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However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of P\n            <jats:sub>2<\/jats:sub>\n            O\n            <jats:sub>5<\/jats:sub>\n            -CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500\u2009\u03bcm of diameter. A total of 14 veterinary clinical cases of appendicular bone defects and maxillary \/ mandibular bone defects are described. In all clinical cases, the synthetic bone substitute was used to fill bone defects, enhancing bone regeneration and complementing the recommended surgical techniques. Results demonstrated that it is an appropriate synthetic bone graft available to be used in veterinary patients. It functioned as a space filler in association with standard orthopaedic and odontological procedures of stabilization, promoting a faster bone fusion without any local or systemic adverse reactions. This procedure improves the animals\u2019 quality of life, decreasing pain and post-operative recovery period, as well as increasing bone stability improving positive clinical outcomes.\n          <\/jats:p>","DOI":"10.1186\/s40824-018-0150-x","type":"journal-article","created":{"date-parts":[[2018,12,29]],"date-time":"2018-12-29T07:25:03Z","timestamp":1546068303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Application of Bonelike\u00ae as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases"],"prefix":"10.34133","volume":"22","author":[{"given":"Jos\u00e9 Miguel","family":"Campos","sequence":"first","affiliation":[{"name":"Escola Universit\u00e1ria Vasco da Gama (EUVG), Hospital Veterin\u00e1rio Universit\u00e1rio de Coimbra, Coimbra, Portugal."},{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"Ana Catarina","family":"Sousa","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV \u2013 U. Porto \u2013 Porto\/Portugal, Departamento de Engenharia Metal\u00fargica e Materiais, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal."}]},{"given":"Pedro Oliv\u00e9rio","family":"Pinto","sequence":"additional","affiliation":[{"name":"Escola Universit\u00e1ria Vasco da Gama (EUVG), Hospital Veterin\u00e1rio Universit\u00e1rio de Coimbra, Coimbra, Portugal."},{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"Jorge","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"Miguel Lacueva","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"Ana Rita","family":"Caseiro","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."},{"name":"REQUIMTE\/LAQV \u2013 U. Porto \u2013 Porto\/Portugal, Departamento de Engenharia Metal\u00fargica e Materiais, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal."}]},{"given":"Mariana Vieira","family":"Branquinho","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"S\u00edlvia Santos","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"Carla","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"Ana","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Biosckin, Molecular and Cell Therapies S.A., Laborat\u00f3rio Criovida, TecMaia, Rua Engenheiro Frederico Ulrich 2650, Moreira da Maia 4470-605, Portugal."}]},{"given":"Jos\u00e9 Domingos","family":"Santos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV \u2013 U. Porto \u2013 Porto\/Portugal, Departamento de Engenharia Metal\u00fargica e Materiais, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal."}]},{"given":"Am\u00e9rico","family":"Afonso","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Dent\u00e1ria da Universidade do Porto (FMDUP), Porto 4200-393, Portugal."}]},{"given":"Lu\u00eds Miguel","family":"Atayde","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"given":"Ana L\u00facia","family":"Lu\u00eds","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-9363","authenticated-orcid":false,"given":"Ana Colette","family":"Maur\u00edcio","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas Veterin\u00e1rias, Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n\u00b0 228, Porto 4050-313, Portugal."},{"name":"Centro de Estudos de Ci\u00eancia Animal (CECA), Instituto de Ci\u00eancias, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Porto, Portugal."}]}],"member":"221","published-online":{"date-parts":[[2018,12,29]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885328208096798"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(10)70014-6"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01224.x"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2018.05.006"},{"key":"e_1_3_5_6_2","doi-asserted-by":"crossref","unstructured":"Ferracini R Martinez Herreros I Russo A Casalini T Rossi F Perale G. 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All the procedures were approved by the ICBAS-UP Animal Welfare Organism of the Ethics Committee (ORBEA) and by the Veterinary Authorities of Portugal (DGAV). Humane end points were followed in accordance to the OECD Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation (2000), and adequate measures were taken to minimize pain and discomfort considering human endpoints for animal suffering and distress. The interaction of Bonelike\u00ae in bone tissue was evaluated in 10 dogs and 4 cats.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors report no financial or other conflicts relates to this report. The authors do not have conflict of interest with any of the materials or companies described in the manuscript. Although A Brand\u00e3o is an employee of Biosckin, Molecular and Cell Therapies, S.A. this does not alter the adherence to policies on sharing data and materials.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"38"}}