{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:39:27Z","timestamp":1777347567543,"version":"3.51.4"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The ability to self-renew, be easily expanded <jats:italic>in vitro<\/jats:italic> and differentiate into different mesenchymal tissues, render mesenchymal stem cells (MSCs) an attractive therapeutic method for degenerative diseases. The subsequent discovery of their immunosuppressive ability encouraged clinical trials in graft-versus-host disease and auto-immune diseases. Despite sharing several immunophenotypic characteristics and functional capabilities, the differences between MSCs arising from different tissues are still unclear and the published data are conflicting.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Here, we evaluate the influence of human MSCs derived from umbilical cord matrix (UCM), bone marrow (BM) and adipose tissue (AT), co-cultured with phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (MNC), on T, B and natural killer (NK) cell activation; T and B cells\u2019 ability to acquire lymphoblast characteristics; mRNA expression of interleukin-2 (IL-2), forkhead box P3 (FoxP3), T-bet and GATA binding protein 3 (GATA3), on purified T cells, and tumor necrosis factor-alpha (TNF-\u03b1), perforin and granzyme B on purified NK cells.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>MSCs derived from all three tissues were able to prevent CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cell activation and acquisition of lymphoblast characteristics and CD56<jats:sup>dim<\/jats:sup> NK cell activation, wherein AT-MSCs showed a stronger inhibitory effect. Moreover, AT-MSCs blocked the T cell activation process in an earlier phase than BM- or UCM-MSCs, yielding a greater proportion of T cells in the non-activated state. Concerning B cells and CD56<jats:sup>bright<\/jats:sup> NK cells, UCM-MSCs did not influence either their activation kinetics or PHA-induced lymphoblast characteristics, conversely to BM- and AT-MSCs which displayed an inhibitory effect. Besides, when co-cultured with PHA-stimulated MNC, MSCs seem to promote Treg and Th1 polarization, estimated by the increased expression of FoxP3 and T-bet mRNA within purified activated T cells, and to reduce TNF-\u03b1 and perforin production by activated NK cells.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Overall, UCM-, BM- and AT-derived MSCs hamper T cell, B cell and NK cell-mediated immune response by preventing their acquisition of lymphoblast characteristics, activation and changing the expression profile of proteins with an important role in immune function, except UCM-MSCs showed no inhibitory effect on B cells under these experimental conditions. Despite the similarities between the three types of MSCs evaluated, we detect important differences that should be taken into account when choosing the MSC source for research or therapeutic purposes.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/scrt336","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T13:01:52Z","timestamp":1381842112000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":224,"title":["Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells"],"prefix":"10.1186","volume":"4","author":[{"given":"Andreia","family":"Ribeiro","sequence":"first","affiliation":[]},{"given":"Paula","family":"Laranjeira","sequence":"additional","affiliation":[]},{"given":"Sandrine","family":"Mendes","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Velada","sequence":"additional","affiliation":[]},{"given":"Cristiana","family":"Leite","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Andrade","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Henriques","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio","family":"Gr\u00e3os","sequence":"additional","affiliation":[]},{"given":"Carla M P","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Martinho","sequence":"additional","affiliation":[]},{"given":"M Lu\u00edsa","family":"Pais","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udia Lobato","family":"da Silva","sequence":"additional","affiliation":[]},{"given":"Joaquim","family":"Cabral","sequence":"additional","affiliation":[]},{"given":"H\u00e9lder","family":"Trindade","sequence":"additional","affiliation":[]},{"given":"Artur","family":"Paiva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"475_CR1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3760\/cma.j.issn.0366-6999.2009.02.021","volume":"122","author":"FJ Cao","year":"2009","unstructured":"Cao FJ, Feng SQ: Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury. 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