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Intensive Care"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify the prevalence and associated factors of cognitive dysfunction, 1\u00a0year after ICU discharge, among adult patients, and it\u00b4s relation with quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter, prospective cohort study including ICUs of 10 tertiary hospitals in Brazil, between May 2014 and December 2018. The patients included were 452 adult ICU survivors (median age 60; 47.6% women) with an ICU stay greater than 72\u00a0h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 12\u00a0months after ICU discharge, a Montreal Cognitive Assessment (tMOCA) telephone score of less than 12 was defined as cognitive dysfunction. At 12\u00a0months, of the 452 ICU survivors who completed the cognitive evaluation 216 (47.8%) had cognitive dysfunction.<\/jats:p>\n                    <jats:p>In multivariable analyses, the factors associated with long-term (1-year) cognitive dysfunction were older age (Prevalence Ratio\u2013PR\u2009=\u20091.44, P\u2009&lt;\u20090.001), absence of higher education (PR\u2009=\u20092.81, P\u2009=\u20090.005), higher comorbidities on admission (PR\u2009=\u20091.089; P\u2009=\u20090.004) and delirium (PR\u2009=\u20091.13, P\u2009&lt;\u20090.001). Health-related Quality of life (HRQoL), assessed by the mental and physical dimensions of the SF-12v2, was significantly better in patients without cognitive dysfunction (Mental SF-12v2 Mean difference\u2009=\u20092.54; CI 95%, \u2212\u00a04.80\/\u2212\u00a00.28; p\u2009=\u20090.028 and Physical SF-12v2 Mean difference\u2009=\u2009\u2212\u00a02.85; CI 95%, \u2212\u00a05.20\/\u2212\u00a00.50; P\u2009=\u20090.018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Delirium was found to be the main modifiable predictor of long-term cognitive dysfunction in ICU survivors. Higher education consistently reduced the probability of having long-term cognitive dysfunction. Cognitive dysfunction significantly influenced patients\u2019 quality of life, leading us to emphasize the importance of cognitive reserve for long-term prognosis after ICU discharge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13613-024-01335-w","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:01:33Z","timestamp":1722211293000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long term cognitive dysfunction among critical care survivors: associated factors and quality of life\u2014a multicenter cohort study"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7415-2133","authenticated-orcid":false,"given":"Isabel","family":"Jesus Pereira","sequence":"first","affiliation":[]},{"given":"Mariana","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Sganzerla","sequence":"additional","affiliation":[]},{"given":"Caroline Cabral","family":"Robinson","sequence":"additional","affiliation":[]},{"given":"Denise","family":"de Souza","sequence":"additional","affiliation":[]},{"given":"Renata","family":"Kochhann","sequence":"additional","affiliation":[]},{"given":"Maicon","family":"Falavigna","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Bozza","sequence":"additional","affiliation":[]},{"given":"Tarek","family":"Sharshar","sequence":"additional","affiliation":[]},{"given":"Regis","family":"Goulart Rosa","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Granja","sequence":"additional","affiliation":[]},{"given":"Cassiano","family":"Teixeira","sequence":"additional","affiliation":[]}],"member":"78","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"issue":"6","key":"1335_CR1","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1097\/01.CCM.0000166866.47020.E5","volume":"33","author":"A Petzold","year":"2005","unstructured":"Petzold A, Downie P, Smith M. 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