be a strategy against COVID-19? Trends Pharmacol Sci. 2020. https:\/\/doi.org\/10.1016\/j.tips.2020.07.003.","journal-title":"Trends Pharmacol Sci."},{"issue":"10","key":"362_CR14","doi-asserted-by":"publisher","first-page":"e13095","DOI":"10.1111\/obr.13095","volume":"21","author":"M Foldi","year":"2020","unstructured":"Foldi M, Farkas N, Kiss S, Zadori N, Vancsa S, Szako L, et al. Obesity is a risk factor for developing critical condition in COVID-19 patients: a systematic review and meta-analysis. Obes Rev. 2020;21(10):e13095.","journal-title":"Obes Rev."},{"issue":"8","key":"362_CR15","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3390\/antiox9080659","volume":"9","author":"P Mendonca","year":"2020","unstructured":"Mendonca P, Soliman KFA. Flavonoids activation of the transcription factor Nrf2 as a hypothesis approach for the prevention and modulation of SARS-CoV-2 infection severity. Antioxidants (Basel). 2020;9(8):659.","journal-title":"Antioxidants (Basel)."},{"key":"362_CR16","doi-asserted-by":"publisher","first-page":"117513","DOI":"10.1016\/j.lfs.2020.117513","volume":"249","author":"FJ Mocayar Maron","year":"2020","unstructured":"Mocayar Maron FJ, Camargo AB, Manucha W. Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases. Life Sci. 2020;249:117513.","journal-title":"Life Sci"},{"issue":"9","key":"362_CR17","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.3390\/nu11092112","volume":"11","author":"M Schwarz","year":"2019","unstructured":"Schwarz M, Lossow K, Kopp JF, Schwerdtle T, Kipp AP. Crosstalk of Nrf2 with the trace elements selenium, iron, zinc, and copper. Nutrients. 2019;11(9):2112.","journal-title":"Nutrients."},{"issue":"1","key":"362_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbrc.2015.01.008","volume":"460","author":"MJ Berridge","year":"2015","unstructured":"Berridge MJ. Vitamin D cell signalling in health and disease. Biochem Biophys Res Commun. 2015;460(1):53\u201371.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"362_CR19","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/v8070184","volume":"8","author":"TS Fung","year":"2016","unstructured":"Fung TS, Liao Y, Liu DX. Regulation of stress responses and translational control by coronavirus. Viruses. 2016;8(7):184.","journal-title":"Viruses."},{"key":"362_CR20","doi-asserted-by":"publisher","first-page":"117842","DOI":"10.1016\/j.lfs.2020.117842","volume":"255","author":"A Banerjee","year":"2020","unstructured":"Banerjee A, Czinn SJ, Reiter RJ, Blanchard TG. Crosstalk between endoplasmic reticulum stress and anti-viral activities: a novel therapeutic target for COVID-19. Life Sci. 2020;255:117842.","journal-title":"Life Sci"},{"issue":"Pt 5","key":"362_CR21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1107\/S0907444911006445","volume":"67","author":"W Cui","year":"2011","unstructured":"Cui W, Li J, Ron D, Sha B. The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallogr D Biol Crystallogr. 2011;67(Pt 5):423\u20138.","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"9","key":"362_CR22","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.molmet.2017.06.001","volume":"6","author":"M Cnop","year":"2017","unstructured":"Cnop M, Toivonen S, Igoillo-Esteve M, Salpea P. Endoplasmic reticulum stress and eIF2alpha phosphorylation: the Achilles heel of pancreatic beta cells. Mol Metab. 2017;6(9):1024\u201339.","journal-title":"Mol Metab"},{"key":"362_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/1743-422X-6-131","volume":"6","author":"S Pfefferle","year":"2009","unstructured":"Pfefferle S, Krahling V, Ditt V, Grywna K, Muhlberger E, Drosten C. Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo. Virol J. 2009;6:131.","journal-title":"Virol J"},{"issue":"2","key":"362_CR24","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1128\/AAC.03659-14","volume":"59","author":"J Kindrachuk","year":"2015","unstructured":"Kindrachuk J, Ork B, Hart BJ, Mazur S, Holbrook MR, Frieman MB, et al. Antiviral potential of ERK\/MAPK and PI3K\/AKT\/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis. Antimicrob Agents Chemother. 2015;59(2):1088\u201399.","journal-title":"Antimicrob Agents Chemother"},{"issue":"15","key":"362_CR25","doi-asserted-by":"publisher","first-page":"5301","DOI":"10.3390\/ijms21155301","volume":"21","author":"TJ Rios-Fuller","year":"2020","unstructured":"Rios-Fuller TJ, Mahe M, Walters B, Abbadi D, Perez-Baos S, Gadi A, et al. Translation regulation by eIF2alpha phosphorylation and mTORC1 signaling pathways in Non-Communicable Diseases (NCDs). Int J Mol Sci. 2020;21(15):5301.","journal-title":"Int J Mol Sci."},{"issue":"2","key":"362_CR26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","volume":"169","author":"RA Saxton","year":"2017","unstructured":"Saxton RA, Sabatini DM. mTOR Signaling in growth, metabolism, and disease. Cell. 2017;169(2):361\u201371.","journal-title":"Cell"},{"key":"362_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","volume":"10","author":"SA Oakes","year":"2015","unstructured":"Oakes SA, Papa FR. The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 2015;10:173\u201394.","journal-title":"Annu Rev Pathol"},{"issue":"8","key":"362_CR28","first-page":"705","volume":"41","author":"JS So","year":"2018","unstructured":"So JS. Roles of endoplasmic reticulum stress in immune responses. Mol Cells. 2018;41(8):705\u201316.","journal-title":"Mol Cells"},{"issue":"8","key":"362_CR29","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.tem.2015.05.007","volume":"26","author":"L Salvado","year":"2015","unstructured":"Salvado L, Palomer X, Barroso E, Vazquez-Carrera M. Targeting endoplasmic reticulum stress in insulin resistance. Trends Endocrinol Metab. 2015;26(8):438\u201348.","journal-title":"Trends Endocrinol Metab"},{"key":"362_CR30","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.mam.2018.11.001","volume":"66","author":"R Villalobos-Labra","year":"2019","unstructured":"Villalobos-Labra R, Subiabre M, Toledo F, Pardo F, Sobrevia L. Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity. Mol Aspects Med. 2019;66:49\u201361.","journal-title":"Mol Aspects Med"},{"issue":"20","key":"362_CR31","doi-asserted-by":"publisher","first-page":"29605","DOI":"10.18632\/oncotarget.8812","volume":"7","author":"M Li","year":"2016","unstructured":"Li M, Wang W, Dan Y, Tong Z, Chen W, Qin L, et al. Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma. Oncotarget. 2016;7(20):29605\u201319.","journal-title":"Oncotarget"},{"issue":"Pt B","key":"362_CR32","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2015.05.027","volume":"88","author":"L Cominacini","year":"2015","unstructured":"Cominacini L, Mozzini C, Garbin U, Pasini A, Stranieri C, Solani E, et al. Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases. Free Radic Biol Med. 2015;88(Pt B):233\u201342.","journal-title":"Free Radic Biol Med"},{"key":"362_CR33","doi-asserted-by":"crossref","unstructured":"Yao C, Bora SA, Parimon T, Zaman T, Friedman OA, Palatinus JA, et al. Cell type-specific immune dysregulation in severely ill COVID-19 patients. medRxiv. 2020.","DOI":"10.1101\/2020.07.23.20161182"},{"issue":"1","key":"362_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11906-012-0323-2","volume":"15","author":"PC Underwood","year":"2013","unstructured":"Underwood PC, Adler GK. The renin angiotensin aldosterone system and insulin resistance in humans. Curr Hypertens Rep. 2013;15(1):59\u201370.","journal-title":"Curr Hypertens Rep"},{"issue":"4","key":"362_CR35","doi-asserted-by":"publisher","first-page":"34","DOI":"10.5494\/wjh.v2.i4.34","volume":"2","author":"H Wen","year":"2012","unstructured":"Wen H, Gwathmey JK, Xie LH. Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. World J Hypertens. 2012;2(4):34\u201344.","journal-title":"World J Hypertens"},{"issue":"6","key":"362_CR36","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3109\/10641963.2014.943402","volume":"36","author":"SR Bhatt","year":"2014","unstructured":"Bhatt SR, Lokhandwala MF, Banday AA. Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B. Clin Exp Hypertens. 2014;36(6):367\u201373.","journal-title":"Clin Exp Hypertens"},{"issue":"5","key":"362_CR37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1055\/a-1155-0501","volume":"52","author":"R Dalan","year":"2020","unstructured":"Dalan R, Bornstein SR, El-Armouche A, Rodionov RN, Markov A, Wielockx B, et al. The ACE-2 in COVID-19: Foe or Friend? Horm Metab Res. 2020;52(5):257\u201363.","journal-title":"Horm Metab Res"},{"issue":"2","key":"362_CR38","doi-asserted-by":"publisher","first-page":"L325","DOI":"10.1152\/ajplung.00189.2020","volume":"319","author":"R Sarzani","year":"2020","unstructured":"Sarzani R, Giulietti F, Di Pentima C, Giordano P, Spannella F. Disequilibrium between the classic renin-angiotensin system and its opposing arm in Sars-Cov-2 related lung injury. Am J Physiol Lung Cell Mol Physiol. 2020;319(2):L325-36.","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"362_CR39","doi-asserted-by":"crossref","unstructured":"Bousquet J, Anto J, Czarlewski W, Haahtela T, Fonseca S, Iaccarino G, et al. Sulforaphane: from death rate heterogeneity in countries to candidate for prevention of severe COVID-19 Allergy. 2020; submitted.","DOI":"10.22541\/au.159493397.79345039"},{"issue":"1","key":"362_CR40","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12933-020-01035-2","volume":"19","author":"H Ren","year":"2020","unstructured":"Ren H, Yang Y, Wang F, Yan Y, Shi X, Dong K, et al. Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19. Cardiovasc Diabetol. 2020;19(1):58.","journal-title":"Cardiovasc Diabetol"},{"issue":"7","key":"362_CR41","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.3390\/jcm9072315","volume":"9","author":"O Villard","year":"2020","unstructured":"Villard O, Morquin D, Molinari N, Raingeard I, Nagot N, Cristol JP, et al. The plasmatic aldosterone and C-reactive protein levels, and the severity of Covid-19: the Dyhor-19 study. J Clin Med. 2020;9(7):2315.","journal-title":"J Clin Med."},{"issue":"1","key":"362_CR42","doi-asserted-by":"publisher","first-page":"8481","DOI":"10.1038\/s41598-019-44834-8","volume":"9","author":"KR Menikdiwela","year":"2019","unstructured":"Menikdiwela KR, Ramalingam L, Allen L, Scoggin S, Kalupahana NS, Moustaid-Moussa N. Angiotensin II increases endoplasmic reticulum stress in adipose tissue and adipocytes. Sci Rep. 2019;9(1):8481.","journal-title":"Sci Rep"},{"issue":"1","key":"362_CR43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12944-019-1145-x","volume":"18","author":"X Cao","year":"2019","unstructured":"Cao X, Lu XM, Tuo X, Liu JY, Zhang YC, Song LN, et al. Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism. Lipids Health Dis. 2019;18(1):207.","journal-title":"Lipids Health Dis"},{"issue":"12","key":"362_CR44","doi-asserted-by":"publisher","first-page":"e0145413","DOI":"10.1371\/journal.pone.0145413","volume":"10","author":"D Murugan","year":"2015","unstructured":"Murugan D, Lau YS, Lau CW, Mustafa MR, Huang Y. Angiotensin 1\u20137 protects against angiotensin II-induced endoplasmic reticulum stress and endothelial dysfunction via mas receptor. PLoS ONE. 2015;10(12):e0145413.","journal-title":"PLoS ONE"},{"issue":"1","key":"362_CR45","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1128\/AAC.03999-14","volume":"59","author":"X Zhao","year":"2015","unstructured":"Zhao X, Guo F, Comunale MA, Mehta A, Sehgal M, Jain P, et al. Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. Antimicrob Agents Chemother. 2015;59(1):206\u201316.","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"362_CR46","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","volume":"1863","author":"SM Ahmed","year":"2017","unstructured":"Ahmed SM, Luo L, Namani A, Wang XJ, Tang X. Nrf2 signaling pathway: Pivotal roles in inflammation. Biochim Biophys Acta Mol Basis Dis. 2017;1863(2):585\u201397.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"3","key":"362_CR47","doi-asserted-by":"publisher","first-page":"R83","DOI":"10.1530\/JOE-14-0662","volume":"225","author":"B Chen","year":"2015","unstructured":"Chen B, Lu Y, Chen Y, Cheng J. The role of Nrf2 in oxidative stress-induced endothelial injuries. J Endocrinol. 2015;225(3):R83-99.","journal-title":"J Endocrinol"},{"issue":"2","key":"362_CR48","doi-asserted-by":"publisher","first-page":"L155","DOI":"10.1152\/ajplung.00449.2016","volume":"312","author":"H Zhao","year":"2017","unstructured":"Zhao H, Eguchi S, Alam A, Ma D. The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury. Am J Physiol Lung Cell Mol Physiol. 2017;312(2):L155\u201362.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"Pt B","key":"362_CR49","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.freeradbiomed.2015.06.014","volume":"88","author":"T Jiang","year":"2015","unstructured":"Jiang T, Harder B, de la Vega MR, Wong PK, Chapman E, Zhang DD. p62 links autophagy and Nrf2 signaling. Free Radic Biol Med. 2015;88(Pt B):199\u2013204.","journal-title":"Free Radic Biol Med."},{"issue":"4","key":"362_CR50","doi-asserted-by":"publisher","first-page":"e1973","DOI":"10.1002\/rmv.1973","volume":"28","author":"A Abdoli","year":"2018","unstructured":"Abdoli A, Alirezaei M, Mehrbod P, Forouzanfar F. Autophagy: The multi-purpose bridge in viral infections and host cells. Rev Med Virol. 2018;28(4):e1973.","journal-title":"Rev Med Virol"},{"key":"362_CR51","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1146\/annurev-micro-020518-115759","volume":"73","author":"TS Fung","year":"2019","unstructured":"Fung TS, Liu DX. Human coronavirus: host-pathogen interaction. Annu Rev Microbiol. 2019;73:529\u201357.","journal-title":"Annu Rev Microbiol"},{"issue":"7","key":"362_CR52","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3390\/cells9071619","volume":"9","author":"M Bello-Perez","year":"2020","unstructured":"Bello-Perez M, Sola I, Novoa B, Klionsky DJ, Falco A. Canonical and noncanonical autophagy as potential targets for COVID-19. Cells. 2020;9(7):1619.","journal-title":"Cells."},{"issue":"10","key":"362_CR53","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.7150\/ijbs.45498","volume":"16","author":"N Yang","year":"2020","unstructured":"Yang N, Shen HM. Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19. Int J Biol Sci. 2020;16(10):1724\u201331.","journal-title":"Int J Biol Sci"},{"key":"362_CR54","doi-asserted-by":"crossref","unstructured":"Miller K, McGrath ME, Hu Z, Ariannejad S, Weston S, Frieman M, et al. Coronavirus interactions with the cellular autophagy machinery. Autophagy. 2020:1\u20139.","DOI":"10.1080\/15548627.2020.1817280"},{"issue":"10","key":"362_CR55","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.it.2020.08.001","volume":"41","author":"A Calender","year":"2020","unstructured":"Calender A, Israel-Biet D, Valeyre D, Pacheco Y. Modeling potential autophagy pathways in COVID-19 and sarcoidosis. Trends Immunol. 2020;41(10):856\u20139.","journal-title":"Trends Immunol"},{"issue":"3","key":"362_CR56","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/cdd.2014.150","volume":"22","author":"G Filomeni","year":"2015","unstructured":"Filomeni G, De Zio D, Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ. 2015;22(3):377\u201388.","journal-title":"Cell Death Differ"},{"key":"362_CR57","doi-asserted-by":"publisher","first-page":"101679","DOI":"10.1016\/j.redox.2020.101679","volume":"36","author":"W Ornatowski","year":"2020","unstructured":"Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, et al. Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. Redox Biol. 2020;36:101679.","journal-title":"Redox Biol"},{"issue":"3","key":"362_CR58","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1042\/BJ20150568","volume":"469","author":"M Dodson","year":"2015","unstructured":"Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J. KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochem J. 2015;469(3):347\u201355.","journal-title":"Biochem J"},{"key":"362_CR59","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.fct.2015.03.020","volume":"80","author":"JR Noh","year":"2015","unstructured":"Noh JR, Kim YH, Hwang JH, Choi DH, Kim KS, Oh WK, et al. Sulforaphane protects against acetaminophen-induced hepatotoxicity. Food Chem Toxicol. 2015;80:193\u2013200.","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"362_CR60","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1080\/08923973.2019.1569049","volume":"41","author":"LD Vuong","year":"2019","unstructured":"Vuong LD, Nguyen QN, Truong VL. Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells. Immunopharmacol Immunotoxicol. 2019;41(3):413\u20139.","journal-title":"Immunopharmacol Immunotoxicol."},{"issue":"6","key":"362_CR61","doi-asserted-by":"publisher","first-page":"8152","DOI":"10.1002\/jcp.27603","volume":"234","author":"H Yaribeygi","year":"2019","unstructured":"Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Insulin resistance: review of the underlying molecular mechanisms. J Cell Physiol. 2019;234(6):8152\u201361.","journal-title":"J Cell Physiol"},{"issue":"7121","key":"362_CR62","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/nature05488","volume":"444","author":"JP Despres","year":"2006","unstructured":"Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881\u20137.","journal-title":"Nature"},{"issue":"2","key":"362_CR63","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.ecl.2004.03.007","volume":"33","author":"A Natali","year":"2004","unstructured":"Natali A, Ferrannini E. Hypertension, insulin resistance, and the metabolic syndrome. Endocrinol Metab Clin North Am. 2004;33(2):417\u201329.","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"362_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ecl.2013.09.009","volume":"43","author":"SL Samson","year":"2014","unstructured":"Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin North Am. 2014;43(1):1\u201323.","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"14","key":"362_CR65","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.jacc.2010.05.034","volume":"56","author":"S Mottillo","year":"2010","unstructured":"Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010;56(14):1113\u201332.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"362_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/obr.12229","volume":"16","author":"S O'Neill","year":"2015","unstructured":"O\u2019Neill S, O\u2019Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev. 2015;16(1):1\u201312.","journal-title":"Obes Rev"},{"issue":"1","key":"362_CR67","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11154-012-9229-1","volume":"14","author":"R Muniyappa","year":"2013","unstructured":"Muniyappa R, Sowers JR. Role of insulin resistance in endothelial dysfunction. Rev Endocr Metab Disord. 2013;14(1):5\u201312.","journal-title":"Rev Endocr Metab Disord"},{"issue":"12","key":"362_CR68","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrneph.2016.145","volume":"12","author":"F Artunc","year":"2016","unstructured":"Artunc F, Schleicher E, Weigert C, Fritsche A, Stefan N, Haring HU. The impact of insulin resistance on the kidney and vasculature. Nat Rev Nephrol. 2016;12(12):721\u201337.","journal-title":"Nat Rev Nephrol"},{"key":"362_CR69","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/978-3-319-63260-5_7","volume":"19","author":"L Letra","year":"2017","unstructured":"Letra L, Sena C. Cerebrovascular disease: consequences of obesity-induced endothelial dysfunction. Adv Neurobiol. 2017;19:163\u201389.","journal-title":"Adv Neurobiol"},{"issue":"8","key":"362_CR70","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1113\/JP270538","volume":"594","author":"S Costantino","year":"2016","unstructured":"Costantino S, Paneni F, Cosentino F. Ageing, metabolism and cardiovascular disease. J Physiol. 2016;594(8):2061\u201373.","journal-title":"J Physiol"},{"issue":"9","key":"362_CR71","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1007\/s00705-020-04706-3","volume":"165","author":"A Warowicka","year":"2020","unstructured":"Warowicka A, Nawrot R, Gozdzicka-Jozefiak A. Antiviral activity of berberine. Arch Virol. 2020;165(9):1935\u201345.","journal-title":"Arch Virol"},{"key":"362_CR72","doi-asserted-by":"publisher","first-page":"912","DOI":"10.3389\/fmicb.2019.00912","volume":"10","author":"D Praditya","year":"2019","unstructured":"Praditya D, Kirchhoff L, Bruning J, Rachmawati H, Steinmann J, Steinmann E. Anti-infective properties of the golden spice curcumin. Front Microbiol. 2019;10:912.","journal-title":"Front Microbiol"},{"issue":"5","key":"362_CR73","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1002\/mc.20170","volume":"45","author":"CS Divya","year":"2006","unstructured":"Divya CS, Pillai MR. Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol Carcinog. 2006;45(5):320\u201332.","journal-title":"Mol Carcinog"},{"issue":"10","key":"362_CR74","doi-asserted-by":"publisher","first-page":"7898","DOI":"10.1002\/jcb.26829","volume":"119","author":"A Hesari","year":"2018","unstructured":"Hesari A, Ghasemi F, Salarinia R, Biglari H, Hassan ATM, Abdoli V, et al. Effects of curcumin on NF-kappaB, AP-1, and Wnt\/beta-catenin signaling pathway in hepatitis B virus infection. J Cell Biochem. 2018;119(10):7898\u2013904.","journal-title":"J Cell Biochem."},{"issue":"2","key":"362_CR75","doi-asserted-by":"publisher","first-page":"C308","DOI":"10.1152\/ajpcell.00003.2016","volume":"311","author":"LJ Shih","year":"2016","unstructured":"Shih LJ, Chen TF, Lin CK, Liu HS, Kao YH. Green tea (-)-epigallocatechin gallate inhibits the growth of human villous trophoblasts via the ERK, p38, AMP-activated protein kinase, and protein kinase B pathways. Am J Physiol Cell Physiol. 2016;311(2):C308\u201321.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"362_CR76","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.freeradbiomed.2011.04.027","volume":"51","author":"MJ Kesic","year":"2011","unstructured":"Kesic MJ, Simmons SO, Bauer R, Jaspers I. Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells. Free Radic Biol Med. 2011;51(2):444\u201353.","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"362_CR77","doi-asserted-by":"publisher","first-page":"e1005581","DOI":"10.1371\/journal.ppat.1005581","volume":"12","author":"AK Furuya","year":"2016","unstructured":"Furuya AK, Sharifi HJ, Jellinger RM, Cristofano P, Shi B, de Noronha CM. Sulforaphane inhibits HIV infection of macrophages through Nrf2. PLoS Pathog. 2016;12(4):e1005581.","journal-title":"PLoS Pathog"},{"issue":"2","key":"362_CR78","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1164\/rccm.200804-535OC","volume":"179","author":"HY Cho","year":"2009","unstructured":"Cho HY, Imani F, Miller-DeGraff L, Walters D, Melendi GA, Yamamoto M, et al. Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med. 2009;179(2):138\u201350.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"362_CR79","doi-asserted-by":"publisher","first-page":"e0152236","DOI":"10.1371\/journal.pone.0152236","volume":"11","author":"JS Yu","year":"2016","unstructured":"Yu JS, Chen WC, Tseng CK, Lin CK, Hsu YC, Chen YH, et al. Sulforaphane suppresses hepatitis c virus replication by up-regulating heme oxygenase-1 expression through PI3K\/Nrf2 pathway. PLoS ONE. 2016;11(3):e0152236.","journal-title":"PLoS ONE"},{"key":"362_CR80","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.antiviral.2018.04.008","volume":"154","author":"J Shen","year":"2018","unstructured":"Shen J, Wang G, Zuo J. Caffeic acid inhibits HCV replication via induction of IFNalpha antiviral response through p62-mediated Keap1\/Nrf2 signaling pathway. Antiviral Res. 2018;154:166\u201373.","journal-title":"Antiviral Res"},{"key":"362_CR81","doi-asserted-by":"publisher","first-page":"104537","DOI":"10.1016\/j.antiviral.2019.104537","volume":"169","author":"Y Nio","year":"2019","unstructured":"Nio Y, Sasai M, Akahori Y, Okamura H, Hasegawa H, Oshima M, et al. Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems. Antiviral Res. 2019;169:104537.","journal-title":"Antiviral Res"},{"key":"362_CR82","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/bs.ai.2016.08.001","volume":"132","author":"JR Teijaro","year":"2016","unstructured":"Teijaro JR. Pleiotropic roles of Type 1 interferons in antiviral immune responses. Adv Immunol. 2016;132:135\u201358.","journal-title":"Adv Immunol"},{"issue":"11","key":"362_CR83","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","volume":"20","author":"M Motwani","year":"2019","unstructured":"Motwani M, Pesiridis S, Fitzgerald KA. DNA sensing by the cGAS-STING pathway in health and disease. Nat Rev Genet. 2019;20(11):657\u201374.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"362_CR84","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1038\/s41467-018-05861-7","volume":"9","author":"D Olagnier","year":"2018","unstructured":"Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, et al. Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. Nat Commun. 2018;9(1):3506.","journal-title":"Nat Commun"},{"key":"362_CR85","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.3389\/fimmu.2019.02101","volume":"10","author":"C Gunderstofte","year":"2019","unstructured":"Gunderstofte C, Iversen MB, Peri S, Thielke A, Balachandran S, Holm CK, et al. Nrf2 Negatively regulates Type I interferon responses and increases susceptibility to herpes genital infection in mice. Front Immunol. 2019;10:2101.","journal-title":"Front Immunol"},{"issue":"7699","key":"362_CR86","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature25986","volume":"556","author":"EL Mills","year":"2018","unstructured":"Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018;556(7699):113\u20137.","journal-title":"Nature"},{"issue":"5","key":"362_CR87","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/aps.2010.30","volume":"31","author":"ZS Wang","year":"2010","unstructured":"Wang ZS, Lu FE, Xu LJ, Dong H. Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. Acta Pharmacol Sin. 2010;31(5):578\u201384.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"362_CR88","doi-asserted-by":"publisher","first-page":"9081","DOI":"10.1038\/s41598-018-27105-w","volume":"8","author":"M Kobori","year":"2018","unstructured":"Kobori M, Takahashi Y, Takeda H, Takahashi M, Izumi Y, Akimoto Y, et al. Dietary intake of curcumin improves eIF2 signaling and reduces lipid levels in the white adipose tissue of obese mice. Sci Rep. 2018;8(1):9081.","journal-title":"Sci Rep"},{"key":"362_CR89","doi-asserted-by":"publisher","first-page":"3480569","DOI":"10.1155\/2019\/3480569","volume":"2019","author":"ZN Md Nesran","year":"2019","unstructured":"Md Nesran ZN, Shafie NH, Ishak AH, Mohd Esa N, Ismail A, Md Tohid SF. Induction of endoplasmic reticulum stress pathway by green tea epigallocatechin-3-gallate (EGCG) in colorectal cancer cells: activation of PERK\/p-eIF2alpha\/ATF4 and IRE1alpha. Biomed Res Int. 2019;2019:3480569.","journal-title":"Biomed Res Int"},{"key":"362_CR90","doi-asserted-by":"publisher","first-page":"15270","DOI":"10.1038\/srep15270","volume":"5","author":"A Modernelli","year":"2015","unstructured":"Modernelli A, Naponelli V, Giovanna Troglio M, Bonacini M, Ramazzina I, Bettuzzi S, et al. EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism. Sci Rep. 2015;5:15270.","journal-title":"Sci Rep"},{"issue":"2","key":"362_CR91","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.bbrc.2018.12.108","volume":"509","author":"S Xia","year":"2019","unstructured":"Xia S, Wang J, Kalionis B, Zhang W, Zhao Y. Genistein protects against acute pancreatitis via activation of an apoptotic pathway mediated through endoplasmic reticulum stress in rats. Biochem Biophys Res Commun. 2019;509(2):421\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"362_CR92","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1165\/rcmb.2006-0149OC","volume":"35","author":"S Nanua","year":"2006","unstructured":"Nanua S, Zick SM, Andrade JE, Sajjan US, Burgess JR, Lukacs NW, et al. Quercetin blocks airway epithelial cell chemokine expression. Am J Respir Cell Mol Biol. 2006;35(5):602\u201310.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"362_CR93","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41419-019-1639-5","volume":"10","author":"CL Yu","year":"2019","unstructured":"Yu CL, Yang SF, Hung TW, Lin CL, Hsieh YH, Chiou HL. Inhibition of eIF2alpha dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner. Cell Death Dis. 2019;10(6):418.","journal-title":"Cell Death Dis"},{"key":"362_CR94","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.exger.2017.11.014","volume":"102","author":"V Palomera-Avalos","year":"2018","unstructured":"Palomera-Avalos V, Grinan-Ferre C, Izquierdo V, Camins A, Sanfeliu C, Canudas AM, et al. Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. Exp Gerontol. 2018;102:3\u201311.","journal-title":"Exp Gerontol"},{"issue":"4","key":"362_CR95","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3109\/0886022X.2016.1149774","volume":"38","author":"C Zhang","year":"2016","unstructured":"Zhang C, Zhou Y, Zhou Y, Lu Y, Wang D. Regulation of eIF2alpha expression and renal interstitial fibrosis by resveratrol in rat renal tissue after unilateral ureteral obstruction. Ren Fail. 2016;38(4):622\u20138.","journal-title":"Ren Fail"},{"key":"362_CR96","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cyto.2015.11.006","volume":"77","author":"J Liu","year":"2016","unstructured":"Liu J, Fan C, Yu L, Yang Y, Jiang S, Ma Z, et al. Pterostilbene exerts an anti-inflammatory effect via regulating endoplasmic reticulum stress in endothelial cells. Cytokine. 2016;77:88\u201397.","journal-title":"Cytokine"},{"key":"362_CR97","doi-asserted-by":"publisher","first-page":"32206","DOI":"10.1038\/srep32206","volume":"6","author":"Q Zhou","year":"2016","unstructured":"Zhou Q, Chen B, Wang X, Wu L, Yang Y, Cheng X, et al. Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways. Sci Rep. 2016;6:32206.","journal-title":"Sci Rep"},{"key":"362_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153062","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Gilmour A, Ahn YH, de la Vega L, Dinkova-Kostova AT. The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner. Phytomedicine. 2019. https:\/\/doi.org\/10.1016\/j.phymed.2019.153062.","journal-title":"Phytomedicine."},{"issue":"6","key":"362_CR99","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4162\/nrp.2017.11.6.445","volume":"11","author":"M Woo","year":"2017","unstructured":"Woo M, Kim M, Noh JS, Park CH, Song YO. Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis. Nutr Res Pract. 2017;11(6):445\u201351.","journal-title":"Nutr Res Pract"},{"issue":"10","key":"362_CR100","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.3390\/nu10101554","volume":"10","author":"M Woo","year":"2018","unstructured":"Woo M, Kim MJ, Song YO. Bioactive compounds in kimchi improve the cognitive and memory functions impaired by amyloid beta. Nutrients. 2018;10(10):1554.","journal-title":"Nutrients."},{"issue":"19","key":"362_CR101","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.1021\/acs.jafc.8b01686","volume":"66","author":"M Woo","year":"2018","unstructured":"Woo M, Noh JS, Cho EJ, Song YO. Bioactive compounds of kimchi inhibit apoptosis by attenuating endoplasmic reticulum stress in the brain of amyloid beta-injected mice. J Agric Food Chem. 2018;66(19):4883\u201390.","journal-title":"J Agric Food Chem"},{"issue":"2","key":"362_CR102","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1089\/jmf.2017.3946","volume":"21","author":"HJ Kim","year":"2018","unstructured":"Kim HJ, Noh JS, Song YO. Beneficial effects of kimchi, a korean fermented vegetable food, on pathophysiological factors related to atherosclerosis. J Med Food. 2018;21(2):127\u201335.","journal-title":"J Med Food"},{"issue":"3","key":"362_CR103","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3390\/ijms19030816","volume":"19","author":"HK Joo","year":"2018","unstructured":"Joo HK, Choi S, Lee YR, Lee EO, Park MS, Park KB, et al. Anthocyanin-rich extract from red chinese cabbage alleviates vascular inflammation in endothelial cells and apo E(-\/-) mice. Int J Mol Sci. 2018;19(3):816.","journal-title":"Int J Mol Sci."},{"issue":"1","key":"362_CR104","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1476-5381.2011.01351.x","volume":"164","author":"JS Shin","year":"2011","unstructured":"Shin JS, Noh YS, Lee YS, Cho YW, Baek NI, Choi MS, et al. Arvelexin from brassica rapa suppresses NF-kappaB-regulated pro-inflammatory gene expression by inhibiting activation of IkappaB kinase. Br J Pharmacol. 2011;164(1):145\u201358.","journal-title":"Br J Pharmacol"},{"key":"362_CR105","doi-asserted-by":"publisher","first-page":"25579","DOI":"10.1038\/srep25579","volume":"6","author":"Y Yao","year":"2016","unstructured":"Yao Y, Wang W, Li M, Ren H, Chen C, Wang J, et al. Curcumin Exerts its anti-hypertensive effect by down-regulating the AT1 receptor in vascular smooth muscle cells. Sci Rep. 2016;6:25579.","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"362_CR106","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11010-017-3142-6","volume":"439","author":"XL Zhan","year":"2018","unstructured":"Zhan XL, Yang XH, Gu YH, Guo LL, Jin HM. Epigallocatechin gallate protects against homocysteine-induced vascular smooth muscle cell proliferation. Mol Cell Biochem. 2018;439(1\u20132):131\u201340.","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"362_CR107","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.2337\/diabetes.50.8.1918","volume":"50","author":"A Malhotra","year":"2001","unstructured":"Malhotra A, Kang BP, Cheung S, Opawumi D, Meggs LG. Angiotensin II promotes glucose-induced activation of cardiac protein kinase C isozymes and phosphorylation of troponin I. Diabetes. 2001;50(8):1918\u201326.","journal-title":"Diabetes"},{"issue":"1","key":"362_CR108","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11605-007-0403-9","volume":"12","author":"R Anandanadesan","year":"2008","unstructured":"Anandanadesan R, Gong Q, Chipitsyna G, Witkiewicz A, Yeo CJ, Arafat HA. Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1\/2 signaling. J Gastrointest Surg. 2008;12(1):57\u201366.","journal-title":"J Gastrointest Surg"},{"issue":"2","key":"362_CR109","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s12012-015-9321-3","volume":"16","author":"Y Gao","year":"2016","unstructured":"Gao Y, Kang L, Li C, Wang X, Sun C, Li Q, et al. Resveratrol ameliorates diabetes-induced cardiac dysfunction through AT1R-ERK\/p38 MAPK signaling pathway. Cardiovasc Toxicol. 2016;16(2):130\u20137.","journal-title":"Cardiovasc Toxicol"},{"key":"362_CR110","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.phymed.2018.08.002","volume":"55","author":"M Yousefian","year":"2019","unstructured":"Yousefian M, Shakour N, Hosseinzadeh H, Hayes AW, Hadizadeh F, Karimi G. The natural phenolic compounds as modulators of NADPH oxidases in hypertension. Phytomedicine. 2019;55:200\u201313.","journal-title":"Phytomedicine"},{"issue":"17","key":"362_CR111","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.2174\/1381612823666170222122822","volume":"23","author":"MS Karimian","year":"2017","unstructured":"Karimian MS, Pirro M, Johnston TP, Majeed M, Sahebkar A. Curcumin and endothelial function: evidence and mechanisms of protective effects. Curr Pharm Des. 2017;23(17):2462\u201373.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"362_CR112","doi-asserted-by":"publisher","first-page":"148","DOI":"10.7150\/ijbs.28874","volume":"15","author":"M Zhang","year":"2019","unstructured":"Zhang M, Xu Y, Qiu Z, Jiang L. Sulforaphane attenuates angiotensin II-induced vascular smooth muscle cell migration via suppression of NOX4\/ROS\/Nrf2 Signaling. Int J Biol Sci. 2019;15(1):148\u201357.","journal-title":"Int J Biol Sci"},{"issue":"49","key":"362_CR113","doi-asserted-by":"publisher","first-page":"25476","DOI":"10.1074\/jbc.M116.760249","volume":"291","author":"G Bendavit","year":"2016","unstructured":"Bendavit G, Aboulkassim T, Hilmi K, Shah S, Batist G. Nrf2 Transcription factor can directly regulate mTOR: Linking cytoprotective gene expression to a major metabolic regulator that generates redox activity. J Biol Chem. 2016;291(49):25476\u201388.","journal-title":"J Biol Chem"},{"issue":"3","key":"362_CR114","doi-asserted-by":"publisher","first-page":"332","DOI":"10.2174\/1567202617666200425205122","volume":"17","author":"K Maiese","year":"2020","unstructured":"Maiese K. The mechanistic target of rapamycin (mTOR): novel considerations as an antiviral treatment. Curr Neurovasc Res. 2020;17(3):332\u20137.","journal-title":"Curr Neurovasc Res"},{"key":"362_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/112_2013_11","volume":"164","author":"B Nilius","year":"2013","unstructured":"Nilius B, Appendino G. Spices: the savory and beneficial science of pungency. Rev Physiol Biochem Pharmacol. 2013;164:1\u201376.","journal-title":"Rev Physiol Biochem Pharmacol"},{"issue":"6971","key":"362_CR116","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature02282","volume":"427","author":"SE Jordt","year":"2004","unstructured":"Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004;427(6971):260\u20135.","journal-title":"Nature"},{"issue":"3","key":"362_CR117","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1179\/1351000214Y.0000000087","volume":"19","author":"SM Tan","year":"2014","unstructured":"Tan SM, de Haan JB. Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much? Redox Rep. 2014;19(3):107\u201317.","journal-title":"Redox Rep"},{"key":"362_CR118","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.phrs.2018.06.013","volume":"134","author":"CA Silva-Islas","year":"2018","unstructured":"Silva-Islas CA, Maldonado PD. Canonical and non-canonical mechanisms of Nrf2 activation. Pharmacol Res. 2018;134:92\u20139.","journal-title":"Pharmacol Res"},{"issue":"12","key":"362_CR119","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1038\/sj.bjc.6604703","volume":"99","author":"S Nair","year":"2008","unstructured":"Nair S, Doh ST, Chan JY, Kong AN, Cai L. Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis. Br J Cancer. 2008;99(12):2070\u201382.","journal-title":"Br J Cancer"},{"issue":"1","key":"362_CR120","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12866-020-01890-9","volume":"20","author":"KK Chen","year":"2020","unstructured":"Chen KK, Minakuchi M, Wuputra K, Ku CC, Pan JB, Kuo KK, et al. Redox control in the pathophysiology of influenza virus infection. BMC Microbiol. 2020;20(1):214.","journal-title":"BMC Microbiol"},{"issue":"12","key":"362_CR121","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/j.biochi.2012.07.015","volume":"94","author":"LM Pedruzzi","year":"2012","unstructured":"Pedruzzi LM, Stockler-Pinto MB, Leite M Jr, Mafra D. Nrf2-keap1 system versus NF-kappaB: the good and the evil in chronic kidney disease? Biochimie. 2012;94(12):2461\u20136.","journal-title":"Biochimie"},{"key":"362_CR122","doi-asserted-by":"publisher","first-page":"110102","DOI":"10.1016\/j.mehy.2020.110102","volume":"143","author":"R Cecchini","year":"2020","unstructured":"Cecchini R, Cecchini AL. SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression. Med Hypotheses. 2020;143:110102.","journal-title":"Med Hypotheses"},{"issue":"6","key":"362_CR123","doi-asserted-by":"publisher","first-page":"e12812","DOI":"10.1111\/sji.12812","volume":"90","author":"J Hawiger","year":"2019","unstructured":"Hawiger J, Zienkiewicz J. Decoding inflammation, its causes, genomic responses, and emerging countermeasures. Scand J Immunol. 2019;90(6):e12812.","journal-title":"Scand J Immunol"},{"key":"362_CR124","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1046\/j.1523-1755.61.s80.20.x","volume":"80","author":"M Morena","year":"2002","unstructured":"Morena M, Cristol JP, Senecal L, Leray-Moragues H, Krieter D, Canaud B. Oxidative stress in hemodialysis patients: is NADPH oxidase complex the culprit? Kidney Int Suppl. 2002;80:109\u201314.","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"362_CR125","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","volume":"15","author":"EB Kurutas","year":"2016","unstructured":"Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: current state. Nutr J. 2016;15(1):71.","journal-title":"Nutr J"},{"key":"362_CR126","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ejphar.2017.06.017","volume":"811","author":"L Delgado-Roche","year":"2017","unstructured":"Delgado-Roche L, Riera-Romo M, Mesta F, Hernandez-Matos Y, Barrios JM, Martinez-Sanchez G, et al. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients. Eur J Pharmacol. 2017;811:148\u201354.","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"362_CR127","doi-asserted-by":"publisher","first-page":"e0134235","DOI":"10.1371\/journal.pone.0134235","volume":"10","author":"MG Song","year":"2015","unstructured":"Song MG, Ryoo IG, Choi HY, Choi BH, Kim ST, Heo TH, et al. NRF2 signaling negatively regulates Phorbol-12-Myristate-13-Acetate (PMA)-induced differentiation of human monocytic U937 cells into pro-inflammatory macrophages. PLoS ONE. 2015;10(7):e0134235.","journal-title":"PLoS ONE"},{"issue":"5","key":"362_CR128","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s00204-015-1536-3","volume":"90","author":"B Herpers","year":"2016","unstructured":"Herpers B, Wink S, Fredriksson L, Di Z, Hendriks G, Vrieling H, et al. Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-kappaB activation and sensitizes toward TNFalpha-induced cytotoxicity. Arch Toxicol. 2016;90(5):1163\u201379.","journal-title":"Arch Toxicol"},{"issue":"11","key":"362_CR129","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","volume":"76","author":"W Li","year":"2008","unstructured":"Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S, et al. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol. 2008;76(11):1485\u20139.","journal-title":"Biochem Pharmacol"},{"key":"362_CR130","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.biopha.2018.10.019","volume":"108","author":"S Mohan","year":"2018","unstructured":"Mohan S, Gupta D. Crosstalk of toll-like receptors signaling and Nrf2 pathway for regulation of inflammation. Biomed Pharmacother. 2018;108:1866\u201378.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"362_CR131","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","volume":"43","author":"JD Wardyn","year":"2015","unstructured":"Wardyn JD, Ponsford AH, Sanderson CM. Dissecting molecular cross-talk between Nrf2 and NF-kappaB response pathways. Biochem Soc Trans. 2015;43(4):621\u20136.","journal-title":"Biochem Soc Trans"},{"issue":"12","key":"362_CR132","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3390\/antiox8120588","volume":"8","author":"B Clavo","year":"2019","unstructured":"Clavo B, Rodriguez-Esparragon F, Rodriguez-Abreu D, Martinez-Sanchez G, Llontop P, Aguiar-Bujanda D, et al. Modulation of oxidative stress by ozone therapy in the prevention and treatment of chemotherapy-induced toxicity: review and prospects. Antioxidants (Basel). 2019;8(12):588.","journal-title":"Antioxidants (Basel)."},{"issue":"4","key":"362_CR133","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/09629359890983","volume":"7","author":"OS Leon","year":"1998","unstructured":"Leon OS, Menendez S, Merino N, Castillo R, Sam S, Perez L, et al. Ozone oxidative preconditioning: a protection against cellular damage by free radicals. Mediators Inflamm. 1998;7(4):289\u201394.","journal-title":"Mediators Inflamm"},{"key":"362_CR134","doi-asserted-by":"publisher","first-page":"6480793","DOI":"10.1155\/2018\/6480793","volume":"2018","author":"T Khatlani","year":"2018","unstructured":"Khatlani T, Algudiri D, Alenzi R, Al Subayyil AM, Abomaray FM, Bahattab E, et al. Preconditioning by hydrogen peroxide enhances multiple properties of human decidua basalis mesenchymal stem\/multipotent stromal cells. Stem Cells Int. 2018;2018:6480793.","journal-title":"Stem Cells Int"},{"issue":"9","key":"362_CR135","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.nut.2015.03.014","volume":"31","author":"J Vide","year":"2015","unstructured":"Vide J, Virsolvy A, Romain C, Ramos J, Jouy N, Richard S, et al. Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet. Nutrition. 2015;31(9):1148\u201354.","journal-title":"Nutrition"},{"issue":"1","key":"362_CR136","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1021\/jf048919f","volume":"53","author":"NA Al-Awwadi","year":"2005","unstructured":"Al-Awwadi NA, Araiz C, Bornet A, Delbosc S, Cristol JP, Linck N, et al. Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats. J Agric Food Chem. 2005;53(1):151\u20137.","journal-title":"J Agric Food Chem"},{"issue":"2","key":"362_CR137","doi-asserted-by":"publisher","first-page":"132","DOI":"10.2174\/1573402111666150529130922","volume":"11","author":"N Sinha","year":"2015","unstructured":"Sinha N, Dabla PK. Oxidative stress and antioxidants in hypertension-a current review. Curr Hypertens Rev. 2015;11(2):132\u201342.","journal-title":"Curr Hypertens Rev"},{"issue":"5","key":"362_CR138","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/antiox9050389","volume":"9","author":"G Martinez-Sanchez","year":"2020","unstructured":"Martinez-Sanchez G, Schwartz A, Donna VD. Potential cytoprotective activity of ozone therapy in SARS-CoV-2\/COVID-19. Antioxidants (Basel). 2020;9(5):389.","journal-title":"Antioxidants (Basel)."},{"issue":"4\u20136","key":"362_CR139","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.mam.2011.10.006","volume":"32","author":"BM Hybertson","year":"2011","unstructured":"Hybertson BM, Gao B, Bose SK, McCord JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011;32(4\u20136):234\u201346.","journal-title":"Mol Aspects Med"},{"key":"362_CR140","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1146\/annurev-pharmtox-010818-021856","volume":"59","author":"M Dodson","year":"2019","unstructured":"Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. Modulating NRF2 in Disease: timing Is everything. Annu Rev Pharmacol Toxicol. 2019;59:555\u201375.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"15","key":"362_CR141","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1093\/hmg\/ddx167","volume":"26","author":"G Hayashi","year":"2017","unstructured":"Hayashi G, Jasoliya M, Sahdeo S, Sacca F, Pane C, Filla A, et al. Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans. Hum Mol Genet. 2017;26(15):2864\u201373.","journal-title":"Hum Mol Genet"},{"key":"362_CR142","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.12688\/f1000research.12111.1","volume":"6","author":"T Satoh","year":"2017","unstructured":"Satoh T, Lipton S. Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate. F1000Res. 2017;6:2138.","journal-title":"F1000Res."},{"issue":"5","key":"362_CR143","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1002\/med.21567","volume":"39","author":"NEB Saidu","year":"2019","unstructured":"Saidu NEB, Kavian N, Leroy K, Jacob C, Nicco C, Batteux F, et al. Dimethyl fumarate, a two-edged drug: current status and future directions. Med Res Rev. 2019;39(5):1923\u201352.","journal-title":"Med Res Rev"},{"issue":"11","key":"362_CR144","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/13543784.2018.1538352","volume":"27","author":"JA Moreno","year":"2018","unstructured":"Moreno JA, Gomez-Guerrero C, Mas S, Sanz AB, Lorenzo O, Ruiz-Ortega M, et al. Targeting inflammation in diabetic nephropathy: a tale of hope. Expert Opin Investig Drugs. 2018;27(11):917\u201330.","journal-title":"Expert Opin Investig Drugs"},{"key":"362_CR145","doi-asserted-by":"crossref","unstructured":"Collaboration NCDRF. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387(10026):1377\u201396.","DOI":"10.1016\/S0140-6736(16)30054-X"},{"issue":"7","key":"362_CR146","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1136\/jech-2016-208322","volume":"71","author":"J Addo","year":"2017","unstructured":"Addo J, Agyemang C, de Aikins GA, Beune E, Schulze MB, Danquah I, et al. Association between socioeconomic position and the prevalence of type 2 diabetes in Ghanaians in different geographic locations: the RODAM study. J Epidemiol Community Health. 2017;71(7):633\u20139.","journal-title":"J Epidemiol Community Health."},{"issue":"1","key":"362_CR147","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/nyas.13204","volume":"1391","author":"C Agyemang","year":"2017","unstructured":"Agyemang C, Beune E, Meeks K, Addo J, Aikins AD, Bahendeka S, et al. Innovative ways of studying the effect of migration on obesity and diabetes beyond the common designs: lessons from the RODAM study. Ann N Y Acad Sci. 2017;1391(1):54\u201370.","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"362_CR148","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12916-016-0709-0","volume":"14","author":"C Agyemang","year":"2016","unstructured":"Agyemang C, Meeks K, Beune E, Owusu-Dabo E, Mockenhaupt FP, Addo J, et al. Obesity and type 2 diabetes in sub-Saharan Africans\u2014is the burden in today\u2019s Africa similar to African migrants in Europe? The RODAM study. BMC Med. 2016;14(1):166.","journal-title":"BMC Med"},{"issue":"11","key":"362_CR149","doi-asserted-by":"publisher","first-page":"e004013","DOI":"10.1161\/CIRCOUTCOMES.117.004013","volume":"10","author":"D Boateng","year":"2017","unstructured":"Boateng D, Agyemang C, Beune E, Meeks K, Smeeth L, Schulze M, et al. Migration and cardiovascular disease risk among ghanaian populations in Europe: the RODAM Study (Research on Obesity and Diabetes Among African Migrants). Circ Cardiovasc Qual Outcomes. 2017;10(11):e004013.","journal-title":"Circ Cardiovasc Qual Outcomes."},{"issue":"2","key":"362_CR150","doi-asserted-by":"publisher","first-page":"020426","DOI":"10.7189\/jogh.09.020426","volume":"9","author":"FP Chilunga","year":"2019","unstructured":"Chilunga FP, Henneman P, Meeks KA, Beune E, Requena-Mendez A, Smeeth L, et al. Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study. J Glob Health. 2019;9(2):020426.","journal-title":"J Glob Health"},{"issue":"1","key":"362_CR151","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41387-018-0029-x","volume":"8","author":"C Galbete","year":"2018","unstructured":"Galbete C, Nicolaou M, Meeks K, Klipstein-Grobusch K, de Aikins GA, Addo J, et al. Dietary patterns and type 2 diabetes among Ghanaian migrants in Europe and their compatriots in Ghana: the RODAM study. Nutr Diabetes. 2018;8(1):25.","journal-title":"Nutr Diabetes."},{"issue":"5","key":"362_CR152","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/jn\/nxz002","volume":"149","author":"D Boateng","year":"2019","unstructured":"Boateng D, Galbete C, Nicolaou M, Meeks K, Beune E, Smeeth L, et al. Dietary patterns are associated with predicted 10-year risk of cardiovascular disease among ghanaian populations: the research on obesity and diabetes in african migrants (RODAM) study. J Nutr. 2019;149(5):755\u201369.","journal-title":"J Nutr"},{"issue":"8","key":"362_CR153","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1007\/s00394-017-1538-4","volume":"57","author":"I Danquah","year":"2018","unstructured":"Danquah I, Galbete C, Meeks K, Nicolaou M, Klipstein-Grobusch K, Addo J, et al. Food variety, dietary diversity, and type 2 diabetes in a multi-center cross-sectional study among Ghanaian migrants in Europe and their compatriots in Ghana: the RODAM study. Eur J Nutr. 2018;57(8):2723\u201333.","journal-title":"Eur J Nutr"},{"issue":"4","key":"362_CR154","doi-asserted-by":"publisher","first-page":"236","DOI":"10.7570\/jomes.2019.28.4.236","volume":"28","author":"GE Nam","year":"2019","unstructured":"Nam GE, Kim YH, Han K, Jung JH, Park YG, Lee KW, et al. Obesity fact sheet in Korea, 2018: data focusing on waist circumference and obesity-related comorbidities. J Obes Metab Syndr. 2019;28(4):236\u201345.","journal-title":"J Obes Metab Syndr"},{"issue":"3","key":"362_CR155","doi-asserted-by":"publisher","first-page":"e12365","DOI":"10.1111\/cob.12365","volume":"10","author":"N Finer","year":"2020","unstructured":"Finer N, Garnett SP, Bruun JM. COVID-19 and obesity. Clin Obes. 2020;10(3):e12365.","journal-title":"Clin Obes"},{"key":"362_CR156","doi-asserted-by":"publisher","DOI":"10.7326\/M20-3742","author":"SY Tartof","year":"2020","unstructured":"Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H, et al. Obesity and mortality among patients diagnosed With COVID-19: results from an integrated health care organization. Ann Intern Med. 2020. https:\/\/doi.org\/10.7326\/M20-3742.","journal-title":"Ann Intern Med."},{"key":"362_CR157","doi-asserted-by":"publisher","DOI":"10.7326\/M20-5677","author":"DA Kass","year":"2020","unstructured":"Kass DA. COVID-19 and severe obesity: a big problem? Ann Intern Med. 2020. https:\/\/doi.org\/10.7326\/M20-5677.","journal-title":"Ann Intern Med."},{"key":"362_CR158","doi-asserted-by":"crossref","unstructured":"Klang E, Kassim G, Soffer S, Freeman R, Levin MA, Reich DL. Severe Obesity as an Independent Risk Factor for COVID-19 Mortality in Hospitalized Patients Younger than 50. Obesity (Silver Spring). 2020.","DOI":"10.1002\/oby.22913"},{"issue":"10","key":"362_CR159","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S2213-8587(20)30271-0","volume":"8","author":"N Holman","year":"2020","unstructured":"Holman N, Knighton P, Kar P, O\u2019Keefe J, Curley M, Weaver A, et al. Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study. Lancet Diabetes Endocrinol. 2020;8(10):823\u201333.","journal-title":"Lancet Diabetes Endocrinol."},{"key":"362_CR160","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejphar.2018.10.026","volume":"843","author":"CK Negi","year":"2019","unstructured":"Negi CK, Jena G. Nrf2, a novel molecular target to reduce type 1 diabetes associated secondary complications: the basic considerations. Eur J Pharmacol. 2019;843:12\u201326.","journal-title":"Eur J Pharmacol"},{"key":"362_CR161","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.clnesp.2020.04.010","volume":"38","author":"O Asbaghi","year":"2020","unstructured":"Asbaghi O, Ghanbari N, Shekari M, Reiner Z, Amirani E, Hallajzadeh J, et al. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: a systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2020;38:43\u20139.","journal-title":"Clin Nutr ESPEN"},{"issue":"4","key":"362_CR162","doi-asserted-by":"publisher","first-page":"E257","DOI":"10.1152\/ajpendo.00348.2014","volume":"308","author":"T Li","year":"2015","unstructured":"Li T, Yang GM, Zhu Y, Wu Y, Chen XY, Lan D, et al. Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation\/miRNA pathway. Am J Physiol Endocrinol Metab. 2015;308(4):E257\u201369.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"362_CR163","doi-asserted-by":"crossref","first-page":"1459497","DOI":"10.1155\/2017\/1459497","volume":"2017","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Chen B, Shen J, Wan L, Zhu Y, Yi T, et al. The beneficial effects of quercetin, curcumin, and resveratrol in obesity. Oxid Med Cell Longev. 2017;2017:1459497.","journal-title":"Oxid Med Cell Longev"},{"issue":"31","key":"362_CR164","doi-asserted-by":"publisher","first-page":"8119","DOI":"10.1021\/acs.jafc.0c00131","volume":"68","author":"Z Goktas","year":"2020","unstructured":"Goktas Z, Zu Y, Abbasi M, Galyean S, Wu D, Fan Z, et al. Recent advances in nano-encapsulation of phytochemicals to combat obesity and its comorbidities. J Agric Food Chem. 2020;68(31):8119\u201331.","journal-title":"J Agric Food Chem."},{"key":"362_CR165","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.critrevonc.2017.09.004","volume":"119","author":"V Mukund","year":"2017","unstructured":"Mukund V, Mukund D, Sharma V, Mannarapu M, Alam A. Genistein: Its role in metabolic diseases and cancer. Crit Rev Oncol Hematol. 2017;119:13\u201322.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"362_CR166","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1080\/21623945.2018.1474669","volume":"7","author":"L Xu","year":"2018","unstructured":"Xu L, Nagata N, Ota T. Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance. Adipocyte. 2018;7(3):218\u201325.","journal-title":"Adipocyte"},{"issue":"11","key":"362_CR167","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1111\/bph.13621","volume":"174","author":"AB Kunnumakkara","year":"2017","unstructured":"Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325\u201348.","journal-title":"Br J Pharmacol"},{"issue":"11","key":"362_CR168","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1038\/ijo.2017.161","volume":"41","author":"L Crovesy","year":"2017","unstructured":"Crovesy L, Ostrowski M, Ferreira D, Rosado EL, Soares-Mota M. Effect of lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials. Int J Obes (Lond). 2017;41(11):1607\u201314.","journal-title":"Int J Obes (Lond)"},{"issue":"2","key":"362_CR169","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3803\/EnM.2020.35.2.425","volume":"35","author":"S Lim","year":"2020","unstructured":"Lim S, Moon JH, Shin CM, Jeong D, Kim B. Effect of lactobacillus sakei, a probiotic derived from kimchi, on body fat in koreans with obesity: a randomized controlled study. Endocrinol Metab (Seoul). 2020;35(2):425\u201334.","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"8","key":"362_CR170","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1002\/jsfa.8898","volume":"98","author":"T Martins","year":"2018","unstructured":"Martins T, Colaco B, Venancio C, Pires MJ, Oliveira PA, Rosa E, et al. Potential effects of sulforaphane to fight obesity. J Sci Food Agric. 2018;98(8):2837\u201344.","journal-title":"J Sci Food Agric"},{"issue":"1","key":"362_CR171","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11154-014-9305-9","volume":"16","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Zhou S, Jiang X, Wang YH, Li F, Wang YG, et al. The role of the Nrf2\/Keap1 pathway in obesity and metabolic syndrome. Rev Endocr Metab Disord. 2015;16(1):35\u201345.","journal-title":"Rev Endocr Metab Disord"},{"key":"362_CR172","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cbpa.2018.09.027","volume":"228","author":"MM Bayliak","year":"2019","unstructured":"Bayliak MM, Abrat OB, Storey JM, Storey KB, Lushchak VI. Interplay between diet-induced obesity and oxidative stress: comparison between drosophila and mammals. Comp Biochem Physiol A Mol Integr Physiol. 2019;228:18\u201328.","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"issue":"2","key":"362_CR173","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/jcb.29392","volume":"121","author":"M Ashrafizadeh","year":"2020","unstructured":"Ashrafizadeh M, Fekri HS, Ahmadi Z, Farkhondeh T, Samarghandian S. Therapeutic and biological activities of berberine: the involvement of Nrf2 signaling pathway. J Cell Biochem. 2020;121(2):1575\u201385.","journal-title":"J Cell Biochem"},{"issue":"5","key":"362_CR174","first-page":"557","volume":"20","author":"J Tabeshpour","year":"2017","unstructured":"Tabeshpour J, Imenshahidi M, Hosseinzadeh H. A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome. Iran J Basic Med Sci. 2017;20(5):557\u201368.","journal-title":"Iran J Basic Med Sci"},{"issue":"1","key":"362_CR175","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/13880209.2016.1257642","volume":"55","author":"H Qiu","year":"2017","unstructured":"Qiu H, Wu Y, Wang Q, Liu C, Xue L, Wang H, et al. Effect of berberine on PPARalpha-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV. Pharm Biol. 2017;55(1):227\u201332.","journal-title":"Pharm Biol"},{"issue":"6","key":"362_CR176","doi-asserted-by":"publisher","first-page":"760","DOI":"10.14336\/AD.2016.0620","volume":"8","author":"Z Xu","year":"2017","unstructured":"Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, et al. Rhizoma Coptidis and Berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation. Aging Dis. 2017;8(6):760\u201377.","journal-title":"Aging Dis"},{"key":"362_CR177","doi-asserted-by":"publisher","first-page":"104505","DOI":"10.1016\/j.phrs.2019.104505","volume":"150","author":"A Hadi","year":"2019","unstructured":"Hadi A, Pourmasoumi M, Ghaedi E, Sahebkar A. The effect of Curcumin\/Turmeric on blood pressure modulation: a systematic review and meta-analysis. Pharmacol Res. 2019;150:104505.","journal-title":"Pharmacol Res"},{"issue":"8","key":"362_CR178","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.3390\/nu11081837","volume":"11","author":"F Pivari","year":"2019","unstructured":"Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients. 2019;11(8):1837.","journal-title":"Nutrients."},{"issue":"11","key":"362_CR179","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1002\/ptr.6477","volume":"33","author":"J Hallajzadeh","year":"2019","unstructured":"Hallajzadeh J, Milajerdi A, Kolahdooz F, Amirani E, Mirzaei H, Asemi Z. The effects of curcumin supplementation on endothelial function: a systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(11):2989\u201395.","journal-title":"Phytother Res"},{"key":"362_CR180","doi-asserted-by":"publisher","first-page":"4159013","DOI":"10.1155\/2018\/4159013","volume":"2018","author":"M Malavolta","year":"2018","unstructured":"Malavolta M, Bracci M, Santarelli L, Sayeed MA, Pierpaoli E, Giacconi R, et al. Inducers of senescence, toxic compounds, and senolytics: the multiple faces of Nrf2-activating phytochemicals in cancer adjuvant therapy. Mediators Inflamm. 2018;2018:4159013.","journal-title":"Mediators Inflamm"},{"issue":"4","key":"362_CR181","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1007\/s10753-019-01010-4","volume":"42","author":"MM Gouda","year":"2019","unstructured":"Gouda MM, Bhandary YP. Acute lung injury: IL-17A-mediated inflammatory pathway and its regulation by curcumin. Inflammation. 2019;42(4):1160\u20139.","journal-title":"Inflammation"},{"key":"362_CR182","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.phrs.2016.11.017","volume":"115","author":"D Lelli","year":"2017","unstructured":"Lelli D, Sahebkar A, Johnston TP, Pedone C. Curcumin use in pulmonary diseases: state of the art and future perspectives. Pharmacol Res. 2017;115:133\u201348.","journal-title":"Pharmacol Res"},{"key":"362_CR183","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2018.12.005","volume":"66","author":"A Mohammadi","year":"2019","unstructured":"Mohammadi A, Blesso CN, Barreto GE, Banach M, Majeed M, Sahebkar A. Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent. J Nutr Biochem. 2019;66:1\u201316.","journal-title":"J Nutr Biochem"},{"issue":"22","key":"362_CR184","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.2174\/1381612825666190722100504","volume":"25","author":"K Yamagata","year":"2019","unstructured":"Yamagata K. Polyphenols regulate endothelial functions and reduce the risk of cardiovascular disease. Curr Pharm Des. 2019a;25(22):2443\u201358.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"362_CR185","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/nu11010039","volume":"11","author":"N Khan","year":"2018","unstructured":"Khan N, Mukhtar H. Tea polyphenols in promotion of human health. Nutrients. 2018;11(1):39.","journal-title":"Nutrients."},{"key":"362_CR186","first-page":"576479","volume":"2013","author":"DC Favarin","year":"2013","unstructured":"Favarin DC, de Oliveira JR, de Oliveira CJ, Rogerio AP. Potential effects of medicinal plants and secondary metabolites on acute lung injury. Biomed Res Int. 2013;2013:576479.","journal-title":"Biomed Res Int"},{"issue":"7","key":"362_CR187","doi-asserted-by":"publisher","first-page":"e8092","DOI":"10.1590\/1414-431x20198092","volume":"52","author":"J Wang","year":"2019","unstructured":"Wang J, Fan SM, Zhang J. Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute lung injury by suppression of TLR4\/NF-kappaB signaling activation. Braz J Med Biol Res. 2019;52(7):e8092.","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"362_CR188","doi-asserted-by":"publisher","first-page":"84","DOI":"10.2174\/1872213X13666190426164124","volume":"13","author":"G Martinez","year":"2019","unstructured":"Martinez G, Mijares MR, De Sanctis JB. Effects of Flavonoids and Its derivatives on immune cell responses. Recent Pat Inflamm Allergy Drug Discov. 2019;13(2):84\u2013104.","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"issue":"3","key":"362_CR189","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/FJC.0000000000000708","volume":"74","author":"K Yamagata","year":"2019","unstructured":"Yamagata K. Soy isoflavones inhibit endothelial cell dysfunction and prevent cardiovascular disease. J Cardiovasc Pharmacol. 2019b;74(3):201\u20139.","journal-title":"J Cardiovasc Pharmacol"},{"key":"362_CR190","doi-asserted-by":"publisher","first-page":"108665","DOI":"10.1016\/j.cbi.2019.05.031","volume":"310","author":"L Weng","year":"2019","unstructured":"Weng L, Zhang F, Wang R, Ma W, Song Y. A review on protective role of genistein against oxidative stress in diabetes and related complications. Chem Biol Interact. 2019;310:108665.","journal-title":"Chem Biol Interact"},{"issue":"1","key":"362_CR191","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/jcmm.14815","volume":"24","author":"L Yi","year":"2020","unstructured":"Yi L, Chang M, Zhao Q, Zhou Z, Huang X, Guo F, et al. Genistein-3\u2019-sodium sulphonate protects against lipopolysaccharide-induced lung vascular endothelial cell apoptosis and acute lung injury via BCL-2 signalling. J Cell Mol Med. 2020;24(1):1022\u201335.","journal-title":"J Cell Mol Med"},{"key":"362_CR192","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejmech.2017.09.001","volume":"153","author":"C Spagnuolo","year":"2018","unstructured":"Spagnuolo C, Moccia S, Russo GL. Anti-inflammatory effects of flavonoids in neurodegenerative disorders. Eur J Med Chem. 2018;153:105\u201315.","journal-title":"Eur J Med Chem"},{"key":"362_CR193","doi-asserted-by":"publisher","first-page":"104663","DOI":"10.1016\/j.phrs.2020.104663","volume":"153","author":"AM Lewis-Mikhael","year":"2020","unstructured":"Lewis-Mikhael AM, Davoodvandi A, Jafarnejad S. Effect of Lactobacillusplantarum containing probiotics on blood pressure: a systematic review and meta-analysis. Pharmacol Res. 2020;153:104663.","journal-title":"Pharmacol Res"},{"key":"362_CR194","first-page":"9478630","volume":"2018","author":"MAK Azad","year":"2018","unstructured":"Azad MAK, Sarker M, Li T, Yin J. Probiotic species in the modulation of gut microbiota: an overview. Biomed Res Int. 2018;2018:9478630.","journal-title":"Biomed Res Int"},{"issue":"6","key":"362_CR195","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.3390\/jcm9061788","volume":"9","author":"K Skonieczna-Zydecka","year":"2020","unstructured":"Skonieczna-Zydecka K, Kazmierczak-Siedlecka K, Kaczmarczyk M, Sliwa-Dominiak J, Maciejewska D, Janda K, et al. The Effect of probiotics and synbiotics on risk factors associated with cardiometabolic diseases in healthy people-a systematic review and meta-analysis with meta-regression of randomized controlled trials. J Clin Med. 2020;9(6):1788.","journal-title":"J Clin Med."},{"issue":"4","key":"362_CR196","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s12603-011-0357-1","volume":"16","author":"G Malaguarnera","year":"2012","unstructured":"Malaguarnera G, Leggio F, Vacante M, Motta M, Giordano M, Bondi A, et al. Probiotics in the gastrointestinal diseases of the elderly. J Nutr Health Aging. 2012;16(4):402\u201310.","journal-title":"J Nutr Health Aging"},{"issue":"5","key":"362_CR197","doi-asserted-by":"publisher","first-page":"e97861","DOI":"10.1371\/journal.pone.0097861","volume":"9","author":"L Khailova","year":"2014","unstructured":"Khailova L, Petrie B, Baird CH, Dominguez Rieg JA, Wischmeyer PE. Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis. PLoS ONE. 2014;9(5):e97861.","journal-title":"PLoS ONE"},{"issue":"3","key":"362_CR198","doi-asserted-by":"publisher","first-page":"871","DOI":"10.4049\/jimmunol.1800927","volume":"202","author":"CM Percopo","year":"2019","unstructured":"Percopo CM, Ma M, Brenner TA, Krumholz JO, Break TJ, Laky K, et al. Critical adverse impact of IL-6 in acute pneumovirus infection. J Immunol. 2019;202(3):871\u201382.","journal-title":"J Immunol"},{"issue":"2","key":"362_CR199","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3390\/molecules22020209","volume":"22","author":"Y Marunaka","year":"2017","unstructured":"Marunaka Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, et al. Actions of quercetin, a polyphenol, on blood pressure. Molecules. 2017;22(2):209.","journal-title":"Molecules."},{"issue":"4","key":"362_CR200","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2174\/0929867323666160909153707","volume":"24","author":"HM Eid","year":"2017","unstructured":"Eid HM, Haddad PS. The antidiabetic potential of quercetin: underlying mechanisms. Curr Med Chem. 2017;24(4):355\u201364.","journal-title":"Curr Med Chem"},{"issue":"2","key":"362_CR201","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1007\/s10753-015-0296-9","volume":"39","author":"F Gerin","year":"2016","unstructured":"Gerin F, Sener U, Erman H, Yilmaz A, Aydin B, Armutcu F, et al. The effects of quercetin on acute lung injury and biomarkers of inflammation and oxidative stress in the rat model of sepsis. Inflammation. 2016;39(2):700\u20135.","journal-title":"Inflammation"},{"issue":"5","key":"362_CR202","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/mnfr.201200721","volume":"57","author":"I Peluso","year":"2013","unstructured":"Peluso I, Raguzzini A, Serafini M. Effect of flavonoids on circulating levels of TNF-alpha and IL-6 in humans: a systematic review and meta-analysis. Mol Nutr Food Res. 2013;57(5):784\u2013801.","journal-title":"Mol Nutr Food Res"},{"issue":"5","key":"362_CR203","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3390\/nu8050250","volume":"8","author":"D Bonnefont-Rousselot","year":"2016","unstructured":"Bonnefont-Rousselot D. Resveratrol and cardiovascular diseases. Nutrients. 2016;8(5):250.","journal-title":"Nutrients."},{"key":"362_CR204","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.biopha.2017.08.070","volume":"95","author":"E Ozturk","year":"2017","unstructured":"Ozturk E, Arslan AKK, Yerer MB, Bishayee A. Resveratrol and diabetes: a critical review of clinical studies. Biomed Pharmacother. 2017;95:230\u20134.","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"362_CR205","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.3390\/ijms20092155","volume":"20","author":"H Li","year":"2019","unstructured":"Li H, Xia N, Hasselwander S, Daiber A. Resveratrol and vascular function. Int J Mol Sci. 2019;20(9):2155.","journal-title":"Int J Mol Sci."},{"issue":"5","key":"362_CR206","first-page":"523","volume":"30","author":"E Conte","year":"2015","unstructured":"Conte E, Fagone E, Fruciano M, Gili E, Iemmolo M, Vancheri C. Anti-inflammatory and antifibrotic effects of resveratrol in the lung. Histol Histopathol. 2015;30(5):523\u20139.","journal-title":"Histol Histopathol"},{"issue":"7","key":"362_CR207","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.clinthera.2018.05.015","volume":"40","author":"M Koushki","year":"2018","unstructured":"Koushki M, Dashatan NA, Meshkani R. Effect of resveratrol supplementation on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Clin Ther. 2018;40(7):1180\u201392 e5.","journal-title":"Clin Ther."},{"key":"362_CR208","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.freeradbiomed.2018.02.004","volume":"122","author":"B Patel","year":"2018","unstructured":"Patel B, Mann GE, Chapple SJ. Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome. Free Radic Biol Med. 2018;122:150\u201360.","journal-title":"Free Radic Biol Med"},{"key":"362_CR209","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preghy.2019.02.002","volume":"16","author":"AG Cox","year":"2019","unstructured":"Cox AG, Gurusinghe S, Abd Rahman R, Leaw B, Chan ST, Mockler JC, et al. Sulforaphane improves endothelial function and reduces placental oxidative stress in vitro. Pregnancy Hypertens. 2019;16:1\u201310.","journal-title":"Pregnancy Hypertens"},{"issue":"8","key":"362_CR210","first-page":"9021","volume":"10","author":"B Zhao","year":"2017","unstructured":"Zhao B, Gao W, Gao X, Leng Y, Liu M, Hou J, et al. Sulforaphane attenuates acute lung injury by inhibiting oxidative stress via Nrf2\/HO-1 pathway in a rat sepsis model. Int J Clin Exp Pathol. 2017;10(8):9021\u20138.","journal-title":"Int J Clin Exp Pathol"},{"issue":"16","key":"362_CR211","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.7150\/thno.33812","volume":"9","author":"C Xie","year":"2019","unstructured":"Xie C, Zhu J, Jiang Y, Chen J, Wang X, Geng S, et al. Sulforaphane inhibits the acquisition of tobacco smoke-induced lung cancer stem cell-like properties via the IL-6\/DeltaNp63alpha\/Notch axis. Theranostics. 2019;9(16):4827\u201340.","journal-title":"Theranostics"},{"issue":"2","key":"362_CR212","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.bbrc.2006.07.095","volume":"348","author":"C Huang","year":"2006","unstructured":"Huang C, Zhang Y, Gong Z, Sheng X, Li Z, Zhang W, et al. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun. 2006;348(2):571\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"362_CR213","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1080\/10408398.2018.1552244","volume":"60","author":"SS Patel","year":"2020","unstructured":"Patel SS, Acharya A, Ray RS, Agrawal R, Raghuwanshi R, Jain P. Cellular and molecular mechanisms of curcumin in prevention and treatment of disease. Crit Rev Food Sci Nutr. 2020;60(6):887\u2013939.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"7","key":"362_CR214","doi-asserted-by":"publisher","first-page":"571","DOI":"10.2174\/187152010793498663","volume":"10","author":"H Zhou","year":"2010","unstructured":"Zhou H, Luo Y, Huang S. Updates of mTOR inhibitors. Anticancer Agents Med Chem. 2010;10(7):571\u201381.","journal-title":"Anticancer Agents Med Chem"},{"issue":"11","key":"362_CR215","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/j.jnutbio.2013.06.003","volume":"24","author":"PV Babu","year":"2013","unstructured":"Babu PV, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem. 2013;24(11):1777\u201389.","journal-title":"J Nutr Biochem"},{"issue":"12","key":"362_CR216","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.3390\/nu10121936","volume":"10","author":"A Negri","year":"2018","unstructured":"Negri A, Naponelli V, Rizzi F, Bettuzzi S. Molecular targets of epigallocatechin-gallate (EGCG): a special focus on signal transduction and cancer. Nutrients. 2018;10(12):1936.","journal-title":"Nutrients."},{"issue":"3","key":"362_CR217","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1080\/01635581.2018.1445762","volume":"70","author":"SK Dhatwalia","year":"2018","unstructured":"Dhatwalia SK, Kumar M, Dhawan DK. Role of EGCG in containing the progression of lung tumorigenesis - a multistage targeting approach. Nutr Cancer. 2018;70(3):334\u201349.","journal-title":"Nutr Cancer"},{"issue":"16","key":"362_CR218","doi-asserted-by":"publisher","first-page":"6463","DOI":"10.7314\/APJCP.2014.15.16.6463","volume":"15","author":"HK Tan","year":"2014","unstructured":"Tan HK, Moad AI, Tan ML. The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. Asian Pac J Cancer Prev. 2014;15(16):6463\u201375.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"362_CR219","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.bcp.2014.07.018","volume":"92","author":"L Wang","year":"2014","unstructured":"Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, et al. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARgamma): a review. Biochem Pharmacol. 2014;92(1):73\u201389.","journal-title":"Biochem Pharmacol"},{"key":"362_CR220","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.3389\/fimmu.2018.02160","volume":"9","author":"SC Gupta","year":"2018","unstructured":"Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Inflammation, a double-edge sword for cancer and other age-related diseases. Front Immunol. 2018;9:2160.","journal-title":"Front Immunol"},{"issue":"34","key":"362_CR221","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.2174\/0929867323666160824162718","volume":"23","author":"SM Pordanjani","year":"2016","unstructured":"Pordanjani SM, Hosseinimehr SJ. The role of NF-kB inhibitors in cell response to radiation. Curr Med Chem. 2016;23(34):3951\u201363.","journal-title":"Curr Med Chem"},{"issue":"2","key":"362_CR222","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1002\/jcb.26356","volume":"119","author":"B Dkhar","year":"2018","unstructured":"Dkhar B, Khongsti K, Thabah D, Syiem D, Satyamoorthy K, Das B. Genistein represses PEPCK-C expression in an insulin-independent manner in HepG2 cells and in alloxan-induced diabetic mice. J Cell Biochem. 2018;119(2):1953\u201370.","journal-title":"J Cell Biochem"},{"issue":"7","key":"362_CR223","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3390\/antiox9070610","volume":"9","author":"Y Kong","year":"2020","unstructured":"Kong Y, Olejar KJ, On SLW, Chelikani V. The potential of Lactobacillus spp. for modulating oxidative stress in the gastrointestinal tract. Antioxidants (Basel). 2020;9(7):610.","journal-title":"Antioxidants (Basel)."},{"issue":"7","key":"362_CR224","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1039\/C9FO00109C","volume":"10","author":"H Wang","year":"2019","unstructured":"Wang H, Cheng X, Zhang L, Xu S, Zhang Q, Lu R. A surface-layer protein from Lactobacillus acidophilus NCFM induces autophagic death in HCT116 cells requiring ROS-mediated modulation of mTOR and JNK signaling pathways. Food Funct. 2019;10(7):4102\u201312.","journal-title":"Food Funct"},{"issue":"11","key":"362_CR225","doi-asserted-by":"publisher","first-page":"1700252","DOI":"10.1002\/mnfr.201700252","volume":"61","author":"DH Kim","year":"2017","unstructured":"Kim DH, Jeong D, Kang IB, Kim H, Song KY, Seo KH. Dual function of Lactobacillus kefiri DH5 in preventing high-fat-diet-induced obesity: direct reduction of cholesterol and upregulation of PPAR-alpha in adipose tissue. Mol Nutr Food Res. 2017;61(11):1700252.","journal-title":"Mol Nutr Food Res."},{"issue":"8","key":"362_CR226","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.4014\/jmb.1905.05066","volume":"29","author":"M Jeong","year":"2019","unstructured":"Jeong M, Kim JH, Yang H, Kang SD, Song S, Lee D, et al. Heat-Killed Lactobacillus plantarum KCTC 13314BP enhances phagocytic activity and immunomodulatory effects via activation of MAPK and STAT3 pathways. J Microbiol Biotechnol. 2019;29(8):1248\u201354.","journal-title":"J Microbiol Biotechnol"},{"key":"362_CR227","doi-asserted-by":"publisher","first-page":"104626","DOI":"10.1016\/j.phrs.2019.104626","volume":"152","author":"A Sanches-Silva","year":"2020","unstructured":"Sanches-Silva A, Testai L, Nabavi SF, Battino M, Pandima Devi K, Tejada S, et al. Therapeutic potential of polyphenols in cardiovascular diseases: regulation of mTOR signaling pathway. Pharmacol Res. 2020;152:104626.","journal-title":"Pharmacol Res"},{"issue":"5","key":"362_CR228","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.ihj.2018.04.006","volume":"70","author":"N Chekalina","year":"2018","unstructured":"Chekalina N, Burmak Y, Petrov Y, Borisova Z, Manusha Y, Kazakov Y, et al. Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease. Indian Heart J. 2018;70(5):593\u20137.","journal-title":"Indian Heart J"},{"issue":"4","key":"362_CR229","doi-asserted-by":"publisher","first-page":"476","DOI":"10.5114\/ceji.2018.81347","volume":"43","author":"Y Shaik","year":"2018","unstructured":"Shaik Y, Caraffa A, Ronconi G, Lessiani G, Conti P. Impact of polyphenols on mast cells with special emphasis on the effect of quercetin and luteolin. Cent Eur J Immunol. 2018;43(4):476\u201381.","journal-title":"Cent Eur J Immunol"},{"key":"362_CR230","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1017\/erm.2013.11","volume":"15","author":"AL Widlund","year":"2013","unstructured":"Widlund AL, Baur JA, Vang O. mTOR: more targets of resveratrol? Expert Rev Mol Med. 2013;15:e10.","journal-title":"Expert Rev Mol Med"},{"key":"362_CR231","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.phrs.2017.02.010","volume":"119","author":"NM Shawky","year":"2017","unstructured":"Shawky NM, Segar L. Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR\/p70S6kinase signaling independent of Nrf2 activation. Pharmacol Res. 2017;119:251\u201364.","journal-title":"Pharmacol Res"},{"issue":"17","key":"362_CR232","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1016\/j.febslet.2014.06.036","volume":"588","author":"C Jo","year":"2014","unstructured":"Jo C, Kim S, Cho SJ, Choi KJ, Yun SM, Koh YH, et al. Sulforaphane induces autophagy through ERK activation in neuronal cells. FEBS Lett. 2014;588(17):3081\u20138.","journal-title":"FEBS Lett"},{"issue":"5","key":"362_CR233","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.3892\/or.2012.1977","volume":"28","author":"NA Doudican","year":"2012","unstructured":"Doudican NA, Wen SY, Mazumder A, Orlow SJ. Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways. Oncol Rep. 2012;28(5):1851\u20138.","journal-title":"Oncol Rep"},{"key":"362_CR234","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6745","author":"FAC Rocha","year":"2020","unstructured":"Rocha FAC, de Assis MR. Curcumin as a potential treatment for COVID-19. Phytother Res. 2020. https:\/\/doi.org\/10.1002\/ptr.6745.","journal-title":"Phytother Res."},{"key":"362_CR235","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6766","author":"A Roy","year":"2020","unstructured":"Roy A, Sarkar B, Celik C, Ghosh A, Basu U, Jana M, et al. Can concomitant use of zinc and curcumin with other immunity-boosting nutraceuticals be the arsenal against COVID-19? Phytother Res. 2020. https:\/\/doi.org\/10.1002\/ptr.6766.","journal-title":"Phytother Res."},{"key":"362_CR236","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6738","author":"F Zahedipour","year":"2020","unstructured":"Zahedipour F, Hosseini SA, Sathyapalan T, Majeed M, Jamialahmadi T, Al-Rasadi K, et al. Potential effects of curcumin in the treatment of COVID-19 infection. Phytother Res. 2020. https:\/\/doi.org\/10.1002\/ptr.6738.","journal-title":"Phytother Res."},{"issue":"7","key":"362_CR237","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1111\/ced.14357","volume":"45","author":"H Gupta","year":"2020","unstructured":"Gupta H, Gupta M, Bhargava S. Potential use of turmeric in COVID-19. Clin Exp Dermatol. 2020;45(7):902\u20133.","journal-title":"Clin Exp Dermatol."},{"issue":"8","key":"362_CR238","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.3390\/molecules22081324","volume":"22","author":"J Xu","year":"2017","unstructured":"Xu J, Xu Z, Zheng W. A review of the antiviral role of green tea catechins. Molecules. 2017;22(8):1337.","journal-title":"Molecules."},{"issue":"14","key":"362_CR239","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.3390\/ijms21145171","volume":"21","author":"M Menegazzi","year":"2020","unstructured":"Menegazzi M, Campagnari R, Bertoldi M, Crupi R, Di Paola R, Cuzzocrea S. Protective effect of epigallocatechin-3-Gallate (EGCG) in diseases with uncontrolled immune activation: could such a scenario be helpful to counteract COVID-19? Int J Mol Sci. 2020;21(14):5171.","journal-title":"Int J Mol Sci."},{"key":"362_CR240","doi-asserted-by":"crossref","unstructured":"Mhatre S, Srivastava T, Naik S, Patravale V. Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review. Phytomedicine. 2020:153286.","DOI":"10.1016\/j.phymed.2020.153286"},{"issue":"5","key":"362_CR241","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s10529-011-0845-8","volume":"34","author":"TT Nguyen","year":"2012","unstructured":"Nguyen TT, Woo HJ, Kang HK, Nguyen VD, Kim YM, Kim DW, et al. Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris. Biotechnol Lett. 2012;34(5):831\u20138.","journal-title":"Biotechnol Lett"},{"key":"362_CR242","doi-asserted-by":"crossref","unstructured":"Russo M, Moccia S, Spagnuolo C, Tedesco I, Russo GL. Roles of flavonoids against coronavirus infection. Chem Biol Interact. 2020:109211.","DOI":"10.1016\/j.cbi.2020.109211"},{"key":"362_CR243","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.2147\/DDDT.S251623","volume":"14","author":"Y Tian","year":"2020","unstructured":"Tian Y, Bao Z, Ji Y, Mei X, Yang H. Epigallocatechin-3-gallate protects H2O2-induced nucleus pulposus cell apoptosis and inflammation by inhibiting cGAS\/Sting\/NLRP3 activation. Drug Des Devel Ther. 2020;14:2113\u201322.","journal-title":"Drug Des Devel Ther"},{"issue":"8","key":"362_CR244","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.jnutbio.2009.04.004","volume":"20","author":"A Andres","year":"2009","unstructured":"Andres A, Donovan SM, Kuhlenschmidt MS. Soy isoflavones and virus infections. J Nutr Biochem. 2009;20(8):563\u20139.","journal-title":"J Nutr Biochem"},{"key":"362_CR245","doi-asserted-by":"crossref","unstructured":"Elfiky AA. Natural products may interfere with SARS-CoV-2 attachment to the host cell. J Biomol Struct Dyn. 2020:1\u201310.","DOI":"10.1080\/07391102.2020.1761881"},{"key":"362_CR246","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3389\/fphys.2020.00699","volume":"11","author":"J Villena","year":"2020","unstructured":"Villena J, Kitazawa H. The modulation of mucosal antiviral immunity by immunobiotics: could they offer any benefit in the SARS-CoV-2 pandemic? Front Physiol. 2020;11:699.","journal-title":"Front Physiol"},{"issue":"6","key":"362_CR247","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.3390\/nu12061737","volume":"12","author":"AHA Morais","year":"2020","unstructured":"Morais AHA, Passos TS, Maciel BLL, da Silva-Maia JK. Can probiotics and diet promote beneficial immune modulation and purine control in coronavirus infection? Nutrients. 2020;12(6):1737.","journal-title":"Nutrients."},{"issue":"3","key":"362_CR248","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3390\/foods9030374","volume":"9","author":"GE Batiha","year":"2020","unstructured":"Batiha GE, Beshbishy AM, Ikram M, Mulla ZS, El-Hack MEA, Taha AE, et al. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020;9(3):374.","journal-title":"Foods."},{"key":"362_CR249","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3389\/fimmu.2020.01451","volume":"11","author":"RML Colunga Biancatelli","year":"2020","unstructured":"Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and vitamin c: an experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19). Front Immunol. 2020;11:1451.","journal-title":"Front Immunol"},{"issue":"5","key":"362_CR250","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3390\/biomedicines8050129","volume":"8","author":"GV Glinsky","year":"2020","unstructured":"Glinsky GV. Tripartite combination of candidate pandemic mitigation agents: vitamin D, quercetin, and estradiol manifest properties of medicinal agents for targeted mitigation of the COVID-19 Pandemic defined by genomics-guided Tracing of SARS-CoV-2 targets in human cells. Biomedicines. 2020;8(5):129.","journal-title":"Biomedicines."},{"key":"362_CR251","doi-asserted-by":"crossref","unstructured":"Pandey P, Rane JS, Chatterjee A, Kumar A, Khan R, Prakash A, et al. Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development. J Biomol Struct Dyn. 2020:1\u201311.","DOI":"10.1080\/07391102.2020.1796811"},{"issue":"6","key":"362_CR252","doi-asserted-by":"publisher","first-page":"105971","DOI":"10.1016\/j.ijantimicag.2020.105971","volume":"55","author":"H Polansky","year":"2020","unstructured":"Polansky H, Lori G. Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-Eden-VIR\/Novirin in SARS-CoV-2 infection. Int J Antimicrob Agents. 2020;55(6):105971.","journal-title":"Int J Antimicrob Agents"},{"key":"362_CR253","doi-asserted-by":"publisher","first-page":"114123","DOI":"10.1016\/j.bcp.2020.114123","volume":"178","author":"G Williamson","year":"2020","unstructured":"Williamson G, Kerimi A. Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction. Biochem Pharmacol. 2020;178:114123.","journal-title":"Biochem Pharmacol"},{"key":"362_CR254","doi-asserted-by":"publisher","first-page":"184241","DOI":"10.1155\/2015\/184241","volume":"2015","author":"Y Abba","year":"2015","unstructured":"Abba Y, Hassim H, Hamzah H, Noordin MM. Antiviral activity of resveratrol against human and animal viruses. Adv Virol. 2015;2015:184241.","journal-title":"Adv Virol"},{"issue":"12","key":"362_CR255","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.7150\/ijms.47836","volume":"17","author":"YJ Han","year":"2020","unstructured":"Han YJ, Ren ZG, Li XX, Yan JL, Ma CY, Wu DD, et al. Advances and challenges in the prevention and treatment of COVID-19. Int J Med Sci. 2020;17(12):1803\u201310.","journal-title":"Int J Med Sci"},{"key":"362_CR256","doi-asserted-by":"crossref","unstructured":"Hooper PL. COVID-19 and heme oxygenase: novel insight into the disease and potential therapies. Cell Stress Chaperones. 2020.","DOI":"10.1007\/s12192-020-01130-z"},{"key":"362_CR257","doi-asserted-by":"crossref","unstructured":"Marinella MA. Indomethacin and resveratrol as potential treatment adjuncts for SARS-CoV-2\/COVID-19. Int J Clin Pract. 2020:e13535.","DOI":"10.1111\/ijcp.13535"},{"key":"362_CR258","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40885-020-00147-x","volume":"26","author":"CS McLachlan","year":"2020","unstructured":"McLachlan CS. The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms. Clin Hypertens. 2020;26:14.","journal-title":"Clin Hypertens"},{"key":"362_CR259","doi-asserted-by":"crossref","unstructured":"Wahedi HM, Ahmad S, Abbasi SW. Stilbene-based natural compounds as promising drug candidates against COVID-19. J Biomol Struct Dyn. 2020:1\u201310.","DOI":"10.1080\/07391102.2020.1762743"},{"key":"362_CR260","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.2147\/IDR.S256773","volume":"13","author":"CY Lin","year":"2020","unstructured":"Lin CY, Yao CA. Potential role of Nrf2 activators with dual antiviral and anti-inflammatory properties in the management of viral pneumonia. Infect Drug Resist. 2020;13:1735\u201341.","journal-title":"Infect Drug Resist"},{"issue":"8","key":"362_CR261","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1142\/S0192415X17500926","volume":"45","author":"Y Zan","year":"2017","unstructured":"Zan Y, Kuai CX, Qiu ZX, Huang F. Berberine ameliorates diabetic neuropathy: TRPV1 modulation by PKC pathway. Am J Chin Med. 2017;45(8):1709\u201323.","journal-title":"Am J Chin Med"},{"key":"362_CR262","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.fitote.2017.09.007","volume":"122","author":"M Nalli","year":"2017","unstructured":"Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L. Effects of curcumin and curcumin analogues on TRP channels. Fitoterapia. 2017;122:126\u201331.","journal-title":"Fitoterapia"},{"issue":"1","key":"362_CR263","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1021\/acschemneuro.8b00493","volume":"10","author":"D Peixoto-Neves","year":"2019","unstructured":"Peixoto-Neves D, Soni H, Adebiyi A. CGRPergic nerve TRPA1 channels contribute to epigallocatechin gallate-induced neurogenic vasodilation. ACS Chem Neurosci. 2019;10(1):216\u201320.","journal-title":"ACS Chem Neurosci"},{"issue":"4","key":"362_CR264","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.bbrc.2018.01.122","volume":"496","author":"R Guo","year":"2018","unstructured":"Guo R, Zhou FM, Su CJ, Liu TT, Zhou Y, Fan L, et al. Epigallocatechin-3-gallate attenuates acute and chronic psoriatic itch in mice: Involvement of antioxidant, anti-inflammatory effects and suppression of ERK and Akt signaling pathways. Biochem Biophys Res Commun. 2018;496(4):1062\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"362_CR265","doi-asserted-by":"publisher","first-page":"14","DOI":"10.4077\/CJP.2018.BAG518","volume":"61","author":"CM Yeh","year":"2018","unstructured":"Yeh CM, Lin YJ, Hsu TH, Ruan T. Genistein suppressing the ROS-induced hypersensitivity of rat vagal lung C-fiber afferents through an ERalpha-mediated mechanism. Chin J Physiol. 2018;61(1):14\u201324.","journal-title":"Chin J Physiol"},{"issue":"1\u20132","key":"362_CR266","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.taap.2005.06.015","volume":"210","author":"S Kikuno","year":"2006","unstructured":"Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, et al. 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. Toxicol Appl Pharmacol. 2006;210(1\u20132):47\u201354.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"362_CR267","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1080\/09168451.2015.1132148","volume":"80","author":"T Nakamura","year":"2016","unstructured":"Nakamura T, Miyoshi N, Ishii T, Nishikawa M, Ikushiro S, Watanabe T. Activation of transient receptor potential ankyrin 1 by quercetin and its analogs. Biosci Biotechnol Biochem. 2016;80(5):949\u201354.","journal-title":"Biosci Biotechnol Biochem"},{"issue":"11","key":"362_CR268","first-page":"5149","volume":"11","author":"Z Li","year":"2018","unstructured":"Li Z, Zhang J, Ren X, Liu Q, Yang X. The mechanism of quercetin in regulating osteoclast activation and the PAR2\/TRPV1 signaling pathway in the treatment of bone cancer pain. Int J Clin Exp Pathol. 2018;11(11):5149\u201356.","journal-title":"Int J Clin Exp Pathol"},{"issue":"14","key":"362_CR269","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1016\/j.bmcl.2017.05.025","volume":"27","author":"S Nakao","year":"2017","unstructured":"Nakao S, Mabuchi M, Wang S, Kogure Y, Shimizu T, Noguchi K, et al. Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. Bioorg Med Chem Lett. 2017;27(14):3167\u201372.","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"362_CR270","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.bmcl.2015.12.065","volume":"26","author":"M Nalli","year":"2016","unstructured":"Nalli M, Ortar G, Moriello AS, Morera E, Di Marzo V, De Petrocellis L. TRPA1 channels as targets for resveratrol and related stilbenoids. Bioorg Med Chem Lett. 2016;26(3):899\u2013902.","journal-title":"Bioorg Med Chem Lett"},{"key":"362_CR271","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1744-8069-9-3","volume":"9","author":"L Yu","year":"2013","unstructured":"Yu L, Wang S, Kogure Y, Yamamoto S, Noguchi K, Dai Y. Modulation of TRP channels by resveratrol and other stilbenoids. Mol Pain. 2013;9:3.","journal-title":"Mol Pain"},{"issue":"8","key":"362_CR272","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1021\/acs.jnatprod.5b00272","volume":"78","author":"Y Terada","year":"2015","unstructured":"Terada Y, Masuda H, Watanabe T. Structure-activity relationship study on isothiocyanates: comparison of TRPA1-activating ability between allyl isothiocyanate and specific flavor components of wasabi, horseradish, and white mustard. J Nat Prod. 2015;78(8):1937\u201341.","journal-title":"J Nat Prod"},{"issue":"12","key":"362_CR273","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1111\/bph.14044","volume":"175","author":"MM Moran","year":"2018","unstructured":"Moran MM, Szallasi A. Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field. Br J Pharmacol. 2018;175(12):2185\u2013203.","journal-title":"Br J Pharmacol"},{"issue":"3","key":"362_CR274","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s13238-016-0353-7","volume":"8","author":"F Yang","year":"2017","unstructured":"Yang F, Zheng J. Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. Protein Cell. 2017;8(3):169\u201377.","journal-title":"Protein Cell"}],"container-title":["Clinical and Translational Allergy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13601-020-00362-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13601-020-00362-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13601-020-00362-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T13:11:54Z","timestamp":1723986714000},"score":1,"resource":{"primary":{"URL":"https:\/\/ctajournal.biomedcentral.com\/articles\/10.1186\/s13601-020-00362-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":274,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["362"],"URL":"https:\/\/doi.org\/10.1186\/s13601-020-00362-7","relation":{},"ISSN":["2045-7022"],"issn-type":[{"value":"2045-7022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"30 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors gave their informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None of the authors declared any competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}