{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T20:02:38Z","timestamp":1763755358933,"version":"3.45.0"},"reference-count":67,"publisher":"Oncology Nursing Society (ONS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJON"],"published-print":{"date-parts":[[2016,8,1]]},"DOI":"10.1188\/16.cjon.e100-e105","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T11:51:29Z","timestamp":1469101889000},"page":"E100-E105","source":"Crossref","is-referenced-by-count":12,"title":["Diarrhea in Multiple Myeloma: A Review of the Literature"],"prefix":"10.1188","volume":"20","author":[{"given":"Beth","family":"Faiman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1302","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Abraham, C., & Cho, J.H. (2009). Inflammatory bowel disease. New England Journal of Medicine, 361, 2066\u20132078. doi:10.1056\/NEJMra0804647","DOI":"10.1056\/NEJMra0804647"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Agarwal, S., & Mayer, L. (2013). Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency. Clinical Gastroenterology and Hepatology, 11, 1050\u20131063. doi:10.1016\/j.cgh.2013.02.024","DOI":"10.1016\/j.cgh.2013.02.024"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Baert, F., Schmit, A., D\u2019Haens, G., Dedeurwaerdere, F., Louis, E., Cabooter, M., . . . Rutgeerts, P. (2002). Budesonide in collagenous colitis: A double-blind placebo-controlled trial with histologic follow-up. Gastroenterology, 122, 20\u201325. doi:10.1053\/gast.2002.30295","DOI":"10.1053\/gast.2002.30295"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Baumgart, D.C., & Sandborn, W.J. (2012). Crohn\u2019s disease. Lancet, 380, 1590\u20131605. doi:10.1016\/s0140-6736(12)60026-9","DOI":"10.1016\/S0140-6736(12)60026-9"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Benson, A.B., III, Ajani, J.A., Catalano, R.B., Engelking, C., Kornblau, S.M., Martenson, J.A., . . . Wadler, S. (2004). Recommended guidelines for the treatment of cancer treatment-induced diarrhea. Journal of Clinical Oncology, 22, 2918\u20132926. doi:10.1200\/jco.2004.04.132","DOI":"10.1200\/JCO.2004.04.132"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Blutt, S.E., & Conner, M.E. (2013). The gastrointestinal frontier: IgA and viruses. Frontiers in Immunology. Retrieved from http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2013.00402\/full","DOI":"10.3389\/fimmu.2013.00402"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Bonderup, O.K., Hansen, J.B., Birket-Smith, L., Vestergaard, V., Teglbjaerg, P.S., & Fallingborg, J. (2003). Budesonide treatment of collagenous colitis: A randomised, double blind, placebo controlled trial with morphometric analysis. Gut, 52, 248\u2013251. doi:10.1136\/gut.52.2.248","DOI":"10.1136\/gut.52.2.248"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Bonderup, O.K., Hansen, J.B., Teglbjaerg, P.S., Christensen, L.A., & Fallingborg, J.F. (2009). Long-term budesonide treatment of collagenous colitis: A randomised, double-blind, placebo-controlled trial. Gut, 58, 68\u201372. doi:10.1136\/gut.2008.156513","DOI":"10.1136\/gut.2008.156513"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Bozzetti, F., Biganzoli, L., Gavazzi, C., Cappuzzo, F., Carnaghi, C., Buzzoni, R., . . . Baietta, E. (1997). Glutamine supplementation in cancer patients receiving chemotherapy: A double-blind randomized study. Nutrition, 13, 748\u2013751. doi:10.1016\/S0899-9007(97)83038-9","DOI":"10.1016\/S0899-9007(97)83038-9"},{"key":"10","unstructured":"Celgene Corporation. (2015). Revlimid\u00ae (lenalidomide) [Package insert]. Summit, NJ: Author."},{"key":"11","doi-asserted-by":"crossref","unstructured":"Chitapanarux, I., Chitapanarux, T., Traisathit, P., Kudumpee, S., Tharavichitkul, E., & Lorvidhaya, V. (2010). Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. Radiation Oncology, 5, 31. doi:10.1186\/1748-717X-5-31","DOI":"10.1186\/1748-717X-5-31"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Cho, H.Y., Kim, M.K., Cho, S.J., Bae, J.W., & Kim, I. (2002). Endometrial stromal sarcoma of the sigmoid colon arising in endometriosis: A case report with a review of literatures. Journal of Korean Medical Science, 17, 412\u2013414. doi:10.3346\/jkms.2002.17.3.412","DOI":"10.3346\/jkms.2002.17.3.412"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Cogbill, C.H., Drobyski, W.R., & Komorowski, R.A. (2011). Gastrointestinal pathology of autologous graft-versus-host disease following hematopoietic stem cell transplantation: A clinicopathological study of 17 cases. Modern Pathology, 24, 117\u2013125. doi:10.1038\/modpathol.2010.163","DOI":"10.1038\/modpathol.2010.163"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Dai, C., Zheng, C.Q., Jiang, M., Ma, X.Y., & Jiang, L.J. (2013). Probiotics and irritable bowel syndrome. World Journal of Gastroenterology, 19, 5973\u20135980. doi:10.3748\/wjg.v19.i36.5973","DOI":"10.3748\/wjg.v19.i36.5973"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Danese, S., & Fiocchi, C. (2011). Ulcerative colitis. New England Journal of Medicine, 365, 1713\u20131725. doi:10.1056\/NEJMra1102942","DOI":"10.1056\/NEJMra1102942"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Deeg, H.J. (2007). How I treat refractory acute GVHD. Blood, 109, 4119\u20134126. doi:10.1182\/blood-2006-12-041889","DOI":"10.1182\/blood-2006-12-041889"},{"key":"17","doi-asserted-by":"crossref","unstructured":"DeSesso, J.M., Jacobson, C.F., & Williams, A.L. (2012). Anatomical and physiological parameters that influence gastrointestinal absorption. Encyclopedia of Drug Metabolism and Interactions. doi:10.1002\/9780470921920.edm022","DOI":"10.1002\/9780470921920.edm022"},{"key":"18","unstructured":"Edsb\u00e4cker, S., & Andersson, T. (2004). Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn\u2019s disease. Clinical Pharmacokinetics, 43, 803\u2013821."},{"key":"19","doi-asserted-by":"crossref","unstructured":"El-Salhy, M. (2012). Irritable bowel syndrome: Diagnosis and pathogenesis. World Journal of Gastroenterology, 18, 5151\u20135163.","DOI":"10.3748\/wjg.v18.i37.5151"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Faiman, B., Sidana, S., Elson, P., Bruening, K., Duong, H.K., Dean, R.M., . . . Reu, F.J. (2013). Lenalidomide related diarrhea correlates with survival in multiple myeloma. Blood, 122, 5397.","DOI":"10.1182\/blood.V122.21.5397.5397"},{"key":"21","unstructured":"Friedman, H.H. (2000). Problem-oriented medical diagnosis (7th ed.). New York, NY: Lippincott Williams and Wilkins."},{"key":"22","doi-asserted-by":"crossref","unstructured":"Greenberg, G.R., Feagan, B.G., Martin, F., Sutherland, L.R., Thomson, A.B., Williams, C.N., . . . Persson, T. (1996). Oral budesonide as maintenance treatment for Crohn\u2019s disease: A placebo-controlled, dose-ranging study. Gastroenterology, 110, 45\u201351. doi:10.1053\/gast.1996.v110.pm8536887","DOI":"10.1053\/gast.1996.v110.pm8536887"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Grundmann, O., & Yoon, S.L. (2014). Complementary and alternative medicines in irritable bowel syndrome: An integrative view. World Journal of Gastroenterology, 20, 346\u2013362. doi:10.3748\/wjg.v20.i2.346","DOI":"10.3748\/wjg.v20.i2.346"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Guerrant, R.L., Van Gilder, T., Steiner, T.S., Thielman, N.M., Slutsker, L., Tauxe, R.V., . . . Pickering, L.K. (2001). Practice guidelines for the management of infectious diarrhea. Clinical Infectious Diseases, 32, 331\u2013351. doi:10.1086\/318514","DOI":"10.1086\/318514"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Heys, S.D., Walker, L.G., Smith, I., & Eremin, O. (1999). Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: A meta-analysis of randomized controlled clinical trials. Annals of Surgery, 229, 467\u2013477. doi:10.1097\/00000658-199904000-00004","DOI":"10.1097\/00000658-199904000-00004"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Hoff, P.M., Saragiotto, D.F., Barrios, C.H., del Giglio, A., Coutinho, A.K., Andrade, A.C., . . . van Eyll, B. (2014). Randomized phase III trial exploring the use of long-acting release octreotide in the prevention of chemotherapy-induced diarrhea in patients with colorectal cancer: The LARCID trial. Journal of Clinical Oncology, 32, 1006\u20131011. doi:10.1200\/jco.2013.50.8077","DOI":"10.1200\/JCO.2013.50.8077"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Hong, S.N., & Rhee, P.L. (2014). Unraveling the ties between irritable bowel syndrome and intestinal microbiota. World Journal of Gastroenterology, 20, 2470\u20132481. doi:10.3748\/wjg.v20.i10.2470","DOI":"10.3748\/wjg.v20.i10.2470"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Hou, C.Y., Xu, L.L., Chen, H., Liu, N., Jiang, M. , Wang, G.Q., . . . Zeng, Y.J. (2013). Intestinal aGVHD and infection after hematopoietic stem cell transplantation. Medical Science Monitor, 19, 802\u2013806. doi:10.12659\/MSM.889408","DOI":"10.12659\/MSM.889408"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Itagaki, R., Koda, K., Yamazaki, M., Shuto, K., Kosugi, C., Hirano, A., . . . Suzuki, M. (2014). Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome. Clinical and Experimental Gastroenterology, 7, 47\u201352. doi:10.2147\/ceg.s55410","DOI":"10.2147\/CEG.S55410"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Johansson, M.E., Sj\u00f6vall, H., & Hansson, G.C. (2013). The gastrointestinal mucus system in health and disease. National Reviews. Gastroenterology and Hepatology, 10, 352\u2013361. doi:10.1038\/nrgastro.2013.35","DOI":"10.1038\/nrgastro.2013.35"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Kim, J.B., Kim, S.H., Cho, Y.K., Ahn, S.B., Jo, Y.J., Park, Y.S., . . . Jung, Y.Y. (2013). A case of colon perforation due to enteropathy-associated T-cell lymphoma. World Journal of Gastroenterology, 19, 1841\u20131844. doi:10.3748\/wjg.v19.i11.1841","DOI":"10.3748\/wjg.v19.i11.1841"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Kinnebrew, M.A., Lee, Y.J., Jenq, R.R., Lipuma, L., Littmann, E.R., Gobourne, A., . . . Taur, Y. (2014). Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation. PLOS One, 9, e90158. doi:10.1371\/journal.pone.0090158","DOI":"10.1371\/journal.pone.0090158"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Kong, F., & Singh, R.P. (2008). Disintegration of solid foods in human stomach. Journal of Food Science, 73, R67\u2013R80. doi:10.1111\/j.1750-3841.2008.00766.x","DOI":"10.1111\/j.1750-3841.2008.00766.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"K\u00f6nig, J., & Brummer, R.J. (2014). Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome. Beneficial Microbes, 5, 247\u2013261. doi:10.3920\/bm2013.0033","DOI":"10.3920\/BM2013.0033"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Lamm, M.E., & Phillips-Quagliata, J.M. (2002). Origin and homing of intestinal IgA antibody-secreting cells. Journal of Experimental Medicine, 195(2), F5\u2013F8. doi:10.1084\/jem.20011910","DOI":"10.1084\/jem.20011910"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Lee, K.J. (2015). Pharmacologic agents for chronic diarrhea. Intestinal Research, 13, 306\u2013312. doi:10.5217\/ir.2015.13.4.306","DOI":"10.5217\/ir.2015.13.4.306"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Lee, Y.J., & Park, K.S. (2014). Irritable bowel syndrome: Emerging paradigm in pathophysiology. World Journal of Gastroenterology, 20, 2456\u20132469. doi:10.3748\/wjg.v20.i10.2456","DOI":"10.3748\/wjg.v20.i10.2456"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Lin, J., Fan, R., Zhao, Z., Cummings, O.W., & Chen, S. (2013). Is the presence of 6 or fewer crypt apoptotic bodies sufficient for diagnosis of graft versus host disease? A decade of experience at a single institution. American Journal of Surgical Pathology, 37, 539\u2013547. doi:10.1097\/PAS.0b013e318272c62a","DOI":"10.1097\/PAS.0b013e318272c62a"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Lokhorst, H., Einsele, H., Vesole, D., Bruno, B., San Miguel, J., San P\u00e9rez-Simon, J.A., . . . Bensinger, W. (2010). International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma. Journal of Clinical Oncology, 28, 4521\u20134530. doi:10.1200\/jco.2010.29.7929","DOI":"10.1200\/JCO.2010.29.7929"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Maroun, J.A., Anthony, L.B., Blais, N., Burkes, R., Dowden, S.D., Dranitsaris, G., . . . Wong, R. (2007). Prevention and management of chemotherapy-induced diarrhea in patients with colorectal cancer: A consensus statement by the Canadian Working Group on Chemotherapy-Induced Diarrhea. Current Oncology, 14, 13\u201320. doi:10.3747\/co.2007.96","DOI":"10.3747\/co.2007.96"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Martenson, J.A., Halyard, M.Y., Sloan, J.A., Proulx, G.M., Miller, R.C., Deming, R.L., . . . Atherton, P.J. (2008). Phase III, double-blind study of depot octreotide versus placebo in the prevention of acute diarrhea in patients receiving pelvic radiation therapy: Results of North Central Cancer Treatment Group N00CA. Journal of Clinical Oncology, 26, 5248\u20135253. doi:10.1200\/jco.2008.17.1546","DOI":"10.1200\/JCO.2008.17.1546"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Melson, J., Jakate, S., Fung, H., Arai, S., & Keshavarzian, A. (2007). Crypt loss is a marker of clinical severity of acute gastrointestinal graft-versus-host disease. American Journal of Hematology, 82, 881\u2013886. doi:10.1002\/ajh.20976","DOI":"10.1002\/ajh.20976"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Miehlke, S., Madisch, A., Bethke, B., Morgner, A., Kuhlisch, E., Henker, C., . . . Stolte, M. (2008). Oral budesonide for maintenance treatment of collagenous colitis: A randomized, double-blind, placebo-controlled trial. Gastroenterology, 135, 1510\u20131516. doi:10.1053\/j.gastro.2008.07.081","DOI":"10.1053\/j.gastro.2008.07.081"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Miehlke, S., Madisch, A., Karimi, D., Wonschik, S., Kuhlisch, E., Beckmann, R., . . . Stolte, M. (2009). Budesonide is effective in treating lymphocytic colitis: A randomized double-blind placebo-controlled study. Gastroenterology, 136, 2092\u20132100.","DOI":"10.1053\/j.gastro.2009.02.078"},{"key":"45","unstructured":"Millennium Pharmaceuticals. (2014). Velcade\u00ae (bortezomib) [Package insert]. Cambridge, MA: Author."},{"key":"46","doi-asserted-by":"crossref","unstructured":"Moris, G. (2014). Inflammatory bowel disease: An increased risk factor for neurologic complications. World Journal of Gastroenterology, 20, 1228\u20131237. doi:10.3748\/wjg.v20.i5.1228","DOI":"10.3748\/wjg.v20.i5.1228"},{"key":"47","doi-asserted-by":"crossref","unstructured":"Muehlbauer, P.M., Thorpe, D., Davis, A., Drabot, R., Rawlings, B.L., & Kiker, E. (2009). Putting Evidence Into Practice: Evidence-based interventions to prevent, manage, and treat chemotherapy- and radiotherapy-induced diarrhea. Clinical Journal of Oncology Nursing, 13, 336\u2013341. doi:10.1188\/09.CJON.336-341","DOI":"10.1188\/09.CJON.336-341"},{"key":"48","doi-asserted-by":"crossref","unstructured":"Nitzan, O., Elias, M., Chazan, B., Raz, R., & Saliba, W. (2013). Clostridium difficile and inflammatory bowel disease: Role in pathogenesis and implications in treatment. World Journal of Gastroenterology, 19, 7577\u20137585. doi:10.3748\/wjg.v19.i43.7577","DOI":"10.3748\/wjg.v19.i43.7577"},{"key":"49","doi-asserted-by":"crossref","unstructured":"Nucci, M., & Anaissie, E. (2009a). Infections in patients with multiple myeloma. Seminars in Hematology, 46, 277\u2013288. doi:10.1053\/j.seminhematol.2009.03.006","DOI":"10.1053\/j.seminhematol.2009.03.006"},{"key":"50","doi-asserted-by":"crossref","unstructured":"Nucci, M., & Anaissie, E. (2009b). Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents. Clinical Infectious Diseases, 49, 1211\u20131225. doi:10.1086\/605664","DOI":"10.1086\/605664"},{"key":"51","unstructured":"Sale, G.E., Lerner, K.G., Barker, E.A., Shulman, H.M., & Thomas, E.D. (1977). The skin biopsy in the diagnosis of acute graft-versus-host disease in man. American Journal of Pathology, 89, 621\u2013635."},{"key":"52","doi-asserted-by":"crossref","unstructured":"Salminen, E., Elomaa, I., Minkkinen, J., Vapaatalo, H., & Salminen, S. (1988). Preservation of intestinal integrity during radiotherapy using live Lactobacillus acidophilus cultures. Clinical Radiology, 39, 435\u2013437. doi:10.1016\/S0009-9260(88)80296-4","DOI":"10.1016\/S0009-9260(88)80296-4"},{"key":"53","doi-asserted-by":"crossref","unstructured":"Siah, K.T., Wong, R.K., & Ho, K.Y. (2014). Melatonin for the treatment of irritable bowel syndrome. World Journal of Gastroenterology, 20, 2492\u20132498. doi:10.3748\/wjg.v20.i10.2492","DOI":"10.3748\/wjg.v20.i10.2492"},{"key":"54","doi-asserted-by":"crossref","unstructured":"Siitonen, S., Vapaatalo, H., Salminen, S., Gordin, A., Saxelin, M., Wikberg, R., & Kirkkola, A.L. (1990). Effect of Lactobacillus GG yoghurt in prevention of antibiotic associated diarrhoea. Annals of Medicine, 22, 57\u201359. doi:10.3109\/07853899009147243","DOI":"10.3109\/07853899009147243"},{"key":"55","doi-asserted-by":"crossref","unstructured":"Simpson, L., Rajkumar, S.V., Dispenzieri, A., Lacy, M.Q., Hayman, S., Roy, V., . . . Kumar, S. (2008). High incidence of diarrhea in patients on long term therapy with lenalidomide and dexamethasone for multiple myeloma. Journal of Clinical Oncology, 26(Suppl.), abstract 8586.","DOI":"10.1200\/jco.2008.26.15_suppl.8586"},{"key":"56","doi-asserted-by":"crossref","unstructured":"Smith, L.C., Bertolotti, P., Curran, K., & Jenkins, B. (2008). Gastrointestinal side effects associated with novel therapies in patients with multiple myeloma: Consensus statement of the IMF Nurse Leadership Board. Clinical Journal of Oncology Nursing, 12(Suppl.), 37\u201352. doi:10.1188\/08.CJON.S1.37-51","DOI":"10.1188\/08.CJON.S1.37-51"},{"key":"57","doi-asserted-by":"crossref","unstructured":"Sornsuvit, C., Komindr, S., Chuncharunee, S., Wanikiat, P., Archararit, N., & Santanirand, P. (2008). Pilot study: Effects of parenteral glutamine dipeptide supplementation on neutrophil functions and prevention of chemotherapy-induced side-effects in acute myeloid leukaemia patients. Journal of International Medical Research, 36, 1383\u20131391. doi:10.1177\/147323000803600628","DOI":"10.1177\/147323000803600628"},{"key":"58","unstructured":"Sun, J., Wang, H., & Hu, H. (2012). Glutamine for chemotherapy induced diarrhea: A meta-analysis. Asia Pacific Journal of Clinical Nutrition, 21, 380\u2013385."},{"key":"59","doi-asserted-by":"crossref","unstructured":"Surawicz, C.M., Brandt, L.J., Binion, D.G., Ananthakrishnan, A.N., Curry, S.R., Gilligan, P.H., . . . Zuckerbraun, B.S. (2013). Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. American Journal of Gastroenterology, 108, 478\u2013498. doi:10.1038\/ajg.2013.4","DOI":"10.1038\/ajg.2013.4"},{"key":"60","doi-asserted-by":"crossref","unstructured":"Tam, C.C., Viviani, L., Rodrigues, L.C., & O\u2019Brien, S.J. (2013). The second study of infectious intestinal disease (IID2): Increased rates of recurrent diarrhoea in individuals aged 65 years and above. BMC Public Health, 13, 739. doi:10.1186\/1471-2458-13-739","DOI":"10.1186\/1471-2458-13-739"},{"key":"61","unstructured":"Thorpe, D.M., Byar, K., Conley, S., Davis, A.B., Drapek, A., Hays, A., . . . Kiker, E. (2016). Putting Evidence Into Practice: Diarrhea. Retrieved from https:\/\/www.ons.org\/practice-resources\/pep\/diarrhea"},{"key":"62","doi-asserted-by":"crossref","unstructured":"Tromm, A., Bunganic, I., Tomsov\u00e1, E., Tulassay, Z., Luk\u00e1\u0161, M., Kykal, J., . . . Greinwald, R. (2011). Budesonide 9 mg is at least as effective as mesalamine 4.5 g in patients with mildly to moderately active Crohn\u2019s disease. Gastroenterology, 140, 425\u2013434. doi:10.1053\/j.gastro.2010.11.004","DOI":"10.1053\/j.gastro.2010.11.004"},{"key":"63","doi-asserted-by":"crossref","unstructured":"Umar, S. (2010). Intestinal stem cells. Current Gastroenterology Reports, 12, 340\u2013348. doi:10.1007\/s11894-010-0130-3","DOI":"10.1007\/s11894-010-0130-3"},{"key":"64","doi-asserted-by":"crossref","unstructured":"Van Gossum, A., Schmit, A., & Peny, M.O. (1998). Oral budesonide for lymphocytic colitis. American Journal of Gastroenterology, 93, 270\u2013270. doi:10.1111\/j.1572-0241.1998.270_1.x","DOI":"10.1111\/j.1572-0241.1998.270_1.x"},{"key":"65","doi-asserted-by":"crossref","unstructured":"Van Neil, C.W., Feudtner, C., Garrison, M.M., & Christakis, D.A. (2002). Lactobacillus therapy for acute infectious diarrhea in children: A meta-analysis. Pediatrics, 109, 678\u2013684. doi:10.1542\/peds.109.4.678","DOI":"10.1542\/peds.109.4.678"},{"key":"66","doi-asserted-by":"crossref","unstructured":"Vighi, G., Marcucci, F., Sensi, L., Di Cara, G., & Frati, F. (2008). Allergy and the gastrointestinal system. Clinical and Experimental Immunology, 153(Suppl. 1), 3\u20136. doi:10.1111\/j.1365-2249.2008.03713.x","DOI":"10.1111\/j.1365-2249.2008.03713.x"},{"key":"67","doi-asserted-by":"crossref","unstructured":"Weiner, H.L. (2000). Oral tolerance, an active immunologic process mediated by multiple mechanisms. Journal of Clinical Investigation, 106, 935\u2013937. doi:10.1172\/JCI11348","DOI":"10.1172\/JCI11348"}],"container-title":["Clinical Journal of Oncology Nursing"],"original-title":[],"link":[{"URL":"http:\/\/cjon.ons.org\/cjon\/20\/4\/diarrhea-multiple-myeloma-review-literature","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:52:34Z","timestamp":1763754754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ons.org\/publications-research\/cjon\/20\/4\/diarrhea-multiple-myeloma-review-literature"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8,1]]}},"URL":"https:\/\/doi.org\/10.1188\/16.cjon.e100-e105","relation":{},"ISSN":["1092-1095","1538-067X"],"issn-type":[{"type":"print","value":"1092-1095"},{"type":"electronic","value":"1538-067X"}],"subject":[],"published":{"date-parts":[[2016,8,1]]}}}