{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:01:38Z","timestamp":1740175298036,"version":"3.37.3"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["6026-51000-010-05S"],"award-info":[{"award-number":["6026-51000-010-05S"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM121293"],"award-info":[{"award-number":["P20GM121293"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI146521."],"award-info":[{"award-number":["R21AI146521."]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nutr"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal diet impacts many physiological systems and can modify risk for developing metabolic disease and obesity later in life. Less well studied is the effect of postnatal diet (e.g., comparing human milk (HM) or milk formula (MF) feeding) on mitochondrial bioenergetics. Such effects may be most profound in splanchnic tissues that would have early exposure to diet-associated or gut microbe-derived factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To address this question, we measured ileal and liver mitochondrial bioenergetics phenotypes in male piglets fed with HM or MF from day 2 to day 21 age. Ileal and liver tissue were processed for mitochondrial respiration (substrate only [pyruvate, malate, glutamate], substrate + ADP, and proton \u201cleak\u201d post-oligomycin; measured by Oroboros methods), mitochondrial DNA (mtDNA) and metabolically-relevant gene expression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences between the diet groups were observed in mitochondrial bioenergetics indices in ileal tissue. In contrast, ADP-dependent liver Complex I-linked OXPHOS capacity and Complex I\u2009+\u2009II-linked OXPHOS capacity were significantly higher in MF animals relative to HM fed piglets. Interestingly, p53, Trap1, and Ppar\u03b2 transcript abundances were higher in MF-fed relative to HM-fed piglets in the liver. Mitochondrial DNA copy numbers (normalized to nuclear DNA) were similar within-tissue regardless of postnatal diet, and were ~\u20092\u20133 times higher in liver vs. ileal tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While mechanisms remain to be identified, the data indicate that neonatal diet can significantly impact liver mitochondrial bioenergetics phenotypes, even in the absence of a change in mtDNA abundance. Since permeabilized liver mitochondrial respiration was increased in MF piglets only in the presence of ADP, it suggests that formula feeding led to a higher ATP turnover. Specific mechanisms and signals involved with neonatal diet-associated differences in liver bioenergetics remain to be elucidated.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s40795-020-00338-7","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T23:04:13Z","timestamp":1586905453000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk"],"prefix":"10.1186","volume":"6","author":[{"given":"Eugenia","family":"Carvalho","sequence":"first","affiliation":[]},{"given":"Sean H.","family":"Adams","sequence":"additional","affiliation":[]},{"given":"Elisabet","family":"B\u00f8rsheim","sequence":"additional","affiliation":[]},{"given":"Michael L.","family":"Blackburn","sequence":"additional","affiliation":[]},{"given":"Kikumi D.","family":"Ono-Moore","sequence":"additional","affiliation":[]},{"given":"Matthew","family":"Cotter","sequence":"additional","affiliation":[]},{"given":"Anne K.","family":"Bowlin","sequence":"additional","affiliation":[]},{"given":"Laxmi","family":"Yeruva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"issue":"5","key":"338_CR1","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1542\/peds.2004-1176","volume":"115","author":"CG Owen","year":"2005","unstructured":"Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics. 2005;115(5):1367\u201377.","journal-title":"Pediatrics"},{"issue":"6","key":"338_CR2","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1093\/ajcn\/82.6.1298","volume":"82","author":"CG Owen","year":"2005","unstructured":"Owen CG, Martin RM, Whincup PH, Davey-Smith G, Gillman MW, Cook DG. The effect of breastfeeding on mean body mass index throughout life: a quantitative review of published and unpublished observational evidence. Am J Clin Nutr. 2005;82(6):1298\u2013307.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"338_CR3","doi-asserted-by":"publisher","first-page":"e12472","DOI":"10.1111\/mcn.12472","volume":"14","author":"Lori Feldman-Winter","year":"2017","unstructured":"Feldman-Winter L, Burnham L, Grossman X, Matlak S, Chen N, Merewood A: Weight gain in the first week of life predicts overweight at 2 years: A prospective cohort study. Matern Child Nutr 2018, 14(1)..","journal-title":"Maternal & Child Nutrition"},{"issue":"3","key":"338_CR4","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3945\/ajcn.111.027284","volume":"95","author":"C Gale","year":"2012","unstructured":"Gale C, Logan KM, Santhakumaran S, Parkinson JR, Hyde MJ, Modi N. Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95(3):656\u201369.","journal-title":"Am J Clin Nutr"},{"issue":"10","key":"338_CR5","doi-asserted-by":"publisher","first-page":"e455","DOI":"10.1111\/apa.12354","volume":"102","author":"F Savino","year":"2013","unstructured":"Savino F, Liguori SA, Benetti S, Sorrenti M, Fissore MF. Cordero di Montezemolo L: high serum leptin levels in infancy can potentially predict obesity in childhood, especially in formula-fed infants. Acta Paediatr. 2013;102(10):e455\u20139.","journal-title":"Acta Paediatr"},{"key":"338_CR6","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neuroimage.2018.09.015","volume":"184","author":"Zheng Liu","year":"2019","unstructured":"Liu Z, Neuringer M, Erdman JW, Jr., Kuchan MJ, Renner L, Johnson EE, Wang X, Kroenke CD: The effects of breastfeeding versus formula-feeding on cerebral cortex maturation in infant rhesus macaques. Neuroimage. 2018;184:372-85.","journal-title":"NeuroImage"},{"issue":"5","key":"338_CR7","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/jn\/nxy038","volume":"148","author":"KE Mercer","year":"2018","unstructured":"Mercer KE, Bhattacharyya S, Diaz-Rubio ME, Piccolo BD, Pack LM, Sharma N, Chaudhury M, Cleves MA, Chintapalli SV, Shankar K, et al. Infant formula feeding increases hepatic cholesterol 7alpha hydroxylase (CYP7A1) expression and fecal bile acid loss in neonatal piglets. J Nutr. 2018;148(5):702\u201311.","journal-title":"J Nutr"},{"issue":"3","key":"338_CR8","doi-asserted-by":"publisher","first-page":"712S","DOI":"10.3945\/ajcn.113.071993","volume":"99","author":"B Lonnerdal","year":"2014","unstructured":"Lonnerdal B. Infant formula and infant nutrition: bioactive proteins of human milk and implications for composition of infant formulas. Am J Clin Nutr. 2014;99(3):712S\u20137S.","journal-title":"Am J Clin Nutr"},{"key":"338_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.earlhumdev.2016.05.018","volume":"100","author":"S Visentin","year":"2016","unstructured":"Visentin S, Vicentin D, Magrini G, Santandreu F, Disalvo L, Sala M, Fasano V, Gonzalez HF. Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. Early Hum Dev. 2016;100:11\u20135.","journal-title":"Early Hum Dev"},{"issue":"1","key":"338_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12887-018-1047-5","volume":"18","author":"ML Gianni","year":"2018","unstructured":"Gianni ML, Roggero P, Baudry C, Fressange-Mazda C, Galli C, Agostoni C, le Ruyet P, Mosca F. An infant formula containing dairy lipids increased red blood cell membrane omega 3 fatty acids in 4 month-old healthy newborns: a randomized controlled trial. BMC Pediatr. 2018;18(1):53.","journal-title":"BMC Pediatr"},{"issue":"7","key":"338_CR11","doi-asserted-by":"publisher","first-page":"nzy025","DOI":"10.1093\/cdn\/nzy025","volume":"2","author":"X Wu","year":"2018","unstructured":"Wu X, Jackson RT, Khan SA, Ahuja J, Pehrsson PR. Human Milk Nutrient Composition in the United States: Current Knowledge, Challenges, and Research Needs. Curr Dev Nutr. 2018;2(7):nzy025.","journal-title":"Curr Dev Nutr"},{"issue":"11","key":"338_CR12","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.jnutbio.2015.05.003","volume":"26","author":"G Trinchese","year":"2015","unstructured":"Trinchese G, Cavaliere G, Canani RB, Matamoros S, Bergamo P, De Filippo C, Aceto S, Gaita M, Cerino P, Negri R, et al. Human, donkey and cow milk differently affects energy efficiency and inflammatory state by modulating mitochondrial function and gut microbiota. J Nutr Biochem. 2015;26(11):1136\u201346.","journal-title":"J Nutr Biochem"},{"key":"338_CR13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fphys.2018.00032","volume":"9","author":"G Trinchese","year":"2018","unstructured":"Trinchese G, Cavaliere G, De Filippo C, Aceto S, Prisco M, Chun JT, Penna E, Negri R, Muredda L, Demurtas A, et al. Human Milk and donkey Milk, compared to cow Milk, reduce inflammatory mediators and modulate glucose and lipid metabolism, Acting on Mitochondrial Function and Oleylethanolamide Levels in Rat Skeletal Muscle. Front Physiol. 2018;9:32.","journal-title":"Front Physiol"},{"issue":"11","key":"338_CR14","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1093\/jn\/nxy170","volume":"148","author":"John J Miklavcic","year":"2018","unstructured":"Miklavcic JJ, Badger TM, Bowlin AK, Matazel KS, Cleves MA, LeRoith T, Saraf MK, Chintapalli SV, Piccolo BD, Shankar K, Yeruva L. Human Breast-Milk Feeding Enhances the Humoral and Cell-Mediated Immune Response in Neonatal Piglets. J Nutr. 2018;148(11):1860-70. https:\/\/doi.org\/10.1093\/jn\/nxy170.","journal-title":"The Journal of Nutrition"},{"issue":"12","key":"338_CR15","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1136\/adc.64.12.1672","volume":"64","author":"SE Balmer","year":"1989","unstructured":"Balmer SE, Wharton BA. Diet and faecal flora in the newborn: breast milk and infant formula. Arch Dis Child. 1989;64(12):1672\u20137.","journal-title":"Arch Dis Child"},{"issue":"6","key":"338_CR16","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.anaerobe.2011.03.009","volume":"17","author":"E Bezirtzoglou","year":"2011","unstructured":"Bezirtzoglou E, Tsiotsias A, Welling GW. Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe. 2011;17(6):478\u201382.","journal-title":"Anaerobe"},{"issue":"2","key":"338_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/19490976.2016.1278104","volume":"8","author":"EC Davis","year":"2017","unstructured":"Davis EC, Wang M, Donovan SM. The role of early life nutrition in the establishment of gastrointestinal microbial composition and function. Gut Microbes. 2017;8(2):143\u201371.","journal-title":"Gut Microbes"},{"issue":"3","key":"338_CR18","first-page":"327","volume":"60","author":"S Fanaro","year":"2008","unstructured":"Fanaro S. Vigi V: [infant formulas supplemented with prebiotics: intestinal microbiota and immune responses]. Minerva Pediatr. 2008;60(3):327\u201335.","journal-title":"Minerva Pediatr"},{"issue":"3","key":"338_CR19","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/ajhb.22254","volume":"24","author":"AL Thompson","year":"2012","unstructured":"Thompson AL. Developmental origins of obesity: early feeding environments, infant growth, and the intestinal microbiome. Am J Hum Biol. 2012;24(3):350\u201360.","journal-title":"Am J Hum Biol"},{"issue":"4","key":"338_CR20","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1017\/S0029665111000589","volume":"70","author":"MS Fewtrell","year":"2011","unstructured":"Fewtrell MS. Breast-feeding and later risk of CVD and obesity: evidence from randomised trials. Proc Nutr Soc. 2011;70(4):472\u20137.","journal-title":"Proc Nutr Soc"},{"issue":"4","key":"338_CR21","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1017\/S0029665111000590","volume":"70","author":"CG Owen","year":"2011","unstructured":"Owen CG, Whincup PH, Cook DG. Breast-feeding and cardiovascular risk factors and outcomes in later life: evidence from epidemiological studies. Proc Nutr Soc. 2011;70(4):478\u201384.","journal-title":"Proc Nutr Soc"},{"key":"338_CR22","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1186\/1471-2458-14-1267","volume":"14","author":"J Yan","year":"2014","unstructured":"Yan J, Liu L, Zhu Y, Huang G, Wang PP. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health. 2014;14:1267.","journal-title":"BMC Public Health"},{"issue":"10","key":"338_CR23","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1111\/all.13476","volume":"73","author":"K Miliku","year":"2018","unstructured":"Miliku K, Robertson B, Sharma AK, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Investigators CS, et al. Human milk oligosaccharide profiles and food sensitization among infants in the CHILD study. Allergy. 2018;73(10):2070\u20133.","journal-title":"Allergy"},{"key":"338_CR24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3389\/fped.2018.00197","volume":"6","author":"S Moossavi","year":"2018","unstructured":"Moossavi S, Miliku K, Sepehri S, Khafipour E, Azad MB. The prebiotic and probiotic properties of human Milk: implications for infant immune development and pediatric asthma. Front Pediatr. 2018;6:197.","journal-title":"Front Pediatr"},{"key":"338_CR25","volume-title":"Nutrient requirements of swine: eleventh revised edition","author":"Council NR","year":"2012","unstructured":"Council NR. Nutrient requirements of swine: eleventh revised edition. Washington, DC: The National Academies Press; 2012."},{"issue":"Pt 16","key":"338_CR26","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1242\/jeb.105916","volume":"217","author":"AJ Chicco","year":"2014","unstructured":"Chicco AJ, Le CH, Schlater A, Nguyen A, Kaye S, Beals JW, Scalzo RL, Bell C, Gnaiger E, Costa DP, et al. High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria. J Exp Biol. 2014;217(Pt 16):2947\u201355.","journal-title":"J Exp Biol"},{"issue":"10","key":"338_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079097","volume":"8","author":"MJ Chu","year":"2013","unstructured":"Chu MJ, Phillips AR, Hosking AW, MacDonald JR, Bartlett AS, Hickey AJ. Hepatic mitochondrial function analysis using needle liver biopsy samples. PLoS One. 2013;8(10):e79097.","journal-title":"PLoS One"},{"issue":"9","key":"338_CR28","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.exger.2004.06.001","volume":"39","author":"I Grattagliano","year":"2004","unstructured":"Grattagliano I, Portincasa P, Cocco T, Moschetta A, Di Paola M, Palmieri VO, Palasciano G. Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. Exp Gerontol. 2004;39(9):1323\u201332.","journal-title":"Exp Gerontol"},{"issue":"2","key":"338_CR29","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1006\/abio.2002.5658","volume":"305","author":"AV Kuznetsov","year":"2002","unstructured":"Kuznetsov AV, Strobl D, Ruttmann E, Konigsrainer A, Margreiter R, Gnaiger E. Evaluation of mitochondrial respiratory function in small biopsies of liver. Anal Biochem. 2002;305(2):186\u201394.","journal-title":"Anal Biochem"},{"issue":"3","key":"338_CR30","doi-asserted-by":"publisher","first-page":"E224","DOI":"10.1152\/ajpendo.00125.2015","volume":"309","author":"C Porter","year":"2015","unstructured":"Porter C, Hurren NM, Cotter MV, Bhattarai N, Reidy PT, Dillon EL, Durham WJ, Tuvdendorj D, Sheffield-Moore M, Volpi E, et al. Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle. Am J Physiol Endocrinol Metab. 2015;309(3):E224\u201332.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"338_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","volume":"810","author":"D Pesta","year":"2012","unstructured":"Pesta D, Gnaiger E. High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol. 2012;810:25\u201358.","journal-title":"Methods Mol Biol"},{"issue":"5","key":"338_CR32","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","volume":"21","author":"C Koliaki","year":"2015","unstructured":"Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, et al. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 2015;21(5):739\u201346.","journal-title":"Cell Metab"},{"key":"338_CR33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-4939-2257-4_22","volume":"1264","author":"G Krumschnabel","year":"2015","unstructured":"Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E. Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol. 2015;1264:245\u201361.","journal-title":"Methods Mol Biol"},{"issue":"5","key":"338_CR34","doi-asserted-by":"publisher","first-page":"E462","DOI":"10.1152\/ajpendo.00206.2014","volume":"307","author":"C Porter","year":"2014","unstructured":"Porter C, Herndon DN, Borsheim E, Chao T, Reidy PT, Borack MS, Rasmussen BB, Chondronikola M, Saraf MK, Sidossis LS. Uncoupled skeletal muscle mitochondria contribute to hypermetabolism in severely burned adults. Am J Physiol Endocrinol Metab. 2014;307(5):E462\u20137.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"338_CR35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/MCO.0000000000000486","volume":"21","author":"M Ost","year":"2018","unstructured":"Ost M, Doerrier C, Gama-Perez P, Moreno-Gomez S. Analysis of mitochondrial respiratory function in tissue biopsies and blood cells. Curr Opin Clin Nutr Metab Care. 2018;21(5):336\u201342.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"338_CR36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3389\/fphys.2017.00319","volume":"8","author":"A Clark","year":"2017","unstructured":"Clark A, Mach N. The crosstalk between the gut microbiota and mitochondria during exercise. Front Physiol. 2017;8:319.","journal-title":"Front Physiol"},{"issue":"5","key":"338_CR37","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1503\/cmaj.121189","volume":"185","author":"MB Azad","year":"2013","unstructured":"Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, et al. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ. 2013;185(5):385\u201394.","journal-title":"CMAJ"},{"issue":"8","key":"338_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012459","volume":"5","author":"V Poroyko","year":"2010","unstructured":"Poroyko V, White JR, Wang M, Donovan S, Alverdy J, Liu DC, Morowitz MJ. Gut microbial gene expression in mother-fed and formula-fed piglets. PLoS One. 2010;5(8):e12459.","journal-title":"PLoS One"},{"key":"338_CR39","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mib.2018.06.003","volume":"44","author":"K Korpela","year":"2018","unstructured":"Korpela K, de Vos WM. Early life colonization of the human gut: microbes matter everywhere. Curr Opin Microbiol. 2018;44:70\u20138.","journal-title":"Curr Opin Microbiol"},{"issue":"441","key":"338_CR40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1651-2227.2003.tb00646.x","volume":"91","author":"S Fanaro","year":"2003","unstructured":"Fanaro S, Chierici R, Guerrini P, Vigi V. Intestinal microflora in early infancy: composition and development. Acta Paediatr Suppl. 2003;91(441):48\u201355.","journal-title":"Acta Paediatr Suppl"},{"issue":"3","key":"338_CR41","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/1574-6941.12434","volume":"90","author":"HM Hesla","year":"2014","unstructured":"Hesla HM, Stenius F, Jaderlund L, Nelson R, Engstrand L, Alm J, Dicksved J. Impact of lifestyle on the gut microbiota of healthy infants and their mothers-the ALADDIN birth cohort. FEMS Microbiol Ecol. 2014;90(3):791\u2013801.","journal-title":"FEMS Microbiol Ecol"},{"issue":"4","key":"338_CR42","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/nu7042930","volume":"7","author":"EP Neis","year":"2015","unstructured":"Neis EP, Dejong CH, Rensen SS. The role of microbial amino acid metabolism in host metabolism. Nutrients. 2015;7(4):2930\u201346.","journal-title":"Nutrients"},{"issue":"8","key":"338_CR43","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nrendo.2014.60","volume":"10","author":"F Kuipers","year":"2014","unstructured":"Kuipers F, Bloks VW, Groen AK. Beyond intestinal soap--bile acids in metabolic control. Nat Rev Endocrinol. 2014;10(8):488\u201398.","journal-title":"Nat Rev Endocrinol"},{"key":"338_CR44","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1146\/annurev-food-041715-033159","volume":"7","author":"SA Joyce","year":"2016","unstructured":"Joyce SA, Gahan CG. Bile acid modifications at the microbe-host Interface: potential for Nutraceutical and pharmaceutical interventions in host health. Annu Rev Food Sci Technol. 2016;7:313\u201333.","journal-title":"Annu Rev Food Sci Technol"},{"issue":"1","key":"338_CR45","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/pathogens3010014","volume":"3","author":"P Gerard","year":"2013","unstructured":"Gerard P. Metabolism of cholesterol and bile acids by the gut microbiota. Pathogens. 2013;3(1):14\u201324.","journal-title":"Pathogens"},{"issue":"4","key":"338_CR46","doi-asserted-by":"publisher","first-page":"e13548","DOI":"10.14814\/phy2.13548","volume":"6","author":"Jean-Philippe Leduc-Gaudet","year":"2018","unstructured":"Leduc-Gaudet JP, Reynaud O, Chabot F, Mercier J, Andrich DE, St-Pierre DH, Gouspillou G: The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiol Rep 2018, 6(4)..","journal-title":"Physiological Reports"},{"issue":"7","key":"338_CR47","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1017\/S0007114515005528","volume":"115","author":"C Coudray","year":"2016","unstructured":"Coudray C, Fouret G, Lambert K, Ferreri C, Rieusset J, Blachnio-Zabielska A, Lecomte J, Ebabe Elle R, Badia E, Murphy MP, et al. A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats. Br J Nutr. 2016;115(7):1155\u201366.","journal-title":"Br J Nutr"},{"issue":"9","key":"338_CR48","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1113\/EP087083","volume":"103","author":"MA Cooper","year":"2018","unstructured":"Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE. Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol. 2018;103(9):1206\u201312.","journal-title":"Exp Physiol"},{"issue":"2","key":"338_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149033","volume":"11","author":"G Cavaliere","year":"2016","unstructured":"Cavaliere G, Trinchese G, Bergamo P, De Filippo C, Mattace Raso G, Gifuni G, Putti R, Moni BH, Canani RB, Meli R, et al. Polyunsaturated fatty acids attenuate diet induced obesity and insulin resistance, modulating mitochondrial respiratory uncoupling in rat skeletal muscle. PLoS One. 2016;11(2):e0149033.","journal-title":"PLoS One"},{"issue":"4","key":"338_CR50","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1139\/apnm-2018-0354","volume":"44","author":"Ghaleb A. Oriquat","year":"2019","unstructured":"Oriquat GA, Ali MA, Mahmoud SA, Eid RM, Hassan R, Kamel MA: Improving hepatic mitochondrial biogenesis as a postulated mechanism for the antidiabetic effect of Spirulina platensis in comparison with metformin. Appl Physiol Nutr Metab. 2019;44(4):357-64.","journal-title":"Applied Physiology, Nutrition, and Metabolism"},{"issue":"3","key":"338_CR51","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10863-010-9284-9","volume":"42","author":"AR Cardoso","year":"2010","unstructured":"Cardoso AR, Cabral-Costa JV, Kowaltowski AJ. Effects of a high fat diet on liver mitochondria: increased ATP-sensitive K+ channel activity and reactive oxygen species generation. J Bioenerg Biomembr. 2010;42(3):245\u201353.","journal-title":"J Bioenerg Biomembr"},{"key":"338_CR52","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fphys.2015.00109","volume":"6","author":"R Putti","year":"2015","unstructured":"Putti R, Sica R, Migliaccio V, Lionetti L. Diet impact on mitochondrial bioenergetics and dynamics. Front Physiol. 2015;6:109.","journal-title":"Front Physiol"}],"container-title":["BMC Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40795-020-00338-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40795-020-00338-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40795-020-00338-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:00:52Z","timestamp":1696028452000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnutr.biomedcentral.com\/articles\/10.1186\/s40795-020-00338-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["338"],"URL":"https:\/\/doi.org\/10.1186\/s40795-020-00338-7","relation":{},"ISSN":["2055-0928"],"issn-type":[{"type":"electronic","value":"2055-0928"}],"subject":[],"published":{"date-parts":[[2020,4,15]]},"assertion":[{"value":"30 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animals were maintained in accordance with the ethical guidelines for animal research established and approved by the Institutional Animal Care and Use Committee at the University of Arkansas for Medical Sciences. All animals used were obtained from Metz Farm that approved the use of animals for research study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13"}}