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Although the efficacy of hydrogen peroxide (H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n ) against the emergent yeast\n Candida auris<\/jats:italic>\n is moderately documented, concerns over the potential induction of resistance after repeated exposure do persist. The main objective of the present study was to evaluate the hypothetical induction of\n Candida auris<\/jats:italic>\n resistance following 30 days of consecutive exposure to lethal and sublethal concentrations of H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n . Furthermore, the authors aimed to elucidate about the rank of efficacy of H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n against\n C. auris<\/jats:italic>\n comparing to other\n Candida<\/jats:italic>\n species and whether different strains of\n C. auris<\/jats:italic>\n may display different susceptibilities to H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n During the induction of resistance assays, both type strains and clinical isolates of\n Candida auris, Candida albicans<\/jats:italic>\n and\n Candida parapsilosis<\/jats:italic>\n were exposed repeatedly to defined concentrations of H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n , for 30 days.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After that period, no significant differences were found when comparing the minimal inhibitory concentration values of H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n in case of the induced strains\n versus<\/jats:italic>\n each respective positive control. Moreover, H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n displayed similar effectiveness against all the tested\n Candida<\/jats:italic>\n species and no differences were demonstrated among the distinct strains of\n C. auris<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The adoption of H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n solutions in routine protocols in order to promote disinfection standards against\n Candida auris<\/jats:italic>\n , improving patient safety and reducing healthcare costs, is certainly welcomed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s13756-023-01281-5","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T21:02:05Z","timestamp":1694034125000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does repeated exposure to hydrogen peroxide induce Candida auris resistance?"],"prefix":"10.1186","volume":"12","author":[{"given":"Luis","family":"Cobrado","sequence":"first","affiliation":[]},{"given":"Elisabete","family":"Ricardo","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"Ramalho","sequence":"additional","affiliation":[]},{"given":"Angela Rita","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Acacio Goncalves","family":"Rodrigues","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"1281_CR1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jhin.2021.03.010","volume":"113","author":"O Assadian","year":"2021","unstructured":"Assadian O, Harbarth S, Vos M, Knobloch JK, Asensio A, Widmer AF. 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