{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T16:49:06Z","timestamp":1774889346176,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Implant Dent"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since the leucocyte-platelet rich fibrin (L-PRF) was published in 2001, many studies have been developed, analyzing its properties, and also verifying new possibilities to improve it. Thereby, it emerges the advanced-platelet rich fibrin (A-PRF) with a protocol that optimizes the properties obtained by the L-PRF. Nonetheless, there is a gap in the literature to landmark the evolutive process concerning the mechanical properties in specific the resistance to tensile strength which consequently may influence the time for membrane degradation. Thus, this study had the goal to compare the resistance to the traction of membranes produced with the original L-PRF and A-PRF protocols, being the first to this direct comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The harvest of blood from a healthy single person, with no history of anticoagulant usage. We performed the protocols described in the literature, within a total of 13 membranes produced for each protocol (<jats:italic>n<\/jats:italic>= 26). Afterward, the membranes were prepared and submitted to a traction test assessing the maximal and the average traction achieved for each membrane. The data were analyzed statistically using the unpaired<jats:italic>t<\/jats:italic>test. Regarding average traction, A-PRF obtained a value of 0.0288\u2009N mm<jats:sup>\u22122<\/jats:sup>and L-PRF 0.0192\u2009N mm<jats:sup>\u22122<\/jats:sup>(<jats:italic>p<\/jats:italic>&lt; 0.05 using unpaired<jats:italic>t<\/jats:italic>test). For maximal traction, A-PRF obtained 0.0752\u2009N mm<jats:sup>\u22122<\/jats:sup>and L-PRF 0.0425\u2009N mm<jats:sup>\u22122<\/jats:sup>(<jats:italic>p<\/jats:italic>&lt; 0.05 using unpaired<jats:italic>t<\/jats:italic>test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With this study, it was possible to conclude that indeed A-PRF has a significative higher maximal traction score and higher average traction compared to L-PRF, indicating that it had a higher resistance when two opposing forces are applied.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40729-020-00284-w","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:04:46Z","timestamp":1610669086000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Tensile strength assay comparing the resistance between two different autologous platelet concentrates (leucocyte-platelet rich fibrin versus advanced-platelet rich fibrin): a pilot study"],"prefix":"10.1186","volume":"7","author":[{"given":"Martim de Almeida N\u00f3brega Correia","family":"Pascoal","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-2290","authenticated-orcid":false,"given":"Nuno Bernardo Malta","family":"dos Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3972-8432","authenticated-orcid":false,"given":"Ant\u00f3nio Manuel Godinho","family":"Completo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-4390","authenticated-orcid":false,"given":"Gustavo Vicentis de Oliveira","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"issue":"3","key":"284_CR1","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","volume":"101","author":"DM Dohan","year":"2006","unstructured":"Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37\u201344.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"284_CR2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","volume":"27","author":"DM Dohan Ehrenfest","year":"2009","unstructured":"Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158\u201367.","journal-title":"Trends Biotechnol"},{"issue":"6","key":"284_CR3","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S1079-2104(98)90029-4","volume":"85","author":"RE Marx","year":"1998","unstructured":"Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):368\u201346.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"11","key":"284_CR4","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/S0278-2391(97)90187-7","volume":"55","author":"H Whitman","year":"1997","unstructured":"Whitman H, Berry L, Green M. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55(11):1294\u20139.","journal-title":"J Oral Maxillofac Surg"},{"issue":"31","key":"284_CR5","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.1016\/j.biomaterials.2007.06.037","volume":"28","author":"E Anitua","year":"2007","unstructured":"Anitua E, S\u00e1nchez M, Orive G, And\u00eda I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28(31):4551\u201360.","journal-title":"Biomaterials."},{"issue":"3","key":"284_CR6","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.jcms.2019.01.012","volume":"47","author":"P Dragonas","year":"2019","unstructured":"Dragonas P, Schiavo JH, Avila-Ortiz G, Palaiologou A, Katsaros T. Plasma rich in growth factors (PRGF) in intraoral bone grafting procedures: a systematic review. J Craniomaxillofac Surg. 2019;47(3):443\u201353.","journal-title":"J Craniomaxillofac Surg"},{"issue":"6","key":"284_CR7","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","volume":"21","author":"RJ Miron","year":"2017","unstructured":"Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, et al. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Investig. 2017;21(6):1913\u201327.","journal-title":"Clin Oral Investig"},{"issue":"3","key":"284_CR8","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1016\/j.tripleo.2005.07.009","volume":"101","author":"DM Dohan","year":"2006","unstructured":"Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e45\u201350.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"284_CR9","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.tripleo.2005.07.010","volume":"101","author":"DM Dohan","year":"2006","unstructured":"Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e51\u20135.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"284_CR10","first-page":"55","volume":"42","author":"J Choukroun","year":"2001","unstructured":"Choukroun J. An opportunity in paroimplantology: PRF. Implantodontie. 2001;42:55\u201362.","journal-title":"Implantodontie."},{"issue":"5","key":"284_CR11","first-page":"7922","volume":"8","author":"E Borie","year":"2015","unstructured":"Borie E, Oliv\u00ed DG, Orsi IA, Garlet K, Weber B, Beltr\u00e1n V, Fuentes R. Platelet-rich fibrin application in dentistry: a literature review. Int J Clin Exp Med. 2015;8(5):7922\u20139.","journal-title":"Int J Clin Exp Med"},{"issue":"6","key":"284_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1563\/aaid-joi-D-14-00138","volume":"40","author":"S Ghanaati","year":"2014","unstructured":"Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implant. 2014;40(6):679\u201389.","journal-title":"J Oral Implant"},{"key":"284_CR13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4103\/jispcd.JISPCD_429_16","volume":"7","author":"UP Verma","year":"2017","unstructured":"Verma UP, Yadav RK, Dixit M, Gupta A. Platelet-rich fibrin: a paradigm in periodontal therapy \u2013 a systematic review. J Int Soc Prevent Communit Dent. 2017;7:227\u201333.","journal-title":"J Int Soc Prevent Communit Dent"},{"issue":"1","key":"284_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00068-017-0767-9","volume":"44","author":"J Choukroun","year":"2018","unstructured":"Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. 2018;44(1):87\u201395.","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"2","key":"284_CR15","doi-asserted-by":"publisher","first-page":"60","DOI":"10.12968\/jowc.2008.17.2.28179","volume":"17","author":"P Steenvoorde","year":"2008","unstructured":"Steenvoorde P, van Doorn LP, Naves C, Oskam J. Use of autologous platelet-rich fibrin on hard-to-heal wounds. J Wound Care. 2008;17(2):60\u20133.","journal-title":"J Wound Care"},{"key":"284_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/jcpe.12643","volume":"44","author":"AB Castro","year":"2017","unstructured":"Castro AB, Meschi N, Temmerman A, Pinto N, Lambrechts P, Teughels W, Quirynen M. Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. J Clin Periodontol. 2017;44:67\u201382.","journal-title":"J Clin Periodontol"},{"key":"284_CR17","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1002\/jemt.20968","volume":"74","author":"LF Rodella","year":"2011","unstructured":"Rodella LF, Favero G, Boninsegna R, Labanca M, Scar\u00ec G, Sacco L, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74:772\u20137.","journal-title":"Microsc Res Tech."},{"key":"284_CR18","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.11607\/jomi.3995","volume":"30","author":"Y Takeda","year":"2015","unstructured":"Takeda Y, Katsutoshi K, Matsuzaka K, Inoue T. The effect of concentrated growth factor on rat bone marrow cells in vitro and on calvarial bone healing in vivo. Int J Oral Maxillofac Implants. 2015;30:1187\u201396.","journal-title":"Int J Oral Maxillofac Implants."},{"issue":"1","key":"284_CR19","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40729-017-0081-7","volume":"3","author":"K Isobe","year":"2017","unstructured":"Isobe K, Watanebe T, Kawabata H, Kitamura Y, Okudera T, Okudera H, et al. Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF). Int J Implant Dent. 2017;3(1):17.","journal-title":"Int J Implant Dent"},{"key":"284_CR20","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1902\/jop.2013.120685","volume":"85","author":"B Kaval","year":"2014","unstructured":"Kaval B, Renaud DE, Scott DA, Buduneli N. The role of smoking and gingival crevicular fluid markers on coronally advanced flap outcomes. J Periodontol. 2014;85:395\u2013405.","journal-title":"J Periodontol"},{"issue":"7","key":"284_CR21","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.2174\/138920112800624382","volume":"13","author":"DMD Ehrenfest","year":"2012","unstructured":"Ehrenfest DMD, Bielecki T, Jimbo R, Barb\u00e9 G, Del Corso M, Inchingolo F, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol. 2012;13(7):1145\u201352.","journal-title":"Curr Pharm Biotechnol"},{"key":"284_CR22","doi-asserted-by":"publisher","first-page":"1849207","DOI":"10.1155\/2016\/1849207","volume":"2016","author":"H Khorshidi","year":"2016","unstructured":"Khorshidi H, Raoofi S, Bagheri R, Banihashemi H. Comparison of the mechanical properties of early leukocyte- and platelet-rich fibrin versus PRGF\/Endoret membranes. Int J Dent. 2016;2016:1849207.","journal-title":"Int J Dent"},{"key":"284_CR23","doi-asserted-by":"publisher","first-page":"8515829","DOI":"10.1155\/2018\/8515829","volume":"2018","author":"H Khorshidi","year":"2018","unstructured":"Khorshidi H, Haddadi P, Raoofi S, Badiee P, Nazhvani AD. Does adding silver nanoparticles to leukocyte- and platelet-rich fibrin improve its properties? Biomed Res Int. 2018;2018:8515829.","journal-title":"Biomed Res Int"},{"key":"284_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/9781119406792","volume-title":"Platelet rich fibrin in regenerative dentistry: biological background and clinical indications: biological background and clinical indications","author":"RJ Miron","year":"2017","unstructured":"Miron RJ, Choukroun J. Platelet rich fibrin in regenerative dentistry: biological background and clinical indications: biological background and clinical indications. Oxford: Wiley; 2017."},{"issue":"1","key":"284_CR25","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/jbm.b.34680","volume":"109","author":"ES Louren\u00e7o","year":"2020","unstructured":"Louren\u00e7o ES, Alves GG, Barbosa RL, Spiegel CN, Mello-Machado RC, Al-Maawi S, Ghanaati S, Mour\u00e3o CFAB. Effects of rotor angle and time after centrifugation on the biological in vitro properties of platelet rich fibrin membranes. J Biomed Mat Res Part B Appl Mat. 2020;109(1):60\u20138.","journal-title":"J Biomed Mat Res Part B Appl Mat"},{"key":"284_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40824-020-00193-4","volume":"24","author":"S Ravi","year":"2020","unstructured":"Ravi S, Santhanakrishnan M. Mechanical, chemical, structural analysis and comparative release of PDGF-AA from L-PRF, A-PRF and T-PRF - an in vitro study. Biomat Res. 2020;24:16.","journal-title":"Biomat Res"},{"key":"284_CR27","first-page":"313","volume-title":"Handbookof polymer testing","author":"S Hawley","year":"1999","unstructured":"Hawley S. Particular requirements for plastics. In: Brown R, editor. Handbookof polymer testing. New York: Marcel Dekker Inc; 1999. p. 313."},{"issue":"11","key":"284_CR28","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.3390\/ijms19113433","volume":"19","author":"D Kardos","year":"2018","unstructured":"Kardos D, Horny\u00e1k I, Simon M, Hinsenkamp A, Marschall B, V\u00e1rdai R, et al. Biological and mechanical properties of platelet-rich fibrin membranes after thermal manipulation and preparation in a single-syringe closed system. Int J Mol Sci. 2018;19(11):3433.","journal-title":"Int J Mol Sci"},{"key":"284_CR29","doi-asserted-by":"crossref","unstructured":"Pinto NR, Ubilla M, Zamora Y, Del Rio V, Dohan Ehrenfest DM, Quirynen M. Leucocyte- and platelet-rich fibrin (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: a prospective cohort study. Platelets. 2017:1\u20138.","DOI":"10.1080\/09537104.2017.1327654"},{"key":"284_CR30","first-page":"2587245","volume":"2019","author":"R Li","year":"2019","unstructured":"Li R, Liu Y, Xu T, Zhao H, Hou J, Wu Y, Zhang D. The additional effect of autologous platelet concentrates to coronally advanced flap in the treatment of gingival recessions: a systematic review and meta-analysis. Biomed Res Int. 2019;2019:2587245.","journal-title":"Biomed Res Int"},{"issue":"3","key":"284_CR31","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ijom.2018.07.007","volume":"48","author":"JVDS Canellas","year":"2019","unstructured":"Canellas JVDS, Medeiros PJD, Figueredo CMDS, Fischer RG, Ritto FG. Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2019;48(3):395\u2013414.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"284_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4103\/GFSC.GFSC_21_18","volume":"1","author":"CF Barros Mour\u00e3o","year":"2018","unstructured":"Barros Mour\u00e3o CF, Gheno E, Louren\u00e7o ES, Barbosa R, Kurtzman GM, Javid K, et al. Characterization of a new membrane from concentrated growth factors associated with denaturized Albumin (Alb-CGF) for clinical applications: a preliminary study. Int J Growth Factors Stem Cells Dent. 2018;1:64\u20139.","journal-title":"Int J Growth Factors Stem Cells Dent"},{"key":"284_CR33","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1097\/00001721-199611000-00002","volume":"7","author":"JM van Gelder","year":"1996","unstructured":"van Gelder JM, Nair CH, Dhall DP. Colloid determination of fibrin network permeability. Blood Coagul Fibrinolysis. 1996;7:747\u201360.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"1","key":"284_CR34","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1902\/jop.2016.160443","volume":"88","author":"M Fujioka-Kobayashi","year":"2017","unstructured":"Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized platelet-rich fibrin with the low-speed concept: growth factor release, biocompatibility, and cellular response. J Periodontol. 2017;88(1):112\u201321.","journal-title":"J Periodontol"},{"issue":"4","key":"284_CR35","doi-asserted-by":"publisher","first-page":"546","DOI":"10.4103\/njcp.njcp_473_18","volume":"22","author":"MG Caymaz","year":"2019","unstructured":"Caymaz MG, Uyanik LO. Comparison of the effect of advanced platelet-rich fibrin and leukocyte- and platelet-rich fibrin on outcomes after removal of impacted mandibular third molar: a randomized split-mouth study. Niger J Clin Pract. 2019;22(4):546\u201352.","journal-title":"Niger J Clin Pract"},{"key":"284_CR36","doi-asserted-by":"publisher","first-page":"372","DOI":"10.2337\/dc06-1625","volume":"30","author":"T Geisler","year":"2007","unstructured":"Geisler T, Anders N, Paterok M, Langer H, Stellos K, Lindemann S, Herdeg C, May AE, Gawaz M. Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation. Diabetes Care. 2007;30:372\u20134.","journal-title":"Diabetes Care"},{"key":"284_CR37","doi-asserted-by":"publisher","first-page":"780","DOI":"10.2337\/diabetes.55.03.06.db05-1394","volume":"55","author":"DJ Angiollo","year":"2006","unstructured":"Angiollo DJ, Fernandez-Ortiz A, Bernardo E, Ram\u00edrez C, Sabat\u00e9 M, Jimenez-Quevedo P, Hern\u00e1ndez R, Moreno R, Escaned J, Alfonso F, Ba\u00f1uelos C, Costa MA, Bass TA, Macaya C. Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease. Diabetes. 2006;55:780\u20134.","journal-title":"Diabetes."},{"key":"284_CR38","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1093\/eurheartj\/ehq494","volume":"32","author":"DJ Angiolillo","year":"2011","unstructured":"Angiolillo DJ, Badimon JJ, Saucedo JF, Frelinger AL, Michelson AD, Jakubowski JA, Zhu B, Ojeh CK, Baker BA, Effron MB. A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the optimizing anti-platelet therapy in diabetes mellitus (OPTIMUS)-3 trial. Eur Heart J. 2011;32:838\u201346.","journal-title":"Eur Heart J"}],"container-title":["International Journal of Implant Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40729-020-00284-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40729-020-00284-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40729-020-00284-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T18:42:45Z","timestamp":1697568165000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalimplantdent.springeropen.com\/articles\/10.1186\/s40729-020-00284-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["284"],"URL":"https:\/\/doi.org\/10.1186\/s40729-020-00284-w","relation":{},"ISSN":["2198-4034"],"issn-type":[{"value":"2198-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]},"assertion":[{"value":"15 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Prior to the beginning, the study was approved by the local Ethics Committee (number 522020), at the Catholic University of Portugal.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors, before submitting the article to the International Journal of Implant Dentistry, agreed to submit and transfer all publication rights to the International Journal of Implant Dentistry including all submitted materials in case of acceptance.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Martim de Almeida N\u00f3brega Correia Pascoal, Nuno Bernardo Malta dos Santos, Ant\u00f3nio Manuel Godinho Completo, and Gustavo Vicentis de Oliveira Fernandes declare no competing interests associated with this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1"}}