{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:51:15Z","timestamp":1792191075290,"version":"4.4.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T00:00:00Z","timestamp":1131580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"TMRC"},{"name":"PRONEX"},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INSERM-FIOCRUZ"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Peripheral blood CD16 (Fc receptor for immunoglobulin G III)-positive monocytes have been shown to expand in different pathological conditions, such as cancer, asthma, sepsis, human immunodeficiency virus infection, and AIDS progression, but data in leishmaniasis are lacking. We found that cutaneous leishmaniasis patients (n=15) displayed a significant increase in the ercentage (3.5 vs. 10.1) as well as mean fluorescent intensity (13.5 vs. 29.2) of ex vivo CD16 expression in monocytes as compared with healthy controls. We observed a significant positive correlation between the percentage of ex vivo CD16+ monocytes and lesion size (P=0.0052, r=0.75) or active transforming growth factor-\u03b2 plasma levels (P=0.0017, r=0.78). In addition, two patients with nonhealing lesions during a 3-year follow-up had high (9.1\u201319.4%) CD16 levels at diagnosis. Our data suggest a deleterious role for CD16 in human leishmaniasis, as well as its possible use as a marker for disease severity and\/or adverse disease outcome.<\/jats:p>","DOI":"10.1189\/jlb.0105040","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T01:44:40Z","timestamp":1131673480000},"page":"36-39","source":"Crossref","is-referenced-by-count":35,"title":["CD16+ monocytes in human cutaneous leishmaniasis: increased ex vivo levels and correlation with clinical data"],"prefix":"10.1093","volume":"79","author":[{"given":"George","family":"Soares","sequence":"first","affiliation":[{"name":"LIMI, LIP, Gon\u00e7alo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ) , Salvador-Bahia, Brazil; and Institute for Immunological Investigation, S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldina","family":"Barral","sequence":"additional","affiliation":[{"name":"LIMI, LIP, Gon\u00e7alo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ) , Salvador-Bahia, Brazil; and Institute for Immunological Investigation, S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson M","family":"Costa","sequence":"additional","affiliation":[{"name":"LIMI, LIP, Gon\u00e7alo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ) , Salvador-Bahia, Brazil; and Institute for Immunological Investigation, S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel","family":"Barral-Netto","sequence":"additional","affiliation":[{"name":"LIMI, LIP, Gon\u00e7alo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ) , Salvador-Bahia, Brazil; and Institute for Immunological Investigation, S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Weyenbergh","sequence":"additional","affiliation":[{"name":"LIMI, LIP, Gon\u00e7alo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ) , Salvador-Bahia, Brazil; and Institute for Immunological Investigation, S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,11,10]]},"reference":[{"key":"2023033022225655700_jlb0036-cit-1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0167-5699(96)10029-3","article-title":"Heterogeneity of human blood monocytes: the CD14+CD16+ subpopulation","volume":"17","author":"Ziegler-Heitbrock","year":"1996","journal-title":"Immunol. 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