{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:24:37Z","timestamp":1773285877623,"version":"3.50.1"},"reference-count":96,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":744,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Due to greater infection susceptibility, sepsis is the main cause of death in burn patients. Quick diagnosis and patient stratification, early and appropriated antimicrobial therapy, and focus control are crucial for patients\u2019 survival. On the other hand, superfluous extension of therapy is associated with adverse events and arousal of microbial resistance. The use of biomarkers, necessarily coupled with close clinical examination, may predict outcomes, stratifying patients who need more intensive care, and monitor the efficacy of antimicrobial therapy, allowing faster de-escalation or stop, reducing the development of resistance and possibly the financial burden, without increasing mortality. The aim of this work is to check the suitability of procalcitonin (PCT) to fulfill these goals in a large sample of septic burn patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred\u00a0and one patients, with 15% or more of total body surface area (TBSA)\u00a0burned, admitted from January 2011 to December 2014 at Coimbra Burns Unit (CBU), in Portugal were included in the sample. All patients had a diagnosis of sepsis, according to the American Burn Association (ABA) criteria. The sample was factored by survival (68 survivors and 33 non-survivors). The maximum value of PCT in each day was used for statistical analysis. Data were summarized by location measures (mean, median,\u00a0minimum, maximum, quartiles) and dispersion measures (standard error and range measures). Statistical analysis was performed with SPSS\u00a9 23.0 IBM\u00a9 for Windows\u00a9.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were statistically significant differences between PCT levels of patients from the survivor and non-survivor groups during the first and the last weeks of hospitalization as well as during the first week after sepsis suspicion, being slightly higher during this period. During the first 7\u00a0days of antimicrobial therapy, PCT was always higher in the non-survivor, still without reaching statistical significance, but when the analysis was extended till the 15th day, PCT increased significantly, rapidly, and steadily, denouncing therapy failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite being not an ideal biomarker, PCT proved to have good prognostic power in septic burn patients, paralleling the evolution of the infectious process and reflecting the efficacy of antimicrobial therapy, and the inclusion of its serial dosing may be advised to reinforce antimicrobial stewardship programs at burn units; meanwhile, more accurate approaches are not available.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1186\/s41038-018-0112-5","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T05:29:54Z","timestamp":1522819794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-5251","authenticated-orcid":false,"given":"Lu\u00eds","family":"Cabral","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery and Burns Unit, Unidade de Queimados Coimbra University Hospital Centre (CHUC) Av. Bissaya Barreto s\/n 3000-075 Coimbra, Portugal"},{"name":"Autonomous Section of Health Sciences (SACS) University of Aveiro Aveiro, Portugal"}]},{"given":"Vera","family":"Afreixo","sequence":"additional","affiliation":[{"name":"CIDMA - Center for Research and Development in Mathematics and Applications, iBiMED, Institute for Biomedicine University of Aveiro Aveiro, Portugal"}]},{"given":"Rita","family":"Meireles","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Unit, Unidade de Queimados Coimbra University Hospital Centre (CHUC) Av. Bissaya Barreto s\/n 3000-075 Coimbra, Portugal"}]},{"given":"Miguel","family":"Vaz","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Unit, Unidade de Queimados Coimbra University Hospital Centre (CHUC) Av. Bissaya Barreto s\/n 3000-075 Coimbra, Portugal"}]},{"given":"Catarina","family":"Chaves","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Coimbra University Hospital Centre (CHUC) Coimbra, Portugal"}]},{"given":"Marisa","family":"Caetano","sequence":"additional","affiliation":[{"name":"Pharmacy Department Coimbra University Hospital Centre (CHUC) Coimbra, Portugal"}]},{"given":"Lu\u00eds","family":"Almeida","sequence":"additional","affiliation":[{"name":"MedinUP, Department of Pharmacology and Therapeutics, Faculty of Medicine University of Porto Porto, Portugal"}]},{"given":"Jos\u00e9 Artur","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Emergency and Intensive Care Medicine Centro Hospitalar S\u00e3o Jo\u00e3o Porto, Portugal"},{"name":"Faculty of Medicine University of Porto, Grupo de Infec\u00e7\u00e3o e S\u00e9psis Porto, 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